KEGG   DRUG: Pirmenol
Entry
D08394                      Drug                                   
Name
Pirmenol (INN)
Formula
C22H30N2O
Exact mass
338.2358
Mol weight
338.4864
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
Chemical structure group: DG01381
Product (DG01381): D01785<JP>
Efficacy
Antiarrhythmic
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
      D08394  Pirmenol
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08394  Pirmenol (INN)
    SCN2A
     D08394  Pirmenol (INN)
    SCN3A
     D08394  Pirmenol (INN)
    SCN4A
     D08394  Pirmenol (INN)
    SCN5A
     D08394  Pirmenol (INN)
    SCN8A
     D08394  Pirmenol (INN)
    SCN9A
     D08394  Pirmenol (INN)
    SCN10A
     D08394  Pirmenol (INN)
    SCN11A
     D08394  Pirmenol (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
Other DBs
CAS: 68252-19-7
PubChem: 96025080
ChEBI: 135436
LigandBox: D08394
NIKKAJI: J252.795B
LinkDB
KCF data

ATOM        25
            1   C8x C    19.9500  -20.3700
            2   C8x C    19.9500  -21.7700
            3   C8x C    21.1400  -22.4700
            4   C8x C    22.3300  -21.7700
            5   C8y C    22.3300  -20.3700
            6   C8x C    21.1400  -19.6700
            7   C1d C    23.5900  -19.6700
            8   C8y C    24.7800  -20.3700
            9   C8x C    24.7800  -21.7700
            10  C8x C    25.9700  -22.4700
            11  C8x C    27.2300  -21.7700
            12  C8x C    27.2300  -20.3700
            13  N5x N    25.9700  -19.6700
            14  C1b C    23.5900  -18.2700
            15  C1b C    24.7800  -17.5700
            16  C1b C    24.7800  -16.1700
            17  N1y N    25.9700  -15.4700
            18  C1y C    27.2300  -16.1700
            19  C1x C    28.4200  -15.4700
            20  C1x C    28.4200  -14.0700
            21  C1x C    27.2300  -13.3700
            22  C1y C    25.9700  -14.0700
            23  C1a C    24.7800  -13.3700
            24  C1a C    27.2300  -17.5700
            25  O1a O    22.4000  -18.9700
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

» Japanese version   » Back

KEGG   DRUG: Pirmenol hydrochloride hydrate
Entry
D01785                      Drug                                   
Name
Pirmenol hydrochloride hydrate (JAN);
Pimenol (TN)
Formula
C22H30N2O. HCl. H2O
Exact mass
392.2231
Mol weight
392.9626
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
Therapeutic category: 2129
Chemical structure group: DG01381
Product (DG01381): D01785<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01785  Pirmenol hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
      D01785  Pirmenol hydrochloride hydrate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D01785  Pirmenol hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN2A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN3A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN4A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN5A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN8A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN9A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN10A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
    SCN11A
     D01785  Pirmenol hydrochloride hydrate (JAN) <JP>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
Other DBs
PubChem: 7848847
ChEBI: 32017
LigandBox: D01785
LinkDB
KCF data

ATOM        27
            1   C8x C    26.8670  -19.6231
            2   C8x C    26.8670  -21.0248
            3   C8x C    28.0838  -21.7256
            4   C8x C    29.2935  -21.0248
            5   C8y C    29.2935  -19.6231
            6   C8x C    28.0838  -18.9223
            7   C1d C    30.5080  -18.9233
            8   C8y C    31.7214  -19.6250
            9   C8x C    31.7148  -21.0246
            10  C8x C    32.9282  -21.7265
            11  C8x C    34.1425  -21.0265
            12  C8x C    34.1435  -19.6248
            13  N5x N    32.9303  -18.9231
            14  C1b C    30.5058  -17.5277
            15  C1b C    31.7163  -16.8269
            16  C1b C    31.7163  -15.4323
            17  N1y N    32.9269  -14.7315
            18  C1y C    34.1391  -15.4294
            19  C1x C    35.3498  -14.7286
            20  C1x C    35.3481  -13.3297
            21  C1x C    34.1357  -12.6318
            22  C1y C    32.9252  -13.3326
            23  C1a C    31.7104  -12.6331
            24  C1a C    34.1408  -16.8311
            25  O1a O    29.2955  -18.2233
            26  X   Cl   38.3976  -18.6187
            27  O0  O    38.7100  -16.8700
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

» Japanese version   » Back

KEGG   DRUG: Pirmenol hydrochloride
Entry
D06517                      Drug                                   
Name
Pirmenol hydrochloride (USAN);
Pirmavar (TN)
Formula
C22H30N2O. HCl
Exact mass
374.2125
Mol weight
374.9473
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
Chemical structure group: DG01381
Product (DG01381): D01785<JP>
Efficacy
Antiarrhythmic, Cardiac depressant
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
      D06517  Pirmenol hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D06517  Pirmenol hydrochloride (USAN)
    SCN2A
     D06517  Pirmenol hydrochloride (USAN)
    SCN3A
     D06517  Pirmenol hydrochloride (USAN)
    SCN4A
     D06517  Pirmenol hydrochloride (USAN)
    SCN5A
     D06517  Pirmenol hydrochloride (USAN)
    SCN8A
     D06517  Pirmenol hydrochloride (USAN)
    SCN9A
     D06517  Pirmenol hydrochloride (USAN)
    SCN10A
     D06517  Pirmenol hydrochloride (USAN)
    SCN11A
     D06517  Pirmenol hydrochloride (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
Other DBs
CAS: 61477-94-9
PubChem: 47208173
LigandBox: D06517
NIKKAJI: J354.310B
LinkDB
KCF data

ATOM        26
            1   C8x C    26.8663  -19.6226
            2   C8x C    26.8663  -21.0243
            3   C8x C    28.0831  -21.7251
            4   C8x C    29.2928  -21.0243
            5   C8y C    29.2928  -19.6226
            6   C8x C    28.0831  -18.9218
            7   C1d C    30.5072  -18.9228
            8   C8y C    31.7206  -19.6245
            9   C8x C    31.7140  -21.0241
            10  C8x C    32.9274  -21.7260
            11  C8x C    34.1417  -21.0260
            12  C8x C    34.1427  -19.6243
            13  N5x N    32.9295  -18.9226
            14  C1b C    30.5050  -17.5273
            15  C1b C    31.7155  -16.8265
            16  C1b C    31.7155  -15.4319
            17  N1y N    32.9261  -14.7311
            18  C1y C    34.1383  -15.4290
            19  C1x C    35.3489  -14.7282
            20  C1x C    35.3472  -13.3294
            21  C1x C    34.1349  -12.6315
            22  C1y C    32.9244  -13.3323
            23  C1a C    31.7096  -12.6328
            24  C1a C    34.1400  -16.8307
            25  O1a O    29.2948  -18.2228
            26  X   Cl   37.2767  -18.6182
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

» Japanese version   » Back

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