KEGG   DRUG: TrifluoperazineHelp
Entry
D08636                      Drug                                   

Name
Trifluoperazine (INN);
Apo-trifluoperazine (TN)
Formula
C21H24F3N3S
Exact mass
407.1643
Mol weight
407.4956
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
Same as: C07168
ATC code: N05AB06
Chemical structure group: DG00877
Product (DG00877): D00799<US>
Efficacy
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB06 Trifluoperazine
      D08636  Trifluoperazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D08636  Trifluoperazine (INN)
BRITE hierarchy
Other DBs
CAS: 117-89-5
PubChem: 96025319
ChEBI: 45951
ChEMBL: CHEMBL422
DrugBank: DB00831
PDB-CCD: TFP[PDBj]
LigandBox: D08636
NIKKAJI: J5.293K
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8y C    21.7000  -20.3700
            2   N1y N    22.8900  -19.6700
            3   C8y C    21.7000  -21.7700
            4   C8x C    20.5100  -19.6700
            5   C8y C    24.1500  -20.4400
            6   C1b C    22.8900  -18.2700
            7   S2x S    22.8900  -22.4700
            8   C8x C    20.5100  -22.4700
            9   C8x C    19.2500  -20.4400
            10  C8y C    24.1500  -21.7700
            11  C8x C    25.3400  -19.7400
            12  C1b C    24.1500  -17.5700
            13  C8x C    19.2500  -21.7700
            14  C8x C    25.3400  -22.4700
            15  C8y C    26.6000  -20.4400
            16  C1b C    24.1500  -16.1700
            17  C8x C    26.6000  -21.7700
            18  N1y N    25.3400  -15.4700
            19  C1x C    25.4100  -14.0700
            20  C1x C    26.6000  -16.1700
            21  C1x C    26.6000  -13.3700
            22  C1x C    27.8600  -15.4700
            23  N1y N    27.8600  -14.0700
            24  C1a C    29.0500  -13.3700
            25  C1d C    27.7900  -19.7400
            26  X   F    28.9800  -19.0400
            27  X   F    28.4900  -20.9300
            28  X   F    27.0900  -18.5500
BOND        31
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   12  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 1
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   21  23 1
            23   23  24 1
            24    7  10 1
            25    9  13 1
            26   15  17 1
            27   22  23 1
            28   15  25 1
            29   25  26 1
            30   25  27 1
            31   25  28 1

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