KEGG   DISEASE: Localized Scleroderma
Entry
H01493                      Disease                                
Name
Localized Scleroderma;
Morphea
Description
Localized scleroderma, also known as morphea, is a rare fibrosing disorder of the skin and underlying tissues. Sclerosis is mainly limited to the skin, but subcutaneous tissue, fascia, and underlying muscles and bone may also be involved. It is generally differentiated from systemic scleroderma by the lack of Raynaud's phenomenon and visceral involvements. Localized scleroderma is classified into plaque morphea, generalized morphea, and linear scleroderma subtypes according to the clinical presentation and depth of tissue involvement. Localized scleroderma generally appears at any age, and onset at 20-50 years old is common, with the exception of the linear type, which often develops in childhood. Extracutaneous manifestations in morphea are not rare. The most common extracutaneous manifestations are arthralgia and myalgia. Neurologic manifestations and ocular complications are the most common in those children with head and neck involvement.
Category
Skin disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01493  Localized Scleroderma
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Scarring or sclerosing inflammatory dermatoses
    EB61  Morphoea
     H01493  Localized Scleroderma
Pathogen
Borrelia burgdorferi [GN:bbu]
Other DBs
ICD-11: EB61
ICD-10: L94.0
MeSH: D012594
Reference
  Authors
Gorkiewicz-Petkow A, Kalinska-Bienias A
  Title
Systemic involvement in localized scleroderma/morphea.
  Journal
Clin Dermatol 33:556-62 (2015)
DOI:10.1016/j.clindermatol.2015.05.009
Reference
  Authors
Toki S, Motegi S, Yamada K, Uchiyama A, Kanai S, Yamanaka M, Ishikawa O
  Title
Clinical and laboratory features of systemic sclerosis complicated with localized scleroderma.
  Journal
J Dermatol 42:283-7 (2015)
DOI:10.1111/1346-8138.12775
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