| Entry |
|
|---|
| Name |
Nicardipine hydrochloride (JP18/USAN);
Cardene (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C26H29N3O6. HCl
|
|---|
| Exact mass |
515.1823
|
|---|
| Mol weight |
515.9859
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
Other
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
Metabolizing enzyme substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2149 |
| Product (DG00323): | D00617<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Disease |
|
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA04 Nicardipine
D00617 Nicardipine hydrochloride (JP18/USAN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents, Dihydropyridines
Nicardipine
D00617 Nicardipine hydrochloride (JP18/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00617 Nicardipine hydrochloride (JP18/USAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00617 Nicardipine hydrochloride (JP18/USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00617 Nicardipine hydrochloride
D00617 Nicardipine hydrochloride injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00617
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 C1y C 19.9164 -15.4819
2 C8y C 19.9164 -16.8638
3 C2y C 21.1058 -14.7939
4 C2y C 18.7210 -14.7939
5 C8x C 21.1175 -17.5519
6 C8x C 18.7327 -17.5519
7 C2y C 21.1058 -13.4118
8 C7a C 22.3071 -15.4819
9 C2y C 18.7210 -13.4118
10 C7a C 17.5256 -15.4877
11 C8y C 21.1234 -18.9280
12 C8x C 18.7327 -18.9339
13 N1x N 19.9164 -12.7238
14 C1a C 22.3071 -12.7238
15 O7a O 23.5024 -14.7939
16 O6a O 22.3071 -16.8638
17 C1a C 17.5256 -12.7238
18 O7a O 16.3244 -14.7939
19 O6a O 17.5256 -16.8638
20 C8x C 19.9280 -19.6220
21 N2b N 22.3245 -19.6220 #+
22 C1b C 24.6976 -15.4819
23 C1a C 15.1290 -15.4877
24 O3a O 23.8231 -18.6598
25 O3a O 22.3536 -21.3130 #-
26 C1b C 25.8989 -14.7880
27 N1c N 27.0884 -15.4819
28 C1b C 28.2837 -14.7880
29 C1a C 27.0943 -16.8638
30 C8y C 29.4791 -15.4760
31 C8x C 29.4791 -16.8581
32 C8x C 30.6804 -14.7880
33 C8x C 30.6804 -17.5461
34 C8x C 31.8757 -15.4760
35 C8x C 31.8757 -16.8581
36 X Cl 35.0069 -16.2400
BOND 37
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 2
11 6 12 1
12 7 13 1
13 7 14 1
14 8 15 1
15 8 16 2
16 9 17 1
17 10 18 1
18 10 19 2
19 11 20 1
20 11 21 1
21 15 22 1
22 18 23 1
23 21 24 2
24 21 25 1
25 22 26 1
26 26 27 1
27 27 28 1
28 27 29 1
29 28 30 1
30 30 31 2
31 30 32 1
32 31 33 1
33 32 34 2
34 33 35 2
35 9 13 1
36 12 20 2
37 34 35 1
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