KEGG   DRUG: Fluvastatin
Entry
D07983                      Drug                                   

Name
Fluvastatin (INN);
Fluvas (TN)
Formula
C24H26FNO4
Exact mass
411.1846
Mol weight
411.4659
Structure
Simcomp
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Same as: C07014
ATC code: C10AA04
Chemical structure group: DG00354
Product (DG00354): D00892<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D07983  Fluvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D07983  Fluvastatin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07983
 Drug transporters
  D07983
Other DBs
CAS: 93957-54-1
PubChem: 96024677
ChEBI: 38561 5136
ChEMBL: CHEMBL350239
DrugBank: DB01095
LigandBox: D07983
NIKKAJI: J360.319I
LinkDB
KCF data

ATOM        30
            1   C8y C    20.9855  -16.8573
            2   C8x C    20.9855  -18.2563
            3   C8x C    22.1746  -18.9557
            4   C8y C    23.4336  -18.2563
            5   C8x C    23.4336  -16.8573
            6   C8x C    22.1746  -16.1579
            7   X   F    19.7964  -16.1579
            8   C8y C    24.6227  -18.9557
            9   C8y C    25.1123  -20.2847
            10  C8y C    26.4413  -20.2847
            11  N4y N    26.8610  -18.9557
            12  C8y C    25.7418  -18.1164
            13  C8x C    24.4129  -21.5437
            14  C8x C    25.1123  -22.8028
            15  C8x C    26.5113  -22.8028
            16  C8x C    27.2107  -21.5437
            17  C2b C    25.7418  -16.7174
            18  C1a C    29.3091  -18.9557
            19  C1c C    28.1200  -18.2563
            20  C1a C    28.1200  -16.8573
            21  C2b C    26.9309  -16.0180
            22  C1c C    26.9309  -14.6191
            23  C1b C    28.1200  -13.9196
            24  C1c C    29.3091  -14.6191
            25  C1b C    30.4982  -13.9196
            26  C6a C    31.6873  -14.6191
            27  O6a O    32.8764  -13.9196
            28  O6a O    31.6873  -16.0180
            29  O1a O    25.7418  -13.9196
            30  O1a O    29.3091  -16.0180
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 2
            14    9  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   10  16 2
            19   12  17 1
            20   18  19 1
            21   11  19 1
            22   19  20 1
            23   17  21 2
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   22  29 1 #Down
            32   24  30 1 #Up

» Japanese version   » Back

KEGG   DRUG: Fluvastatin sodium
Entry
D00892                      Drug                                   

Name
Fluvastatin sodium (JAN/USP);
Lescol (TN)
Product
  Generic
Formula
C24H25FNO4. Na
Exact mass
433.1665
Mol weight
433.4478
Structure
Simcomp
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Therapeutic category: 2189
ATC code: C10AA04
Chemical structure group: DG00354
Product (DG00354): D00892<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Hypercholesterolemia (Heterozygous familial) [DS:H00155]
Mixed dyslipidemia [DS:H01635]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Transporter inhibition: ABCB11 [HSA:8647]
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA04 Fluvastatin
      D00892  Fluvastatin sodium (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Fluvastatin
    D00892  Fluvastatin sodium (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D00892  Fluvastatin sodium (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D00892  Fluvastatin sodium (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00892
 Drug transporters
  D00892
Other DBs
CAS: 93957-55-2
PubChem: 7847956
ChEBI: 5137
ChEMBL: CHEMBL241778
DrugBank: DB01095
LigandBox: D00892
NIKKAJI: J556.740H
LinkDB
KCF data

ATOM        31
            1   Z   Na   25.8336  -11.8516 #+
            2   C8y C    12.5783  -14.7270
            3   C8x C    12.5783  -16.1297
            4   C8x C    13.7706  -16.8311
            5   C8y C    15.0330  -16.1297
            6   C8x C    15.0330  -14.7270
            7   C8x C    13.7706  -14.0257
            8   X   F    11.3861  -14.0257
            9   C8y C    16.2253  -16.8311
            10  C8y C    16.7162  -18.1636
            11  C8y C    18.0488  -18.1636
            12  N4y N    18.4696  -16.8311
            13  C8y C    17.3474  -15.9895
            14  C8x C    16.0149  -19.3559
            15  C8x C    16.7162  -20.6183
            16  C8x C    18.1189  -20.6183
            17  C8x C    18.8203  -19.3559
            18  C2b C    17.3474  -14.5868
            19  C1a C    20.9243  -16.8311
            20  C1c C    19.7320  -16.1297
            21  C1a C    19.7320  -14.7270
            22  C2b C    18.5397  -13.8854
            23  C1c C    18.5397  -12.4828
            24  C1b C    19.7320  -11.7814
            25  C1c C    20.9243  -12.4828
            26  C1b C    22.1165  -11.7814
            27  C6a C    23.3088  -12.4828
            28  O6a O    24.5011  -11.7814 #-
            29  O6a O    23.3088  -13.8854
            30  O1a O    17.3474  -11.7814
            31  O1a O    20.9243  -13.8854
BOND        32
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     5   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 2
            14   10  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   11  17 2
            19   13  18 1
            20   19  20 1
            21   12  20 1
            22   20  21 1
            23   18  22 2
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   27  29 2
            31   23  30 1 #Down
            32   25  31 1 #Up

» Japanese version   » Back

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