KEGG   ORTHOLOGY: K00107
Entry
K00107                      KO                                     
Symbol
ALO
Name
D-arabinono-1,4-lactone oxidase [EC:1.1.3.37]
Pathway
map00053  Ascorbate and aldarate metabolism
map01100  Metabolic pathways
Reaction
R02715  D-arabinono-1,4-lactone:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K00107  ALO; D-arabinono-1,4-lactone oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.37  D-arabinono-1,4-lactone oxidase
     K00107  ALO; D-arabinono-1,4-lactone oxidase
Other DBs
COG: COG0277
GO: 0003885
Genes
BBEL: 109465946
BGT: 106075236
HRF: 124141685
SCE: YML086C(ALO1)
SEUB: DI49_4004
SPAO: SPAR_M00450
AGO: AGOS_AFR440C
ERC: Ecym_1386
KLA: KLLA0_C16896g
KMX: KLMA_70261(ALO1)
LTH: KLTH0F06820g
VPO: Kpol_309p4
ZRO: ZYRO0A00836g
CGR: 2888523(GVI51_H03927)
NCS: NCAS_0C00130(NCAS0C00130)
NDI: NDAI_0K00250(NDAI0K00250)
TPF: TPHA_0I00160(TPHA0I00160)
TBL: TBLA_0B02960(TBLA0B02960)
TGB: HG536_0H00300
TDL: TDEL_0B00300(TDEL0B00300)
KAF: KAFR_0L02030(KAFR0L02030)
KNG: KNAG_0J00130(KNAG0J00130)
ZMK: HG535_0C05800
SLUD: SCDLUD_001293
DHA: DEHA2A02904g
PIC: PICST_88335(ALO1)
PGU: PGUG_01601
SPAA: SPAPADRAFT_59163
LEL: PVL30_002468(ALO1)
LBG: 92207107(LODBEIA_P19110)
CAL: CAALFM_CR09790WA(ALO1)
CTP: CTRG_05879
COT: CORT_0G01540
CDU: CD36_34940
CTEN: 18246692(ALO1)
CLU: CLUG_02182
CLUS: A9F13_02g01177
CAUR: CJI96_0004650
PPA: PAS_chr2-1_0197
PKZ: C5L36_0E05670
BNN: FOA43_001988
BBRX: BRETT_004030
OPA: HPODL_00171
YLI: 2906352(YALI2_A00352g)
SLB: AWJ20_4935(ALO1)
NCR: NCU03188
NTE: NEUTE1DRAFT150135(NEUTE1DRAFT_150135)
SMP: 10805869(SMAC4_02909)
PAN: PODANSg4195
PBEL: QC761_117130(ALO1)
PPSD: QC762_117130(ALO1)
PPSP: QC763_117130(ALO1)
PPSA: QC764_117130(ALO1)
TTT: THITE_119824
MTM: MYCTH_2297573
CTHR: CTHT_0014270
MGR: MGG_02689
PPEI: PpBr36_09745
PGRI: PgNI_10720
TMN: UCRPA7_1407
SSCK: SPSK_03251
FGR: FGSG_08694
FPU: FPSE_11718
FPOA: FPOAC1_004821
FVN: FVRRES_05328
FVR: FVEG_01967
FOX: FOXG_03104
NHE: NECHADRAFT_59191
FFC: NCS54_00406800
FKR: NCS57_00411700
FMU: J7337_008320
TRE: TRIREDRAFT_5135
TRR: M419DRAFT_87210
TATV: 25786214(TrAtP1_012800)
TASP: 36608408(TrAFT101_009952)
MAW: 19249189(ALO1_2)
MAJ: MAA_09098
MBRN: 26244723(G6M90_00g060940)
PCHM: VFPPC_08578 VFPPC_12354
CMT: CCM_03419
AMUS: LMH87_002178
PLJ: 28888088(PLICBS_003300)
PTKZ: JDV02_000542(ALO1)
VAL: VDBG_01837
VDA: VDAG_01715
CFJ: CFIO01_11235
CLUP: CLUP02_11184
CHIG: CH63R_07224 CH63R_08599
ELA: UCREL1_10706
PFY: PFICI_03003
SSL: SS1G_14188
BFU: BCIN_09g06500(Bcalo1)
MBE: MBM_09631
PSCO: LY89DRAFT_187667
GLZ: GLAREA_02371
ANI: ANIA_00836
AFM: AFUA_1G14950
ACT: ACLA_020400
NFI: NFIA_010460
AOR: AO090005001234
ANG: An03g03460
AFV: AFLA_004052
ALUC: AKAW2_50743A(ALO1)
ACHE: ACHE_30591S(ALO1)
APUU: APUU_50980S(ALO1)
PCS: N7525_010338
PDP: PDIP_65760
POU: POX_c03985
TMF: EYB26_006062
TRG: TRUGW13939_09041
CIM: CIMG_03293
CPW: CPC735_009020
URE: UREG_07129
ABE: ARB_01878
TVE: TRV_07142
PBL: PAAG_05474
PBN: PADG_06827
AJE: HCAG_02422
