KEGG   ORTHOLOGY: K00186
Entry
K00186                      KO                                     
Symbol
vorA
Name
2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7]
Pathway
map00280  Valine, leucine and isoleucine degradation
map01100  Metabolic pathways
map01210  2-Oxocarboxylic acid metabolism
Reaction
R07160  3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating)
R08566  4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
R08567  (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00186  vorA; 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.7  3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
     K00186  vorA; 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid oxidizing enzymes
  K00186
Other DBs
COG: COG0674
GO: 0043807
Genes
HMR: Hipma_0797
DAV: DESACE_01540(porA)
PEF: A7E78_02855
DEK: DSLASN_10400(porA_1)
AFW: Anae109_4114
AORY: AMOR_34170(porA)
FWA: DCMF_13980
CALK: HUE98_02350(porA)
PBU: L21SP3_01137(korA_1)
PBP: STSP1_01192(korA_1)
PBAS: SMSP2_01216(korA)
ORP: MOP44_03550(vorB)
SUS: Acid_1871
THYD: TTHT_1225(porA)
GEP: Q9293_11035(vorB)
CABY: Cabys_3126
MMP: MMP1272(vorB)
MMD: GYY_07195
MMAD: MMJJ_15730(korA_3)
MVO: Mvol_0719
MTH: MTH_704
MMG: MTBMA_c10910(vorB)
MWO: MWSIV6_1080(vorB)
MTEE: MTTB_10550
METC: MTCT_0632
METE: tca_00679(korA_2)
MRU: mru_1432(vorA)
MSI: Msm_0332
MMIL: sm9_0693(vorA)
MOL: YLM1_0933
METH: MBMB1_0179(vorB)
MFC: BRM9_2124(vorA)
MFI: DSM1535_1556(vorB)
MCUB: MCBB_0194(vorB)
MFV: Mfer_0416
GAC: GACE_2154
GAH: GAH_00571
PFU: PF0969
PFI: PFC_04075(vorA)
PHO: PH0680(PH0680)
PAB: PAB1472
PYN: PNA2_1294
PYS: Py04_1080
PYC: TQ32_04855(porA)
TKO: TK1980
TON: TON_1478
TGA: TGAM_0265(vorA)
TSI: TSIB_1382
THE: GQS_08130(vorA)
THA: TAM4_1460
THM: CL1_1247
TLT: OCC_07491(porA)
THS: TES1_1553
TNU: BD01_1943
TEU: TEU_01675(porA)
TGY: X802_03765(porA)
TPEP: A0127_05005(porA)
TPIE: A7C91_04900(porA)
TGG: A3K92_07965(porA)
TCE: A3L02_06805(porA)
TBS: A3L01_08190(porA)
THH: CDI07_07390(porA)
TSL: A3L11_01540(porA)
TTD: A3L14_10585(porA)
TPRF: A3L09_01315(porA)
TRL: A3L10_07580(porA)
TPAF: A3L08_01315(porA)
THY: A3L12_04025(porA)
TIC: FH039_11785(porA)
TCQ: TIRI35C_1961(vorA)
THEM: FPV09_09750(porA)
THEI: K1720_10005(porA)
PPAC: PAP_04310(porA)
MBAR: MSBR2_0148
MBAK: MSBR3_1065
MAC: MA_2910(vorB)
MMA: MM_3182(vorB)
MMAC: MSMAC_2850
METM: MSMTP_1762
MTHR: MSTHT_0825
MTHE: MSTHC_2446
MHOR: MSHOH_1580
MFZ: AOB57_012380(vorB)
MBU: Mbur_0606
MMET: MCMEM_1078
MMH: Mmah_1011
MPY: Mpsy_0060
MEHF: MmiHf6_00130(korA)
MEES: MmiEs2_10530(korA)
MTP: Mthe_0156
MCJ: MCON_0779(vorB)
MHI: Mhar_0584
HAHS: HSRCO_0563(porA2)
TAC: Ta0628
MEAR: Mpt1_c05550(vorB)
ABI: Aboo_0300
IAG: Igag_1136
STO: STK_15320
SSO: SSO1207(porA-1)
SOL: Ssol_2171
SSOA: SULA_2206
SSOL: SULB_2207
SSOF: SULC_2204
SID: M164_0396
SII: LD85_0384
SIH: SiH_0373
SIR: SiRe_0364
SIC: SiL_0352
 » show all
Reference
PMID:8550513 (P.furiosus)
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
PMID:8550425
  Authors
Kletzin A, Adams MW
  Title
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
  Journal
J Bacteriol 178:248-57 (1996)
DOI:10.1128/JB.178.1.248-257.1996
  Sequence
