KEGG ORTHOLOGY: K00071

ORTHOLOGY: K00071

Entry

K00071                      KO

Symbol

HSD11B2

Name

corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04960

Aldosterone-regulated sodium reabsorption

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Reaction

R02834

cortisol:NAD+ 11-oxidoreductase

R03847

corticosterone:NAD+ 11-oxidoreductase

Disease

H00259

Apparent mineralocorticoid excess syndrome

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00071  HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2
09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00071  HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2

Genes

HSA:	3291(HSD11B2)

PTR:	468001(HSD11B2)

PPS:	100993079(HSD11B2)

GGO:	101153708(HSD11B2)

PON:	100443811(HSD11B2)

PPYG:

129015629(HSD11B2)

NLE:	100602616(HSD11B2)

HMH:	116471391(HSD11B2)

SSYN:

129492982(HSD11B2)

MCC:	574396(HSD11B2)

MCF:	102115494(HSD11B2)

MTHB:

126944026

MNI:	105491423(HSD11B2)

CSAB:

103233278(HSD11B2)

CATY:

105586879(HSD11B2)

PANU:

101015473(HSD11B2)

TGE:	112613784(HSD11B2)

MLEU:

105551461(HSD11B2)

RRO:	104655689(HSD11B2)

RBB:	108515358(HSD11B2) 108525856

TFN:	117087948(HSD11B2)

PTEH:

111541348(HSD11B2)

CANG:

105504626(HSD11B2) 105522087

CJC:	100385196(HSD11B2)

SBQ:	101046859(HSD11B2)

CIMI:

108311747(HSD11B2)

ANAN:

105727956(HSD11B2)

CSYR:

103269055(HSD11B2)

MMUR:

105859009(HSD11B2)

LCAT:

123625206(HSD11B2)

ERUF:

138373714(HSD11B2)

PCOQ:

105823311(HSD11B2)

OGA:	100947083(HSD11B2)

MMU:	15484(Hsd11b2)

MCAL:

110300601(Hsd11b2)

MPAH:

110337576(Hsd11b2)

RNO:	25117(Hsd11b2)

MCOC:

116070055(Hsd11b2)

ANU:	117723205(Hsd11b2)

ASYL:

127671526(Hsd11b2)

MUN:	110545706(Hsd11b2)

CGE:	100766725(Hsd11b2)

MAUA:

101828027(Hsd11b2)

PROB:

127234645(Hsd11b2)

PLEU:

114681097(Hsd11b2)

PMAV:

102916653(Hsd11b2)

MORG:

121446705(Hsd11b2)

MFOT:

126502653

AAMP:

119802261(Hsd11b2)

CNL:	130863731(Hsd11b2)

NGI:	103738923(Hsd11b2)

HGL:	101712460(Hsd11b2)

CPOC:

100733422(Hsd11b2)

CCAN:

109691244(Hsd11b2)

DORD:

105983164(Hsd11b2)

DSP:	122126079(Hsd11b2)

DMER:

138806997 138815411

PLOP:

125358292(Hsd11b2)

NCAR:

124967242

MMMA:

107150989(Hsd11b2)

ITI:	101957674(Hsd11b2)

OCU:	100009531(HSD11B2)

OPI:	101522466(HSD11B2)

OCZ:	121158002 121167692

TUP:	102494408(HSD11B2)

GVR:	103586493(HSD11B2)

CFA:	489758(HSD11B2)

CLUD:

112646491(HSD11B2)

VVP:	112929518(HSD11B2)

VLG:	121500635(HSD11B2)

NPO:	129497880(HSD11B2)

AML:	100473624(HSD11B2)

UMR:	103673726(HSD11B2)

UAH:	113252365(HSD11B2)

UAR:	123803429(HSD11B2)

ELK:

111152836

LLV:

125089624

MPUF:

101675060(HSD11B2)

MNP:	132005037(HSD11B2)

MLK:	131817906(HSD11B2)

NVS:	122911343(HSD11B2)

ORO:	101363668(HSD11B2)

EJU:	114203823(HSD11B2)

ZCA:	113935327(HSD11B2)