BGH: BDBG_08395
PNO: SNOG_01863
PTE: PTT_10151
PTRR: 6348875(PtrM4_079850)
BZE: COCCADRAFT_84782
BSC: COCSADRAFT_41756
BOR: COCMIDRAFT_94913
AALT: CC77DRAFT_1022132
ARAB: EKO05_0007074
ZTR: MYCGRDRAFT_68116
PFJ: MYCFIDRAFT_150619
FFU: CLAFUR5_03068
CBET: CB0940_02807
BCOM: BAUCODRAFT_282374
NPA: UCRNP2_2775
TML: GSTUM_00000898001
SPO: 2543430(alo1)
SOM: SOMG_03271(alo1)
 » show all
Reference
PMID:10094636
  Authors
Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Baek YW, Hwang CS, Lee JS, Kang SO
  Title
D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 30:895-903 (1998)
DOI:10.1046/j.1365-2958.1998.01133.x
  Sequence
[sce:YML086C]
LinkDB

KEGG   ENZYME: 1.1.3.37
Entry
EC 1.1.3.37                 Enzyme                                 
Name
D-arabinono-1,4-lactone oxidase;
D-arabinono-gamma-lactone oxidase;
ALO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
D-arabinono-1,4-lactone:oxygen oxidoreductase
Reaction(IUBMB)
D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 [RN:R02715]
Reaction(KEGG)
R02715
Substrate
D-arabinono-1,4-lactone [CPD:C00652];
O2 [CPD:C00007]
Product
dehydro-D-arabinono-1,4-lactone [CPD:C06316];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1].
History
EC 1.1.3.37 created 1999
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K00107  D-arabinono-1,4-lactone oxidase
Genes
BBEL: 109465946
BGT: 106075236
HRF: 124141685
SCE: YML086C(ALO1)
SEUB: DI49_4004
SPAO: SPAR_M00450
AGO: AGOS_AFR440C
ERC: Ecym_1386
KLA: KLLA0_C16896g
KMX: KLMA_70261(ALO1)
LTH: KLTH0F06820g
VPO: Kpol_309p4
ZRO: ZYRO0A00836g
CGR: 2888523(GVI51_H03927)
NCS: NCAS_0C00130(NCAS0C00130)
NDI: NDAI_0K00250(NDAI0K00250)
TPF: TPHA_0I00160(TPHA0I00160)
TBL: TBLA_0B02960(TBLA0B02960)
TGB: HG536_0H00300
TDL: TDEL_0B00300(TDEL0B00300)
KAF: KAFR_0L02030(KAFR0L02030)
KNG: KNAG_0J00130(KNAG0J00130)
ZMK: HG535_0C05800
SLUD: SCDLUD_001293
DHA: DEHA2A02904g
PIC: PICST_88335(ALO1)
PGU: PGUG_01601
SPAA: SPAPADRAFT_59163
LEL: PVL30_002468(ALO1)
LBG: 92207107(LODBEIA_P19110)
CAL: CAALFM_CR09790WA(ALO1)
CTP: CTRG_05879
COT: CORT_0G01540
CDU: CD36_34940
CTEN: 18246692(ALO1)
CLU: CLUG_02182
CLUS: A9F13_02g01177
CAUR: CJI96_0004650
PPA: PAS_chr2-1_0197
PKZ: C5L36_0E05670
BNN: FOA43_001988
BBRX: BRETT_004030
OPA: HPODL_00171
YLI: 2906352(YALI2_A00352g)
SLB: AWJ20_4935(ALO1)
NCR: NCU03188
NTE: NEUTE1DRAFT150135(NEUTE1DRAFT_150135)
SMP: 10805869(SMAC4_02909)
PAN: PODANSg4195
PBEL: QC761_117130(ALO1)
PPSD: QC762_117130(ALO1)
PPSP: QC763_117130(ALO1)
PPSA: QC764_117130(ALO1)
TTT: THITE_119824
MTM: MYCTH_2297573
CTHR: CTHT_0014270
MGR: MGG_02689
PPEI: PpBr36_09745
PGRI: PgNI_10720
TMN: UCRPA7_1407
SSCK: SPSK_03251
FGR: FGSG_08694
FPU: FPSE_11718
FPOA: FPOAC1_004821
FVN: FVRRES_05328
FVR: FVEG_01967
FOX: FOXG_03104
NHE: NECHADRAFT_59191
FFC: NCS54_00406800
FKR: NCS57_00411700
FMU: J7337_008320
TRE: TRIREDRAFT_5135
TRR: M419DRAFT_87210
TATV: 25786214(TrAtP1_012800)
TASP: 36608408(TrAFT101_009952)
MAW: 19249189(ALO1_2)
MAJ: MAA_09098
MBRN: 26244723(G6M90_00g060940)
