KEGG   DRUG: Ersodetug
Entry
D12912                      Drug                                   
Name
Ersodetug (USAN/INN)
Formula
C6462H9960N1744O2018S56
Exact mass
146071.4721
Mol weight
146162.45
Sequence
(Heavy chain)
EVQLVETGGG VVQPGRSLRL SCAASGFTFS SYAMHWVRQA PGKGLEWVAV ISYDGSNKYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARHE WGFGMDVWGQ GTTVTVSSAS
TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVT SSNFGTQTYT CNVDHKPSNT KVDKTVERKC CVECPPCPAP PVAGPSVFLF
PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV QFNWYVDGME VHNAKTKPRE EQFNSTFRVV
SVLTVVHQDW LNGKEYKCKV SNKGLPAPIE KTISKTKGQP REPQVYTLPP SREEMTKNQV
SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPMLDSDGS FFLYSKLTVD KSRWQQGNVF
SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DVVMTQSPLS LSVTLGQPAS ISCRSSLSLV YGDENTYLNW FQQRPGQSPR RLLYKVSDRD
SGVPDRFSGS GSGTDFTLKI SRVEADDVGV YYCMQGTHWP YTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H132-L219, H145-H201, H220-H'220, H221-H'221, H224-H'224, H227-H'227, H258-H318, H364-H422, H'22-H'96, H'132-L'219, H'145-L'201, H'258-H'318, H'364-H'422, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Antihypoglycaemic, Insulin receptor allosteric inhibitor
  Type
Monoclonal antibody
Comment
Treatment of hypoglycemia
Target
INSR [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
Other DBs
CAS: 2410976-61-1
PubChem: 497621325
LinkDB

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