KEGG   DRUG: Warfarin
Entry
D08682                      Drug                                   

Name
Warfarin (INN);
Warfarine;
Choice (TN)
Formula
C19H16O4
Exact mass
308.1049
Mol weight
308.3279
Structure
Simcomp
Class
Cardiovascular agent
 DG01708  Coumarin anticoagulant
  DG01760  Warfarin and analog
 DG01950  Antithrombotic agent
  DG01708  Coumarin anticoagulant
   DG01760  Warfarin and analog
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Same as: C01541
ATC code: B01AA03
Chemical structure group: DG00149
Product (DG00149): D00564<US> D01280<JP>
Efficacy
Anticoagulant, Vitamin K antagonist
Comment
coumarin derivative
Target
VKORC1 [HSA:79001] [KO:K05357]
NQO1 [HSA:1728] [KO:K00355]
  Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AA Vitamin K antagonists
     B01AA03 Warfarin
      D08682  Warfarin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   NAD(P)H dehydrogenase
    NQO1
     D08682  Warfarin (INN)
   Vitamin-K-epoxide reductase
    VKORC1
     D08682  Warfarin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08682
Other DBs
CAS: 81-81-2
PubChem: 96025365
ChEBI: 10033
ChEMBL: CHEMBL1464
DrugBank: DB00682
LigandBox: D08682
NIKKAJI: J3.862H J489.785D
LinkDB
KCF data

ATOM        23
            1   C8y C    24.1500  -16.5900
            2   C1c C    25.4100  -17.2900
            3   C8y C    22.9600  -17.2900
            4   C8y C    24.1500  -15.1900
            5   C8y C    25.4100  -18.6200
            6   C1b C    26.6000  -16.5900
            7   C8y C    21.7700  -16.5900
            8   O1a O    22.9600  -18.7600
            9   O7x O    22.9600  -14.4200
            10  O6a O    25.3400  -14.4900
            11  C8x C    24.1500  -19.3200
            12  C8x C    26.6000  -19.3200
            13  C5a C    27.7900  -17.2200
            14  C8y C    21.7700  -15.1900
            15  C8x C    20.5100  -17.2900
            16  C8x C    24.1500  -20.7200
            17  C8x C    26.6000  -20.7200
            18  C1a C    27.7900  -18.7600
            19  O5a O    28.9800  -16.5900
            20  C8x C    20.5100  -14.4900
            21  C8x C    19.3200  -16.5900
            22  C8x C    25.4100  -21.4200
            23  C8x C    19.3200  -15.1900
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    7  15 1
            15   11  16 1
            16   12  17 2
            17   13  18 1
            18   13  19 2
            19   14  20 1
            20   15  21 2
            21   16  22 2
            22   20  23 2
            23    9  14 1
            24   17  22 1
            25   21  23 1

» Japanese version   » Back

KEGG   DRUG: Warfarin sodium
Entry
D00564                      Drug                                   

Name
Warfarin sodium (USP);
Coumadin (TN);
Jantoven (TN)
Product
  Generic
WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (Amneal Pharmaceuticals LLC), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Exelan Pharmaceuticals), WARFARIN SODIUM (Golden State Medical Supply), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (A-S Medication Solutions), WARFARIN SODIUM (American Health Packaging), WARFARIN SODIUM (American Health Packaging), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Aphena Pharma Solutions - Tennessee), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Bryant Ranch Prepack), WARFARIN SODIUM (Cadila Healthcare Limited), WARFARIN SODIUM (Cardinal Health), WARFARIN SODIUM (Cardinal Health), WARFARIN SODIUM (Clinical Solutions Wholesale), WARFARIN SODIUM (DIRECT RX), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Denton Pharma), WARFARIN SODIUM (Golden State Medical Supply), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (NuCare Pharmaceuticals), WARFARIN SODIUM (PD-Rx Pharmaceuticals), WARFARIN SODIUM (Preferred Pharmaceuticals), WARFARIN SODIUM (Preferred Pharmaceuticals), WARFARIN SODIUM (Preferred Pharmaceuticals), WARFARIN SODIUM (Proficient Rx LP), WARFARIN SODIUM (Proficient Rx LP), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (REMEDYREPACK), WARFARIN SODIUM (RedPharm Drug), WARFARIN SODIUM (RedPharm Drug), WARFARIN SODIUM (Rising Health), WARFARIN SODIUM (St. Mary's Medical Park Pharmacy), WARFARIN SODIUM (Taro Pharmaceuticals U.S.A.), WARFARIN SODIUM (Teva Pharmaceuticals USA), JANTOVEN (Upsher-Smith Laboratories), WARFARIN SODIUM (Zydus Pharmaceuticals (USA))
Formula
C19H15O4. Na
Exact mass
330.0868
Mol weight
330.3098
Structure
Simcomp
Class
Cardiovascular agent
 DG01708  Coumarin anticoagulant
  DG01760  Warfarin and analog
 DG01950  Antithrombotic agent
  DG01708  Coumarin anticoagulant
   DG01760  Warfarin and analog
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: B01AA03
Chemical structure group: DG00149
Product (DG00149): D00564<US> D01280<JP>
Efficacy
Anticoagulant, Vitamin K antagonist
Comment
coumarin derivative
Target
VKORC1 [HSA:79001] [KO:K05357]
NQO1 [HSA:1728] [KO:K00355]
  Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AA Vitamin K antagonists
     B01AA03 Warfarin
      D00564  Warfarin sodium (USP) <US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Vitamin K Antagonist
    Warfarin
     D00564  Warfarin sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   NAD(P)H dehydrogenase
    NQO1
     D00564  Warfarin sodium (USP) <US>
   Vitamin-K-epoxide reductase
    VKORC1
     D00564  Warfarin sodium (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00564
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00564
Other DBs
CAS: 129-06-6
PubChem: 7847630
ChEBI: 10034
ChEMBL: CHEMBL1200879
DrugBank: DB00682
LigandBox: D00564
NIKKAJI: J5.420H
LinkDB
KCF data

