KEGG   ORTHOLOGY: K00021
Entry
K00021                      KO                                     
Symbol
HMGCR
Name
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04152  AMPK signaling pathway
map04976  Bile secretion
Module
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R02082  (R)-mevalonate:NADP+ oxidoreductase (CoA acylating)
Disease
H00593  Limb-girdle muscular dystrophy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
Other DBs
COG: COG1257
GO: 0004420
Genes
HSA: 3156(HMGCR)
PTR: 471516(HMGCR)
PPS: 100990336(HMGCR)
GGO: 101136625(HMGCR)
PON: 100173499(HMGCR)
PPYG: 129036875(HMGCR)
NLE: 100597442(HMGCR)
HMH: 116462468(HMGCR)
SSYN: 129468073(HMGCR)
MCC: 705479(HMGCR)
MCF: 101926249(HMGCR)
MTHB: 126957065
MNI: 105475132(HMGCR)
CSAB: 103223243(HMGCR)
CATY: 105599201(HMGCR)
PANU: 101005142(HMGCR)
TGE: 112625905(HMGCR)
MLEU: 105551327(HMGCR)
RBB: 108513080(HMGCR)
TFN: 117065272(HMGCR)
PTEH: 111539937(HMGCR)
CANG: 105524122(HMGCR)
CJC: 100403990(HMGCR)
SBQ: 101033204(HMGCR)
CIMI: 108303725(HMGCR)
ANAN: 105723900(HMGCR)
CSYR: 103273609(HMGCR)
MMUR: 105881833(HMGCR)
LCAT: 123648553(HMGCR)
PCOQ: 105826599(HMGCR)
OGA: 100965474(HMGCR)
MMU: 15357(Hmgcr)
MCAL: 110307857(Hmgcr)
MPAH: 110328787(Hmgcr)
RNO: 25675(Hmgcr)
MCOC: 116083242(Hmgcr)
ANU: 117700463(Hmgcr)
MUN: 110562396(Hmgcr)
CGE: 100756363(Hmgcr)
MAUA: 101843185(Hmgcr)
PROB: 127221099(Hmgcr)
PLEU: 114687932 114694656(Hmgcr)
MORG: 121455744(Hmgcr)
AAMP: 119808971(Hmgcr)
NGI: 103731354(Hmgcr)
HGL: 101717005(Hmgcr)
CPOC: 100726509(Hmgcr)
CCAN: 109700493(Hmgcr)
DORD: 105992420(Hmgcr)
DSP: 122117118(Hmgcr)
PLOP: 125367607(Hmgcr)
NCAR: 124987348
MMMA: 107152270(Hmgcr)
OCU: 100357791
OPI: 101520422(HMGCR)
TUP: 102480274(HMGCR)
GVR: 103598511(HMGCR)
CFA: 479182(HMGCR)
CLUD: 112653350(HMGCR)
VVP: 112919751(HMGCR)
VLG: 121489192(HMGCR)
AML: 100464316(HMGCR)
UMR: 103663564(HMGCR)
UAH: 113255200(HMGCR)
UAR: 123800202(HMGCR)
LLV: 125100135
MPUF: 101694441(HMGCR)
MNP: 132028734(HMGCR)
MLK: 131832360(HMGCR)
NVS: 122918489(HMGCR)
ORO: 101368294(HMGCR)
EJU: 114217572(HMGCR)
ZCA: 113928970(HMGCR)
MLX: 118016904(HMGCR)
NSU: 110591087(HMGCR)
LWW: 102725694(HMGCR)
FCA: 101098922(HMGCR)
PYU: 121014418(HMGCR)
PCOO: 112860354(HMGCR)
PBG: 122489870(HMGCR)
PVIV: 125171263(HMGCR)
LRUF: 124518177
PTG: 102963640(HMGCR)
PPAD: 109274990(HMGCR)
PUC: 125935747
AJU: 106974837
HHV: 120226596 120240725(HMGCR)
BTA: 407159(HMGCR)
BOM: 102270355(HMGCR)
BIU: 109564640(HMGCR)
BBUB: 102394647(HMGCR)
BBIS: 104994134(HMGCR)
CHX: 102169762(HMGCR)
OAS: 101108919(HMGCR)
BTAX: 128054047(HMGCR)
CCAD: 122442980(HMGCR)
MBEZ: 129562799(HMGCR)
SSC: 100144446(HMGCR)
CFR: 102507285(HMGCR)
CBAI: 105064373(HMGCR)
CDK: 105084800(HMGCR)
VPC: 102543088(HMGCR)
BMUS: 118892135(HMGCR)
LVE: 103081068(HMGCR)
OOR: 101275846(HMGCR)
DLE: 111185263(HMGCR)
PCAD: 102983040(HMGCR)
PSIU: 116750950(HMGCR)
NASI: 112391416(HMGCR)
ECB: 100065577(HMGCR)
EPZ: 103555449(HMGCR)
EAI: 106824005(HMGCR)
MYB: 102262745(HMGCR)
MYD: 102767367(HMGCR)
MMYO: 118655928(HMGCR)
MLF: 102436294(HMGCR)
MDT: 132233518(HMGCR)
PKL: 118703505(HMGCR)
EFUS: 103305199(HMGCR)
MNA: 107531218(HMGCR)
DRO: 112307523(HMGCR)
SHON: 118977261(HMGCR)
AJM: 119062428(HMGCR)
PDIC: 114494235(HMGCR)
PHAS: 123824707(HMGCR)
MMF: 118642218(HMGCR)
PPAM: 129074621(HMGCR)
HAI: 109381933(HMGCR)
RFQ: 117024888(HMGCR)
PALE: 102890076(HMGCR)
PGIG: 120598500(HMGCR)
PVP: 105302180(HMGCR)
RAY: 107506449(HMGCR)
MJV: 108408321(HMGCR)
TOD: 119260566(HMGCR)
SARA: 101539442(HMGCR)
SETR: 126001477(HMGCR)
LAV: 100661990(HMGCR)
TMU: 101360660
ETF: 101646675(HMGCR)
DNM: 101422332(HMGCR)
MDO: 100014439(HMGCR)
GAS: 123236693(HMGCR)
SHR: 100922433(HMGCR)
AFZ: 127558817
PCW: 110216572(HMGCR)
TVP: 118853358(HMGCR)
OAA: 100086613(HMGCR)
GGA: 395145(HMGCR)
PCOC: 116239242(HMGCR)
MGP: 104915886(HMGCR)
CJO: 107306044(HMGCR)
TPAI: 128089730(HMGCR)
LMUT: 125686886(HMGCR)
NMEL: 110389857(HMGCR)
APLA: 101805369(HMGCR)
ACYG: 106042919(HMGCR)
CATA: 118251497(HMGCR)
AFUL: 116500427(HMGCR)
TGU: 100228972(HMGCR)
LSR: 110471283(HMGCR)
SCAN: 103819488(HMGCR)
PMOA: 120511968(HMGCR)
OTC: 121341292(HMGCR)
PRUF: 121363659(HMGCR)
GFR: 102039836(HMGCR)
FAB: 101812070(HMGCR)
OMA: 130264830(HMGCR)
PHI: 102101959(HMGCR)
PMAJ: 107215886(HMGCR)
CCAE: 111940640(HMGCR)
CCW: 104685133(HMGCR)
CBRC: 103620024(HMGCR)
ETL: 114057167(HMGCR)
ZAB: 102070063(HMGCR)
ZLE: 135459766(HMGCR)
ACHL: 103797889
SVG: 106859685(HMGCR)
MMEA: 130572249(HMGCR)
HRT: 120765481(HMGCR)
SATI: 136374142(HMGCR)
FPG: 101915600(HMGCR)
FCH: 102052105(HMGCR)
CCRI: 104167304(HMGCR)
NNT: 104399950(HMGCR)
SHAB: 115619708(HMGCR)
ACUN: 113490251(HMGCR)
TALA: 104358103(HMGCR)
ACHC: 115336962(HMGCR) 121232774
HALD: 104316803(HMGCR)
HLE: 104841274(HMGCR)
GCL: 127029035
CSTI: 104554649(HMGCR)
LDI: 104354014(HMGCR)
MNB: 103776975(HMGCR)
DPUB: 104299688(HMGCR)
AVIT: 104267777(HMGCR)
BRHI: 104493501(HMGCR)
EGZ: 104124861(HMGCR)
NNI: 104013038(HMGCR) 104017611
PCRI: 104030224(HMGCR)
PCAO: 104046161(HMGCR)
PADL: 103919697(HMGCR)
AFOR: 103899769(HMGCR)
FGA: 104082402(HMGCR)
GSTE: 104251283(HMGCR)
CLV: 102088196(HMGCR)
MUI: 104534211(HMGCR)
PGUU: 104472022(HMGCR)
PLET: 104614533(HMGCR)
EHS: 104517362(HMGCR)
CMAC: 104479439(HMGCR)
CUCA: 104056378(HMGCR)
TEO: 104379220(HMGCR)
BREG: 104636134(HMGCR)
OHA: 104331138(HMGCR)
ACAR: 104529373(HMGCR)
CPEA: 104395804(HMGCR)
CVF: 104285757(HMGCR) 104295812
RTD: 128901989 128902471(HMGCR)
AAM: 106489268
AROW: 112961814(HMGCR)
NPD: 112944911(HMGCR)
TGT: 104567556(HMGCR) 104571572
DNE: 112987050(HMGCR)
SCAM: 104152937(HMGCR)
ASN: 102386377(HMGCR)
AMJ: 102571444(HMGCR)
CPOO: 109308025(HMGCR)
GGN: 109297712(HMGCR)
PSS: 102459565(HMGCR)
CMY: 102947767(HMGCR)
CCAY: 125636488(HMGCR)
DCC: 119856262(HMGCR)
CPIC: 101931267(HMGCR)
TST: 117878840(HMGCR)
CABI: 116816474(HMGCR)
MRV: 120407831(HMGCR)
ACS: 100555648(hmgcr)
ASAO: 132767071(HMGCR)
PVT: 110084573
SUND: 121922562(HMGCR)
PBI: 103059006(HMGCR)
PMUR: 107291177(HMGCR)
CTIG: 120317399(HMGCR)
TSR: 106550050(HMGCR)
PGUT: 117679301(HMGCR)
APRI: 131192013(HMGCR)
PTEX: 113447636(HMGCR)
NSS: 113413962(HMGCR)
VKO: 123031296(HMGCR)
PMUA: 114606284(HMGCR)
PRAF: 128423514(HMGCR)
ZVI: 118076836(HMGCR)
HCG: 128346175(HMGCR)
GJA: 107118163(HMGCR)
STOW: 125436468(HMGCR)
EMC: 129334716(HMGCR)
XLA: 108707262(hmgcr.S) 397750(hmgcr.L)
XTR: 100380121(hmgcr)
NPR: 108796370(HMGCR)
RTEM: 120929647(HMGCR)
MUO: 115463074(HMGCR)
GSH: 117353053(HMGCR)
DRE: 541479(hmgcrb) 559054(hmgcra)
PTET: 122332519 122345041(hmgcra)
LROH: 127152779(hmgcrb) 127165704(hmgcra)
OMC: 131528310(hmgcrb) 131540343(hmgcra)
PPRM: 120471286(hmgcrb) 120471903(hmgcra)
RKG: 130072736(hmgcra) 130073040(hmgcrb)
MAMB: 125252378 125252751(hmgcrb) 125267502(hmgcra)
CERY: 137013331(hmgcrb) 137034537(hmgcra)
TROS: 130550344(hmgcra) 130569927(hmgcrb)
TDW: 130407552(hmgcrb) 130419877(hmgcra)
MANU: 129423206(hmgcrb)
IPU: 108255489(hmgcra) 108278928(hmgcrb)
IFU: 128622029 128625564(hmgcra)
PHYP: 113535726 113536911(hmgcr)
SMEO: 124380523(hmgcra) 124397681(hmgcrb)
TFD: 113642276(hmgcra) 113646450(hmgcrb)