[pfu:PF0969]
Reference
PMID:9108258
  Authors
Tersteegen A, Linder D, Thauer RK, Hedderich R
  Title
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
  Journal
Eur J Biochem 244:862-8 (1997)
DOI:10.1111/j.1432-1033.1997.00862.x
  Sequence
LinkDB

KEGG   ORTHOLOGY: K00187
Entry
K00187                      KO                                     
Symbol
vorB
Name
2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7]
Pathway
map00280  Valine, leucine and isoleucine degradation
map01100  Metabolic pathways
map01210  2-Oxocarboxylic acid metabolism
Reaction
R07160  3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating)
R08566  4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
R08567  (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00187  vorB; 2-oxoisovalerate ferredoxin oxidoreductase beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.7  3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
     K00187  vorB; 2-oxoisovalerate ferredoxin oxidoreductase beta subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid oxidizing enzymes
  K00187
Other DBs
COG: COG1013
GO: 0043807
Genes
HMR: Hipma_0798
DAV: DESACE_01535
PEF: A7E78_02850
DALK: DSCA_29970
DLI: dnl_19240(porB)
DMM: dnm_023500
AFW: Anae109_4113
PBU: L21SP3_01138(korB_1)
PBP: STSP1_01193(korB_1)
PBAS: SMSP2_01215(korB)
SUS: Acid_1870
THYD: TTHT_1226(porB)
CABY: Cabys_3127
MMP: MMP1271(vorA)
MMD: GYY_07190
MMAD: MMJJ_15740(korB_3)
MVO: Mvol_0718
MTH: MTH_705
MMG: MTBMA_c10920(vorA1) MTBMA_c10930(vorA2)
MWO: MWSIV6_1081(vorA)
MTEE: MTTB_10560
METC: MTCT_0633
METE: tca_00680(korB_2)
MRU: mru_1431(vorB)
MSI: Msm_0333
MMIL: sm9_0692(vorB)
MEYE: TL18_03385
MOL: YLM1_0932
METH: MBMB1_0180(vorA)
MFC: BRM9_2123(vorB)
MFI: DSM1535_1557(vorA)
MCUB: MCBB_0195(vorA)
MFV: Mfer_0417
PFU: PF0968
PFI: PFC_04070
PHO: PH0681(PH0681)
PAB: PAB1473
PYN: PNA2_1295
PYS: Py04_1079
TKO: TK1981
TON: TON_1479
TGA: TGAM_0264(vorB)
TSI: TSIB_1381
THE: GQS_08125
THA: TAM4_1398
THM: CL1_1246
TLT: OCC_07486
THS: TES1_1552
TNU: BD01_1944
TEU: TEU_01670
TCQ: TIRI35C_1962(vorB)
PPAC: PAP_04315
MBAR: MSBR2_0149
MBAK: MSBR3_1064
MAC: MA_2909(vorA)
MMA: MM_3183(vorA)
MMAC: MSMAC_2849
METM: MSMTP_1763
MTHR: MSTHT_0824
MTHE: MSTHC_2447
MHOR: MSHOH_1579
MBU: Mbur_0605
MMET: MCMEM_1077
MMH: Mmah_1012
MPY: Mpsy_0061
MTP: Mthe_0157
MCJ: MCON_0778(vorA)
MHI: Mhar_0583
TAC: Ta0629
TVO: TVG0872869(TVG0872869)
MEAR: Mpt1_c05540(vorA)
ABI: Aboo_0301
 » show all
Reference
PMID:8550513 (P.furiosus)
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
PMID:8550425
  Authors
Kletzin A, Adams MW
  Title
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
  Journal
J Bacteriol 178:248-57 (1996)
DOI:10.1128/JB.178.1.248-257.1996
  Sequence
[pfu:PF0968]
Reference
PMID:9108258
  Authors
Tersteegen A, Linder D, Thauer RK, Hedderich R
  Title
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
  Journal
Eur J Biochem 244:862-8 (1997)
DOI:10.1111/j.1432-1033.1997.00862.x
  Sequence
LinkDB

KEGG   ORTHOLOGY: K00189
Entry
K00189                      KO                                     
Symbol
vorG, porG
Name
2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00020  Citrate cycle (TCA cycle)
