Entry
Name
aminobutyraldehyde dehydrogenase;
gamma-guanidinobutyraldehyde dehydrogenase (ambiguous);
ABAL dehydrogenase;
4-aminobutyraldehyde dehydrogenase;
4-aminobutanal dehydrogenase;
gamma-aminobutyraldehyde dehydroganase;
1-pyrroline dehydrogenase;
ABALDH;
YdcW
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-aminobutanal:NAD+ 1-oxidoreductase
Reaction(IUBMB)
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN:
R02549 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC
1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].
History
EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)
Pathway
ec00330 Arginine and proline metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K00137 aminobutyraldehyde dehydrogenase
Genes
ECW : EcE24377A_1624(ydcW)
EDJ : ECDH1ME8569_1387(ydcW)
REE : electrica_02654(prr)
RTG : NCTC13098_03893(prr_1)
CENS : P2W74_11880(patD) P2W74_18235(patD)
CLAP : NCTC11466_02200(prr_2)
KIE : NCTC12125_01425(prr_1)
LAX : APT61_10690 APT61_19745
LEI : C2U54_07560(patD) C2U54_16950(patD)
LEH : C3F35_09125(patD) C3F35_22970(patD)
LEE : DVA44_11590(patD) DVA44_21215(patD)
LER : GNG29_02805(patD) GNG29_11505(patD)
LEA : GNG26_02405(patD) GNG26_11675(patD)
LEY : DVA43_05845(patD) DVA43_15145(patD)
BSEL : RHD99_10325(patD) RHD99_11485(patD)
AHN : NCTC12129_02711(ydcW)
METY : MRY16398_29490(prr)
SMAR : SM39_3240 SM39_3245
SMAC : SMDB11_3030 SMDB11_3035
SMW : SMWW4_v1c37430(prr) SMWW4_v1c37480
SRL : SOD_c35710(prr1) SOD_c35760(prr)
SRY : M621_19325 M621_19350
SLQ : M495_18735 M495_18760
SERF : L085_09875 L085_09900
SERS : SERRSCBI_18225 SERRSCBI_18250
SFW : WN53_00865 WN53_00890
SFG : AV650_23635 AV650_23660
SQU : E4343_22500 E4343_22525(patD)
SFJ : SAMEA4384070_3752(prr_1) SAMEA4384070_3757(prr_2)
SSUR : ATE40_015345 ATE40_015370
SURI : J0X03_05160 J0X03_05185(patD)
SENP : KHA73_18260(patD) KHA73_18285
SNEM : NLX84_18780(patD) NLX84_18805
SNEV : OI978_13430 OI978_13455(patD)
SGRI : SGBXF1_03707(prr_1) SGBXF1_03712(prr_2)
SSAR : SSARUM_003625(patD) SSARUM_003630
SFO : Z042_05130 Z042_05155
ROX : BV494_23765 BV494_23790
RBON : QNM34_09395 QNM34_09420
RIU : I2123_23205 I2123_23230
GQU : AWC35_17535 AWC35_17560
SERA : Ser39006_017230(patD) Ser39006_021825 Ser39006_021850
SERQ : CWC46_17230(patD) CWC46_21835 CWC46_21860
PROD : PCO85_03600 PCO85_03625 PCO85_13730(patD)
PAQU : DMB82_0013370(patD)
PARL : PEC302110_13870(patD)
DIC : Dpoa569_002380(patD)
BRB : EH207_07650 EH207_07675 EH207_11275(patD)
LBQ : CKQ53_11625 CKQ53_11650(patD)
LPOP : I6N93_10110(patD) I6N93_10135
HAV : AT03_05225 AT03_05250
HPAR : AL518_00470(patD) AL518_00495
PRE : PCA10_19590(prr) PCA10_22460(prr) PCA10_45930(prr) PCA10_45980(prr)
PFUW : KF707C_33410 KF707C_45880 KF707C_45930
POJ : PtoMrB4_28860 PtoMrB4_28910(prr)
PLAL : FXN65_10355 FXN65_22250 FXN65_22275
PCQ : PcP3B5_28820(prr_1) PcP3B5_38780(prr_2) PcP3B5_48730(prr_3) PcP3B5_48780(prr_4)
PMUI : G4G71_22805 G4G71_25105 G4G71_25130
PNT : G5B91_08865 G5B91_08890 G5B91_11650
PPU : PP_1481(patD) PP_2801(prr)
PPUH : B479_05715 B479_13870
PPUD : DW66_1080 DW66_1414
PALD : LU682_016625 LU682_023475
PMOS : O165_000600 O165_007935
PFE : PSF113_1076 PSF113_1081
PZA : HU749_006280 HU749_006305
PFO : Pfl01_1044 Pfl01_1049
PTV : AA957_08025 AA957_08050
PCG : AXG94_20915 AXG94_20940
PVR : PverR02_06270 PverR02_06295
PAZO : AYR47_13260 AYR47_13285
PRX : HRH33_06870 HRH33_06895
PMED : E3Z27_05285 E3Z27_05310 E3Z27_11125
PMAB : U0037_06060 U0037_06085
PFW : PF1751_v1c11600 PF1751_v1c11650
PFF : PFLUOLIPICF702285 PFLUOLIPICF702310
PFX : A7318_05280 A7318_05305
PBA : PSEBR_a1008 PSEBR_a1013
PPUU : PputUW4_01032(ydcW1) PputUW4_01037(ydcW2)
PSV : PVLB_10550 PVLB_10575 PVLB_19745
PSK : U771_07220 U771_07245
PKC : PKB_1111(prr1) PKB_1116(prr3) PKB_1908(prr5)
PCH : EY04_04945 EY04_04970
PCZ : PCL1606_49760 PCL1606_49810
PCP : JM49_24680 JM49_24705