TVC: 132854985(hmgcra) 132859902(hmgcrb)
TRN: 134330193(hmgcrb) 134335066(hmgcra)
AMEX: 103033046(hmgcra) 103037085(hmgcrb)
CMAO: 118819954(hmgcrb) 118827647(hmgcra)
EEE: 113573726 113574964(hmgcr)
CHAR: 122132208(hmgcra)
TRU: 101066905(hmgcr) 101078757
LCO: 104926606 104937871(hmgcr)
NCC: 104951831 104964565(hmgcr)
TBEN: 117472804(hmgcra) 117476808
CGOB: 115013403(hmgcr) 115016396
ELY: 117252815(hmgcra) 117269947
EFO: 125878674 125890946(hmgcra)
PLEP: 121944864(hmgcra)
SLUC: 116050416(hmgcra) 116063008
PFLV: 114555718(hmgcr) 114571423
MSAM: 119891223(hmgcra) 119914994
SCHU: 122865699 122876893(hmgcra)
CUD: 121509299(hmgcra) 121525459
OAU: 116315906 116316679(hmgcra)
OML: 112137795(hmgcra) 112162813
CSAI: 133450784(hmgcra) 133455072
XMA: 102229336 102237239(hmgcr)
XCO: 114149006 114155192(hmgcr)
XHE: 116724027 116729469(hmgcr)
PRET: 103470679(hmgcr) 103473284
CVG: 107090374 107093682(hmgcr)
KMR: 108244757 108250729(hmgcra)
CSEM: 103389902 103397369(hmgcr)
POV: 109626244 109640161(hmgcr)
SSEN: 122758554 122762082(hmgcra)
SMAU: 118300401 118314132(hmgcra)
LCF: 108873800 108878542(hmgcra)
SLAL: 111647996(hmgcr) 111666845
XGL: 120805848(hmgcra) 120806513
HCQ: 109510552(hmgcr) 109525561
BPEC: 110157405 110172435(hmgcr)
SASA: 100380797(hmdh) 106570829(hmgcr)
STRU: 115159718 115200549(hmgcr)
OMY: 100135848(hmgcra) 110523461
OGO: 124036620(hmgcra) 124049075
ONE: 115121148 115140349(hmgcr)
OKI: 109868044 109896210(hmgcr)
SNH: 120026347 120063420(hmgcra)
CCLU: 121530724(hmgcra) 121582634
ELS: 105009321(hmgcr) 105015131
SFM: 108925108(hmgcr)
PKI: 111849962(hmgcr)
AANG: 118206679(hmgcra) 118212698
LOC: 102687067(hmgcr)
PSEX: 120532437(hmgcra)
LCM: 102361998(HMGCR)
CMK: 103186373(hmgcra)
RTP: 109936281(hmgcra)
CPLA: 122558616(hmgcra)
HOC: 132822683(hmgcra)
LERI: 129695300(hmgcra)
PMRN: 116950826(HMGCR)
LRJ: 133354303(HMGCR)
BFO: 118410303
BBEL: 109480740
CIN: 100187175
SPU: 373355(HMGCR)
LPIC: 129262576
APLC: 110986789
ARUN: 117295951
AJC: 117101197
SKO: 100369866
DME: Dmel_CG10367(Hmgcr)
DER: 6554339
DSE: 6607617
DSI: Dsimw501_GD21034(Dsim_GD21034)
DAN: 6499055
DSR: 110185563
DPO: 4801558
DPE: 6587844
DMN: 108154668
DWI: 6649674
DGR: 6567232
DAZ: 108621175
DNV: 108658955
DVI: 6630786
CCAT: 101460833
BOD: 106624299
BDR: 105226753
AOQ: 129246813
TDA: 119679998
MDE: 101892909
SCAC: 106093867
LCQ: 111690994
LSQ: 119601698
GFS: 119634515
ECOE: 129941450
CLON: 129611677
HIS: 119652831
AGA: 1269263
ACOZ: 120951773
AARA: 120908621
AMER: 121589719
ASTE: 118503565
AFUN: 125765774
AMOU: 128299172
AALI: 118460664
AAG: 5571790
ASUA: 134204958
CPII: 120415604
CNS: 116339559
BCOO: 119069314
AME: 550724
ACER: 108002157
ALAB: 122715961
ADR: 102680698
AFLR: 100868218
BIM: 100746066
BBIF: 117212391
BVK: 117240093
BVAN: 117163952
BTER: 100651787
BAFF: 126919098
BPYO: 122567149
BPAS: 132910938
FVI: 122538338
CCAL: 108629833
OBB: 114875877
OLG: 117600718
MGEN: 117229252
NMEA: 116433296
CGIG: 122399914
MPHA: 105831385
AEC: 105152804
ACEP: 105625102
PBAR: 105429601
HST: 105189357
DQU: 106746505
CFO: 105256970
FEX: 115233175
LHU: 105667949(Hmgcr)
PGC: 109859982
OBO: 105283012
PCF: 106788979
PFUC: 122522114
VPS: 122637486
VCRB: 124427635
VVE: 124946587
NVI: 100117068
CSOL: 105363952
TPRE: 106654786
LHT: 122499939
LBD: 127288428
MDL: 103572658
CGLO: 123259728
FAS: 105264725
DAM: 107037730
AGIF: 122852283
CINS: 118066889
VCAN: 122415058
CCIN: 107270502
DSM: 124414649
NPT: 124223615
NFB: 124186204
NLO: 107218478
NVG: 124309352
AROA: 105692988
APLN: 108741355
BMOR: 100101204(Hmg-r)
BMAN: 114252510
MSEX: 115456465
BANY: 112053778
MJU: 123879195
NIQ: 126779177
VCD: 124541020
MCIX: 123667956
PMAC: 106715604
PXU: 106124466
PRAP: 110997222
PBX: 123717059
PNAP: 125055077
ZCE: 119836387
CCRC: 123704086
LSIN: 126975379
AAGE: 121734942
HAW: 110382245(Hmgcr)
HZE: 124643356
SLIU: 111349908
OFU: 114351394
ATRA: 106141026
GMW: 113515794
PXY: 105398578
PGW: 126378354
LGLY: 125238726
CFEL: 113381684
CCRN: 123295005
DNX: 107170987
AGS: 114121337
RMD: 113557321
ACOO: 126836171
DVT: 126896415
DCI: 103516433
HHAL: 106681606 106683368(Hmgcr)
NLU: 111049687
HVI: 124355125
FOC: 113208675
TPAL: 117645219
ZNE: 110835092
CSEC: 111863546
SGRE: 126272744
BROR: 134532505
IEL: 124168837
DPX: DAPPUDRAFT_346929(Hmgcr)
DMK: 116915733
DPZ: 124313997
PVM: 113803763
PJA: 122247259
PCHN: 125046595
HAME: 121862368
PCLA: 123767677
CQD: 128697816
PTRU: 123509823
ESN: 126986655
MNZ: 135218347
HAZT: 108677200
EAF: 111711023
LSM: 121129247
TCF: 131890318
PPOI: 119102464
DSV: 119435783
RSAN: 119389523
RMP: 119182155
VDE: 111252553
VJA: 111258905
TUT: 107360294
DPTE: 113798075
DFR: 124493323
CSCU: 111640814
CVS: 136979762(Hmgcr)
PTEP: 107444292
ABRU: 129989549
UDV: 129217472
SDM: 118193349
CEL: CELE_F08F8.2(hmgr-1)
CBR: CBG_15296
TSP: Tsp_10921
PVUL: 126817480
PCAN: 112553957
BGT: 106073836
HRF: 124146826
HRJ: 124290969
CRG: 105320820
CANU: 128178148
CVN: 111128327
OED: 125650996
MYI: 110454220
PMAX: 117334622
MCAF: 127734329
MMER: 123523035
RPHI: 132741263
DPOL: 127878002
MAEA: 128226934
OBI: 106880618
LJP: 135472314
LAK: 106162017
LLON: 135483155
NVE: 5508715
EPA: 110243168
ATEN: 116294624
ADF: 107344111
AMIL: 114954020
PDAM: 113672697
SPIS: 111330985
DGT: 114522592
XEN: 124459523
HMG: 100215451
HSY: 130630546
RES: 135686993
AQU: 100635846
ATH: AT1G76490(HMG1) AT2G17370(HMG2)
BVG: 104904096
ATRI: 130825523
OSA: 4346017(HMG3) 4347443 9272427(HMG1)
ATR: 18439724
SCE: YLR450W(HMG2) YML075C(HMG1)
ERC: Ecym_1136
KMX: KLMA_40445(HMG1)
CGR: 2890968(GVI51_L11451)
NCS: NCAS_0A06180(NCAS0A06180)
NDI: NDAI_0D03170(NDAI0D03170)
TPF: TPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBL: TBLA_0E04740(TBLA0E04740)
TDL: TDEL_0D00740(TDEL0D00740)
KAF: KAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
KNG: KNAG_0B06690(KNAG0B06690) KNAG_0E04090(KNAG0E04090)
PIC: PICST_72872(HMG1)
LEL: PVL30_001319(HMG1)
LBG: 92208258(LODBEIA_P30620)
CAL: CAALFM_C103780CA(HMG1)
CTEN: 18248642(HMG1)
YLI: 2912214(YALI2_E00109g)
SLB: AWJ20_1837(HMG1)
NCR: NCU00712
NTE: NEUTE1DRAFT89746(NEUTE1DRAFT_89746)
SMP: 10810184(SMAC4_01392)
PBEL: QC761_104850(HMG1)
PPSD: QC762_104850(HMG1)
PPSP: QC763_104850(HMG1)
PPSA: QC764_104850(HMG1)
MGR: MGG_08975
PGRI: PgNI_04424
SSCK: SPSK_01389
FPU: FPSE_03466(HMR1)
NHE: NECHADRAFT_105420(NhHMR1)
TATV: 25775746(TrAtP1_000156)
TASP: 36611988(TrAFT101_002173)
MAW: 19247102(HMG1_1) 90963495(HMG1_2)
MAJ: MAA_05256
MBRN: 26237379(HMGR_0)
CMT: CCM_04994
PLJ: 28892300(PLICBS_009952)
PTKZ: JDV02_002825(HMG1_1) JDV02_008855(HMG1_2)
CDET: 87943724(CDEST_07221) 87948382(CDEST_11882)
MBE: MBM_03374
ALUC: AKAW2_11444A(HMG1_1) AKAW2_51101A(HMG1_2)
ACHE: ACHE_20686A(HMG1)
APUU: APUU_20079S(HMG1_1) APUU_40582S(HMG1_2)
ABE: ARB_00275
TVE: TRV_00650
PTE: PTT_07524
PTRR: 6349013(PtrM4_081330)
ZTR: MYCGRDRAFT_64888(HMG1)
SPO: 2538999(hmg1)
SOM: SOMG_04795(hmg1)
CNE: CNF04830
CNB: CNBF0070
CDEU: CNBG_2019
CDEP: 91088346(L203_104136)
KMG: 30162276(I203_107714)
KNE: 92182898(IAR55_005640)
TASA: A1Q1_01564
CCAC: CcaHIS019_0109720(HMG1)
ABP: AGABI1DRAFT64187(AGABI1DRAFT_64187)
ABV: AGABI2DRAFT208992(AGABI2DRAFT_208992)