PCHM: VFPPC_08578 VFPPC_12354
CMT: CCM_03419
AMUS: LMH87_002178
PLJ: 28888088(PLICBS_003300)
PTKZ: JDV02_000542(ALO1)
VAL: VDBG_01837
VDA: VDAG_01715
CFJ: CFIO01_11235
CLUP: CLUP02_11184
CHIG: CH63R_07224 CH63R_08599
ELA: UCREL1_10706
PFY: PFICI_03003
SSL: SS1G_14188
BFU: BCIN_09g06500(Bcalo1)
MBE: MBM_09631
PSCO: LY89DRAFT_187667
GLZ: GLAREA_02371
ANI: ANIA_00836
AFM: AFUA_1G14950
ACT: ACLA_020400
NFI: NFIA_010460
AOR: AO090005001234
ANG: An03g03460
AFV: AFLA_004052
ALUC: AKAW2_50743A(ALO1)
ACHE: ACHE_30591S(ALO1)
APUU: APUU_50980S(ALO1)
PCS: N7525_010338
PDP: PDIP_65760
POU: POX_c03985
TMF: EYB26_006062
TRG: TRUGW13939_09041
CIM: CIMG_03293
CPW: CPC735_009020
URE: UREG_07129
ABE: ARB_01878
TVE: TRV_07142
PBL: PAAG_05474
PBN: PADG_06827
AJE: HCAG_02422
BGH: BDBG_08395
PNO: SNOG_01863
PTE: PTT_10151
PTRR: 6348875(PtrM4_079850)
BZE: COCCADRAFT_84782
BSC: COCSADRAFT_41756
BOR: COCMIDRAFT_94913
AALT: CC77DRAFT_1022132
ARAB: EKO05_0007074
ZTR: MYCGRDRAFT_68116
PFJ: MYCFIDRAFT_150619
FFU: CLAFUR5_03068
CBET: CB0940_02807
BCOM: BAUCODRAFT_282374
NPA: UCRNP2_2775
TML: GSTUM_00000898001
SPO: 2543430(alo1)
SOM: SOMG_03271(alo1)
 » show all
Reference
1  [PMID:7957197]
  Authors
Huh WK, Kim ST, Yang KS, Seok YJ, Hah YC, Kang SO.
  Title
Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231.
  Journal
Eur J Biochem 225:1073-9 (1994)
DOI:10.1111/j.1432-1033.1994.1073b.x
Reference
2  [PMID:10094636]
  Authors
Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Baek YW, Hwang CS, Lee JS, Kang SO
  Title
D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 30:895-903 (1998)
DOI:10.1046/j.1365-2958.1998.01133.x
  Sequence
[sce:YML086C]
Reference
3  [PMID:10508108]
  Authors
Lee BH, Huh WK, Kim ST, Lee JS, Kang SO.
  Title
Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli.
  Journal
Appl Environ Microbiol 65:4685-7 (1999)
DOI:10.1128/AEM.65.10.4685-4687.1999
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.37
IUBMB Enzyme Nomenclature: 1.1.3.37
ExPASy - ENZYME nomenclature database: 1.1.3.37
BRENDA, the Enzyme Database: 1.1.3.37
CAS: 182372-12-9
LinkDB

KEGG   REACTION: R02715
Entry
R02715                      Reaction                               
Name
D-arabinono-1,4-lactone:oxygen oxidoreductase
Definition
D-Arabinono-1,4-lactone + Oxygen <=> Dehydro-D-arabinono-1,4-lactone + Hydrogen peroxide
Equation
C00652 + C00007 <=> C06316 + C00027
Reaction class
RC00195  C00652_C06316
RC02755  C00007_C00027
Enzyme
1.1.3.37
Pathway
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.37
     R02715  D-Arabinono-1,4-lactone + Oxygen <=> Dehydro-D-arabinono-1,4-lactone + Hydrogen peroxide
Orthology
K00107  D-arabinono-1,4-lactone oxidase [EC:1.1.3.37]
Reference
1  [PMID:8841374]
  Authors
Kim ST, Huh WK, Kim JY, Hwang SW, Kang SO.
  Title
D-arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans.
  Journal
Biochim Biophys Acta 1297:1-8 (1996)
Other DBs
RHEA: 23759
LinkDB

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