KEGG   DRUG: NiraparibHelp
Entry
D10140                      Drug                                   

Name
Niraparib (USAN);
Zejula (TN)
Product
Formula
C19H20N4O
Exact mass
320.1637
Mol weight
320.3883
Structure
Mol fileKCF fileDB search
Remark
ATC code: L01XX54
Product: D10140<US>
Efficacy
Antineoplastic, PARP inhibitor
  Disease
Epithelial ovarian cancer [DS:H00027]
Fallopian tube cancer [DS:H01554]
Primary peritoneal cancer [DS:H01665]
Target
PARP1 [HSA:142] [KO:K10798]
PARP2 [HSA:10038] [KO:K10798]
  Pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX54 Niraparib
      D10140  Niraparib (USAN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Pentosyltransferases
    PARP1
     D10140  Niraparib (USAN) <US>
    PARP2
     D10140  Niraparib (USAN) <US>
Antineoplastics [br08340.html]
 D10140
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10140
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10140
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10140
Pharmacogenomic biomarkers [br08341.html]
 Companion diagnostics
  D10140
BRITE hierarchy
Other DBs
CAS: 1038915-60-4
PubChem: 135626858
ChEMBL: CHEMBL1094636
PDB-CCD: 3JD[PDBj]
LigandBox: D10140
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C     6.9300  -16.1000
            2   C8x C     6.9300  -17.5000
            3   C8x C     8.1424  -18.2000
            4   C8y C     9.3549  -17.5000
            5   C8y C     9.3549  -16.1000
            6   C8y C     8.1424  -15.4000
            7   C8x C    10.6864  -17.9326
            8   N4y N    11.5093  -16.8000
            9   N5x N    10.6864  -15.6674
            10  C5a C     8.1424  -14.0002
            11  O5a O     6.9132  -13.2903
            12  N1a N     9.3380  -13.3098
            13  C8y C    12.8800  -16.8000
            14  C8x C    13.5800  -18.0124
            15  C8x C    14.9800  -18.0124
            16  C8y C    15.6800  -16.8000
            17  C8x C    14.9800  -15.5876
            18  C8x C    13.5800  -15.5876
            19  C1y C    17.0800  -16.8000
            20  C1x C    17.7800  -18.0124
            21  N1x N    19.1800  -18.0124
            22  C1x C    19.8800  -16.8000
            23  C1x C    19.1800  -15.5876
            24  C1x C    17.7800  -15.5876
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 2
            8     7   8 1
            9     8   9 1
            10    5   9 2
            11    6  10 1
            12   10  11 2
            13   10  12 1
            14    8  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   19  16 1 #Down
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1

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