KEGG DISEASE: African trypanosomiasis

KEGG

DISEASE: African trypanosomiasis

Entry

H00357                      Disease

Name

African trypanosomiasis;
Sleeping sickness

Description

African trypanosomiasis is a parasitic disease affecting both humans and livestock. It is one of the most common serious protozoan infections in sub-Saharan Africa, especially in areas of conflict. Its causative agent is Trypanosoma brucei, whose protein has been shown to induce apoptosis in human brain.

Category

Parasitic infectious disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Parasitic diseases
   Nonintestinal protozoal diseases
    1F51  African trypanosomiasis
     H00357  African trypanosomiasis
Genome-based classification of infectious diseases [BR:br08401]
Parasitic infections (protists)
  Infections caused by Euglenozoa
   H00357  African trypanosomiasis

Disease
pathway

African trypanosomiasis

Pathogen

Trypanosoma brucei [GN:tbr tbg]

Drug

Fexinidazole [DR:D11252]

Comment

Vector: Glossina pallidipes (tsetse fly)

Other DBs

ICD-11:

ICD-10:

MeSH:

MedlinePlus:

Reference

Authors

Hotez PJ, Kamath A

Title

Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.

Journal

PLoS Negl Trop Dis 3:e412 (2009)
DOI:10.1371/journal.pntd.0000412

Reference

Authors

Stiles JK, Whittaker J, Sarfo BY, Thompson WE, Powell MD, Bond VC

Title

Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells.

Journal

Mol Biochem Parasitol 133:229-40 (2004)
DOI:10.1016/j.molbiopara.2003.10.011

LinkDB

» Japanese version

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