KEGG   DISEASE: Non-Hodgkin lymphoma
Entry
H02418                      Disease                                
Name
Non-Hodgkin lymphoma
  Subgroup
Chronic lymphocytic leukemia [DS:H00005]
Lymphoplasmacytic lymphoma [DS:H00011]
Hairy cell leukemia [DS:H00006]
Follicular lymphoma [DS:H01613]
Mantle cell lymphoma [DS:H01464]
Burkitt lymphoma [DS:H00008]
Peripheral T cell lymphoma [DS:H01892]
B-cell acute lymphoblastic leukemia [DS:H00001]
Mycosis fungoides [DS:H01463]
Anaplastic large-cell lymphoma [DS:H01601]
Diffuse large B-cell lymphoma, not otherwise specified [DS:H02434]
Description
Non-Hodgkin lymphoma (NHL) is one of the most common hematologic malignancies worldwide. NHL includes malignant tumors of the lymphoid tissues variously resulting from the clonal growth of B cells, T cells and natural killer cells. NHL can be broadly classified based on the type of lymphocyte involved: B lymphocyte (B cell) or T lymphocyte (T cell) and is further classified by other factors, including whether it is aggressive or indolent. Aggressive NHL is fast-growing disease. It mainly includes mantle cell lymphoma, diffuse large B-cell lymphoma, Burkitt's lymphoma, lymphoblastic lymphoma and peripheral T-cell lymphoma. On the other hand, indolent NHL is slow-growing disease. It mainly includes follicular lymphoma, cutaneous T-cell lymphoma, lymphoplasmacytic lymphoma and MALT lymphoma.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of haematopoietic and lymphoid tissues
   H02418  Non-Hodgkin lymphoma
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   2B33  Malignant haematopoietic neoplasms without further specification
    H02418  Non-Hodgkin lymphoma
Related
pathway
hsa03440 Homologous recombination   
hsa04210 Apoptosis   
Network
nt06506  Double-strand break repair
Gene
RAD54L [HSA:8438] [KO:K10875]
RAD54B [HSA:25788] [KO:K10877]
CASP10 [HSA:843] [KO:K04400]
PRF1 [HSA:5551] [KO:K07818]
Drug
Bendamustine hydrochloride [DR:D07085]
Carmustine [DR:D00254]
Methotrexate sodium [DR:D02115]
Vincristine sulfate [DR:D02197]
Doxorubicin hydrochloride [DR:D01275]
Bleomycin sulfate [DR:D02177]
Rituximab [DR:D02994] (CD20-positive)
Plerixafor [DR:D08971]
Other DBs
ICD-11: 2B33.5
ICD-10: C82 C83 C84 C91
MeSH: D008228
OMIM: 605027
Reference
PMID:10362365 (RAD54L)
  Authors
Matsuda M, Miyagawa K, Takahashi M, Fukuda T, Kataoka T, Asahara T, Inui H, Watatani M, Yasutomi M, Kamada N, Dohi K, Kamiya K
  Title
Mutations in the RAD54 recombination gene in primary cancers.
  Journal
Oncogene 18:3427-30 (1999)
DOI:10.1038/sj.onc.1202692
Reference
PMID:10362364 (RAD54B)
  Authors
Hiramoto T, Nakanishi T, Sumiyoshi T, Fukuda T, Matsuura S, Tauchi H, Komatsu K, Shibasaki Y, Inui H, Watatani M, Yasutomi M, Sumii K, Kajiyama G, Kamada N, Miyagawa K, Kamiya K
  Title
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
  Journal
Oncogene 18:3422-6 (1999)
DOI:10.1038/sj.onc.1202691
Reference
PMID:12010812 (CASP10)
  Authors
Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN, Lee JH, Park JY, Jang JJ, Kim CW, Kim SH, Lee JY, Yoo NJ, Lee SH
  Title
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.
  Journal
Blood 99:4094-9 (2002)
DOI:10.1182/blood.v99.11.4094
Reference
PMID:15728124 (PRF1)
  Authors
Clementi R, Locatelli F, Dupre L, Garaventa A, Emmi L, Bregni M, Cefalo G, Moretta A, Danesino C, Comis M, Pession A, Ramenghi U, Maccario R, Arico M, Roncarolo MG
  Title
A proportion of patients with lymphoma may harbor mutations of the perforin gene.
  Journal
Blood 105:4424-8 (2005)
DOI:10.1182/blood-2004-04-1477
LinkDB

» Japanese version

DBGET integrated database retrieval system