KEGG   ORTHOLOGY: K00223
Entry
K00223                      KO                                     
Symbol
ERG4
Name
Delta24(24(1))-sterol reductase [EC:1.3.1.71]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K00223  ERG4; Delta24(24(1))-sterol reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.71  Delta24(241)-sterol reductase
     K00223  ERG4; Delta24(24(1))-sterol reductase
Other DBs
RN: R05641
GO: 0000246
Genes
NLU: 120348988
QSU: 111998108
MIS: MICPUN_75586
MPP: MICPUCDRAFT_45028
SCE: YGL012W(ERG4)
SEUB: DI49_1955
SPAO: SPAR_G02220
AGO: AGOS_AGL087C
KLA: KLLA0_A05071g
KMX: KLMA_40436(ERG4)
NCS: NCAS_0A03520(NCAS0A03520)
NDI: NDAI_0A03360(NDAI0A03360)
TPF: TPHA_0F00690(TPHA0F00690)
TBL: TBLA_0C04060(TBLA0C04060)
TDL: TDEL_0F02340(TDEL0F02340)
KAF: KAFR_0A06700(KAFR0A06700) KAFR_0F03420(KAFR0F03420)
KNG: KNAG_0D03530(KNAG0D03530)
CAL: CAALFM_C300760WA(ERG4)
SLB: AWJ20_5335(ERG4)
BNN: FOA43_002797(ERG4)
BBRX: BRETT_002677(ERG4)
NCR: NCU01333
NTE: NEUTE1DRAFT57468(NEUTE1DRAFT_57468)
MGR: MGG_02465
SSCK: SPSK_05103
CMT: CCM_00528
MBE: MBM_00042
ANG: ANI_1_1230064(An07g09690) ANI_1_1524124(An14g05780)
ALUC: AKAW2_11325S(ERG4_1) AKAW2_41204S(ERG4_2)
ACHE: ACHE_11303S(ERG4_1) ACHE_80094A(ERG4_2)
APUU: APUU_41300A(ERG4_1) APUU_71128S(ERG4_2)
PTE: PTT_20197
ZTR: MYCGRDRAFT_77785(ERG4)
SPO: SPAC20G4.07c(sts1)
CNE: CNC04470
CNB: CNBC2700
TASA: A1Q1_07922
ABP: AGABI1DRAFT112024(AGABI1DRAFT_112024)
ABV: AGABI2DRAFT193266(AGABI2DRAFT_193266)
SCM: SCHCO_01121912(SCHCODRAFT_01121912) SCHCO_02619321(SCHCODRAFT_02619321)
WSE: WALSEDRAFT_61402(sts1)
MGL: MGL_2410
MRT: MRET_3238
CBU: CBU_1206
CBD: CBUD_1293
CBG: CbuG_0804
CBC: CbuK_1070
 » show all
Reference
  Authors
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
  Title
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
  Journal
FEBS Lett 470:83-7 (2000)
DOI:10.1016/S0014-5793(00)01290-4
LinkDB

KEGG   ENZYME: 1.3.1.71
Entry
EC 1.3.1.71                 Enzyme                                 
Name
Delta24(241)-sterol reductase;
sterol Delta24(28)-methylene reductase;
sterol Delta24(28)-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
ergosterol:NADP+ Delta24(241)-oxidoreductase
Reaction(IUBMB)
ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ [RN:R05641]
Reaction(KEGG)
R05641
Substrate
ergosterol [CPD:C01694];
NADP+ [CPD:C00006]
Product
ergosta-5,7,22,24(241)-tetraen-3beta-ol;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(241)-double bond.
