KEGG   ORTHOLOGY: K00051
Entry
K00051                      KO                                     
Symbol
E1.1.1.82
Name
malate dehydrogenase (NADP+) [EC:1.1.1.82]
Pathway
map00620  Pyruvate metabolism
map00710  Carbon fixation in photosynthetic organisms
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00172  C4-dicarboxylic acid cycle, NADP - malic enzyme type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K00051  E1.1.1.82; malate dehydrogenase (NADP+)
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00051  E1.1.1.82; malate dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.82  malate dehydrogenase (NADP+)
     K00051  E1.1.1.82; malate dehydrogenase (NADP+)
Other DBs
RN: R00343
COG: COG2055 COG0039
Genes
AJM: 119059285
ATH: AT5G58330
ALY: 9300640
CRB: 17876624
CSAT: 104726404 104735427 104761929
EUS: EUTSA_v10013555mg
BRP: 103845258 103851645 103856701
BNA: 106387162 106388230 106420432 106435756
BOE: 106317800 106326990 106335373
RSZ: 108828026 108842484 108842485 108844945 108847633
THJ: 104824214
CIT: 102622984
MINC: 123228376
TCC: 18586537
GRA: 105780485
GAB: 108457850
DZI: 111310364
EGR: 104421754
GMX: 100782567
VRA: 106772560
VAR: 108321953
VUN: 114192784
CCAJ: 109805341
APRC: 113871024
CAM: 101499870
ADU: 107466651
AIP: 107618478
FVE: 101299807
RCN: 112174171
PPER: 18785428
PMUM: 103331480
PAVI: 110760803
PDUL: 117617069
ZJU: 107413281
MNT: 21391387
CSV: 101211170
CMO: 103489426
BHJ: 120081316
MCHA: 111010262
CMAX: 111467500
CMOS: 111449691
CPEP: 111801663
RCU: 8271083
JCU: 105648670
HBR: 110646716
POP: 7479845
PEU: 105130696
PALZ: 118060285
QSU: 111992093
QLO: 115957569
TWL: 119988885
VVI: 100247974
VRI: 117929166
SLY: 778287(chMDH)
ECAD: 122600620
LSV: 111911144
CCAV: 112524411
DCR: 108210185
BVG: 104884197
SOE: 110802517
NCOL: 116252083
OSA: 4346332
DOSA: Os08t0562100-01(Os08g0562100)
OBR: 102709764
BDI: 100837587
ATS: 109767185
ZMA: 542374
PHAI: 112896482
PDA: 103705497
EGU: 105055621
MUS: 103973387
DCT: 110099942
PEQ: 110020784
AOF: 109850210
ATR: 18432968
 » show all
Reference
  Authors
Heyno E, Innocenti G, Lemaire SD, Issakidis-Bourguet E, Krieger-Liszkay A
  Title
Putative role of the malate valve enzyme NADP-malate dehydrogenase in H2O2 signalling in Arabidopsis.
  Journal
Philos Trans R Soc Lond B Biol Sci 369:20130228 (2014)
DOI:10.1098/rstb.2013.0228
  Sequence
[ath:AT5G58330]
LinkDB

