Gestational choriocarcinoma is a highly malignant epithelial tumor that can be associated with any type of gestational event, most often a complete hydatidiform mole (CM). CM occur in about one per 1000 pregnancies, and about 5-20% of CM progress to invasive moles or choriocarcinoma. Several molecular studies have been done to establish the expression of tumor-associated proteins in choriocarcinoma. In the p53 pathway, overexpression of the p53 protein and the p53-associated protein, MDM2, have been detected. Synergistic upregulation of c-MYC, c-ERB-2, c-FMS, and BCL-2 oncoproteins have also been suggested to have an important role in the pathogenesis of choriocarcinoma. Moreover, choriocarcinomas have been shown to express increased concentrations of MMP and decreased concentrations of TIMP to help with tumor invasion and metastasis.
Human diseases [BR:
Cancers of the breast and female genital organs
Human diseases in ICD-11 classification [BR:
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of female genital organs
2C75 Malignant neoplasms of placenta
Tumor markers [
Pathways in cancer
p53 (overexpression) [HSA:
MdM2 (overexpression) [HSA:
EGFR (overexpression) [HSA:
c-MYC (overexpression) [HSA:
ERBB2 (overexpression) [HSA:
c-FMS (overexpression) [HSA:
Bcl-2 (overexpression) [HSA:
MMP-1 (overexpression) [HSA:
MMP-2 (overexpression) [HSA:
Methotrexate sodium [DR:
Vinblastine sulfate [DR:
Bleomycin sulfate [DR:
ICD-O: 9100/3, Tumor type: Choriocarcinoma
(description, gene, tumor type)
Gestational trophoblastic neoplasia--pathogenesis and potential therapeutic targets.
Lancet Oncol 8:642-50 (2007)
Li HW, Tsao SW, Cheung AN
Current understandings of the molecular genetics of gestational trophoblastic diseases.
Placenta 23:20-31 (2002)
(gene, tumor type)
Garner EI, Goldstein DP, Feltmate CM, Berkowitz RS.
Gestational trophoblastic disease.
Clin Obstet Gynecol 50:112-22 (2007)
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