SCM: SCHCO_02637526(SCHCODRAFT_02637526)
MGL: MGL_3624
MRT: MRET_0384
DDI: DDB_G0269142(hmgA) DDB_G0276615(hmgB)
DFA: DFA_02965(hmgB) DFA_07220
SPAR: SPRG_01272
LMA: LMJF_30_3190(HMGR)
LIF: LINJ_30_3230(HMGR)
LMAT: 92513985(LSCM1_03943)
LPAN: LPMP_303150(HMGR)
LOI: 92358214(LSCM4_02246)
LEIS: 94178389(GH5_02888)
LENR: 94170479(CUR178_03233)
LEIN: 94187289(JIQ42_03613)
PHET: 94289208(JKF63_03110)
PLU: plu4507
VCH: VC_A0723
VCS: MS6_A0769
VCE: Vch1786_II0408(hmgA)
VCI: O3Y_16913
VCR: VC395_A0589(hmgA)
VCM: VCM66_A0681(hmgA)
VVU: VV2_0117
VVY: VVA0625
VPA: VPA0968
VAG: N646_4347
VSP: VS_II0457
VAN: VAA_01552
VAU: VANGNB10_cII0695(hmgA)
VTA: B0124(hmgA)
VPL: SA104470976_03471(hmgA)
VFI: VF_A0841
PSIL: PMA3_24025
PSOA: PSm6_56390
GNI: GNIT_1294(hmg1)
PAT: Patl_0427
MVS: MVIS_1670(hmgA)
SAGA: M5M_16240
CBD: CBUD_0151 CBUD_0622(hmgA)
CBG: CbuG_0298 CbuG_1393(hmgA)
CBC: CbuK_0218 CbuK_1440(hmgA)
CEY: CleRT_04160(hmgA)
CENO: CEAn_00165
TCX: Tcr_1717
HMAR: HVMH_0539
DNO: DNO_0797
SVA: SVA_3750
CVI: CV_1806
BOK: DM82_1348
BOC: BG90_3346
BSAV: WS86_15315
LAA: WSI_04450
LSO: CKC_03800
LAR: lam_722(hMG1)
MALU: KU6B_29570
GAK: X907_0130
SAY: TPY_0167
HFV: R50_2653
MUL: MUL_3522
MMI: MMAR_3214
MSHO: MSHO_46160
CKP: ckrop_0031(mvaA)
CVA: CVAR_1983(mvaA)
CTER: A606_07960
COA: DR71_1489
CPRE: Csp1_09290
NFA: NFA_22110
SDV: BN159_7954(hmgA3)
STRE: GZL_00237
SFK: KY5_0603c
GMN: GMOLON4_2400(mvaA)
IDO: I598_0505
BSD: BLASA_0285(hmgA)
SEN: SACE_5541
SACG: FDZ84_37460(panC)
GBA: J421_4295
SGN: SGRA_2249
FAE: FAES_4555(hmgA)
HSW: Hsw_4017
FLM: MY04_1691
SRU: SRU_2422
SRM: SRM_02640(hmgA)
CPRV: CYPRO_0371
MJA: MJ_0705
MESG: MLAUSG7_1185(hmgA)
MESA: MLASG1_0627(hmgA)
MMP: MMP0087(hmgA)
MMD: GYY_00445
MMAK: MMKA1_00920(hmgA)
MMAO: MMOS7_01170(hmgA)
MMAD: MMJJ_10070
MAE: Maeo_0718
MVO: Mvol_1440
METF: CFE53_04475(hmgA)
MTH: MTH_562
MMG: MTBMA_c09500(hmgA)
MWO: MWSIV6_0926(hmgA)
MTEE: MTTB_09960
METC: MTCT_0489
METE: tca_00533
METK: FVF72_08715(hmgA)
MTHM: FZP57_04445(hmgA)
METJ: FZP68_04910(hmgA)
MST: Msp_0584(hmgA)
MEIS: PXD04_06485(hmgA)
MRU: mru_1092(hmgA)
MSI: Msm_0227
MEB: Abm4_0894(hmgA)
MMIL: sm9_0824(hmgA)
MEYE: TL18_06175
MOL: YLM1_0775
METV: K4897_01595(hmgA)
METH: MBMB1_1357(hmgA)
MFC: BRM9_0582(hmgA)
MFI: DSM1535_0563(hmgA)
MCUB: MCBB_1594(hmgA)
METT: CIT01_10430(hmgA)
METO: CIT02_11195(hmgA)
MEME: HYG87_00385(hmgA)
MEER: NKF70_03550(hmgA)
MFV: Mfer_0012
MKA: MK0355(hmg1)
PFU: PF1848
PFI: PFC_09350
PHO: PH1805(PH1805)
PAB: PAB2106
PYN: PNA2_0404
PYS: Py04_1729
TKO: TK0914
TON: TON_0399
TGA: TGAM_1146(hmgA)
TSI: TSIB_0612
THE: GQS_03225
THA: TAM4_2137
THM: CL1_0345
TLT: OCC_04595
THS: TES1_0465
TNU: BD01_0308
TEU: TEU_07265
THH: CDI07_02645(hmgA)
TIC: FH039_05035(hmgA)
TCQ: TIRI35C_0764(hmgA)
THEM: FPV09_04160(hmgA)
THEI: K1720_06130(hmgA)
PPAC: PAP_03560
MBAR: MSBR2_1683
MBAK: MSBR3_1674
MAC: MA_3073(hmgA)
MMA: MM_0335
MMAC: MSMAC_0968
METM: MSMTP_2268
MTHR: MSTHT_2527
MTHE: MSTHC_0758
MHOR: MSHOH_1143
MFZ: AOB57_002710(hmgA)
MBU: Mbur_1098
MMET: MCMEM_1587
MELO: J7W08_06890(hmgA)
MMH: Mmah_0566
MPY: Mpsy_2819
MZI: HWN40_08650(hmgA)
MMAV: RE476_01590(hmgA)
MSEB: RE474_11245(hmgA)
MHU: Mhun_3004
MRTJ: KHC33_01880(hmgA)
MLA: Mlab_1655
MBG: BN140_2503(hmgA)
MEMA: MMAB1_3364
MSUM: OH143_06095(hmgA)
MRC: R6Y96_02455(hmgA)
MPI: Mpet_0546
MEND: L6E24_05740(hmgA)
MEFW: F1737_08480(hmgA)
MAQE: RJ40_08430(hmgA)
MFK: E2N92_08655(hmgA)
MOU: OU421_08210(hmgA)
MESB: L1S32_11485(hmgA)
MANQ: L1994_08700(hmgA)
MBN: Mboo_0137
MPL: Mpal_2647
MPD: MCP_3002(hmgA-2)
MEZ: Mtc_0456(hmgA-2)
RCI: RCIX1027(hmgA)
MJK: N2V74_00960(hmgA) N2V74_04900(hmgA)
HAL: VNG_1875G(mvaA)
HSL: OE_3637R(hmgA)
HANR: LJ422_07545(hmgA)
HHB: Hhub_3224(hmgA)
HAGS: JT689_08890(hmgA)
HABO: JRZ79_07295(hmgA)
HNO: LT974_12855(hmgA)
HLU: LT972_02025(hmgA)
HSU: HLASF_1924(hmgA)
HSF: HLASA_1910(hmgA)
HAHS: HSRCO_2549(hmg1-2)
SALR: FQU85_07365(hmgA)
HALR: EFA46_001930(hmgA)
HDO: MUK72_12750(hmgA)
HALX: M0R89_03720(hmgA)
HAXZ: M0R88_03910(hmgA)
HAYC: NGM10_11295(hmgA)
HAXY: NGM07_08375(hmgA)
SALI: L593_03550
SAIM: K0C01_04905(hmgA)
HARA: AArcS_3008(hmg1)
HMA: rrnAC3412(mvaA)
HHI: HAH_0640(hmg)
HALJ: G9465_17050(hmgA)
HSIN: KDQ40_10325(hmgA)
NPH: NP_0368A(hmgA2) NP_2422A(hmgA1)
NMO: Nmlp_2407(hmgA)
NSAL: HWV07_16915(hmgA)
HUT: Huta_0276
HTI: HTIA_0459
HALA: Hrd1104_06135(hmgA)
HASV: SVXHr_1308(hmg1)
HABN: HBNXHr_1292(hmg1)
HMU: Hmuk_1499
HALZ: E5139_10630(hmgA)
HALL: LC1Hm_0815(hmg1)
HAZP: GBQ70_10625(hmgA)
HSN: DV733_04170(hmgA) DV733_04175(hmgA)
HDS: HSR122_0368(hmg1) HSR122_0753(hmg12)
HRR: HZS55_02025(hmgA)
HPEL: HZS54_01690(hmgA)
HLT: I7X12_11245(hmgA)
SSAI: N0B31_03920(hmgA)
HAAD: MW046_08125(hmgA)
HWA: HQ_3215A(hmgA)
HWC: Hqrw_3777(hmgA)
HVO: HVO_2583(hmgA)
HALE: G3A49_16610(hmgA)
HLN: SVXHx_2015(hmga)
HME: HFX_2609(hmgR)
HLS: KU306_00025(hmgA)
HAQ: DU484_05000(hmgA)
HAJ: DU500_05440(hmgA)
HAER: DU502_03160(hmgA)
HRA: EI982_10175(hmgA)
HLM: DV707_03295(hmgA)
HALM: FCF25_02765(hmgA)
HLA: Hlac_2019
HALP: DOS48_10695(hmgA)
HALB: EKH57_14585(hmgA)
HEZZ: EO776_10075(hmgA)
HALQ: Hrr1229_009810(hmgA)
HSS: J7656_05360(hmgA)
HSAI: HPS36_10575(hmgA)
HAZZ: KI388_09390(hmgA)
SRUB: C2R22_15940(hmgA)
HALN: B4589_010190(hmgA)
HALG: HUG10_01610(hmgA)
HALU: HUG12_15790(hmgA)
HMP: K6T50_15030(hmgA)
HRE: K6T36_14990(hmgA)
HRM: K6T25_01320(hmgA)
HACB: Hbl1158_07135(hmgA)
HTU: Htur_0537
HSAL: JMJ58_06425(hmgA)
HAKZ: J0X25_10075(hmgA)
NMG: Nmag_2929(hmgA)
NAT: NJ7G_4215
NVR: FEJ81_16145(hmgA)
NPL: FGF80_15215(hmgA)
NAY: HYG81_12750(hmgA)
HALY: HYG82_17865(hmgA)
HJT: DVR14_07455(hmgA)
HLO: J0X27_15550(hmgA)
SAWL: NGM29_02140(hmgA)
HALV: NGM15_11760(hmgA)
NARA: QQ977_12515(hmgA)
NBG: DV706_08730(hmgA)
NAS: GCU68_03355(hmgA)
MEAR: Mpt1_c04890(hmgA)
MEUZ: KRP56_04190(hmgA)
MARC: AR505_0768
APE: APE_1869(hmgA)
ACJ: ACAM_1174(hmgA)
SMR: Smar_1337
IHO: Igni_0476
IIS: EYM_00605
IPC: IPA_02310
DKA: DKAM_0388
HBU: Hbut_1531
PABI: PABY_23980(hmgA)
PARE: PYJP_01130(hmgA)
STO: STK_13520(hmgA)
SOH: D1869_07615(hmgA)
SSO: SSO0531
SOL: Ssol_1610
SSOA: SULA_1637(hmgA)
SSOL: SULB_1638(hmgA)
SSOF: SULC_1636(hmgA)
SCAS: SACC_04360
SAI: Saci_1359
SID: M164_1581
SII: LD85_1792
SIH: SiH_1551
SIR: SiRe_1459
SIC: SiL_1461
SULE: GFS03_08990(hmgA)
SULL: EWF20_08795(hmgA)
MSE: Msed_1649
MEMJ: MJ1HA_1876
MCN: Mcup_0580
MHK: DFR87_10465(hmgA)
MPRU: DFR88_10025(hmgA)
MTEN: GWK48_01835(hmgA)
AHO: Ahos_1305
ASUL: DFR86_09305(hmgA)
AAMB: D1866_01440(hmgA)
ACIH: HS5_27060
SAZO: D1868_04870(hmgA)
CSTY: KN1_25810
STEP: IC006_1049
SMET: RQ359_000843(hmgA)
SAHS: HS7_19200
PAI: PAE2182
PIS: Pisl_0814
PCL: Pcal_1085
PAS: Pars_0796
PYR: P186_0419
POG: Pogu_1536
TNE: Tneu_1359
CMA: Cmaq_0412
TTN: TTX_0171(mvaA)
TUZ: TUZN_1176
VDI: Vdis_1666
VMO: VMUT_2295
ASC: ASAC_1038
ACIA: SE86_06315
MARH: Mia14_0330
 » show all
Reference
PMID:2991281
  Authors
Luskey KL, Stevens B
  Title
Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.
  Journal
J Biol Chem 260:10271-7 (1985)
  Sequence
[hsa:3156]
Reference
PMID:1556098
  Authors
Lam WL, Doolittle WF
  Title
Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii.
