KEGG   DRUG: Prazosin
Entry
D08411                      Drug                                   
Name
Prazosin (INN);
Minipress (TN)
Formula
C19H21N5O4
Exact mass
383.1594
Mol weight
383.40
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
 DG01739  Peripherally-acting antiadrenergic
 DG03231  Antihypertensive
Transporter inhibitor
 DG02881  SLC22A3 inhibitor
Remark
Same as: C07368
ATC code: C02CA01
Chemical structure group: DG00253
Product (DG00253): D00609<JP/US>
Efficacy
Antihypertensive, Vasodilator (peripheric), alpha1-Adrenergic receptor antagonist
Comment
Prazosin derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Transporter inhibition: SLC22A3 [HSA:6581]
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA01 Prazosin
      D08411  Prazosin (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00253  Prazosin
      D08411  Prazosin
  DG01739  Peripherally-acting antiadrenergic
   DG00253  Prazosin
    D08411  Prazosin
  DG03231  Antihypertensive
   DG00253  Prazosin
    D08411  Prazosin
 Transporter inhibitor
  DG02881  SLC22A3 inhibitor
   DG00253  Prazosin
    D08411  Prazosin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08411  Prazosin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D08411
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00253  Prazosin
  DG01739  Peripherally-acting antiadrenergic
   DG00253  Prazosin
  DG03231  Antihypertensive
   DG00253  Prazosin
 Transporter inhibitor
  DG02881  SLC22A3 inhibitor
   DG00253  Prazosin
Other DBs
CAS: 19216-56-9
PubChem: 96025097
ChEBI: 8364
PDB-CCD: XRA[PDBj]
LigandBox: D08411
NIKKAJI: J10.000E
LinkDB
KCF data

ATOM        28
            1   C8y C    27.1600  -19.6700
            2   C8y C    27.1600  -18.2700
            3   C8x C    28.3500  -20.3700
            4   C8y C    25.9000  -20.3700
            5   N5x N    25.9000  -17.5700
            6   C8x C    28.3500  -17.5700
            7   C8y C    29.5400  -19.6700
            8   N5x N    24.7100  -19.6700
            9   N1a N    25.9000  -21.7700
            10  C8y C    24.7100  -18.2700
            11  C8y C    29.5400  -18.2700
            12  O2a O    30.8000  -20.3700
            13  N1y N    23.5200  -17.5700
            14  O2a O    30.8000  -17.5700
            15  C1a C    31.9900  -19.6700
            16  C1x C    23.5200  -16.2400
            17  C1x C    22.2600  -18.2700
            18  C1a C    31.9900  -18.2700
            19  C1x C    22.2600  -15.4700
            20  C1x C    21.0700  -17.5700
            21  N1y N    21.0700  -16.2400
            22  C5a C    19.8800  -15.4700
            23  C8y C    18.6200  -16.2400
            24  O5a O    19.8800  -14.0700
            25  C8x C    18.2700  -17.5700
            26  O2x O    17.5000  -15.4000
            27  C8x C    16.8700  -17.5700
            28  C8x C    16.3800  -16.3100
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28    7  11 1
            29    8  10 1
            30   20  21 1
            31   27  28 2

» Japanese version   » Back

KEGG   DRUG: Prazosin hydrochloride
Entry
D00609                      Drug                                   
Name
Prazosin hydrochloride (JP18/USP);
Minipress (TN)
Product
  Generic
PRAZOSIN (Lannett Company), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HYDROCHLORIDE (A-S Medication Solutions), PRAZOSIN HYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAZOSIN HYDROCHLORIDE (Alembic Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (American Health Packaging), PRAZOSIN HYDROCHLORIDE (American Health Packaging), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aurobindo Pharma Limited), PRAZOSIN HYDROCHLORIDE (Biocon Pharma), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Cardinal Health 107), PRAZOSIN HYDROCHLORIDE (Cardinal Health 107), PRAZOSIN HYDROCHLORIDE (Exelan Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Golden State Medical Supply), PRAZOSIN HYDROCHLORIDE (Granules Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Greenstone LLC), PRAZOSIN HYDROCHLORIDE (Lifestar Pharma LLC), PRAZOSIN HYDROCHLORIDE (Major Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Marlex Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Mylan Institutional), PRAZOSIN HYDROCHLORIDE (Mylan Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Novitium Pharma LLC), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Prasco Laboratories), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (Quality Care Products), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C19H21N5O4. HCl
Exact mass
419.1360
Mol weight
419.86
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
 DG01739  Peripherally-acting antiadrenergic
 DG03231  Antihypertensive
Transporter inhibitor
 DG02881  SLC22A3 inhibitor
Remark
Therapeutic category: 2149
ATC code: C02CA01
Chemical structure group: DG00253
Product (DG00253): D00609<JP/US>
Efficacy
Antihypertensive, alpha1-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Prazosin derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Transporter inhibition: SLC22A3 [HSA:6581]
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA01 Prazosin
      D00609  Prazosin hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Prazosin
    D00609  Prazosin hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00609  Prazosin hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00253  Prazosin
      D00609  Prazosin hydrochloride
  DG01739  Peripherally-acting antiadrenergic
   DG00253  Prazosin
    D00609  Prazosin hydrochloride
  DG03231  Antihypertensive
   DG00253  Prazosin
    D00609  Prazosin hydrochloride
 Transporter inhibitor
  DG02881  SLC22A3 inhibitor
   DG00253  Prazosin
    D00609  Prazosin hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00609  Prazosin hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00609  Prazosin hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00609  Prazosin hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00609
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00253  Prazosin
  DG01739  Peripherally-acting antiadrenergic
   DG00253  Prazosin
  DG03231  Antihypertensive
   DG00253  Prazosin
 Transporter inhibitor
  DG02881  SLC22A3 inhibitor
   DG00253  Prazosin
Other DBs
CAS: 19237-84-4
PubChem: 7847675
ChEBI: 8365
LigandBox: D00609
NIKKAJI: J246.878F
LinkDB
KCF data

ATOM        29
            1   C8y C    33.1529  -18.8898
            2   C8y C    33.1529  -17.4829
            3   C8x C    34.3789  -19.5962
            4   C8y C    31.9444  -19.5962
            5   N5x N    31.9444  -16.7997
            6   C8x C    34.3789  -16.7997
            7   C8y C    35.5815  -18.8898
            8   N5x N    30.7358  -18.8898
            9   N1a N    31.9444  -20.9974
            10  C8y C    30.7358  -17.4829
            11  C8y C    35.5815  -17.4829
            12  O2a O    36.8134  -19.5962
            13  N1y N    29.5273  -16.7997
            14  O2a O    36.8134  -16.7997
            15  C1a C    38.0162  -18.8839
            16  C1x C    29.5273  -15.4044
            17  C1x C    28.3071  -17.4829
            18  C1a C    38.0162  -17.4944
            19  C1x C    28.3071  -14.6979
            20  C1x C    27.0985  -16.7997
            21  N1y N    27.0985  -15.4044
            22  C5a C    25.8726  -14.6979
            23  C8y C    24.6581  -15.4044
            24  O5a O    25.8726  -13.2909
            25  C8x C    24.2844  -16.7355
            26  O2x O    23.5022  -14.6220
            27  C8x C    22.8541  -16.7063
            28  C8x C    22.3929  -15.4803
            29  X   Cl   41.7809  -18.0958
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   23  26 1
            26   25  27 1
            27   26  28 1
            28    7  11 1
            29    8  10 1
            30   20  21 1
            31   27  28 2

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