map00280  Valine, leucine and isoleucine degradation
map00620  Pyruvate metabolism
map00633  Nitrotoluene degradation
map00640  Propanoate metabolism
map00650  Butanoate metabolism
map00680  Methane metabolism
map00720  Other carbon fixation pathways
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01210  2-Oxocarboxylic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Reaction
R01196  pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
R01199  2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating)
R07160  3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating)
R08034  
R08566  4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
R08567  (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00020 Citrate cycle (TCA cycle)
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00620 Pyruvate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00640 Propanoate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00650 Butanoate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00680 Methane metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.1  pyruvate synthase
     K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
    1.2.7.7  3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
     K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid oxidizing enzymes
  K00189
Other DBs
COG: COG1014
GO: 0043807 0019164
Genes
HMR: Hipma_0796
DAV: DESACE_01545
DBK: DGMP_23530
DEK: DSLASN_10380
DAW: HS1_001571(porC)
AORY: AMOR_34150
DHR: LGS26_04510
SEDM: RBQ61_13285
SSID: SPSIL_057850(padE_2)
CALK: HUE98_02340
AMYZ: HUW46_01359(porC)
PFU: PF0971
PFI: PFC_04085
PHO: PH0678(PH0678)
PAB: PAB1470
PYN: PNA2_1292
PYS: Py04_1082
TKO: TK1978
TON: TON_1476
TGA: TGAM_0267(porG)
TSI: TSIB_1384
THE: GQS_08140
THA: TAM4_1107
THM: CL1_1249
TLT: OCC_07501
THS: TES1_1555
TNU: BD01_1941
TEU: TEU_01685
TCQ: TIRI35C_1959(porG)
PPAC: PAP_04300
MAQE: RJ40_07300
HAHS: HSRCO_0562(porG)
TAC: Ta0626
ABI: Aboo_0298
IPC: IPA_03975
PABI: PABY_00170
PARE: PYJP_01300
 » show all
Reference
PMID:8550513 (P.furiosus)
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
PMID:8550425
  Authors
Kletzin A, Adams MW
  Title
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
  Journal
J Bacteriol 178:248-57 (1996)
DOI:10.1128/JB.178.1.248-257.1996
  Sequence
[pfu:PF0971]
LinkDB

KEGG   ORTHOLOGY: K00188
Entry
K00188                      KO                                     
Symbol
vorD
Name
2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7]
Pathway
map00280  Valine, leucine and isoleucine degradation
map01100  Metabolic pathways
map01210  2-Oxocarboxylic acid metabolism
Reaction
R07160  3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating)
R08566  4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
R08567  (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00188  vorD; 2-oxoisovalerate ferredoxin oxidoreductase delta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.7  3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
     K00188  vorD; 2-oxoisovalerate ferredoxin oxidoreductase delta subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid oxidizing enzymes