ATOM        24
            1   C8y C    24.8370  -17.3313
            2   C1c C    26.0487  -18.0418
            3   C8y C    23.6253  -18.0245
            4   C8y C    24.8428  -15.9389
            5   C1b C    27.2662  -17.3429
            6   C8y C    22.4252  -17.3137
            7   O1a O    23.6894  -19.4226 #-
            8   O7x O    23.6427  -15.2398
            9   O6a O    26.0661  -15.2515
            10  C5a C    28.4721  -18.0534
            11  C8y C    22.4311  -15.9215
            12  C8x C    21.2135  -18.0245
            13  C1a C    28.4662  -19.4576
            14  O5a O    29.6837  -17.3604
            15  C8x C    21.2193  -15.2224
            16  C8x C    20.0077  -17.3196
            17  C8x C    20.0077  -15.9156
            18  C8y C    26.0423  -19.4449
            19  C8x C    24.8108  -20.1486
            20  C8x C    24.8046  -21.5475
            21  C8x C    26.0129  -22.2524
            22  C8x C    27.2445  -21.5486
            23  C8x C    27.2507  -20.1497
            24  Z   Na   21.3600  -19.4568 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15   12  16 2
            16   15  17 2
            17    8  11 1
            18   16  17 1
            19    2  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1

» Japanese version   » Back

KEGG   DRUG: Warfarin potassium
Entry
D01280                      Drug                                   

Name
Warfarin potassium (JP18);
Athrombin-K (TN)
Formula
C19H15O4. K
Exact mass
346.0607
Mol weight
346.4183
Structure
Simcomp
Class
Cardiovascular agent
 DG01708  Coumarin anticoagulant
  DG01760  Warfarin and analog
 DG01950  Antithrombotic agent
  DG01708  Coumarin anticoagulant
   DG01760  Warfarin and analog
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 3332
ATC code: B01AA03
Chemical structure group: DG00149
Product (DG00149): D00564<US> D01280<JP>
Efficacy
Anticoagulant, Vitamin K antagonist
Comment
coumarin derivative
Target
VKORC1 [HSA:79001] [KO:K05357]
NQO1 [HSA:1728] [KO:K00355]
  Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AA Vitamin K antagonists
     B01AA03 Warfarin
      D01280  Warfarin potassium (JP18) <JP>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Vitamin K Antagonist
    Warfarin
     D01280  Warfarin potassium (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3332  Dicumarols
     D01280  Warfarin potassium (JP18)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   NAD(P)H dehydrogenase
    NQO1
     D01280  Warfarin potassium (JP18) <JP>
   Vitamin-K-epoxide reductase
    VKORC1
     D01280  Warfarin potassium (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01280  Warfarin potassium
  D01280  Warfarin potassium tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01280
Other DBs
CAS: 2610-86-8
PubChem: 7848343
ChEBI: 32301
ChEMBL: CHEMBL1200772
DrugBank: DB00682
LigandBox: D01280
NIKKAJI: J7.630I
LinkDB
KCF data

ATOM        24
            1   C8y C    24.8561  -17.2746
            2   C1c C    26.0688  -17.9857
            3   C8y C    23.6435  -17.9683
            4   C8y C    24.8620  -15.8811
            5   C1b C    27.2872  -17.2862
            6   C8y C    22.4425  -17.2570
            7   O1a O    23.6376  -19.3675 #-
            8   O7x O    23.6609  -15.1815
            9   O6a O    26.0862  -15.1932
            10  C5a C    28.4940  -17.9973
            11  C8y C    22.4484  -15.8637
            12  C8x C    21.2299  -17.9683
            13  C1a C    28.4881  -19.4025
            14  O5a O    29.7066  -17.3037
            15  C8x C    21.2357  -15.1641
            16  C8x C    20.0231  -17.2629
            17  C8x C    20.0231  -15.8578
            18  C8y C    26.0624  -19.3898
            19  C8x C    24.8299  -20.0941
            20  C8x C    24.8237  -21.4941
            21  C8x C    26.0330  -22.1995
            22  C8x C    27.2655  -21.4952
            23  C8x C    27.2717  -20.0952
            24  Z   K    21.3765  -19.4017 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   11  15 1
            15   12  16 2
            16   15  17 2
            17    8  11 1
            18   16  17 1
            19    2  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1

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