  Journal
J Biol Chem 267:5829-34 (1992)
  Sequence
[hvo:HVO_2583]
LinkDB

KEGG   ENZYME: 1.1.1.34
Entry
EC 1.1.1.34                 Enzyme                                 
Name
hydroxymethylglutaryl-CoA reductase (NADPH);
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl CoA reductase (NADPH);
S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
NADPH-hydroxymethylglutaryl-CoA reductase;
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA);
3-hydroxy-3-methylglutaryl CoA reductase (NADPH);
hydroxymethylglutaryl-CoA reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN:R02082]
Reaction(KEGG)
R02082
Substrate
(R)-mevalonate [CPD:C00418];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
History
EC 1.1.1.34 created 1961
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00021  hydroxymethylglutaryl-CoA reductase (NADPH)
Genes
HSA3156(HMGCR)
PTR471516(HMGCR)
PPS100990336(HMGCR)
GGO101136625(HMGCR)
PON100173499(HMGCR)
PPYG129036875(HMGCR)
NLE100597442(HMGCR)
HMH116462468(HMGCR)
SSYN129468073(HMGCR)
MCC705479(HMGCR)
MCF101926249(HMGCR)
MTHB126957065
MNI105475132(HMGCR)
CSAB103223243(HMGCR)
CATY105599201(HMGCR)
PANU101005142(HMGCR)
TGE112625905(HMGCR)
MLEU105551327(HMGCR)
RRO104653755(HMGCR) 115895907 115896021 115896068
RBB108513080(HMGCR)
TFN117065272(HMGCR)
PTEH111539937(HMGCR)
CANG105524122(HMGCR)
CJC100403990(HMGCR)
SBQ101033204(HMGCR)
CIMI108303725(HMGCR)
ANAN105723900(HMGCR)
CSYR103273609(HMGCR)
MMUR105881833(HMGCR)
LCAT123648553(HMGCR)
PCOQ105826599(HMGCR)
OGA100965474(HMGCR)
MMU15357(Hmgcr)
MCAL110307857(Hmgcr)
MPAH110328787(Hmgcr)
RNO25675(Hmgcr)
MCOC116083242(Hmgcr)
ANU117700463(Hmgcr)
MUN110562396(Hmgcr)
CGE100756363(Hmgcr)
MAUA101843185(Hmgcr)
PROB127221099(Hmgcr)
PLEU114687932 114694656(Hmgcr)
MORG121455744(Hmgcr)
MFOT126496070 126508518
AAMP119808971(Hmgcr)
NGI103731354(Hmgcr)
HGL101717005(Hmgcr)
CPOC100726509(Hmgcr)
CCAN109700493(Hmgcr)
DORD105992420(Hmgcr)
DSP122117118(Hmgcr)
PLOP125367607(Hmgcr)
NCAR124987348
MMMA107152270(Hmgcr)
OCU100357791
OPI101520422(HMGCR)
TUP102480274(HMGCR)
GVR103598511(HMGCR)
CFA479182(HMGCR)
CLUD112653350(HMGCR)
VVP112919751(HMGCR)
VLG121489192(HMGCR)
NPO129503361 129507793 129521048(HMGCR)
AML100464316(HMGCR)
UMR103663564(HMGCR)
UAH113255200(HMGCR)
UAR123800202(HMGCR)
ELK111140105 111148417
LLV125100135
MPUF101694441(HMGCR)
MNP132028734(HMGCR)
MLK131832360(HMGCR)
NVS122918489(HMGCR)
ORO101368294(HMGCR)
EJU114217572(HMGCR)
ZCA113928970(HMGCR)
MLX118016904(HMGCR)
NSU110591087(HMGCR)
LWW102725694(HMGCR)
FCA101098922(HMGCR)
PYU121014418(HMGCR)
PCOO112860354(HMGCR)
PBG122489870(HMGCR)
PVIV125171263(HMGCR)
LRUF124518177
PTG102963640(HMGCR)
PPAD109274990(HMGCR)
PUC125935747
AJU106974837
HHV120226596 120240725(HMGCR)
BTA407159(HMGCR)
BOM102270355(HMGCR)
BIU109564640(HMGCR)
BBUB102394647(HMGCR)
BBIS104994134(HMGCR)
CHX102169762(HMGCR)
OAS101108919(HMGCR)
BTAX128054047(HMGCR)
ODA120852611 120860962
CCAD122442980(HMGCR)
MBEZ129562799(HMGCR)
SSC100144446(HMGCR)
CFR102507285(HMGCR)
CBAI105064373(HMGCR)
CDK105084800(HMGCR)
VPC102543088(HMGCR)
BACU103000968 103010372(HMGCR) 103020890
BMUS118892135(HMGCR)
LVE103081068(HMGCR)
OOR101275846(HMGCR)
DLE111185263(HMGCR)
PCAD102983040(HMGCR)
PSIU116750950(HMGCR)
NASI112391416(HMGCR)
ECB100065577(HMGCR)
EPZ103555449(HMGCR)
EAI106824005(HMGCR)
MYB102262745(HMGCR)
MYD102767367(HMGCR)
MMYO118655928(HMGCR)
MLF102436294(HMGCR)
MDT132233518(HMGCR)
PKL118703505(HMGCR)
EFUS103305199(HMGCR)
MNA107531218(HMGCR)
DRO112307523(HMGCR)
SHON118977261(HMGCR)
AJM119062428(HMGCR)
PDIC114494235(HMGCR)
PHAS123824707(HMGCR)
MMF118642218(HMGCR)
PPAM129074621(HMGCR)
HAI109381933(HMGCR)
RFQ117024888(HMGCR)
PALE102890076(HMGCR)
PGIG120598500(HMGCR)
PVP105302180(HMGCR)
RAY107506449(HMGCR)
MJV108408321(HMGCR)
TOD119260566(HMGCR)
SARA101539442(HMGCR)
SETR126001477(HMGCR)
LAV100661990(HMGCR)
TMU101360660
ETF101646675(HMGCR)
DNM101422332(HMGCR)
MDO100014439(HMGCR)
GAS123236693(HMGCR)
SHR100922433(HMGCR)
AFZ127558817
PCW110216572(HMGCR)
TVP118853358(HMGCR)
OAA100086613(HMGCR)
GGA395145(HMGCR)
PCOC116239242(HMGCR)
MGP104915886(HMGCR)
CJO107306044(HMGCR)
TPAI128089730(HMGCR)
LMUT125686886(HMGCR)
NMEL110389857(HMGCR)
APLA101805369(HMGCR)
ACYG106042919(HMGCR)
CATA118251497(HMGCR)
AFUL116500427(HMGCR)
TGU100228972(HMGCR)
LSR110471283(HMGCR)
SCAN103819488(HMGCR)
PMOA120511968(HMGCR)
OTC121341292(HMGCR)
PRUF121363659(HMGCR)
GFR102039836(HMGCR)
FAB101812070(HMGCR)
OMA130264830(HMGCR)
PHI102101959(HMGCR)
PMAJ107215886(HMGCR)
CCAE111940640(HMGCR)
CCW104685133(HMGCR)
CBRC103620024(HMGCR)
ETL114057167(HMGCR)
ZAB102070063(HMGCR)
ZLE135459766(HMGCR)
ACHL103797889
SVG106859685(HMGCR)
MMEA130572249(HMGCR)
HRT120765481(HMGCR)
SATI136374142(HMGCR)
FPG101915600(HMGCR)
FCH102052105(HMGCR)
CCRI104167304(HMGCR)
NNT104399950(HMGCR)
SHAB115619708(HMGCR)
ACUN113490251(HMGCR)
TALA104358103(HMGCR)
ACHC115336962(HMGCR) 121232774
HALD104316803(HMGCR)
HLE104841274(HMGCR)
AGEN126035249 126035717
GCL127029035
CSTI104554649(HMGCR)
LDI104354014(HMGCR)
MNB103776975(HMGCR)
DPUB104299688(HMGCR)
AVIT104267777(HMGCR)
BRHI104493501(HMGCR)
EGZ104124861(HMGCR)
NNI104013038(HMGCR) 104017611
PCRI104030224(HMGCR)
PCAO104046161(HMGCR)
PADL103919697(HMGCR)
AFOR103899769(HMGCR)
FGA104082402(HMGCR)
GSTE104251283(HMGCR)
CLV102088196(HMGCR)
MUI104534211(HMGCR)
PGUU104472022(HMGCR)
PLET104614533(HMGCR)
EHS104517362(HMGCR)
CMAC104479439(HMGCR)
CUCA104056378(HMGCR)
TEO104379220(HMGCR)
BREG104636134(HMGCR)
OHA104331138(HMGCR)
ACAR104529373(HMGCR)
CPEA104395804(HMGCR)
CVF104285757(HMGCR) 104295812
RTD128901989 128902471(HMGCR)
AAM106489268
AROW112961814(HMGCR)
NPD112944911(HMGCR)
TGT104567556(HMGCR) 104571572
DNE112987050(HMGCR)
SCAM104152937(HMGCR)
ASN102386377(HMGCR)
AMJ102571444(HMGCR)
CPOO109308025(HMGCR)
GGN109297712(HMGCR)
PSS102459565(HMGCR)
CMY102947767(HMGCR)
CCAY125636488(HMGCR)
DCC119856262(HMGCR)
CPIC101931267(HMGCR)
TST117878840(HMGCR)
CABI116816474(HMGCR)
MRV120407831(HMGCR)
ACS100555648(hmgcr)
ASAO132767071(HMGCR)
PVT110084573
SUND121922562(HMGCR)
PBI103059006(HMGCR)
PMUR107291177(HMGCR)
CTIG120317399(HMGCR)
TSR106550050(HMGCR)
PGUT117679301(HMGCR)
APRI131192013(HMGCR)
PTEX113447636(HMGCR)
NSS113413962(HMGCR)
VKO123031296(HMGCR)
PMUA114606284(HMGCR)
PRAF128423514(HMGCR)
ZVI118076836(HMGCR)
HCG128346175(HMGCR)
GJA107118163(HMGCR)
STOW125436468(HMGCR)
EMC129334716(HMGCR)
XLA108707262(hmgcr.S) 397750(hmgcr.L)
XTR100380121(hmgcr)
NPR108796370(HMGCR)
RTEM120929647(HMGCR)
BBUF120992439 120992442 120992446
BGAR122924719 122924720 122935929 122935954 122935962
MUO115463074(HMGCR)
GSH117353053(HMGCR)
DRE541479(hmgcrb) 559054(hmgcra)
SRX107713481 107720287 107731091 107756298
SANH107653362 107675784 107699716 107703249
SGH107555490 107568540 107585692 107587518
CCAR109055857 109056491 109067925 109070312
CAUA113038995 113039106 113049089 113049608 113080269
CGIB127958121 127985512 127998847
PTET122332519 122345041(hmgcra)
LROH127152779(hmgcrb) 127165704(hmgcra)
OMC131528310(hmgcrb) 131540343(hmgcra)
PPRM120471286(hmgcrb) 120471903(hmgcra)
RKG130072736(hmgcra) 130073040(hmgcrb)
MAMB125252378 125252751(hmgcrb) 125267502(hmgcra)
CIDE127503285 127512176
CERY137013331(hmgcrb) 137034537(hmgcra)
MASI127424367 127429240 127430821 127440097
TROS130550344(hmgcra) 130569927(hmgcrb)
TDW130407552(hmgcrb) 130419877(hmgcra)
MANU129423206(hmgcrb)
IPU108255489(hmgcra) 108278928(hmgcrb)
IFU128622029 128625564(hmgcra)
PHYP113535726 113536911(hmgcr)
SMEO124380523(hmgcra) 124397681(hmgcrb)
TFD113642276(hmgcra) 113646450(hmgcrb)
TVC132854985(hmgcra) 132859902(hmgcrb)
TRN134330193(hmgcrb) 134335066(hmgcra)
AMEX103033046(hmgcra) 103037085(hmgcrb)
CMAO118819954(hmgcrb) 118827647(hmgcra)
EEE113573726 113574964(hmgcr)
CHAR122132208(hmgcra)
TRU101066905(hmgcr) 101078757
TFS130516957 130525560
TNGGSTEN00007211G001 GSTEN00025237G001
LCO104926606 104937871(hmgcr)
NCC104951831 104964565(hmgcr)
TBEN117472804(hmgcra) 117476808
CGOB115013403(hmgcr) 115016396
PGEO117452762 117456259
GACU117534986 117561391
EMAC134868509 134874020
ELY117252815(hmgcra) 117269947
EFO125878674 125890946(hmgcra)
PLEP121944864(hmgcra)
SLUC116050416(hmgcra) 116063008
ECRA117945081 117959134