MLX:	118023670(HSD11B2)

MANO:

123855355(HSD11B2)

NSU:	110594247(HSD11B2)

LWW:	102728555(HSD11B2)

FCA:	100529249(HSD11B2)

PYU:	121045453(HSD11B2)

PCOO:

112857270(HSD11B2)

PBG:	122494380(HSD11B2)

PVIV:

125153037(HSD11B2)

LRUF:

124511397

LGF:	123579312(HSD11B2)

AJU:

106972318

PTG:	102969498(HSD11B2)

PPAD:

109270765(HSD11B2)

PUC:

125916315

PLEZ:

122207616(HSD11B2)

HHV:	120224259(HSD11B2)

CCRU:

144224547(HSD11B2)

BTA:	282434(HSD11B2)

BOM:	102284703(HSD11B2)

BIU:	109572237(HSD11B2)

BBUB:

102409353(HSD11B2)

BKE:	129630802(HSD11B2)

BBIS:

104996755(HSD11B2)

CHX:	102183447(HSD11B2)

OAS:	443530(HSD11B2)

BTAX:

128063723(HSD11B2)

CSUM:

138097082(HSD11B2)

ODA:	120872734(HSD11B2)

CCAD:

122420474(HSD11B2)

MREE:

136161069(HSD11B2)

OVR:	110131925(HSD11B2)

MBEZ:

129547006(HSD11B2)

SSC:	396948(HSD11B2)

CFR:	102516692(HSD11B2)

CBAI:

105074827(HSD11B2)

CDK:	105088484(HSD11B2)

VPC:	102530525(HSD11B2)

BACU:

103015303(HSD11B2)

BMUS:

118885537(HSD11B2)

LVE:	103078561(HSD11B2)

OOR:	101289432(HSD11B2)

LALB:

132509129(HSD11B2)

GMF:	115856938(HSD11B2)

DDP:	132415898(HSD11B2)

DLE:	111179633(HSD11B2)

PCAD:

102976970(HSD11B2)

PSIU:

116743561(HSD11B2)

PPHC:

136140504(HSD11B2)

NASI:

112392274(HSD11B2)

ECB:	100034124(HSD11B2)

EPZ:	103542727(HSD11B2)

EAI:	106822426(HSD11B2)

MYB:	102247970(HSD11B2)

MYD:	102767517(HSD11B2)

MMYO:

118674874(HSD11B2)

MLF:	102438657(HSD11B2)

MDT:	132217469(HSD11B2)

MYUM:

138997088(HSD11B2)

PKL:	118720390(HSD11B2)

EFUS:

103284579(HSD11B2)

MNA:	107542883(HSD11B2)

DRO:	112300862(HSD11B2)

SHON:

118983864(HSD11B2)

AJM:	119061951(HSD11B2)

PDIC:

114488167(HSD11B2)

PHAS:

123805910(HSD11B2)

MMF:	118639227(HSD11B2)

PPAM:

129075087(HSD11B2)

HAI:	109388643(HSD11B2)

RFQ:	117035286(HSD11B2)

PALE:

102897175(HSD11B2)

PGIG:

120623070(HSD11B2)

PVP:	105305718(HSD11B2)

RAY:	107520210(HSD11B2)

MJV:	108390360(HSD11B2)

TOD:	119248950(HSD11B2)

SARA:

101547906(HSD11B2)

SFUM:

130043712(HSD11B2)

SETR:

126027414(HSD11B2)

LAV:	100660892(HSD11B2)

TMU:

101359521

ETF:	101641620(HSD11B2)

DNM:	101417292(HSD11B2)

MDO:	103100097(HSD11B2)

GAS:	123236796(HSD11B2)

SHR:	116421329(HSD11B2)

AFZ:

127547902

PCW:	110210411(HSD11B2)

TVP:	118844697(HSD11B2)

PBRV:

138159420(HSD11B2)

MLAO:

141499730(HSD11B2)

OAA:	100081477(HSD11B2)

TACU:

119919882(HSD11B2)

GGA:	100858361(HSD11B2)

PCOC:

116244036(HSD11B2)

MGP:	100548201(HSD11B2)