  K00188
Other DBs
COG: COG1144
GO: 0043807
Genes
PFAA: MM59RIKEN_15740
EVN: NQ558_06000
CHYL: CE91St63_20520
HPRF: HLPR_01110(porD)
GBX: SANA_01720
SSID: SPSIL_057840(napF_6)
PBU: L21SP3_01136
PBP: STSP1_01191
PBAS: SMSP2_01217
VBC: C5Q97_08000
MMP: MMP1273(vorC)
MMD: GYY_07200
MMAD: MMJJ_15720
MVO: Mvol_0720
MTH: MTH_703
MMG: MTBMA_c10900(vorC)
MWO: MWSIV6_1079(vorC)
MTEE: MTTB_10540
METC: MTCT_0631
METE: tca_00678
MRU: mru_1433(vorC)
MSI: Msm_0331
MMIL: sm9_0694(vorC)
MOL: YLM1_0934
METH: MBMB1_0178
MFC: BRM9_2125(vorC)
MCUB: MCBB_0193(vorC)
MFV: Mfer_0506
PFU: PF0970
PFI: PFC_04080(vorD)
PHO: PH0679(PH0679)
PAB: PAB1471
PYN: PNA2_1293
PYS: Py04_1081
PYC: TQ32_04850(vorD)
TKO: TK1979
TON: TON_1477
TGA: TGAM_0266(vorD)
TSI: TSIB_1383
THE: GQS_08135(vorD)
THA: TAM4_1406
THM: CL1_1248
TLT: OCC_07496(vorD)
THS: TES1_1554
TNU: BD01_1942
TEU: TEU_01680(vorD)
TGY: X802_03770(vorD)
TPEP: A0127_05000(vorD)
TPIE: A7C91_04905(vorD)
TGG: A3K92_07960(vorD)
TCE: A3L02_06810(vorD)
TBS: A3L01_08185(vorD)
THH: CDI07_07395(vorD)
TSL: A3L11_01535(vorD)
TTD: A3L14_10580(vorD)
TPRF: A3L09_01310(vorD)
TRL: A3L10_07575(vorD)
TPAF: A3L08_01310(vorD)
THY: A3L12_04020(vorD)
TCQ: TIRI35C_1960(vorD)
PPAC: PAP_04305(vorD)
MBAR: MSBR2_0147
MBAK: MSBR3_1066
MAC: MA_2911(vorC)
MMA: MM_3181(vorC)
MMAC: MSMAC_2851
METM: MSMTP_1761
MTHR: MSTHT_0826
MTHE: MSTHC_2445
MHOR: MSHOH_1581
MBU: Mbur_0607
MMET: MCMEM_1079
MMH: Mmah_1010
MPY: Mpsy_0059
HAAA: AArcCO_0208(porD)
TAC: Ta0627
MER: MMINT_12450(vorD)
ABI: Aboo_0299
 » show all
Reference
PMID:8550513 (P.furiosus)
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
PMID:8550425
  Authors
Kletzin A, Adams MW
  Title
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
  Journal
J Bacteriol 178:248-57 (1996)
DOI:10.1128/JB.178.1.248-257.1996
  Sequence
[pfu:PF0970]
Reference
PMID:9108258
  Authors
Tersteegen A, Linder D, Thauer RK, Hedderich R
  Title
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
  Journal
Eur J Biochem 244:862-8 (1997)
DOI:10.1111/j.1432-1033.1997.00862.x
  Sequence
LinkDB

KEGG   ENZYME: 1.2.7.7
Entry
EC 1.2.7.7                  Enzyme                                 
Name
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin);
2-ketoisovalerate ferredoxin reductase;
3-methyl-2-oxobutanoate synthase (ferredoxin);
VOR;
branched-chain ketoacid ferredoxin reductase;
branched-chain oxo acid ferredoxin reductase;
keto-valine-ferredoxin oxidoreductase;
ketoisovalerate ferredoxin reductase;
2-oxoisovalerate ferredoxin reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
Sysname
3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)
Reaction(IUBMB)
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+ [RN:R07160]
Reaction(KEGG)
R07160;
(other) R08566 R08567
Substrate
3-methyl-2-oxobutanoate [CPD:C00141];
CoA [CPD:C00010];
oxidized ferredoxin [CPD:C00139]
Product
S-(2-methylpropanoyl)-CoA;
CO2 [CPD:C00011];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, and 2-oxobutanoate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyse the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase.
