KEGG   DRUG: Ansuvimab
Entry
D11875                      Drug                                   

Name
Ansuvimab (USAN);
Ansuvimab-zykl;
Ebanga (TN)
Product
Formula
C6368H9924N1724O1994S44
Exact mass
143859.5861
Mol weight
143948.1486
Sequence
(Heavy chain)
EVQLVESGGG LIQPGGSLRL SCAASGFALR MYDMHWVRQT IDKRLEWVSA VGPSGDTTYA
DSVKGRFAVS RENAKNSLSL QMNSLTAGDT AIYYCVRSDR GVAGLFDSWG QGILVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRIT ITCRASQAFD NYVAWYQQRP GKVPKLLISA ASALHAGVPS
RFSGSGSGTH FTLTISSLQP EDVATYYCQN YNSAPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H146-H202, H222-L214, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'95, H'146-H'202, H'222-L'214, H'263-H'323, H'369-H'427, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
Product: D11875<US>
Efficacy
Antiviral
  Disease
Zaire ebolavirus infection [DS:H00283]
Comment
Monoclonal antibody
Treatment of Ebola virus
Target
Zaire ebolavirus glycoprotein GP1 [KO:K24534]
Brite
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   Ebolavirus glycoprotein
    D11875  Ansuvimab (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11875
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11875
Other DBs
CAS: 2266625-91-4
LinkDB

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