ESP116689589 116703914
PFLV114555718(hmgcr) 114571423
GAT120815257 120831700
PPUG119224957 119226451
AFB129101368 129101975
CLUM117736344 117740793
PSWI130196519 130205072
MSAM119891223(hmgcra) 119914994
SCHU122865699 122876893(hmgcra)
CUD121509299(hmgcra) 121525459
ALAT119019401 119029640
MZE101481565 101484560
ONL100694446 100697646
OAU116315906 116316679(hmgcra)
OLA100125499 101166888
OML112137795(hmgcra) 112162813
CSAI133450784(hmgcra) 133455072
XMA102229336 102237239(hmgcr)
XCO114149006 114155192(hmgcr)
XHE116724027 116729469(hmgcr)
PRET103470679(hmgcr) 103473284
PFOR103132185 103135855 103155668(hmgcr)
PLAI106935197 106942092 106943151
PMEI106910235 106912233 106928741
GAF122828243 122846943
PPRL129355319 129355378 129374174
CVG107090374 107093682(hmgcr)
CTUL119788290 119795598
GMU124872271 124878210
NFU107374826 107396143
KMR108244757 108250729(hmgcra)
ALIM106531768 106536933
NWH119412939 119425000
AOCE111575348 111579328
MCEP124997022 125012064
CSEM103389902 103397369(hmgcr)
POV109626244 109640161(hmgcr)
SSEN122758554 122762082(hmgcra)
HHIP117767822 117771485
HSP118098219 118115435
PPLT128438388 128462286
SMAU118300401 118314132(hmgcra)
LCF108873800 108878542(hmgcra)
SDU111217813 111227716
SLAL111647996(hmgcr) 111666845
XGL120805848(hmgcra) 120806513
HCQ109510552(hmgcr) 109525561
SSCV125979273 125994742
SBIA133490806 133499409
PEE133400465 133414074
PTAO133475443 133490102
BPEC110157405 110172435(hmgcr)
MALB109959666 109967764
BSPL114845428 114866612
SJO128365272 128380286
SASA100380797(hmdh) 106570829(hmgcr)
STRU115159718 115200549(hmgcr)
OTW112220299 112262535
OMY100135848(hmgcra) 110523461
OGO124036620(hmgcra) 124049075
ONE115121148 115140349(hmgcr)
OKI109868044 109896210(hmgcr)
OKE118357975 118387436
SALP111957595 111961745
SNH120026347 120063420(hmgcra)
CCLU121530724(hmgcra) 121582634
ELS105009321(hmgcr) 105015131
SFM108925108(hmgcr)
PKI111849962(hmgcr)
AANG118206679(hmgcra) 118212698
LOC102687067(hmgcr)
PSPA121305348 121313494
ARUT117403715 117973436
PSEX120532437(hmgcra)
LCM102361998(HMGCR)
CMK103186373(hmgcra)
RTP109936281(hmgcra)
CPLA122558616(hmgcra)
HOC132822683(hmgcra)
LERI129695300(hmgcra)
PMRN116950826(HMGCR)
LRJ133354303(HMGCR)
BFO118410303
BBEL109480740
CIN100187175
SCLV120331473 120331474
SPU373355(HMGCR)
LPIC129262576
APLC110986789
ARUN117295951
AJC117101197
SKO100369866
DMEDmel_CG10367(Hmgcr)
DER6554339
DSE6607617
DSIDsimw501_GD21034(Dsim_GD21034)
DYADyak_GE10390
DAN6499055
DSR110185563
DPO4801558
DPE6587844
DMN108154668
DWI6649674
DGR6567232
DMODmoj_GI10363
DAZ108621175
DNV108658955
DHE111602661 115483796
DVI6630786
CCAT101460833
BOD106624299
BDR105226753
RZE108369213 108381086
AOQ129246813
TDA119679998
MDE101892909
SCAC106093867
LCQ111690994
LSQ119601698
GFS119634515
ECOE129941450
CLON129611677
HIS119652831
AGA1269263
ACOZ120951773
AARA120908621
AMER121589719
ASTE118503565
AFUN125765774
AMOU128299172
AALI118460664
AAG5571790
AALB109430221 115257652
ASUA134204958
CQUCpipJ_CPIJ004077
CPII120415604
CNS116339559
BCOO119069314
AME550724
ACER108002157
ALAB122715961
ADR102680698
AFLR100868218
BIM100746066
BBIF117212391
BVK117240093
BVAN117163952
BTER100651787
BAFF126919098
BPYO122567149
BPAS132910938
FVI122538338
CCAL108629833
OBB114875877
OLG117600718
MGEN117229252
NMEA116433296
CGIG122399914
SOC105197351 105202303 105203277
MPHA105831385
AEC105152804
ACEP105625102
PBAR105429601
VEM105557592 105567004
HST105189357
DQU106746505
CFO105256970
FEX115233175
LHU105667949(Hmgcr)
PGC109859982
OBO105283012
PCF106788979
PFUC122522114
VPS122637486
VCRB124427635
VVE124946587
NVI100117068
CSOL105363952
TPRE106654786
LHT122499939
LBD127288428
MDL103572658
CGLO123259728
FAS105264725
DAM107037730
AGIF122852283
CINS118066889
VCAN122415058
CCIN107270502
DSM124414649
NPT124223615
NFB124186204
NLO107218478
NVG124309352
AROA105692988
TCA661937 662673
DPA109532915 109536860
SOY115876682 115887958
AGRG126748370 126750170
ATD109595467 109604743
CSET123306661 123321602
AGB108908023 108916896
LDC111511512 111515886
DVV114329359 114334477
NVL108556671 108569169
APLN108741355
PPYR116165087 116165442 116165673
OTU111414153 111423256
BMOR100101204(Hmg-r)
BMAN114252510
MSEX115456465
DPLKGM_213891
BANY112053778
MJU123879195
NIQ126779177
VCD124541020
MCIX123667956
PMAC106715604
PXU106124466
PRAP110997222
PBX123717059
PNAP125055077
ZCE119836387
CCRC123704086
LSIN126975379
AAGE121734942
HAW110382245(Hmgcr)
HZE124643356
TNL113504116 113506649
SLIU111349908
OFU114351394
ATRA106141026
GMW113515794
PXY105398578
PGW126378354
LGLY125238726
CFEL113381684
CCRN123295005
API100165462 100165708
DNX107170987
AGS114121337
RMD113557321
ACOO126836171
DVT126896415
BTAB109033237 109043605
DCI103516433
CLEC106662464 106665424
HHAL106681606 106683368(Hmgcr)
NLU111049687
HVI124355125
MQU128996230 128996791
PHUPhum_PHUM388720
FOC113208675
TPAL117645219
ZNE110835092
CSEC111863546
SGRE126272744
BROR134532505
IEL124168837
FCD110843199 110848874
DPXDAPPUDRAFT_346929(Hmgcr)
DMK116915733
DPZ124313997
PVM113803763
PJA122247259
PCHN125046595
PMOO119569787 119591446
HAME121862368
PCLA123767677
CQD128697816
PTRU123509823
ESN126986655
MNZ135218347
HAZT108677200
EAF111711023
LSM121129247
TCF131890318
PPOI119102464
DSV119435783
RSAN119389523
RMP119182155
VDE111252553
VJA111258905
TUT107360294
DPTE113798075
DFR124493323
CSCU111640814
CVS136979762(Hmgcr)
PTEP107444292
ABRU129989549
UDV129217472
SDM118193349
LPOL106465812 106468291 106472382
PMEO129587202 129590750
CELCELE_F08F8.2(hmgr-1)
CBRCBG_15296
CRQGCK72_008691
NAINECAME_06176
LOALOAG_01960
TSPTsp_10921
HROHELRODRAFT_100685
LGILOTGIDRAFT_126248
PVUL126817480
PCAN112553957
BGT106073836
GAE121386239 121391285
HRF124146826
HRJ124290969
CRG105320820
CANU128178148
CVN111128327
OED125650996
MYI110454220
PMAX117334622
MCAF127734329
MMER123523035
RPHI132741263
DPOL127878002
MAEA128226934
OBI106880618
OSN115220261 115231806
LJP135472314
LAK106162017
SMMSmp_138590
OVIT265_09380
LLON135483155
NVE5508715
EPA110243168
ATEN116294624
ADF107344111
AMIL114954020
PDAM113672697
SPIS111330985
DGT114522592
XEN124459523
HMG100215451
HSY130630546
RES135686993
TADTRIADDRAFT_37359
AQU100635846
ATHAT1G76490(HMG1) AT2G17370(HMG2)
ALY9320120 9325151
CRB17891091 17891700 17894738
CSAT104702412 104713314 104747554 104751544 104767040 104791012
EUSEUTSA_v10018320mg EUTSA_v10022614mg
BRP103832111 103845964 103853029
BNA106381415 106393352 106397583 106413095 106421619 106447170 111206800
BOE106298164 106302431 106327567
RSZ108806082 108815848 108817716 108823330
THJ104807413 104809909 104812013 104819699
CPAP110818015 110822502 110826423
CIT102609952 102629783
CICCICLE_v10000761mg CICLE_v10028082mg
PVY116125840 116127722 116128530
MINC123199305 123203268 123213049 123229190
TCC18592079 18608389 18610613
GRA105762693 105773783 105780523 105783325 105785336 105795019 105795020 105795021 105795022
GHI107894010 107898896 107900974 107908970 107908971 107908972 107908973 107920223 107921012 107928879 107929696 107939227 107939234 107939235 107942380 107949229 121203148
GAB108464595 108464823 108472665 108474412 108476033 108476034 108476102 108478449 108483316
HSYR120123805 120128061 120133880 120149648 120151081 120153680 120160409 120161963 120171390 120171763 120175361 120178064 120178707 120188478 120214975
DZI111282133 111294897 111295040 111309162
EGR104415928 104415929 104419056 104419554 104448961 104450349
GMX100777317 100779932 100784330 100786956 100790033 100811237 100815480
GSJ114368900 114372874 114384333 114390548 114400556 114403720 114418926
PVUPHAVU_002G118900g PHAVU_003G271800g PHAVU_006G008200g PHAVU_008G208900g
VRA106765004 106769498 106775852 106777775
VAR108323852 108336049 108338409 108343207
VUN114166587 114178197 114188075 114194282
VUM124820624 124835565 124844661
CCAJ109789279 109807923 109809026 109817020
APRC113846336 113856008 113868520
MTR11407896 11409457 11410653 11415590 11416526 11416581 11432311 11435433 11441531 120580464 120580466
TPRA123881442 123907437 123907438 123907439 123907456 123921307
CAM101499627 101506157 101507469
PSAT127074798 127117940 127119955 127119956
VVO131615967 131624615 131641374 131641424 131641540 131643031 131651938 131651939 131651940 131651941