History
EC 1.2.7.7 created 2003
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
Orthology
K00186  2-oxoisovalerate ferredoxin oxidoreductase alpha subunit
K00187  2-oxoisovalerate ferredoxin oxidoreductase beta subunit
K00188  2-oxoisovalerate ferredoxin oxidoreductase delta subunit
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
Genes
HMRHipma_0796 Hipma_0797 Hipma_0798
DAVDESACE_01535 DESACE_01540(porA) DESACE_01545
PEFA7E78_02850 A7E78_02855
DBKDGMP_23530
DALKDSCA_29970
DLIdnl_19240(porB)
DMMdnm_023500
DEKDSLASN_10380 DSLASN_10400(porA_1)
DAWHS1_001571(porC)
AFWAnae109_4113 Anae109_4114
AORYAMOR_34150 AMOR_34170(porA)
DHRLGS26_04510
PFAAMM59RIKEN_15740
FWADCMF_13980
EVNNQ558_06000
CHYLCE91St63_20520
HPRFHLPR_01110(porD)
GBXSANA_01720
SEDMRBQ61_13285
SSIDSPSIL_057840(napF_6) SPSIL_057850(padE_2)
CALKHUE98_02340 HUE98_02350(porA)
MPAGC0J29_14490
AMYZHUW46_01359(porC)
LMAJGKN94_01220
PBUL21SP3_01136 L21SP3_01137(korA_1) L21SP3_01138(korB_1)
PBPSTSP1_01191 STSP1_01192(korA_1) STSP1_01193(korB_1)
PBASSMSP2_01215(korB) SMSP2_01216(korA) SMSP2_01217
VBCC5Q97_08000 C5Q97_08005 C5Q97_08010
SLRL21SP2_0405 L21SP2_0406 L21SP2_0407
ABAAcid345_0952 Acid345_0953
ORPMOP44_03550(vorB) MOP44_03555
SUSAcid_1870 Acid_1871
PFERIRI77_33000 IRI77_33005
THYDTTHT_1225(porA) TTHT_1226(porB)
GEXGETHOR_18790 GETHOR_18800
GEPQ9293_11035(vorB) Q9293_11040
GETQOZ81_002117
MSILMETEAL_31510
MSEAMETESE_27950
DUQE7745_05455
CABYCabys_3126 Cabys_3127
FBNHY931_02725
MMPMMP1271(vorA) MMP1272(vorB) MMP1273(vorC)
MMQMmarC5_0318 MmarC5_0319 MmarC5_0320
MMXMmarC6_1400 MmarC6_1401 MmarC6_1402
MMZMmarC7_0517 MmarC7_0518 MmarC7_0519
MMDGYY_07190 GYY_07195 GYY_07200
MMAKMMKA1_14960 MMKA1_14970 MMKA1_14980
MMAOMMOS7_13780 MMOS7_13790 MMOS7_13800
MMADMMJJ_15720 MMJJ_15730(korA_3) MMJJ_15740(korB_3)
MVNMevan_0583 Mevan_0584 Mevan_0585
MVOMvol_0718 Mvol_0719 Mvol_0720
MTHMTH_703 MTH_704 MTH_705
MMGMTBMA_c10900(vorC) MTBMA_c10910(vorB) MTBMA_c10920(vorA1) MTBMA_c10930(vorA2)
MWOMWSIV6_1079(vorC) MWSIV6_1080(vorB) MWSIV6_1081(vorA)
MTEEMTTB_10540 MTTB_10550 MTTB_10560
METCMTCT_0631 MTCT_0632 MTCT_0633
METEtca_00678 tca_00679(korA_2) tca_00680(korB_2)
METZMETMT2_0337 METMT2_0338 METMT2_0339
METKFVF72_08025 FVF72_08030 FVF72_08035
MTHMFZP57_05120 FZP57_05125 FZP57_05130
METJFZP68_01095 FZP68_01100 FZP68_01105
MRUmru_1431(vorB) mru_1432(vorA) mru_1433(vorC)
MSIMsm_0331 Msm_0332 Msm_0333