PCHP : C4K32_1191 C4K32_1197
PSEM : TO66_05625 TO66_05650
PSEC : CCOS191_2905(prr1) CCOS191_4196(prr2)
PSOS : POS17_1125 POS17_1130(ydcW)
PFK : PFAS1_17090 PFAS1_17115
PSET : THL1_1957 THL1_2262 THL1_4632 THL1_4637
PYM : AK972_4772 AK972_4778
PKE : DLD99_05580 DLD99_05605
PUM : HGP31_05655 HGP31_05680 HGP31_17910
PGY : AWU82_18635 AWU82_18660 AWU82_29445 AWU82_29470
PVK : EPZ47_05490 EPZ47_05515 EPZ47_10880
PEZ : HWQ56_06055 HWQ56_06080
PBZ : GN234_12870 GN234_12895
PMAO : PMYSY11_3334(patD) PMYSY11_3340(patD)
PZE : HU754_006750 HU754_006775
PMOE : HV782_006290 HV782_006315
PVW : HU752_006650 HU752_006675
PTRT : HU722_0007125 HU722_0007150
PXA : KSS93_23840 KSS93_23865
PTZ : HU718_006340 HU718_006365
PQI : KH389_05465 KH389_05480 KH389_05665
PASG : KSS96_06875 KSS96_06900
PFAK : KSS94_21230 KSS94_21255
PMAM : KSS90_14225 KSS90_20360
PAZE : KSS91_06020 KSS91_06045 KSS91_17220
PALV : KSS97_18000 KSS97_23555 KSS97_23580
PCAS : LOY40_23385 LOY40_23410
PTW : TUM18999_47620 TUM18999_47670(prr)
PWY : HU734_004320 HU734_004425 HU734_004450
PGF : J0G10_06505 J0G10_06530
PCAV : D3880_06245 D3880_06275
PIZ : LAB08_R10290 LAB08_R10340
PPEG : KUA23_06135 KUA23_06160
PFIT : KJY40_06360 KJY40_06385
PNB : NK667_21890 NK667_21915
PSOA : PSm6_08180 PSm6_08230(prr)
PKJ : Q1W70_05045 Q1W70_05070
PHOM : KJF94_02270 KJF94_02295 KJF94_13860
PTRL : OU419_11635 OU419_21705 OU419_21730
PSHS : JJN09_02105 JJN09_02130
PLIS : NN484_01805 NN484_01830
PSNC : C0058_05910 C0058_05940
PBEJ : PSH84_09935 PSH84_09960
PBAM : NUH87_11845 NUH87_11870
PDEU : QEP73_05440 QEP73_10320 QEP73_10345
PDEN : F1C79_00875 F1C79_00895
PALC : A0T30_07035 A0T30_07065
MSQ : BKP64_14690 BKP64_14720
MME : Marme_2681 Marme_2687
MPC : Mar181_1377 Mar181_1383
AEL : NCTC12917_03714(prr)
BTD : BTI_4424(prr) BTI_5265(prr)
PLG : NCTC10937_01417(prr)
MAMO : A6B35_06910 A6B35_29580
SAME : SAMCFNEI73_Ch2536(prr)
RPHA : AMC79_CH03853(prr-1) AMC79_PD00734(prr-2)
RHK : Kim5_CH04027(prr-1) Kim5_PD00138(prr-2)
DEQ : XM25_12825 XM25_20880
YTI : FNA67_02205 FNA67_16545
SPSE : SULPSESMR1_01346(prr)
PAED : G5B38_20590 G5B38_20605
MAUU : NCTC10437_01143(prr_1) NCTC10437_01581(prr_3)
MTY : MTOK_07690 MTOK_15580
MARZ : MARA_21800(prr) MARA_25150
RKO : JWS14_04090 JWS14_14705 JWS14_18020 JWS14_38410
RPSK : JWS13_24235 JWS13_30500
PAYJ : HMI59_02150 HMI59_24215
BALA : DSM104299_03773(prr)
CWO : Cwoe_0985 Cwoe_2601 Cwoe_4237
DHI : LH044_09050 LH044_19175
» show all
Taxonomy
Reference
Authors
Callewaert DM, Rosemblatt MS, Tchen TT.
Title
Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species.
Journal
J Biol Chem 249:1737-41 (1974)
Reference
2
Authors
Jakoby WB.
Title
Aldehyde dehydrogenases.
Journal
In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 7. New York: Academic Press; 1963. p. 203-221.
Reference
Authors
JAKOBY WB, FREDERICKS J.
Title
Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase.
Journal
J Biol Chem 234:2145-50 (1959)
Reference
Authors
Matsuda H, Suzuki Y.
Title
gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves.
Journal
Reference
5
Authors
Yorifuji T, Koike K, Sakurai T, Yokoyama K.
Title
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida.
Journal
Agric Biol Chem 50:2009-2016 (1986)
Reference
Authors
Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A.
Title
A pathway for putrescine catabolism in Escherichia coli.
Journal
Reference
Authors
Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A.
Title
Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.
Journal
Reference
Authors
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR
Title
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.
Journal
Sequence
Reference
Authors
Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C
Title
Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.19
ExPASy - ENZYME nomenclature database: 1.2.1.19
LinkDB
All DBs