KEGG   DRUG: Rabeprazole
Entry
D08463                      Drug                                   
Name
Rabeprazole (INN);
Eraloc (TN)
Formula
C18H21N3O3S
Exact mass
359.1304
Mol weight
359.4426
Structure
Simcomp
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07864
ATC code: A02BC04
Chemical structure group: DG00022
Product (DG00022): D00724<JP/US>
Product (mixture): D10519<JP>
Efficacy
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D08463  Rabeprazole (INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
     D08463  Rabeprazole
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
    D08463  Rabeprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole
     D08463  Rabeprazole
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D08463  Rabeprazole (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08463
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole
Other DBs
CAS: 117976-89-3
PubChem: 96025149
ChEBI: 8768
LigandBox: D08463
NIKKAJI: J395.966J
LinkDB
KCF data

ATOM        25
            1   C8x C    16.8700  -17.6400
            2   C8x C    16.8700  -19.0400
            3   C8x C    18.0600  -19.7400
            4   C8y C    19.2500  -19.0400
            5   C8y C    19.2500  -17.6400
            6   C8x C    18.0600  -16.9400
            7   N5x N    20.5800  -19.4600
            8   C8y C    21.4200  -18.3400
            9   N4x N    20.5800  -17.2200
            10  S4a S    22.8200  -18.3400
            11  C1b C    23.5200  -19.6000
            12  O3c O    23.5200  -17.1500
            13  C8y C    24.9200  -19.6000
            14  C8y C    25.6200  -20.7900
            15  C8y C    27.0200  -20.7900
            16  C8x C    27.7200  -19.5300
            17  C8x C    27.0200  -18.3400
            18  N5x N    25.6200  -18.3400
            19  C1a C    24.9200  -21.9800
            20  O2a O    27.7200  -21.9800
            21  C1b C    29.1200  -21.9800
            22  C1b C    29.8200  -23.1700
            23  C1b C    31.2200  -23.1700
            24  O2a O    31.9200  -24.3600
            25  C1a C    33.3200  -24.3600
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1

» Japanese version   » Back

KEGG   DRUG: Rabeprazole sodium
Entry
D00724                      Drug                                   
Name
Rabeprazole sodium (JP18/USP);
Aciphex (TN);
Pariet (TN)
Product
  Generic
RABEPRAZOLE SODIUM (Amneal Pharmaceuticals LLC), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (Advagen Pharma Limited), RABEPRAZOLE SODIUM (Advanced Rx Pharmacy of Tennessee), RABEPRAZOLE SODIUM (Advanced Rx Pharmacy of Tennessee), RABEPRAZOLE SODIUM (Ascend Laboratories), RABEPRAZOLE SODIUM (Asclemed USA), RABEPRAZOLE SODIUM (Asclemed USA), RABEPRAZOLE SODIUM (Aurobindo Pharma Limited), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (DIRECT RX), RABEPRAZOLE SODIUM (DIRECT RX), RABEPRAZOLE SODIUM (Golden State Medical Supply), RABEPRAZOLE SODIUM (Lannett Company), RABEPRAZOLE SODIUM (Lupin Pharmaceuticals), RABEPRAZOLE SODIUM (Medsource Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Quality Care Products), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), RABEPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), RABEPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), RABEPRAZOLE SODIUM (medsource pharmaceuticals), RABERPRAZOLE SODIUM D/R (DIRECT RX), RABERPRAZOLE SODIUM D/R (Direct_Rx)
Formula
C18H20N3O3S. Na
Exact mass
381.1123
Mol weight
381.4245
Structure
Simcomp
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07865
Therapeutic category: 2329
ATC code: A02BC04
Chemical structure group: DG00022
Product (DG00022): D00724<JP/US>
Product (mixture): D10519<JP> D10520<JP>
Efficacy
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
  Disease
Erosive or ulcerative GERD [DS:H01602]
Duodenal ulcer [DS:H01634]
Helicobacter pylori eradication [DS:H00320]
Zollinger-Ellison syndrome [DS:H01522]
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D00724  Rabeprazole sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D00724  Rabeprazole sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00724  Rabeprazole sodium (JP18/USP)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
     D00724  Rabeprazole sodium
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
    D00724  Rabeprazole sodium
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole
     D00724  Rabeprazole sodium
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01646  Proton pump inhibitor (PPI)
   D00724  Rabeprazole sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D00724  Rabeprazole sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00724  Rabeprazole sodium
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00724
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00724
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00724
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00724
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole
Other DBs
CAS: 117976-90-6
PubChem: 7847789
ChEBI: 8769
LigandBox: D00724
NIKKAJI: J561.822C
LinkDB
KCF data

ATOM        26
            1   Z   Na   14.9181  -21.7880 #+
            2   C8x C    11.7600  -23.5900
            3   C8x C    11.7600  -24.9900
            4   C8x C    12.9724  -25.6900
            5   C8y C    14.1849  -24.9900
            6   C8y C    14.1849  -23.5900
            7   C8x C    12.9724  -22.8900
            8   N5x N    15.5164  -25.4226
            9   C8y C    16.3393  -24.2900
            10  N4x N    15.5164  -23.1574 #-
            11  S4a S    17.7100  -24.2900
            12  C1b C    18.4100  -25.5024
            13  O3c O    18.4100  -23.0776
            14  C8y C    19.8098  -25.5024
            15  C8y C    20.5003  -26.6980
            16  C8y C    21.9003  -26.6978
            17  C8x C    22.6001  -25.4853
            18  C8x C    21.9097  -24.2898
            19  N5x N    20.5097  -24.2899
            20  C1a C    19.8149  -27.8852
            21  O2a O    22.5910  -27.8932
            22  C1b C    24.0096  -27.8932
            23  C1b C    24.6956  -29.0806
            24  C1b C    26.1097  -29.0806
            25  O2a O    26.7968  -30.2700
            26  C1a C    28.2097  -30.2699
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   15  20 1
            22   16  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1

» Japanese version   » Back

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