KEGG   DRUG: Orphenadrine
Entry
D08305                      Drug                                   
Name
Orphenadrine (INN);
Mialgin (TN)
Formula
C18H23NO
Exact mass
269.178
Mol weight
269.3813
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
Musculo-skeletal system agent
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
Remark
Same as: C07935
Chemical structure group: DG01252
Product (DG01252): D00774<US>
Efficacy
Skeletal muscle relaxant, Muscarinic acetylcholine receptor antagonist, H1 receptor antagonist
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
     D08305  Orphenadrine
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
     D08305  Orphenadrine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D08305  Orphenadrine (INN)
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D08305  Orphenadrine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
Other DBs
CAS: 83-98-7
PubChem: 96024992
ChEBI: 7789
LigandBox: D08305
NIKKAJI: J4.888G
LinkDB
KCF data

ATOM        20
            1   C1a C    19.3200  -19.3200
            2   N1c N    20.5100  -18.6200
            3   C1b C    21.7700  -19.3200
            4   C1b C    22.9600  -18.6200
            5   O2a O    24.1500  -19.3200
            6   C1c C    25.4100  -18.6200
            7   C8y C    26.6000  -19.3200
            8   C8y C    25.4100  -17.2200
            9   C8x C    26.6000  -16.5200
            10  C8x C    26.6000  -15.1200
            11  C8x C    25.3400  -14.4200
            12  C8x C    24.1500  -15.1200
            13  C8y C    24.1500  -16.5200
            14  C8x C    26.6000  -20.7200
            15  C8x C    27.7900  -21.4200
            16  C8x C    29.0500  -20.7200
            17  C8x C    29.0500  -19.3200
            18  C8x C    27.7900  -18.6200
            19  C1a C    22.9600  -17.2200
            20  C1a C    20.5100  -17.2200
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     6   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13    8  13 1
            14    7  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19    7  18 2
            20   13  19 1
            21    2  20 1

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KEGG   DRUG: Orphenadrine citrate
Entry
D00774                      Drug                                   
Name
Orphenadrine citrate (USP);
Norflex (TN)
Product
  Generic
Formula
C18H23NO. C6H8O7
Exact mass
461.205
Mol weight
461.5048
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
Musculo-skeletal system agent
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
Remark
ATC code: M03BC01
Chemical structure group: DG01252
Product (DG01252): D00774<US>
Product (mixture): D11849<US>
Efficacy
Skeletal muscle relaxant
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
    M03BC Ethers, chemically close to antihistamines
     M03BC01 Orphenadrine (citrate)
      D00774  Orphenadrine citrate (USP) <US>
USP drug classification [BR:br08302]
 Skeletal Muscle Relaxants
  Orphenadrine
   D00774  Orphenadrine citrate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
     D00774  Orphenadrine citrate
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
     D00774  Orphenadrine citrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00774  Orphenadrine citrate (USP) <US>
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D00774  Orphenadrine citrate (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
Other DBs
CAS: 4682-36-4
PubChem: 7847839
ChEBI: 7790
LigandBox: D00774
NIKKAJI: J244.696K
LinkDB
KCF data

ATOM        33
            1   C1d C    30.7401  -20.6868
            2   C1b C    29.5286  -21.3832
            3   C1b C    31.9516  -21.3772
            4   C6a C    31.4307  -19.4693
            5   O1a O    30.0318  -19.4693
            6   C6a C    28.3229  -20.6926
            7   C6a C    31.9399  -22.7762
            8   O6a O    30.7225  -18.2521
            9   O6a O    32.8354  -19.4693
            10  O6a O    27.1115  -21.3949
            11  O6a O    28.3812  -19.2939
            12  O6a O    33.1515  -23.4785
            13  O6a O    30.7225  -23.4726
            14  C1a C    15.8780  -22.1988
            15  N1c N    17.0919  -21.4980
            16  C1b C    18.3057  -22.1988
            17  C1b C    19.5196  -21.4980
            18  O2a O    20.7334  -22.1988
            19  C1c C    21.9472  -21.4980
            20  C8y C    23.1611  -22.1988
            21  C8y C    21.9472  -20.0965
            22  C8x C    23.1483  -19.4030
            23  C8x C    23.1482  -18.0013
            24  C8x C    21.9343  -17.3006
            25  C8x C    20.7333  -17.9941
            26  C8y C    20.7334  -19.3958
            27  C8x C    23.1611  -23.6005
            28  C8x C    24.3750  -24.3013
            29  C8x C    25.5889  -23.6005
            30  C8x C    25.5889  -22.1988
            31  C8x C    24.3750  -21.4980
            32  C1a C    19.5237  -20.0943
            33  C1a C    17.0919  -20.0964
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   19  21 1
            20   21  22 2
            21   22  23 1
            22   23  24 2
            23   24  25 1
            24   25  26 2
            25   21  26 1
            26   20  27 1
            27   27  28 2
            28   28  29 1
            29   29  30 2
            30   30  31 1
            31   20  31 2
            32   26  32 1
            33   15  33 1

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KEGG   DRUG: Orphenadrine hydrochloride
Entry
D02599                      Drug                                   
Name
Orphenadrine hydrochloride;
Disipal (TN)
Formula
C18H23NO. HCl
Exact mass
305.1546
Mol weight
305.8423
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
Musculo-skeletal system agent
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
Remark
ATC code: N04AB02
Chemical structure group: DG01252
Product (DG01252): D00774<US>
Efficacy
Skeletal muscle relaxant, Muscarinic acetylcholine receptor antagonist, H1 receptor antagonist
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AB Ethers chemically close to antihistamines
     N04AB02 Orphenadrine (chloride)
      D02599  Orphenadrine hydrochloride
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
     D02599  Orphenadrine hydrochloride
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
     D02599  Orphenadrine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D02599  Orphenadrine hydrochloride
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D02599  Orphenadrine hydrochloride
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG01252  Orphenadrine
 Musculo-skeletal system agent
  DG02029  Muscle relaxant
   DG01974  Centrally acting muscle relaxant
    DG01252  Orphenadrine
Other DBs
CAS: 341-69-5
PubChem: 17396769
ChEBI: 60902
LigandBox: D02599
NIKKAJI: J2.205.659J
LinkDB
KCF data

ATOM        21
            1   X   Cl   41.4554  -19.1198
            2   C1a C    30.9280  -20.7988
            3   N1c N    32.1419  -20.0980
            4   C1b C    33.3557  -20.7988
            5   C1b C    34.5696  -20.0980
            6   O2a O    35.7834  -20.7988
            7   C1c C    36.9972  -20.0980
            8   C8y C    38.2111  -20.7988
            9   C8y C    36.9972  -18.6965
            10  C8x C    38.1983  -18.0030
            11  C8x C    38.1982  -16.6013
            12  C8x C    36.9843  -15.9006
            13  C8x C    35.7833  -16.5941
            14  C8y C    35.7834  -17.9958
            15  C8x C    38.2111  -22.2005
            16  C8x C    39.4250  -22.9013
            17  C8x C    40.6389  -22.2005
            18  C8x C    40.6389  -20.7988
            19  C8x C    39.4250  -20.0980
            20  C1a C    34.5737  -18.6943
            21  C1a C    32.1419  -18.6964
BOND        21
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     7   9 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14    8  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19    8  19 2
            20   14  20 1
            21    3  21 1

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