KEGG   DRUG: Frovocimab
Entry
D11398                      Drug                                   
Name
Frovocimab (USAN/INN)
Formula
C6506H10062N1718O2036S46
Exact mass
146306.3781
Mol weight
146396.87
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFPFS KLGMVWVRQA PGKGLEWVST ISSGGGYTYY
PDSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCAREG ISFQGGTYTY VMDYWGQGTL
VTVSSASTKG PSVFPLAPCS RSTSESTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA
VLQSSGLYSL SSVVTVPSSS LGTKTYTCNV DHKPSNTKVD KRVESKYGPP CPPCPAPEAA
GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSQEDPEVQF NWYVDGVEVH NAKTKPREEQ
FNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KGLPSSIEKT ISKAKGQPRE PQVYTLPPSQ
EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSRLTVDKS
RWQEGNVFSC SVMHEALHNH YTQKSLSLSL G
(Light chain)
1DIVMTQSPLS LPVTPGEPAS ISCRSSKSLL HRNGITYSYW YLQKPGQSPQ
LLIYQLSNLA SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCYQNLELP LTFGQGTKVE
IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE
QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H139-L219, H152-H208, H231-H'231, H234-H'234, H266-H326, H372-H430, H'22-H'96, H'139-L'219, H'152-H'208, H'266-H'326, H'372-H'430, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG03128  Anti-PCSK9 antibody and siRNA
Efficacy
Antihyperlipidemic, Anti-PCSK9 antibody
  Type
Monoclonal antibody
Comment
Treatment of hypercholesterolemia
Target
PCSK9 [HSA:255738] [KO:K13050]
  Pathway
hsa04979  Cholesterol metabolism
Interaction
Brite
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG03128  Anti-PCSK9 antibody and siRNA
    D11398  Frovocimab
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Subtilisin family
    PCSK9
     D11398  Frovocimab (USAN/INN)
Other DBs
CAS: 1643672-70-1
PubChem: 384585376
LinkDB

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