KEGG   DISEASE: Non-Hodgkin lymphoma
H02418                      Disease                                
Non-Hodgkin lymphoma
Chronic lymphocytic leukemia [DS:H00005]
Lymphoplasmacytic lymphoma [DS:H00011]
Hairy cell leukemia [DS:H00006]
Follicular lymphoma [DS:H01613]
Mantle cell lymphoma [DS:H01464]
Burkitt lymphoma [DS:H00008]
Peripheral T cell lymphoma [DS:H01892]
B-cell acute lymphoblastic leukemia [DS:H00001]
Mycosis fungoides [DS:H01463]
Anaplastic large-cell lymphoma [DS:H01601]
Diffuse large B-cell lymphoma, not otherwise specified [DS:H02434]
Non-Hodgkin lymphoma (NHL) is one of the most common hematologic malignancies worldwide. NHL includes malignant tumors of the lymphoid tissues variously resulting from the clonal growth of B cells, T cells and natural killer cells. NHL can be broadly classified based on the type of lymphocyte involved: B lymphocyte (B cell) or T lymphocyte (T cell) and is further classified by other factors, including whether it is aggressive or indolent. Aggressive NHL is fast-growing disease. It mainly includes mantle cell lymphoma, diffuse large B-cell lymphoma, Burkitt's lymphoma, lymphoblastic lymphoma and peripheral T-cell lymphoma. On the other hand, indolent NHL is slow-growing disease. It mainly includes follicular lymphoma, cutaneous T-cell lymphoma, lymphoplasmacytic lymphoma and MALT lymphoma.
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   2B33  Malignant haematopoietic neoplasms without further specification
    H02418  Non-Hodgkin lymphoma
Pathway-based classification of diseases [BR:br08402]
 Replication and repair
  nt06506  Double-strand break repair
   H02418  Non-Hodgkin lymphoma
hsa03440  Homologous recombination
hsa04210  Apoptosis
nt06506 Double-strand break repair
RAD54L [HSA:8438] [KO:K10875]
RAD54B [HSA:25788] [KO:K10877]
CASP10 [HSA:843] [KO:K04400]
PRF1 [HSA:5551] [KO:K07818]
Bendamustine hydrochloride [DR:D07085]
Carmustine [DR:D00254]
Methotrexate sodium [DR:D02115]
Vincristine sulfate [DR:D02197]
Doxorubicin hydrochloride [DR:D01275]
Bleomycin sulfate [DR:D02177]
Rituximab [DR:D02994] (CD20-positive)
Plerixafor [DR:D08971]
Other DBs
ICD-11: 2B33.5
ICD-10: C82 C83 C84 C91
MeSH: D008228
OMIM: 605027
PMID:10362365 (RAD54L)
Matsuda M, Miyagawa K, Takahashi M, Fukuda T, Kataoka T, Asahara T, Inui H, Watatani M, Yasutomi M, Kamada N, Dohi K, Kamiya K
Mutations in the RAD54 recombination gene in primary cancers.
Oncogene 18:3427-30 (1999)
PMID:10362364 (RAD54B)
Hiramoto T, Nakanishi T, Sumiyoshi T, Fukuda T, Matsuura S, Tauchi H, Komatsu K, Shibasaki Y, Inui H, Watatani M, Yasutomi M, Sumii K, Kajiyama G, Kamada N, Miyagawa K, Kamiya K
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
Oncogene 18:3422-6 (1999)
PMID:12010812 (CASP10)
Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN, Lee JH, Park JY, Jang JJ, Kim CW, Kim SH, Lee JY, Yoo NJ, Lee SH
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.
Blood 99:4094-9 (2002)
PMID:15728124 (PRF1)
Clementi R, Locatelli F, Dupre L, Garaventa A, Emmi L, Bregni M, Cefalo G, Moretta A, Danesino C, Comis M, Pession A, Ramenghi U, Maccario R, Arico M, Roncarolo MG
A proportion of patients with lymphoma may harbor mutations of the perforin gene.
Blood 105:4424-8 (2005)

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