LJA130733393 130740335
ADU107475678 107487384 107496702 127743928
AIP107609115 107622205
AHF112702186 112747624 112766610 112786654 112797557 112800231
LANG109331148 109332949 109333207 109340936 109348976 109360654
PCIN129297237 129303705
QSAO6P43_016400 O6P43_018800 O6P43_024982 O6P43_033488
FVE101292247 101308137 101308723 101309304 101314281 105349649
RCN112169394 112170031 112170480 112170950 112172112 112173409 112187592
PPER18766576 18769510 18770980
PMUM103334636 103340474 103340524 103340675
PAVI110748888 110748889 110753313
PDUL117634036 117634124 117634319 117636586
MDM103406991 103410649 103412133 103420907 103421562 103455059 114823477 114827471
MSYL126584724 126603659 126608760 126608765 126621351 126621687
PXB103949512 103950192 103959146 103959147
ZJU107416066 107424303 107425621
MNT21396915 21407526
CSAV115702836 115711722
CSV101210779 101213994 101219178
CMO103490442 103492557 103502601
BHJ120069047 120075609 120078703
MCHA111007941 111011297 111022898
CMAX111468156 111469777 111483921 111486441 111493947
CMOS111435117 111448960 111450384 111451663 111455316
CPEP111777784 111786647 111792545 111795892 111805274 111811700
RCU8258747 8273668 8285370
MEAN126655495 126676938 126677268
JCU105635170 105636809 105646344
HBR110632308 110639682 110659189 110666401 110669274
MESC110602324 110609571 110610776 110611890 110615710
POP18098173 7463352 7474548 7480368 7489052 7494728
PEU105108290 105130080 105132797 105135092 105137286
PALZ118032272 118038875 118040723 118042028 118049007 118049008 118061881
PNZ133679553 133691539 133694789 133696353 133699780 133702972
JRE108997419 109006674 109007712
CILL122310732 122313723 122314005 122316648
CAVE132166922 132172388 132189614
QSU112003066 112029959 136063819
QLO115968248 115974715
TWL120002099 120009517 120010889
VVI100243051 100245191 100265082
VRI117906950 117911449 117913554
SLY101265292(HMG2) 101266490 101266800 543702(HMGR)
SPEN107009176 107011154 107013488 107014402 107014404
SOT102577467(HMG3) 102577654(HMGR) 102577889(HMG2) 102577899 102585007 102599791(hmg1)
SSTN125847643 125849310 125856126 125856209 125858547 125862908
SDUL129873330 129873690 129895646 129902939
CANN107857553 107859749 107866760 107868268
LBB132606360 132616896 132625211 132628261
NTA107759218 107765219 107770799 107772124 107772411 107777769(HMGR2) 107832729(HMGR1)
NSY104229786 104230282 104234010
NTO104085779 104095021 104096414
NAU109212119 109212162 109214780
INI109156531 109156539 109157709 109157710 109157803 109157858 109163672 109166302 109167689 109172644 109177861 109179200 109179210 109179221
ITR115998205 115998206 115999126 115999210 115999417 115999661 116013453 116020998 116025432 116031547
SIND105158861 105172989
OEU111376622 111387406 111387692 111396504 111396750 111401248 111409359 111410512
EGT105953664 105954672 105959439
SSPL121746493 121750355 121755257 121759913 121761201 121761327 121762577 121763864 121763865 121763866 121763867 121765864 121792911
SMIL130995288 131011022 131020849 131020852
SHIS125188964 125198417 125198418 125201139 125201391 125221166 125222005
APAN127242677 127246395 127248373 127252564
HAN110872304 110877312 110892686 110911984 110915593 110926479
ECAD122580131 122586774 122596882 122602162 122606915
LSV111876391 111878449 111887736 111896566 111903696 111903697 111903698 111916003
CCAV112509112 112510297 112510721 112512356 112522594 112523899 112524109 112524280 112524499 112525038 112525047
DCR108211606 108221269 108223417
CSIN114258298 114278875 114283426 114303870 114310350 114313128 114314342
RVL131299050 131304380 131307834 131330784
AEW130758818 130775973 130777253 130777463 130778431 130784651 130785155
BVG104904096
SOE110786630 110806054
CQI110682124 110682133 110695305 110696360 110718708
ATRI130825523
MOF131155386 131162962
NNU104603825 104606863
MING122074500 122084512
TSS122658227 122661473
PSOM113279850 113283586 113289689 113296423 113299434 113305346 113325202 113326281 113343154 113356776
OSA4346017(HMG3) 4347443 9272427(HMG1)
OBR102709438 102714400 102718298
OGL127761214 127782400 127784566
BDI100828238 100832962 100840327
ATS109746630 109752372 109782286
TDC119302075 119309763 119317635 119320070 119329263 119337418
TAES123104204 123112452 123121961 123128173 123137982 123145269 123151295 123159445 123165516
TUA125514343 125519905 125530574
LPER127302135 127306435 127316790
LRD124649117 124654551 124681478 124688160
SBI8054742 8057903 8071789
ZMA100191922 100280335 100383280 103627645
MFLO136476804 136476881 136500727 136500932 136542097 136549954
SITA101754923 101777103 101777901
SVS117844885 117860868 117863085
PVIR120650124 120654228 120661101 120680035 120683379 120712834
PHAI112873522 112881963 112896992
PDA103698006 103702268 103711741 103713865
EGU105036971 105039425 105049376 105050594 105052870
MUS103973856 103974403 103981049 103992389
ZOF121969888 121974998 121980478 121981507 121984392 122008140 122016369 122038097
DCT110098248 110104601 110110287 110115939
PEQ110021706 110024026
AOF109842511 109843683
MSIN131219180 131222354
NCOL116256633 116259657
ATR18439724
SMOSELMODRAFT_177513 SELMODRAFT_272011
PPP112276414 112278455 112288197
GSLGasu_35770
SCEYLR450W(HMG2) YML075C(HMG1)
SEUBDI49_3943 DI49_4014
SPAOSPAR_L04530 SPAR_M00560
AGOAGOS_AER152W
ERCEcym_1136
KLAKLLA0_B04642g
KMXKLMA_40445(HMG1)
LTHKLTH0D16786g
VPOKpol_1001p4 Kpol_520p23
ZROZYRO0B14696g
CGR2890968(GVI51_L11451)
NCSNCAS_0A06180(NCAS0A06180)
NDINDAI_0D03170(NDAI0D03170)
TPFTPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBLTBLA_0E04740(TBLA0E04740)
TGBHG536_0C06050
TDLTDEL_0D00740(TDEL0D00740)
KAFKAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
KNGKNAG_0B06690(KNAG0B06690) KNAG_0E04090(KNAG0E04090)
ZMKHG535_0E01650
SLUDSCDLUD_004349
DHADEHA2D09372g
PICPICST_72872(HMG1)
PGUPGUG_04712
SPAASPAPADRAFT_130779
LELPVL30_001319(HMG1)
LBG92208258(LODBEIA_P30620)
CALCAALFM_C103780CA(HMG1)
CTPCTRG_04347
COTCORT_0B11440
CDUCD36_03520
CTEN18248642(HMG1)
CLUCLUG_04490
CLUSA9F13_04g00077
CAURCJI96_0001761
PPAPAS_chr2-2_0230
PKZC5L36_0C09050
BNNFOA43_000423
BBRXBRETT_003034
OPAHPODL_01644
YLI2912214(YALI2_E00109g)
SLBAWJ20_1837(HMG1)
NCRNCU00712
NTENEUTE1DRAFT89746(NEUTE1DRAFT_89746)
SMP10810184(SMAC4_01392)
PANPODANSg09736
PBELQC761_104850(HMG1)
PPSDQC762_104850(HMG1)
PPSPQC763_104850(HMG1)
PPSAQC764_104850(HMG1)
TTTTHITE_135005
MTMMYCTH_114008
CTHRCTHT_0055290
MGRMGG_08975
PPEIPpBr36_00640
PGRIPgNI_04424
TMNUCRPA7_8502
SSCKSPSK_01389
FGRFGSG_09197
FPUFPSE_03466(HMR1)
FPOAFPOAC1_012495
FVNFVRRES_13590
FVRFVEG_03711
FOXFOXG_05833
NHENECHADRAFT_105420(NhHMR1)
FFCNCS54_01220000
FKRNCS57_01207300
FMUJ7337_003723
TRETRIREDRAFT_71380
TRRM419DRAFT_94495
TATV25775746(TrAtP1_000156)
TASP36611988(TrAFT101_002173)
MAW19247102(HMG1_1) 90963495(HMG1_2)
MAJMAA_05256
MBRN26237379(HMGR_0)
PCHMVFPPC_08796
CMTCCM_04994
AMUSLMH87_007408
PLJ28892300(PLICBS_009952)
PTKZJDV02_002825(HMG1_1) JDV02_008855(HMG1_2)
VALVDBG_09884
VDAVDAG_06169
CFJCFIO01_06610
CLUPCLUP02_13165
CHIGCH63R_05417 CH63R_10650
CDET87943724(CDEST_07221) 87948382(CDEST_11882)
SAPOSAPIO_CDS1344
ELAUCREL1_10439
PFYPFICI_13524
SSLSS1G_06018
BFUBCIN_05g03150
MBEMBM_03374
PSCOLY89DRAFT_572605
GLZGLAREA_08377
ANIANIA_03817
AFMAFUA_1G11230 AFUA_2G03700
ACTACLA_090820
NFINFIA_009850 NFIA_014400 NFIA_036050
AORAO090103000311 AO090120000217
ANGAn04g00610 An07g08280
AFVAFLA_009435 AFLA_013213
ALUCAKAW2_11444A(HMG1_1) AKAW2_51101A(HMG1_2)
ACHEACHE_20686A(HMG1)
APUUAPUU_20079S(HMG1_1) APUU_40582S(HMG1_2)
PCSN7525_000489
PDPPDIP_71160
POUPOX_b02618
TMFEYB26_003456
TRGTRUGW13939_10027
CIMCIMG_04488
CPWCPC735_072790
UREUREG_01707
ABEARB_00275
TVETRV_00650
PBLPAAG_05791
PBNPADG_07596
AJEHCAG_04488
BGHBDBG_04749
PNOSNOG_09830
PTEPTT_07524
PTRR6349013(PtrM4_081330)
BZECOCCADRAFT_109709
BSCCOCSADRAFT_89878
BORCOCMIDRAFT_95702
AALTCC77DRAFT_941513
ARABEKO05_0002654
ZTRMYCGRDRAFT_64888(HMG1)
PFJMYCFIDRAFT_203708
FFUCLAFUR5_04207
CBETCB0940_02342 CB0940_07492
BCOMBAUCODRAFT_119400
NPAUCRNP2_4660 UCRNP2_6917
TMLGSTUM_00009050001
SPO2538999(hmg1)
SOMSOMG_04795(hmg1)
CNECNF04830
CNBCNBF0070
CNGCNAG_06534