CJO:	107319159(HSD11B2)

TPAI:

128081798(HSD11B2)

LMUT:

125699201(HSD11B2)

NMEL:

110404219(HSD11B2)

APLA:

101790751(HSD11B2)

AACU:

137862083(HSD11B2)

OJA:	118172633(HSD11B2)

ACYG:

106033128(HSD11B2)

CATA:

118246491(HSD11B2)

AFUL:

116494068(HSD11B2)

TGU:	100222854(HSD11B2)

LSR:	110476218(HSD11B2)

VMC:	128813039(HSD11B2)

VCHA:

128793766(HSD11B2)

AIB:	137481280(HSD11B2)

SCAN:

103816835(HSD11B2)

PMOA:

120508164(HSD11B2)

OTC:	121334004(HSD11B2)

PRUF:

121348956(HSD11B2)

ATRC:

139596352(HSD11B2)

MATE:

118691382(HSD11B2)

GFR:	102043738(HSD11B2)

FAB:	101815475(HSD11B2)

OMA:	130257628(HSD11B2)

PHI:	102111344(HSD11B2)

PMAJ:

107209832(HSD11B2)

CCAE:

111934511(HSD11B2)

CCW:	104691776(HSD11B2)

CBRC:

103620274(HSD11B2)

ACOE:

138117021(HSD11B2)

ETL:	114063449(HSD11B2)

ZAB:	102069420(HSD11B2)

ZLE:	135452975(HSD11B2)

ACHL:

103798935(HSD11B2)

SVG:	106855805(HSD11B2)

MMEA:

130579561(HSD11B2)

HRT:	120757922(HSD11B2)

SATI:

136366563(HSD11B2)

CCIC:

134048498(HSD11B2)

FPG:	101912301(HSD11B2)

FCH:	102059634(HSD11B2)

CCRI:

104165908(HSD11B2)

NNT:

104412120

SHAB:

115601168(HSD11B2)

ACUN:

113484560(HSD11B2)

ANOC:

141963924(HSD11B2)

SURA:

141948633(HSD11B2)

TALA:

116960317(HSD11B2)

ACHC:

115345875(HSD11B2)

HLE:	104842688(HSD11B2)

AGEN:

126041385

HHAR:

128146567(HSD11B2)

BBUT:

142036810(HSD11B2)

GCL:

127021305

LDI:	104343713(HSD11B2)

MNB:	103774092(HSD11B2)

PPUS:

135184622(HSD11B2)

IIN:	128973370(HSD11B2)

NNI:	104017487(HSD11B2)

PCRI:

104036029(HSD11B2)

PCAO:

104046440(HSD11B2)

PARX:

142061159(HSD11B2)

PADL:

103922269(HSD11B2)

AFOR:

103908459(HSD11B2)

CBOR:

142087116(HSD11B2)

CBOY:

140656891(HSD11B2)

MAME:

142414135(HSD11B2)

CLV:	102085620(HSD11B2)

CNIC:

135992226(HSD11B2)

MUI:	104535003(HSD11B2)

CMAC:

104478534(HSD11B2)

CUCA:

104068378(HSD11B2)

GAME:

129212467(HSD11B2)

OHA:	104328618(HSD11B2)

CPEA:

104391719(HSD11B2)

CVF:	104284880(HSD11B2)

RTD:	128908365(HSD11B2)

CRID:

134515293(HSD11B2)

LMIC:

141742001(HSD11B2)

NARQ:

141467282(HSD11B2)

AAM:

106484515

AROW:

112973285(HSD11B2)

NPD:	112943191(HSD11B2)

TGT:	104564362(HSD11B2)

DNE:	112985418(HSD11B2)

SCAM:

104145304(HSD11B2)

ASN:	102377421(HSD11B2)

AMJ:	102567313(HSD11B2)

PSS:	102451930(HSD11B2)

CIZ:	142020917(HSD11B2)

CMY:	102944464(HSD11B2)

CCAY:

125645286(HSD11B2)

LKP:	140896119(HSD11B2)

NDS:	141996437(HSD11B2)

DCC:	119841208(HSD11B2)

CPIC:

101949646(HSD11B2)

TST:	117886527(HSD11B2)

CABI:

116829588(HSD11B2)

MRV:	120384495(HSD11B2)

ACS:

100564096

ASAO:

132783137(HSD11B2)

PVT:

110081292

SUND:

121914368(HSD11B2)

PBI:	103054046(HSD11B2)

PMUR:

107284155(HSD11B2)

CTIG:

120312622(HSD11B2)

TSR:	106551703(HSD11B2)

PCAE:

139323714(HSD11B2)

APRI:

131184350

PTEX:

113445291(HSD11B2)

NSS:	113422991(HSD11B2)

VKO:	123025347(HSD11B2)

PMUA:

114601878(HSD11B2)

PRAF:

128419098(HSD11B2)

ZVI:	118086875(HSD11B2)

HCG:	128334486(HSD11B2)

GJA:	107108017(HSD11B2)

STOW:

125443907(HSD11B2)

EMC:	129343959(HSD11B2)

XLA:	444491(hsd11b2.L)

XTR:	100489854(hsd11b2)

NPR:	108789587(HSD11B2)

RTEM:

120917630(HSD11B2)

ACAT:

141112517(HSD11B2)

PADS:

140338621(HSD11B2)

BBUF:

120980810(HSD11B2)

BGAR:

122920919(HSD11B2)

DTC:	141089709(HSD11B2)

PWL:	138268186(HSD11B2)

MUO:	115470483(HSD11B2)

DRE:	334098(hsd11b2)

SRX:	107740467 107755122

SANH:

107657103 107696685

SGH:	107548951 107563464

CCAR:

109051628 109060187

CAUA:

113051480

CGIB:

127961969 128016872

PTET:

122348584(hsd11b2)

LROH:

127168972(hsd11b2)

GRF:	141331155(hsd11b2)

OMC:	131544272(hsd11b2)

PPRM:

120491032(hsd11b2)

RKG:	130099638(hsd11b2)

MAMB:

125264825(hsd11b2)

CIDE:

127516058

CERY:

137031358(hsd11b2)

MASI:

127416162 127448455

TROS:

130553747(hsd11b2)

TDW:	130419125(hsd11b2)

MANU:

129444563(hsd11b2)

PDAB:

135749330(hsd11b2)

IPU:

108259637

IFU:	128602953(hsd11b2)

PHYP:

113540912(hsd11b2)

SMEO:

124379973(hsd11b2)

TFD:	113636794(hsd11b2)

TVC:	132838532(hsd11b2)

CGAR:

128519000(hsd11b2)

NGRA:

132874914(hsd11b2)

TRN:	134303925(hsd11b2)

AMEX:

103026519(hsd11b2)

CMAO:

118817455(hsd11b2)

EEE:	113582733(hsd11b2)

CHAR:

105899795(hsd11b2)

SPIL:

134095701(hsd11b2)

ASAD:

121682189(hsd11b2)

TRU:

101064958

TFS:	130520131(hsd11b2)

TNG:	GSTEN00019356G001

LCO:

104939420

TBEN:

117468670(hsd11b2)

CGOB:

115005229

EMAC:

134863630(hsd11b2)

ELY:	117252875(hsd11b2)

EFO:	125900091(hsd11b2)

SLUC:

116063141(hsd11b2)

ECRA:

117956687

PFLV:

114561247

GAT:	120831413(hsd11b2)

PPUG:

119197279(hsd11b2)

AFB:	129102842(hsd11b2)

CLUM:

117728800(hsd11b2)

PSWI:

130193256(hsd11b2)

CANA:

137789280(hsd11b2)

CVE:	137886376(hsd11b2)

MSAM:

119890151(hsd11b2)

SCHU:

122875086(hsd11b2)

EARM:

139301430(hsd11b2)

CUD:	121508837(hsd11b2)

SPUL:

138584985(hsd11b2)

LMIX:

132983651(hsd11b2)

HTC:	141788285(hsd11b2)

ALAT:

119018393(hsd11b2)

ASTR:

137603256(hsd11b2)

PKLU:

139201744(hsd11b2) 139225401

MZE:	101471311(hsd11b2)