MMILsm9_0692(vorB) sm9_0693(vorA) sm9_0694(vorC)
MEYETL18_03385
MOLYLM1_0932 YLM1_0933 YLM1_0934
MAROMarbSA_03660 MarbSA_03670 MarbSA_03680
METVK4897_02170 K4897_02175 K4897_02180
MELMetbo_2452 Metbo_2453 Metbo_2454
MEWMSWAN_0187 MSWAN_0188 MSWAN_0189
METHMBMB1_0178 MBMB1_0179(vorB) MBMB1_0180(vorA)
MFCBRM9_2123(vorB) BRM9_2124(vorA) BRM9_2125(vorC)
MFIDSM1535_1555 DSM1535_1556(vorB) DSM1535_1557(vorA)
MCUBMCBB_0193(vorC) MCBB_0194(vorB) MCBB_0195(vorA)
MSUBBK009_10645 BK009_10650 BK009_10655
METNBK008_06270 BK008_06275 BK008_06280
METTCIT01_01270 CIT01_01275 CIT01_01280
METOCIT02_06140 CIT02_06145 CIT02_06150
MEMEHYG87_02760 HYG87_02765 HYG87_02770
MFEGGCM10025860_09900 GCM10025860_09920 GCM10025860_09930
MEERNKF70_07595 NKF70_07605
MFVMfer_0416 Mfer_0417 Mfer_0506
ASTAsulf_00880
GACGACE_2154
GAHGAH_00571
PFUPF0968 PF0969 PF0970 PF0971
PFIPFC_04070 PFC_04075(vorA) PFC_04080(vorD) PFC_04085
PHOPH0678(PH0678) PH0679(PH0679) PH0680(PH0680) PH0681(PH0681)
PABPAB1470 PAB1471 PAB1472 PAB1473
PYNPNA2_1292 PNA2_1293 PNA2_1294 PNA2_1295
PYAPYCH_06630 PYCH_06640 PYCH_06650 PYCH_06660
PYSPy04_1079 Py04_1080 Py04_1081 Py04_1082
PYCTQ32_04845 TQ32_04850(vorD) TQ32_04855(porA) TQ32_04860
TKOTK1978 TK1979 TK1980 TK1981
TONTON_1476 TON_1477 TON_1478 TON_1479
TGATGAM_0264(vorB) TGAM_0265(vorA) TGAM_0266(vorD) TGAM_0267(porG)
TSITSIB_1381 TSIB_1382 TSIB_1383 TSIB_1384
TBATERMP_01557 TERMP_01558 TERMP_01559 TERMP_01560
THEGQS_08125 GQS_08130(vorA) GQS_08135(vorD) GQS_08140
THATAM4_1107 TAM4_1398 TAM4_1406 TAM4_1460
THMCL1_1246 CL1_1247 CL1_1248 CL1_1249
TLTOCC_07486 OCC_07491(porA) OCC_07496(vorD) OCC_07501
THSTES1_1552 TES1_1553 TES1_1554 TES1_1555
TNUBD01_1941 BD01_1942 BD01_1943 BD01_1944
TEUTEU_01670 TEU_01675(porA) TEU_01680(vorD) TEU_01685
TGYX802_03760 X802_03765(porA) X802_03770(vorD) X802_03775
THVADU37_CDS14440 ADU37_CDS14450 ADU37_CDS14460 ADU37_CDS14470
TCHCHITON_0665 CHITON_0666 CHITON_0667 CHITON_0668
TPEPA0127_04995 A0127_05000(vorD) A0127_05005(porA) A0127_05010
TPIEA7C91_04895 A7C91_04900(porA) A7C91_04905(vorD) A7C91_04910
TGGA3K92_07955 A3K92_07960(vorD) A3K92_07965(porA) A3K92_07970
TCEA3L02_06800 A3L02_06805(porA) A3L02_06810(vorD) A3L02_06815
TBSA3L01_08180 A3L01_08185(vorD) A3L01_08190(porA) A3L01_08195
THHCDI07_07385 CDI07_07390(porA) CDI07_07395(vorD) CDI07_07400
TSLA3L11_01530 A3L11_01535(vorD) A3L11_01540(porA) A3L11_01545
