KEGG   DRUG: PonezumabHelp
Entry
D09952                      Drug                                   

Name
Ponezumab (USAN/INN)
Formula
C6552H10158N1730O2090S52
Exact mass
148178.7239
Mol weight
148270.4779
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYYTE AYYIHWVRQA
PGQGLEWMGR IDPATGNTKY APRLQDRVTM TRDTSTSTVY MELSSLRSED TAVYYCASLY
SLPVYWGQGT TVTVSSASTK GPSVFPLAPC SRSTSESTAA LGCLVKDYFP EPVTVSWNSG
ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS NFGTQTYTCN VDHKPSNTKV DKTVERKCCV
ECPPCPAPPV AGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVQF NWYVDGVEVH
NAKTKPREEQ FNSTFRVVSV LTVVHQDWLN GKEYKCKVSN KGLPSSIEKT ISKTKGQPRE
PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PMLDSDGSFF
LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Disulfide bridge: 22-96; 143-199; 256-316; 362-420, Dimer: 218; 219; 222; 225)
(Light chain) DVVMTQSPLS LPVTLGQPAS ISCKSSQSLL YSDAKTYLNW
FQQRPGQSPR RLIYQISRLD PGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCLQGTHYP
VLFGQGTRLE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: 23-93; 139-199; H130-L219, Dimer)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Agents for Alzheimer-type dementia
Efficacy
Dementia therapeutic agent
Comment
Monoclonal antibody
Treatment of Alzheimer's disease
Target
beta-amyloid
Interaction
Drug interaction
Other DBs
CAS: 1178862-65-1
PubChem: 124490631
LinkDB All DBs

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