CGICGB_F0040W
CDEUCNBG_2019
CDEP91088346(L203_104136)
KMG30162276(I203_107714)
KNE92182898(IAR55_005640)
TMSTREMEDRAFT_44404
TASAA1Q1_01564
CCACCcaHIS019_0109720(HMG1)
TVSTRAVEDRAFT_129862
DSQDICSQDRAFT_102019
PCOPHACADRAFT_201693 PHACADRAFT_202359 PHACADRAFT_207672 PHACADRAFT_253538 PHACADRAFT_253580
SHSSTEHIDRAFT_171644
HIRHETIRDRAFT_461040
PSQPUNSTDRAFT_86951
ADLAURDEDRAFT_110195
FMEFOMMEDRAFT_103364
GTRGLOTRDRAFT_78610
RSXRhiXN_08428
LBCLACBIDRAFT_165672 LACBIDRAFT_184183
CCICC1G_05275
ABPAGABI1DRAFT64187(AGABI1DRAFT_64187)
ABVAGABI2DRAFT208992(AGABI2DRAFT_208992)
PCUBJR316_0010214 JR316_0011137
MRRMoror_7164
MOREE1B28_008255
SCMSCHCO_02637526(SCHCODRAFT_02637526)
CPUTCONPUDRAFT_62715
SLASERLADRAFT_405423
WSEWALSEDRAFT_27329
WICJ056_002244
UMAUMAG_15002
PFPPFL1_01200
SGRAEX895_005665
MGLMGL_3624
MRTMRET_0384
MSYMMSY001_1360
PGRPGTG_07649
PTRCPtA15_13A483
PSTRPst134EA_024106
MLRMELLADRAFT_39863
ECUECU10_1720
EINEint_101690
EHEEHEL_101760
EROEROM_101620
NCENCER_100738
VNXVNE69_04095
RIEOCT59_029771
MBRMONBRDRAFT_32700
SREPTSG_07314
DDIDDB_G0269142(hmgA) DDB_G0276615(hmgB)
DPPDICPUDRAFT_149815 DICPUDRAFT_38386
DFADFA_02965(hmgB) DFA_07220
ACANACA1_063120 ACA1_275640
PTIPHATRDRAFT_16870
FCYFRACYDRAFT_268919
TPSTHAPSDRAFT_33680
SPARSPRG_01272
EHXEMIHUDRAFT_438210(HMGR2) EMIHUDRAFT_444446(HMGR3) EMIHUDRAFT_462270(HMGR1) EMIHUDRAFT_471368
TBRTb927.6.4540
TBGTbgDal_VI4330
TCR506831.40 509167.20
LMALMJF_30_3190(HMGR)
LIFLINJ_30_3230(HMGR)
LDOLDBPK_303230
LMILMXM_29_3190
LMAT92513985(LSCM1_03943)
LBZLBRM_30_3180
LPANLPMP_303150(HMGR)
LOI92358214(LSCM4_02246)
LEIS94178389(GH5_02888)
LENR94170479(CUR178_03233)
LEIN94187289(JIQ42_03613)
PHET94289208(JKF63_03110)
NGRNAEGRDRAFT_54929 NAEGRDRAFT_81695
KCOBWI95_06510
KOTEH164_03265
KOBHF650_20345
PLUplu4507
PLUMA4R40_22315
PAYPAU_02226 PAU_04010
PTTVY86_10495
PAKHB0X70_22705
PLUICE143_22745
VCHVC_A0723
VCFIR04_03105
VCSMS6_A0769
VCEVch1786_II0408(hmgA)
VCQEN18_01965
VCJVCD_000596
VCIO3Y_16913
VCOVC0395_0662
VCRVC395_A0589(hmgA)
VCMVCM66_A0681(hmgA)
VCLVCLMA_B0508
VCXVAA049_2228
VCZVAB027_457
VVUVV2_0117
VVYVVA0625
VVMVVMO6_03614
VVLVV93_v1c36260
VPAVPA0968
VPBVPBB_A0880
VPKM636_04215
VPFM634_22740
VPHVPUCM_20853
VHAVIBHAR_05704
VCAM892_23125
VAGN646_4347
VEXVEA_000087
VDBAL552_07475
VHRAL538_24540
VNAPN96_20395
VOWA9237_21380
VROBSZ04_08150
VSPVS_II0457
VEJVEJY3_19636
VFUvfu_B00350
VNIVIBNI_A3467 VIBNI_B1293
VANVAA_01552
LAGN175_15310
VAUVANGNB10_cII0695(hmgA)
VCYIX92_19900
VCTJV59_19410
VTUIX91_20035
VEUIXK98_07875
VSIMTO69_13840
VFLAL536_02785
VMIAL543_03440
VBRA6E01_00555
VSCVSVS12_01749
VSHBSZ05_22230
VQICCZ37_15165
VTAB0124(hmgA)
VAFD1115_19080
VNLD3H41_18010
VCCFAZ90_15760
VASGT360_14555
VAQFIV01_16280
VKABTD91_14925
VGIMID13_20870
VSLLTQ54_22200
VPLSA104470976_03471(hmgA)
VJPNP165_13645
VPGLZI70_15580
VOSKNV97_02345
VTICEQ48_04780
VCRAIS519_22955
VNPKW548_23965
VLEISX51_20280
VSYK08M4_39220
VMTQYQ96_13735
VIBVspSTUT11_42280
VISVspSTUT16_47330
VFIVF_A0841
VFMVFMJ11_A0972
VSAVSAL_II0253
AWDAWOD_II_0948
PGBH744_1c1071
PSILPMA3_24025
POJPtoMrB4_28080
PTWTUM18999_34650
PFITKJY40_24520
PSOAPSm6_56390
KAKKalk_12770
MBAHHYN46_11365
TPSYRGQ13_11455
TNNRI845_08230
TFTRI844_02145
AMCMADE_1004060 MADE_1018245
AMHI633_18730
AMAAamad1_03765 amad1_18215
AMALI607_03660 I607_17150
AMAEI876_03870 I876_17535
AMAOI634_04025 I634_17350
AMADI636_03755 I636_17420
AMAII635_03730 I635_18180
AMAGI533_03595 I533_17100
AMACMASE_03270 MASE_17135
AMBAMBAS45_03525 AMBAS45_17525
AMGAMEC673_03470 AMEC673_17255
AMKAMBLS11_03435 AMBLS11_16635
ALTambt_19605
AALEP13_16935
ASPAOR13_3918 AOR13_3978
ASQAVL57_18825 AVL57_19105
AAWAVL56_17615 AVL56_17925
ALRDS731_03105
ALEAV939_17795 AV939_18075
ALZAV940_17495 AV940_17775
ALTEALT761_03680 ALT761_03738
ALTMBM527_03260 BM527_16995
ALTRBM528_03495 BM528_16205
GAGGlaag_0498
GNIGNIT_1294(hmg1)
GPSC427_2773 C427_3860
PMESFX988_02156
PATPatl_0427
LALAT746_06285 AT746_15995
PAEWKIH87_09385 KIH87_14665
ASEMNNL22_06690
ALIIQR722_02155 QR722_07790 QR722_17615 QR722_19305
PMAWMACH26_16240 MACH26_18470 MACH26_24340
MVSMVIS_1670(hmgA)
SAGAM5M_16240
SNANI6N98_14005
ZALAZF00_18255
OSGBST96_16785
HJABST95_07275
HALCEY643_05795
AFUSEYZ66_05910
PAQME0F26_07915
CBUCBU_0030 CBU_0610
CBSCOXBURSA331_A0723(hmgA) COXBURSA331_A2174
CBDCBUD_0151 CBUD_0622(hmgA)
CBGCbuG_0298 CbuG_1393(hmgA)
CBCCbuK_0218 CbuK_1440(hmgA)
CEYCleRT_04160(hmgA)
CENOCEAn_00165
ALGAQULUS_04670
ASIPAQUSIP_18620
TCXTcr_1717
HTREPV75_09285
HMARHVMH_0539
TCYThicy_1409
TAOTHIAE_09030
THIOAYJ59_04650
TMHJX580_02700
PSALPSLF89_1251
THIGFE785_08490
TXAHQN79_03345
TIBTHMIRHAM_16910
TLHNR989_08665
TSETHMIRHAS_19630
TZOTHMIRHAT_05370
HAAA5892_17860
MARSA8C75_06230
MGEOCFI10_03820
MSECLN244_12910
MARLHH196_01475
MRZKDW95_09975
NCUF0U83_11860
NJPNEJAP_2671
NIKF5I99_04660
AJPAMJAP_2619
GSNYC6258_05103
OMEOLMES_2399
DNODNO_0797
CHJNCTC10426_01118
SUTRL0B52_04535
FCEJN531_005955
SVASVA_3750
GPBHDN1F_02380 HDN1F_32470
CVICV_1806
BOKDM82_1348
BOCBG90_3346
BUUWS70_08460
BSAVWS86_15315
BSTLBBJ41_20815
PGISI6I06_02550
LIMNHKT17_10310
LTORGQ30_22460
LASCLIBASIA_04615
LAAWSI_04450
LATCGUJ_04615
LSOCKC_03800
LCCB488_07220
LARlam_722(hMG1)
LAUG293_00025
BVVBHK69_25795
BOSBSY19_2095
BAPABBC0178_004050
CMETK6K41_06355
LABRCHH27_07265
RCONK3740_08385
CEHCEW89_09450
MALUKU6B_29570
LSALKBK07_02995
PSEBEOK75_04355
PBAEP8S53_19635
RBGBG454_14970
GAKX907_0130
PBRPB2503_02617
PACEA6070_07265
DESDSOUD_3298
MSDMYSTI_05827
MFBMFUL124B02_20210
MLANJY572_37790
CFUSCYFUS_006500
PAUUE8A73_025630
HAXBALOs_1159
BLRBRLA_c023930
BRWGOP56_04785
SAYTPY_0167
SAPSulac_0144
STHRBXT84_01365
HFVR50_2653
MULMUL_3522
MMIMMAR_3214
MMAEMMARE11_31140
MLIMULP_03440
MSHOMSHO_46160
CKPckrop_0031(mvaA)
CVACVAR_1983(mvaA)
CTERA606_07960
COADR71_1489
CLWCLAC_02245
CSPHCSPHI_01955
CPRECsp1_09290
CAMCI6I65_09555
NFANFA_22110
NFRERS450000_01887
NBRO3I_007950 O3I_033255
NSRNS506_07103
NOZDMB37_04630
NAHF5544_04350 F5544_24665
NADNCTC11293_04512
NIEKV110_32260
NTCKHQ06_31740
ROZCBI38_28920
DTMBJL86_0267
SDVBN159_7954(hmgA3)
STREGZL_00237
SNRSNOUR_41640
SFKKY5_0603c
SQZFQU76_00360 FQU76_32140 FQU76_33380
SPADDVK44_34365
SROIIAG44_38260
SRUGF0345_27715
SNIGHEK616_79450
SXTKPP03845_300053
SYUNMOV08_00760
SCOAQU709_19835
KBUQ4V64_43025
SCAJO1G22_43820
MIOAOA12_09725
MPALBO218_02445
MPRTET475_11190
MICSC1N74_08750
MBINLXM64_08650
MELYL2X98_31070
MARKQUC20_08710
MPLNVC184_08155
MICEEHF32_04250
MHOTPU630_03735
MGABKV396_14200
MCHNHCR76_06945
CUMNI26_12895
CUBBJK06_11790
CUGC1N91_13300
CQFGBG65_03325
CCITQPK07_13380
CUFKM842_00645
CUYI8920_12630
CPOIOE229_16835
PLAPEAO79_16935
PFLUBWO91_13295
LTREVS81_04305
LALLMUN78_14075
AGGC1N71_05255
GMNGMOLON4_2400(mvaA)
RKRI6G21_01450
AULDCC27_011095
AIGQDX25_11015
CMUAP8192_12815
BRXBH708_11775
BRVCFK39_07220
BKIM4486_02090
BHHBra3105_00340
DVADAD186_12890
DJJCOP05_04535
DHMCYJ49_010015
IDOI598_0505
CELCK5O09_05940
PSEIGCE65_00135
PSEKGCM125_28620
ORNDV701_01030
BLYA2T55_00985
BSPOL1F31_00295
NBEBack2_11360
NBISHK19_09175
BSDBLASA_0285(hmgA)
BLAPMVA48_14965
BBRGU6N30_32080
SENSACE_5541
SACGFDZ84_37460(panC)
MICBMicB006_2916
MSAGGCM10017556_12010
MCHLPVK74_09535
AOUACTOB_004881
PSUUPsuf_091270
AUUCJ184_004535
ATIMCYJ17_0005010
FSLEJO69_10215
FLHEJ997_11980
BALADSM104299_02782
PBAJLRS13_10710
PARNNBH00_14340
LETO77CONTIG1_03946
THEUHPC62_10920
TOGHNI00_14530
CAPCLDAP_00280
PBFCFX0092_A0001
LUOHHL09_01870
SOAG3M56_010095
VBSEGM51_07400
AMUCPan181_12900
VBLL21SP4_00972
TAERGT409_05415
TPSCRBB77_17135
SUSAcid_5728 Acid_6132
CTMCabther_B0332
CVLJ8C06_13685
CHLOJ8C02_14360
SCORJ3U87_32995
STRSterm_1947
GBAJ421_4295
SGNSGRA_2249
SPHNBV902_16795
SPDRG6053_11155
SSPII6J01_08485
SSIYJVX97_14965
SPIRCWM47_28475
SPIKEXU85_23505
SPIBG8759_25390
STAEHNV11_07580
SFOLH3H32_26885
SENFGJR95_24205
RSIRunsl_1402
RUNDR864_15885
FAEFAES_4555(hmgA)
FLIFleli_2723
HSWHsw_4017
HYMN008_09435
HYDPK28_00775
HYEAM218_15260
HYGAUC43_07350
HYPA0257_15725
HYZAXW84_00700
HNVDDQ68_16370 DDQ68_17100
HYHD3Y59_12305
HYJFHG12_09680
HQIH9L05_08315
HRSHER32_08935
HBNGUY19_13090
HTSHMJ29_06065
HMTMTP16_02850
HTBMTX78_00665
HYKO9Z63_16050
HSKH4317_01365
HCWO3303_14030
HSBMWH26_16905
HCUMUN79_03380
HVLMUN86_00470