TTDA3L14_10575 A3L14_10580(vorD) A3L14_10585(porA) A3L14_10590
TPRFA3L09_01305 A3L09_01310(vorD) A3L09_01315(porA) A3L09_01320
TRLA3L10_07570 A3L10_07575(vorD) A3L10_07580(porA) A3L10_07585
TPAFA3L08_01305 A3L08_01310(vorD) A3L08_01315(porA) A3L08_01320
THYA3L12_04015 A3L12_04020(vorD) A3L12_04025(porA) A3L12_04030
TICFH039_11775 FH039_11780 FH039_11785(porA) FH039_11790
TCQTIRI35C_1959(porG) TIRI35C_1960(vorD) TIRI35C_1961(vorA) TIRI35C_1962(vorB)
THEMFPV09_09745 FPV09_09750(porA) FPV09_09755 FPV09_09760
THEIK1720_10000 K1720_10005(porA) K1720_10010 K1720_10015
PPACPAP_04300 PAP_04305(vorD) PAP_04310(porA) PAP_04315
MBAMbar_A2173 Mbar_A2174 Mbar_A2175
MBYMSBRM_2262 MSBRM_2263 MSBRM_2264
MBWMSBRW_2566 MSBRW_2567 MSBRW_2568
MBARMSBR2_0147 MSBR2_0148 MSBR2_0149
MBAKMSBR3_1064 MSBR3_1065 MSBR3_1066
MACMA_2909(vorA) MA_2910(vorB) MA_2911(vorC)
MMAMM_3181(vorC) MM_3182(vorB) MM_3183(vorA)
MMAZMmTuc01_3277 MmTuc01_3278 MmTuc01_3279
MMJMSMAS_1506 MSMAS_1507 MSMAS_1508
MMACMSMAC_2849 MSMAC_2850 MSMAC_2851
MVCMSVAZ_1286 MSVAZ_1287 MSVAZ_1288
MEKMSKOL_1230 MSKOL_1231 MSKOL_1232
MLSMSLAZ_2008 MSLAZ_2009 MSLAZ_2010
METMMSMTP_1761 MSMTP_1762 MSMTP_1763
MEFMSWH1_1307 MSWH1_1308 MSWH1_1309
MEQMSWHS_1391 MSWHS_1392 MSWHS_1393
MSJMSSAC_2721 MSSAC_2722 MSSAC_2723
MSZMSSIH_1391 MSSIH_1392 MSSIH_1393
MSWMSSIT_1429 MSSIT_1430 MSSIT_1431
MTHRMSTHT_0824 MSTHT_0825 MSTHT_0826
MTHEMSTHC_2445 MSTHC_2446 MSTHC_2447
MHORMSHOH_1579 MSHOH_1580 MSHOH_1581
MFZAOB57_012375 AOB57_012380(vorB) AOB57_012385
MBUMbur_0605 Mbur_0606 Mbur_0607
MMETMCMEM_1077 MCMEM_1078 MCMEM_1079
MELOJ7W08_03845 J7W08_03850 J7W08_03855
MMHMmah_1010 Mmah_1011 Mmah_1012
MHAZBHR79_08510 BHR79_08515 BHR79_08520
MPOTBKM01_04760 BKM01_04765 BKM01_04770
MZHMzhil_0902 Mzhil_0903 Mzhil_0904
MPYMpsy_0059 Mpsy_0060 Mpsy_0061
MZIHWN40_07260 HWN40_07265 HWN40_07270
MMAVRE476_03225 RE476_03230 RE476_03235
MSEBRE474_12875 RE474_12880 RE474_12885
MHZMetho_2048 Metho_2049 Metho_2050
MEHFMmiHf6_00120 MmiHf6_00130(korA) MmiHf6_00140
MEESMmiEs2_10520 MmiEs2_10530(korA) MmiEs2_10540
MTPMthe_0156 Mthe_0157
MCJMCON_0778(vorA) MCON_0779(vorB)
MHIMhar_0583 Mhar_0584
MAQERJ40_07300
MFKE2N92_07470
HAHSHSRCO_0562(porG) HSRCO_0563(porA2)
HAAAAArcCO_0208(porD)
TACTa0626 Ta0627 Ta0628 Ta0629
TVOTVG0872869(TVG0872869)
MERMMINT_12450(vorD) MMINT_12470
MEARMpt1_c05540(vorA) Mpt1_c05550(vorB)
ABIAboo_0298 Aboo_0299 Aboo_0300 Aboo_0301
ACFAciM339_0763 AciM339_0764 AciM339_0765 AciM339_0766
