KEGG   DISEASE: 多嚢胞性卵巣症候群
エントリ  
H01739                                                             
名称    
多嚢胞性卵巣症候群
概要    
Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Clinical signs of PCOS include elevated luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels, whereas follicle-stimulating hormone (FSH) levels are muted or unchanged. As a result of the increase in GnRH, stimulation of the ovarian theca cells, in turn, produces more androgens. Risk factors for PCOS in adults includes insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. PCOS can be described as an oligogenic disorder in which the interaction of a number of genetic and environmental factors determine the heterogeneous, clinical, and biochemical phenotype. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology.
カテゴリ  
内分泌系疾患; 生殖系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 生殖系疾患
  生殖系疾患
   H01739  多嚢胞性卵巣症候群
ICD-11 による疾患分類 [BR:jp08403]
 05 内分泌, 栄養, 代謝の疾患
  内分泌疾患
   性腺ホルモン系の疾患
    5A80  卵巣機能障害
     H01739  多嚢胞性卵巣症候群
治療薬   
精製下垂体性性腺刺激ホルモン [DR:D06459]
ホリトロピンアルファ [DR:D04429]
リンク   
ICD-11: 5A80.1
ICD-10: E28.2
MeSH: D011085
文献    
  著者
Sirmans SM, Pate KA
  タイトル
Epidemiology, diagnosis, and management of polycystic ovary syndrome.
  雑誌
Clin Epidemiol 6:1-13 (2013)
DOI:10.2147/CLEP.S37559
文献    
PMID:23946629 (description, drug)
  著者
Ndefo UA, Eaton A, Green MR
  タイトル
Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches.
  雑誌
P T 38:336-55 (2013)
文献    
  著者
Barthelmess EK, Naz RK
  タイトル
Polycystic ovary syndrome: current status and future perspective.
  雑誌
Front Biosci (Elite Ed) 6:104-19 (2014)
DOI:10.2741/e695
LinkDB    

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