ONL:	100534505(hsd11b2)

OAU:	116323384(hsd11b2)

OLA:

100125474

OML:	112136609(hsd11b2)

CSAI:

133457342(hsd11b2)

XMA:	106700365 111608364

XCO:

114142819

XHE:	116716455 116718833 116719174

PFOR:

103129140

PLAI:

106939977

PMEI:

106908095(hsd11b2)

GAF:	122823382(hsd11b2)

PPRL:

129352200

CVG:	107096253 107096268

CTUL:

119780159 119780173

GMU:	124866492(hsd11b2)

NFU:	107381516(hsd11b2)

KMR:	108247994(hsd11b2)

ALIM:

106532172

NWH:

119430299

AOCE:

111567954(hsd11b2)

EJA:	138196863(hsd11b2)

BFRE:

138614749(hsd11b2)

MCEP:

125005565(hsd11b2)

CSEM:

103378825(hsd11b2)

SSEN:

122771956(hsd11b2)

SSOE:

131459821(hsd11b2)

HHIP:

117751992(hsd11b2)

HSP:	118099985(hsd11b2)

PPLT:

128445574(hsd11b2)

SMAU:

118301988(hsd11b2)

LCF:

108894260

SDU:	111225487(hsd11b2)

SLAL:

111652849

XGL:	120793488(hsd11b2)

HCQ:	109529762(hsd11b2)

SSCV:

125966658(hsd11b2)

SBIA:

133497525

PEE:

133417096

PTAO:

133469747(hsd11b2)

BPEC:

110169004

ENY:	140381228(hsd11b2)

MALB:

109961670(hsd11b2)

BSPL:

114852388(hsd11b2)

SJO:	128359576(hsd11b2)

SSCO:

133982358(hsd11b2)

TTY:	137196002(hsd11b2)

GMH:	115558887(hsd11b2)

SASA:

106588007 106594819

STRU:

115203547

OTW:	112240117(hsd11b2)

OMY:	100135822(hsd11b2) 118944412

OGO:	124029507 124029581

OKI:	116359610(hsd11b2) 116359622

OKE:	127927392(hsd11b2)

OMM:	135530511 135530538 135531217 135535304

OCLA:

139384730

SFON:

129854506(hsd11b2)

CCLU:

121548192 121563521

ELS:	105025474(hsd11b2)

OEP:	134028281(hsd11b2)

SFM:	108926334 108928316

PKI:	111832736 111843556

AANG:

118215222(hsd11b2) 118227915

AROT:

135242776 135255101

CCOG:

133112112(hsd11b2) 133131475

LOC:	102694386(hsd11b2)

PSPA:

121296730 121325157(hsd11b2)

ARUT:

117424366 117425367

PSEX:

120535239(hsd11b2)

LCM:	102360976(HSD11B2)

CMK:

103190838

RTP:

109915214

CPLA:

122558478 122558479

CPUN:

140453078(hsd11b2) 140453080

HOC:	132823752(hsd11b2) 132823983

SCAU:

119971375(hsd11b2) 119971378

LERI:

129705101(hsd11b2) 129705103

HAKA:

140740595 140740596(hsd11b2)

LSAX:

BGT:

CVN:

MMER:

RPHI:

DPOL:

Reference

PMID:18573267

Authors

Gong R, Morris DJ, Brem AS

Title

Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells.

Journal

Steroids 73:1187-96 (2008)
DOI:10.1016/j.steroids.2008.05.009

Sequence

[hsa:3291]

LinkDB

REACTION: R02834

Entry

R02834                      Reaction

Name

cortisol:NAD+ 11-oxidoreductase

Definition

Cortisol + NAD+ <=> Cortisone + NADH + H+

Equation

C00735 + C00003 <=> C00762 + C00004 + C00080

Comment

NADP+ (see R02836)

Reaction class

RC00001

C00003_C00004

RC00154

C00735_C00762

Enzyme

1.1.1.-

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R02834  Cortisol + NAD+ <=> Cortisone + NADH + H+

Orthology

K00071

corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]

Other DBs

RHEA:

50211

LinkDB

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