HCFMUN80_03630
MTTFtrac_1626
MHAAQ3Y49_01900
FLMMY04_1691
FLLEI427_10205
FYAKMW28_07730
FKAKM029_00290
CLITOQ292_12520
FBTD770_01355
TPELP0M28_07155
FGLEM308_13115
FPBNLJ00_01640
FPECQ1W71_13230
OLLCW732_06015
KOSKORDIASMS9_02117
PSYNE9099_04160
FLUCHH17_07855
CRMK6119_10895
CHYDH4K34_00225
SRUSRU_2422
SRMSRM_02640(hmgA)
CPRVCYPRO_0371
PRFPeribacterA2_0671
TMGUS01_C0001G0064
MIBUY43_C0001G1154
MJAMJ_0705
MFEMefer_1084
MVUMetvu_1468
MFSMFS40622_1470
MIFMetin_1136
MJHJH146_1195
MESGMLAUSG7_1185(hmgA)
MESAMLASG1_0627(hmgA)
MIGMetig_1485
MMPMMP0087(hmgA)
MMQMmarC5_1589
MMXMmarC6_0860
MMZMmarC7_1086
MMDGYY_00445
MMAKMMKA1_00920(hmgA)
MMAOMMOS7_01170(hmgA)
MMADMMJJ_10070
MAEMaeo_0718
MVNMevan_1099
MVOMvol_1440
MOKMetok_1349
METFCFE53_04475(hmgA)
MTHMTH_562
MMGMTBMA_c09500(hmgA)
MWOMWSIV6_0926(hmgA)
MTEEMTTB_09960
METCMTCT_0489
METEtca_00533
METZMETMT2_0839
METKFVF72_08715(hmgA)
MTHMFZP57_04445(hmgA)
METJFZP68_04910(hmgA)
MSTMsp_0584(hmgA)
METBAW729_04300
MEISPXD04_06485(hmgA)
MRUmru_1092(hmgA)
MSIMsm_0227
MEBAbm4_0894(hmgA)
MMILsm9_0824(hmgA)
MEYETL18_06175
MOLYLM1_0775
MAROMarbSA_01080
METVK4897_01595(hmgA)
MELMetbo_0627
MEWMSWAN_1731
METHMBMB1_1357(hmgA)
MFCBRM9_0582(hmgA)
MFIDSM1535_0563(hmgA)
MCUBMCBB_1594(hmgA)
MSUBBK009_05765
METNBK008_01310
METTCIT01_10430(hmgA)
METOCIT02_11195(hmgA)
MEMEHYG87_00385(hmgA)
MFEGGCM10025860_27540
MEERNKF70_03550(hmgA)
MFVMfer_0012
MKAMK0355(hmg1)
PFUPF1848
PFIPFC_09350
PHOPH1805(PH1805)
PABPAB2106
PYNPNA2_0404
PYAPYCH_01180
PYSPy04_1729
PYCTQ32_07720
TKOTK0914
TONTON_0399
TGATGAM_1146(hmgA)
TSITSIB_0612
TBATERMP_00401
THEGQS_03225
THATAM4_2137
THMCL1_0345
TLTOCC_04595
THSTES1_0465
TNUBD01_0308
TEUTEU_07265
TGYX802_08090
THVADU37_CDS13760
TCHCHITON_2091
TPEPA0127_00535
TPIEA7C91_08010
TGGA3K92_05430
TCEA3L02_09345
TBSA3L01_02690
THHCDI07_02645(hmgA)
TSLA3L11_06655
TTDA3L14_04240
TPRFA3L09_07845
TRLA3L10_03890
TPAFA3L08_05690
THYA3L12_06050
TICFH039_05035(hmgA)
TCQTIRI35C_0764(hmgA)
THEMFPV09_04160(hmgA)
THEIK1720_06130(hmgA)
PPACPAP_03560
MBAMbar_A1972
MBYMSBRM_0693
MBWMSBRW_2767
MBARMSBR2_1683
MBAKMSBR3_1674
MACMA_3073(hmgA)
MMAMM_0335
MMAZMmTuc01_0343
MMJMSMAS_0966
MMACMSMAC_0968
MVCMSVAZ_1179
MEKMSKOL_1131
MLSMSLAZ_2113
METMMSMTP_2268
MEFMSWH1_0969
MEQMSWHS_1039
MSJMSSAC_2968
MSZMSSIH_2606
MSWMSSIT_2646
MTHRMSTHT_2527
MTHEMSTHC_0758
MHORMSHOH_1143
MFZAOB57_002710(hmgA)
MBUMbur_1098
MMETMCMEM_1587
MELOJ7W08_06890(hmgA)
MMHMmah_0566
MHAZBHR79_00575
MPOTBKM01_07835
MEVMetev_1366
MZHMzhil_0722
MPYMpsy_2819
MZIHWN40_08650(hmgA)
MMAVRE476_01590(hmgA)
MSEBRE474_11245(hmgA)
MHZMetho_0696
MEHFMmiHf6_03090
MEESMmiEs2_05820
MHUMhun_3004
MRTJKHC33_01880(hmgA)
MLAMlab_1655
MEMMemar_2365
MBGBN140_2503(hmgA)
MEMAMMAB1_3364
MCHKMchiMG62_00950
MSUMOH143_06095(hmgA)
MRCR6Y96_02455(hmgA)
MPIMpet_0546
MENDL6E24_05740(hmgA)
MEFWF1737_08480(hmgA)
MAQERJ40_08430(hmgA)
MFKE2N92_08655(hmgA)
MOUOU421_08210(hmgA)
MESBL1S32_11485(hmgA)
MANQL1994_08700(hmgA)
MBNMboo_0137
MFOMetfor_0027
MPLMpal_2647
MPDMCP_3002(hmgA-2)
MEZMtc_0456(hmgA-2)
RCIRCIX1027(hmgA)
MJKN2V74_00960(hmgA) N2V74_04900(hmgA)
HALVNG_1875G(mvaA)
HSLOE_3637R(hmgA)
HANRLJ422_07545(hmgA)
HDLHALDL1_14430
HHBHhub_3224(hmgA)
HAGSJT689_08890(hmgA)
HABOJRZ79_07295(hmgA)
HNOLT974_12855(hmgA)
HLULT972_02025(hmgA)
HSUHLASF_1924(hmgA)
HSFHLASA_1910(hmgA)
HAHSHSRCO_2549(hmg1-2)
SALRFQU85_07365(hmgA)
HALREFA46_001930(hmgA)
HJEHacjB3_06610
HDOMUK72_12750(hmgA)
HALXM0R89_03720(hmgA)
HAXZM0R88_03910(hmgA)
HAYCNGM10_11295(hmgA)
HAXYNGM07_08375(hmgA)
SALIL593_03550
SAIMK0C01_04905(hmgA)
HARAAArcS_3008(hmg1)
HMArrnAC3412(mvaA)
HHIHAH_0640(hmg)
HHNHISP_03300
HABSG26_11065
HTABVU17_03145
HALJG9465_17050(hmgA)
HSINKDQ40_10325(hmgA)
NPHNP_0368A(hmgA2) NP_2422A(hmgA1)
NMONmlp_2407(hmgA)
NHOHWV23_05615 HWV23_13980(hmgA)
NSALHWV07_16915(hmgA)
HUTHuta_0276
HTIHTIA_0459
HALAHrd1104_06135(hmgA)
HASVSVXHr_1308(hmg1)
HABNHBNXHr_1292(hmg1)
HMUHmuk_1499
HALZE5139_10630(hmgA)
HALLLC1Hm_0815(hmg1)
HAZPGBQ70_10625(hmgA)
HALIBV210_09730 BV210_12520
HSNDV733_04170(hmgA) DV733_04175(hmgA)
HDSHSR122_0368(hmg1) HSR122_0753(hmg12)
HRRHZS55_02025(hmgA)
HPELHZS54_01690(hmgA)
HLTI7X12_11245(hmgA)
HARCHARCEL1_05980
SSAIN0B31_03920(hmgA)
HAADMW046_08125(hmgA)
HWAHQ_3215A(hmgA)
HWCHqrw_3777(hmgA)
HVOHVO_2583(hmgA)
HALEG3A49_16610(hmgA)
HLNSVXHx_2015(hmga)
HMEHFX_2609(hmgR)
HGIABY42_12950
HLSKU306_00025(hmgA)
HBOHbor_10010
HAQDU484_05000(hmgA)
HAJDU500_05440(hmgA)
HAERDU502_03160(hmgA)
HRAEI982_10175(hmgA)
HLMDV707_03295(hmgA)
HALMFCF25_02765(hmgA)
HLAHlac_2019
HALPDOS48_10695(hmgA)
HALBEKH57_14585(hmgA)
HEZZEO776_10075(hmgA)
HALQHrr1229_009810(hmgA)
HSSJ7656_05360(hmgA)
HSAIHPS36_10575(hmgA)
HAZZKI388_09390(hmgA)
SRUBC2R22_15940(hmgA)
HAEhalTADL_0487
HALNB4589_010190(hmgA)
HALGHUG10_01610(hmgA)
HALUHUG12_15790(hmgA)
HMPK6T50_15030(hmgA)
HREK6T36_14990(hmgA)
HRMK6T25_01320(hmgA)
HACBHbl1158_07135(hmgA)
HDFAArcSl_2743
HAHHalar_2836
HTUHtur_0537
HSALJMJ58_06425(hmgA)
HAKZJ0X25_10075(hmgA)
NMGNmag_2929(hmgA)
HXAHalxa_1856
NATNJ7G_4215
NPENatpe_3461
NVRFEJ81_16145(hmgA)
NPLFGF80_15215(hmgA)
NAYHYG81_12750(hmgA)
HALYHYG82_17865(hmgA)
HJTDVR14_07455(hmgA)
HLOJ0X27_15550(hmgA)
NGENatgr_1105
HRUHalru_1124
SAWLNGM29_02140(hmgA)
HALVNGM15_11760(hmgA)
NOUNatoc_0374
HLRHALLA_06515
HLCCHINAEXTREME01700
NAJB1756_11275
NAGAArcMg_3165
NANAArc1_3074
NARAQQ977_12515(hmgA)
NBGDV706_08730(hmgA)
NASGCU68_03355(hmgA)
HDABB347_11255
TARTALC_00910
MAXMMALV_07920
MERMMINT_08450
MEARMpt1_c04890(hmgA)
MEUZKRP56_04190(hmgA)
MARCAR505_0768
APEAPE_1869(hmgA)
ACJACAM_1174(hmgA)
SMRSmar_1337
SHCShell_1110
IHOIgni_0476
IISEYM_00605
IPCIPA_02310
DKADKAM_0388
HBUHbut_1531
PFMPyrfu_1581
PDLPyrde_0242
PABIPABY_23980(hmgA)
PAREPYJP_01130(hmgA)
STOSTK_13520(hmgA)
SOHD1869_07615(hmgA)
SSOSSO0531
SOLSsol_1610
SSOASULA_1637(hmgA)
SSOLSULB_1638(hmgA)
SSOFSULC_1636(hmgA)
SSHIJ5U23_02855
SCASSACC_04360
SAISaci_1359
SACNSacN8_06630
SACRSacRon12I_06620
SACSSUSAZ_06500
SISLS215_1692
SIAM1425_1584
SIMM1627_1700
SIDM164_1581
SIYYG5714_1588
SINYN1551_1248
SIILD85_1792
SIHSiH_1551
SIRSiRe_1459
SICSiL_1461
SULABFU36_04415
SULEGFS03_08990(hmgA)
SULLEWF20_08795(hmgA)
MSEMsed_1649
MEMJMJ1HA_1876
MCNMcup_0580
MHKDFR87_10465(hmgA)
MPRUDFR88_10025(hmgA)
MTENGWK48_01835(hmgA)
MJNMjAS7_2764
AHOAhos_1305
AMANB6F84_10965
ASULDFR86_09305(hmgA)
AAMBD1866_01440(hmgA)
ACIHHS5_27060
SACDHS1genome_1143
SAZOD1868_04870(hmgA)
CSTYKN1_25810
STEPIC006_1049
SMETRQ359_000843(hmgA)
SAHSHS7_19200
PAIPAE2182
PISPisl_0814
PCLPcal_1085
PASPars_0796
PYRP186_0419
POGPogu_1536
TNETneu_1359
PYWPYWP30_01439
CMACmaq_0412
TTNTTX_0171(mvaA)
TUZTUZN_1176
VDIVdis_1666
VMOVMUT_2295
VSOVsou_01870
ASCASAC_1038
ACIASE86_06315
CLGCalag_0496
MARHMia14_0330
FLTSv326_1148
 » show all
Reference
1  [PMID:13805544]
  Authors
BUCHER NL, OVERATH P, LYNEN F
  Title
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
  Journal
Biochim Biophys Acta 40:491-501 (1960)
DOI:10.1016/0006-3002(60)91390-1
Reference
2  [PMID:13818862]
  Authors
DURR IF, RUDNEY H.
  Title
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid.
  Journal
J Biol Chem 235:2572-8 (1960)
Reference
3  [PMID:4985697]
  Authors
Kawachi T, Rudney H.
  Title
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver.
  Journal
Biochemistry 9:1700-5 (1970)
DOI:10.1021/bi00810a008
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.34
IUBMB Enzyme Nomenclature: 1.1.1.34
ExPASy - ENZYME nomenclature database: 1.1.1.34
BRENDA, the Enzyme Database: 1.1.1.34
CAS: 9028-35-7
LinkDB

KEGG   REACTION: R02082
Entry
R02082                      Reaction                               
Name
(R)-mevalonate:NADP+ oxidoreductase (CoA acylating)
Definition
(R)-Mevalonate + CoA + 2 NADP+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Equation
C00418 + C00010 + 2 C00006 <=> C00356 + 2 C00005 + 2 C00080
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00356
RC00644  C00356_C00418
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34
     R02082  (R)-Mevalonate + CoA + 2 NADP+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Orthology
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Other DBs
RHEA: 15992
LinkDB

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