IPCIPA_03975
IAGIgag_1136
PABIPABY_00170
PAREPYJP_01300
STOSTK_15320
SOHD1869_08595
SSOSSO1207(porA-1)
SOLSsol_2171
SSOASULA_2206
SSOLSULB_2207
SSOFSULC_2204
SSHIJ5U23_01993
SISLS215_0396
SIAM1425_0372
SIMM1627_0380
SIDM164_0396
SIYYG5714_0374
SINYN1551_2681
SIILD85_0384
SIHSiH_0373
SIRSiRe_0364
SICSiL_0352
SULEGFS03_03425
SULOGFS33_07805
SULLEWF20_09765
MTENGWK48_07885
AMANB6F84_13225
ASULDFR86_11210
SMETRQ359_000910
CCAINAS2_0099 NAS2_0791
FLTSv326_0312
LOBNEF87_002289 NEF87_002291 NEF87_002419
PSYTDSAG12_00253 DSAG12_00810
AGWQT03_C0001G0327
 » show all
Reference
1  [PMID:5800441]
  Authors
Buchanan BB.
  Title
Role of ferredoxin in the synthesis of alpha-ketobutyrate from propionyl coenzyme A and carbon dioxide by enzymes from photosynthetic and nonphotosynthetic bacteria.
  Journal
J Biol Chem 244:4218-23 (1969)
Reference
2  [PMID:8550513]
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
3  [PMID:9108258]
  Authors
Tersteegen A, Linder D, Thauer RK, Hedderich R
  Title
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
  Journal
Eur J Biochem 244:862-8 (1997)
DOI:10.1111/j.1432-1033.1997.00862.x
Reference
4  [PMID:11265457]
  Authors
Schut GJ, Menon AL, Adams MW.
  Title
2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis.
  Journal
Methods Enzymol 331:144-58 (2001)
DOI:10.1016/S0076-6879(01)31053-4
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.7
IUBMB Enzyme Nomenclature: 1.2.7.7
ExPASy - ENZYME nomenclature database: 1.2.7.7
BRENDA, the Enzyme Database: 1.2.7.7
LinkDB

KEGG   REACTION: R08566
Entry
R08566                      Reaction                               
Name
4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
Definition
4-Methyl-2-oxopentanoate + CoA + 2 Oxidized ferredoxin <=> 3-Methylbutanoyl-CoA + CO2 + 2 Reduced ferredoxin + H+
Equation
Reaction class
RC00004  C00010_C02939
RC02833  C00233_C02939
Enzyme
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.7
     R08566  4-Methyl-2-oxopentanoate + CoA + 2 Oxidized ferredoxin <=> 3-Methylbutanoyl-CoA + CO2 + 2 Reduced ferredoxin + H+
Orthology
K00186  2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7]
K00187  2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7]
K00188  2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7]
K00189  2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
LinkDB

DBGET integrated database retrieval system