KEGG   ORTHOLOGY: K00037
Entry
K00037                      KO                                     
Symbol
AKR1C4
Name
3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Pathway
map00120  Primary bile acid biosynthesis
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map05208  Chemical carcinogenesis - reactive oxygen species
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
   00140 Steroid hormone biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.225  chlordecone reductase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Other DBs
RN: R02476 R02477 R04309 R04310 R04818 R04819 R04824 R04825 R04829 R04830 R04832 R04833 R04835 R04836 R04837 R04838 R04842 R04843 R04845 R04846 R08963
GO: 0047042 0047743
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989(AKR1C4)
GGO: 101148343
PON: 100434557(AKR1C4)
NLE: 100605385
MCC: 711440 722490(AKR1C4)
MCF: 102116844 102117205(AKR1C4)
CSAB: 103237814
CATY: 105597444 105597447
PANU: 101022938
TGE: 112631314
RRO: 104674748
RBB: 108521035
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
OGA: 100940488
ECB: 100057251
EPZ: 103540777
EAI: 106827243
LAV: 100660861
DNM: 101426998
XLA: 108712557(akr1c4.S)
XTR: 496490(akr1c4)
NPR: 108799292
RTEM: 120932842
BBUF: 121003666
BGAR: 122926607
 » show all
Reference
PMID:3479982
  Authors
Penning TM, Sharp RB
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9
Reference
PMID:8172617
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545
  Sequence
[hsa:1109]
Reference
PMID:2187532
  Authors
Winters CJ, Molowa DT, Guzelian PS
  Title
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.
  Journal
Biochemistry 29:1080-7 (1990)
DOI:10.1021/bi00456a034
  Sequence
[hsa:1109]
LinkDB

KEGG   ENZYME: 1.1.1.50
Entry
EC 1.1.1.50                 Enzyme                                 
Name
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
History
EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
Pathway
ec00120  Primary bile acid biosynthesis
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA1109(AKR1C4)
PTR450274(AKR1C4)
PPS100987989(AKR1C4)
GGO101148343
PON100434557(AKR1C4)
NLE100605385
MCC711440 722490(AKR1C4)
MCF102116844 102117205(AKR1C4)
CSAB103237814
CATY105597444 105597447
PANU101022938
TGE112631314
RRO104674748
RBB108521035
TFN117082119 117082359
CJC100405255 100405615(AKR1C4)
SBQ101041915
OGA100940488
ECB100057251
EPZ103540777
EAI106827243
LAV100660861
DNM101426998
XLA108712557(akr1c4.S)
XTR496490(akr1c4)
NPR108799292
RTEM120932842
BBUF121003666
BGAR122926607
 » show all
Reference
1  [PMID:14406805]
  Authors
JARABAK J, TALALAY P.
  Title
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 235:2147-51 (1960)
Reference
2  [PMID:13405910]
  Authors
KOCHAKIAN CD, CARROLL BR, UHRI B.
  Title
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.
  Journal
J Biol Chem 224:811-8 (1957)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:3479982]
  Authors
Penning TM, Sharp RB
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.50
IUBMB Enzyme Nomenclature: 1.1.1.50
ExPASy - ENZYME nomenclature database: 1.1.1.50
BRENDA, the Enzyme Database: 1.1.1.50
CAS: 9028-56-2
LinkDB

KEGG   REACTION: R02476
Entry
R02476                      Reaction                               
Name
Androsterone:NAD+ oxidoreductase
Definition
Androsterone + NAD+ <=> 5alpha-Androstane-3,17-dione + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00144  C00523_C00674
Enzyme
1.1.1.50        1.1.1.209       1.1.1.213
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Other DBs
RHEA: 20384
LinkDB

KEGG   REACTION: R02477
Entry
R02477                      Reaction                               
Name
Androsterone:NADP+ oxidoreductase
Definition
Androsterone + NADP+ <=> 5alpha-Androstane-3,17-dione + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00144  C00523_C00674
Enzyme
1.1.1.50        1.1.1.209       1.1.1.213
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Other DBs
RHEA: 20380
LinkDB

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