KEGG   ENZYME: 1.1.1.82
Entry
EC 1.1.1.82                 Enzyme                                 
Name
malate dehydrogenase (NADP+);
NADP+-malic enzyme;
NADP+-malate dehydrogenase;
malic dehydrogenase (nicotinamide adenine dinucleotide phosphate);
malate NADP+ dehydrogenase;
NADP+ malate dehydrogenase;
NADP+-linked malate dehydrogenase;
malate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NADP+ oxidoreductase
Reaction(IUBMB)
(S)-malate + NADP+ = oxaloacetate + NADPH + H+ [RN:R00343]
Reaction(KEGG)
R00343
Substrate
(S)-malate [CPD:C00149];
NADP+ [CPD:C00006]
Product
oxaloacetate [CPD:C00036];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Activated by light.
History
EC 1.1.1.82 created 1972
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation in photosynthetic organisms
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00051  malate dehydrogenase (NADP+)
Genes
AJM119059285
ATHAT5G58330
ALY9300640
CRB17876624
CSAT104726404 104735427 104761929
EUSEUTSA_v10013555mg
BRP103845258 103851645 103856701
BNA106387162 106388230 106420432 106435756
BOE106317800 106326990 106335373
RSZ108828026 108842484 108842485 108844945 108847633
THJ104824214
CIT102622984
CICCICLE_v10031559mg
MINC123228376
TCC18586537
GRA105780485
GHI107904294 107943658
GAB108457850
DZI111310364
EGR104421754
GMX100782567
GSJ114372222 114403577
PVUPHAVU_007G140600g
VRA106772560
VAR108321953
VUN114192784
CCAJ109805341
APRC113871024
MTRMTR_1g090730
CAM101499870
ADU107466651
AIP107618478
AHF112711491 112776877
LANG109335149 109346097
FVE101299807
RCN112174171
PPER18785428
PMUM103331480
PAVI110760803
PDUL117617069
MDM103402801 103408309
PXB103937854 103938371 103951716
ZJU107413281
MNT21391387
CSV101211170
CMO103489426
BHJ120081316
MCHA111010262
CMAX111467500
CMOS111449691
CPEP111801663
RCU8271083
JCU105648670
HBR110646716
MESC110619296 110623872
POP7479845
PEU105130696
PALZ118060285
JRE108983075 109011340
QSU111992093
QLO115957569
TWL119988885
VVI100247974
VRI117929166
SLY778287(chMDH)
HAN110872415 110894838
ECAD122600620
LSV111911144
CCAV112524411
DCR108210185
CSIN114321212 114322741
BVG104884197
SOE110802517
CQI110698354 110726180
NNU104587331 104604574
MING122074587 122081181
TSS122651918 122655837
NCOL116252083
OSA4346332
DOSAOs08t0562100-01(Os08g0562100)
OBR102709764
BDI100837587
ATS109767185
TDC119293070 119298570 119329390 119336111
TAES123054367 123097218 123101856 123154897 123159028 123165753
SBI110436993 8057802
ZMA542374
SITA101754520 101775740
SVS117842197 117859844
PVIR120679202 120713117
PHAI112896482
PDA103705497
EGU105055621
MUS103973387
DCT110099942
PEQ110020784
AOF109850210
ATR18432968
SMOSELMODRAFT_175392 SELMODRAFT_270710
CRECHLRE_09g410700v5
VCNVOLCADRAFT_76573
OLUOSTLU_42336
OTAOT_ostta08g00930
 » show all
Reference
1  [PMID:5689906]
  Authors
Connelly JL, Danner DJ, Bowden JA.
  Title
Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase.
  Journal
J Biol Chem 243:1198-203 (1968)
Reference
2  [PMID:4397919]
  Authors
Johnson HS.
  Title
NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis.
  Journal
Biochem Biophys Res Commun 43:703-9 (1971)
DOI:10.1016/0006-291X(71)90672-3
Reference
3  [PMID:4395182]
  Authors
Johnson HS, Hatch MD.
  Title
Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis.
  Journal
Biochem J 119:273-80 (1970)
DOI:10.1042/bj1190273
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.82
IUBMB Enzyme Nomenclature: 1.1.1.82
ExPASy - ENZYME nomenclature database: 1.1.1.82
BRENDA, the Enzyme Database: 1.1.1.82
CAS: 37250-19-4
LinkDB

KEGG   REACTION: R00343
Entry
R00343                      Reaction                               
Name
(S)-malate:NADP+ oxidoreductase
Definition
(S)-Malate + NADP+ <=> Oxaloacetate + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00031  C00036_C00149
Enzyme
1.1.1.82        1.1.1.299
Pathway
rn00620  Pyruvate metabolism
rn00710  Carbon fixation in photosynthetic organisms
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00172  C4-dicarboxylic acid cycle, NADP - malic enzyme type
Orthology
K00051  malate dehydrogenase (NADP+) [EC:1.1.1.82]
Other DBs
RHEA: 10827
LinkDB

DBGET integrated database retrieval system