KEGG   DISEASE: Epidemic typhus
Entry
H00322                      Disease                                
Name
Epidemic typhus
Description
Epidemic typhus is caused by gram-negative rickettsia species in the typhus biogroup that are transmitted by infective louse and flea. The disease is widely distributed in tropical and subtropical areas. Most patients present with an acute febrile disease with constitutional symptom and maculopapular exanthema.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by alpha proteobacteria
   H00322  Epidemic typhus
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   Rickettsioses
    1C30  Typhus fever
     H00322  Epidemic typhus
Pathogen
Rickettsia prowazekii [GN:rpr rpq rpl rpn] (epidemic louse-borne typhus)
Rickettsia typhi [GN:rty] (murine flea-borne typhus)
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Comment
Vectors: Prediculus humanus (human body louse); Xenopsylla cheopis (rat flea) and Polyplax spinulos (rat louse)
Other DBs
ICD-11: 1C30
ICD-10: A75
MeSH: D014437 D014438
MedlinePlus: 001363
Reference
  Authors
Rolain JM, Jensenius M, Raoult D
  Title
Rickettsial infections--a threat to travellers?
  Journal
Curr Opin Infect Dis 17:433-7 (2004)
DOI:10.1097/00001432-200410000-00008
Reference
  Authors
Jensenius M, Fournier PE, Raoult D
  Title
Rickettsioses and the international traveler.
  Journal
Clin Infect Dis 39:1493-9 (2004)
DOI:10.1086/425365
Reference
  Authors
Parola P, Davoust B, Raoult D
  Title
Tick- and flea-borne rickettsial emerging zoonoses.
  Journal
Vet Res 36:469-92 (2005)
DOI:10.1051/vetres:2005004
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