KEGG   DRUG: Elexacaftor, ivacaftor and tezacaftorHelp
Entry
D11700            Mixture   Drug                                   

Name
Elexacaftor, ivacaftor and tezacaftor;
Trikafta (TN)
Product
Component
Elexacaftor [DR:D11507], Ivacaftor [DR:D09916], Tezacaftor [DR:D11041]
Remark
Product: D11700<US>
Efficacy
Cystic fibrosis treatment
  Disease
Cystic fibrosis (CFTR F508del mutation) [DS:H00218]
Target
CFTR* [HSA_VAR:1080v1] [HSA:1080] [KO:K05031]
  Pathway
hsa02010  ABC transporters
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    CFTR* [HSA_VAR:1080v1]
     D11700  Elexacaftor, ivacaftor and tezacaftor <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11700
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11700
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