KEGG   DRUG: VesencumabHelp
Entry
D10494                      Drug                                   

Name
Vesencumab (USAN/INN)
Formula
C6430H9948N1708O2016S48
Exact mass
144883.5011
Mol weight
144973.1421
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSQ ISPAGGYTNY
ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCARGE LPYYRMSKVM DVWGQGTLVT
VSSASTKGPS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS
REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQYFS SYLAWYQQKP GKAPKLLIYG ASSRASGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YLGSPPTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer, disulfide bridges: H22-H96, H150-H206, H226-L214, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'150-H'206, H'226-L'214, H'267-H'327, H'373-H'431, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Anti-neuropilin 1 antibody
Comment
Monoclonal antibody
Treatment of solid malignancies
Target
NRP1 (CD304) [HSA:8829] [KO:K06724]
  Pathway
hsa04360  Axon guidance
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    NRP1 (CD304)
     D10494  Vesencumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1205533-60-3
PubChem: 172232587
LinkDB All DBs

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