History
EC 1.3.1.71 created 2001, modified 2002
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00223  Delta24(24(1))-sterol reductase
Genes
NLU120348988
QSU111998108
MISMICPUN_75586
MPPMICPUCDRAFT_45028
SCEYGL012W(ERG4)
SEUBDI49_1955
SPAOSPAR_G02220
AGOAGOS_AGL087C
KLAKLLA0_A05071g
KMXKLMA_40436(ERG4)
LTHKLTH0E07832g
VPOKpol_1061p43
ZROZYRO0G10208g
CGRCAGL0A00429g
NCSNCAS_0A03520(NCAS0A03520)
NDINDAI_0A03360(NDAI0A03360)
TPFTPHA_0F00690(TPHA0F00690)
TBLTBLA_0C04060(TBLA0C04060)
TDLTDEL_0F02340(TDEL0F02340)
TGBHG536_0D04420
KAFKAFR_0A06700(KAFR0A06700) KAFR_0F03420(KAFR0F03420)
KNGKNAG_0D03530(KNAG0D03530)
ZMKHG535_0E03920
PPAPAS_chr4_0063
DHADEHA2A08756g
PICPICST_29811
PGUPGUG_03519
SPAASPAPADRAFT_61883
LELLELG_02214
CALCAALFM_C300760WA(ERG4)
CTPCTRG_05501
COTCORT_0D06470
CDUCD36_80690
CTENCANTEDRAFT_114466
YLIYALI0D19206g
CLUCLUG_01341
CLUSA9F13_06g01507
CAURCJI97_002908
SLBAWJ20_5335(ERG4)
PKZC5L36_0E04860
BNNFOA43_002797(ERG4)
BBRXBRETT_002677(ERG4)
OPAHPODL_04197
SLUDSCDLUD_001495
NCRNCU01333
NTENEUTE1DRAFT57468(NEUTE1DRAFT_57468)
PANPODANSg8084
TTTTHITE_112329
MTMMYCTH_111214
CTHRCTHT_0066940
MGRMGG_02465
PPEIPpBr36_07054
TMNUCRPA7_2614 UCRPA7_3454
SSCKSPSK_05103
FGRFGSG_10003
FPUFPSE_03901
FVRFVEG_02775
FOXFOXG_05355 FOXG_16547
NHENECHADRAFT_104411
TRETRIREDRAFT_71655
TRRM419DRAFT_25295
MAWMAC_01149 MAC_06970
MAJMAA_05585 MAA_06762
CMTCCM_00528
PLJVFPFJ_09382
VALVDBG_00632 VDBG_07313
VDAVDAG_00245 VDAG_06020
CFJCFIO01_02390
CLUPCLUP02_11139
CHIGCH63R_03797 CH63R_08737
SAPOSAPIO_CDS10820 SAPIO_CDS4611
ELAUCREL1_6997
PFYPFICI_00050 PFICI_07263
SSLSS1G_04854
BFUBCIN_09g00250 BCIN_11g04530
MBEMBM_00042
PSCOLY89DRAFT_685926
GLZGLAREA_11045 GLAREA_12838
ANIAN2684.2 AN5184.2
AFMAFUA_1G07140 AFUA_5G14350
ACTACLA_017250 ACLA_027450
NFINFIA_017580 NFIA_072530
AORAO090005000559 AO090012000966 AO090026000130
ANGANI_1_1230064(An07g09690) ANI_1_1524124(An14g05780)
AFVAFLA_002693 AFLA_003367 AFLA_006174
ALUCAKAW2_11325S(ERG4_1) AKAW2_41204S(ERG4_2)
ACHEACHE_11303S(ERG4_1) ACHE_80094A(ERG4_2)
APUUAPUU_41300A(ERG4_1) APUU_71128S(ERG4_2)
PCSPc13g12750 Pc20g13170 Pc22g11560
PDPPDIP_25850 PDIP_26810
TMFPMAA_096590
TRGTRUGW13939_11455
CIMCIMG_02468 CIMG_02803
CPWCPC735_036310 CPC735_040900
UREUREG_03241
PBLPAAG_07980
PBNPADG_02082
ABEARB_04196 ARB_05318
TVETRV_06009 TRV_06893
AJEHCAG_01378 HCAG_01705
BGHBDBG_03553 BDBG_06155
PNOSNOG_00937
PTEPTT_20197
BZECOCCADRAFT_30688
BSCCOCSADRAFT_159355
BORCOCMIDRAFT_4741
AALTCC77DRAFT_910557 CC77DRAFT_979736
ZTRMYCGRDRAFT_77785(ERG4)
PFJMYCFIDRAFT_30104
FFUCLAFUR5_14230
BCOMBAUCODRAFT_31753
NPAUCRNP2_1275 UCRNP2_9268
TMLGSTUM_00002482001
SPOSPAC20G4.07c(sts1)
CNECNC04470
CNBCNBC2700
CNGCNAG_02830
CGICGB_C6580C
TMSTREMEDRAFT_45737
TASAA1Q1_07922
TVSTRAVEDRAFT_168609
DSQDICSQDRAFT_100750
PCOPHACADRAFT_129697
SHSSTEHIDRAFT_79157
HIRHETIRDRAFT_445714
PSQPUNSTDRAFT_136760
ADLAURDEDRAFT_113235
FMEFOMMEDRAFT_16309
GTRGLOTRDRAFT_110752
LBCLACBIDRAFT_171141
CCICC1G_00893
ABPAGABI1DRAFT112024(AGABI1DRAFT_112024)
ABVAGABI2DRAFT193266(AGABI2DRAFT_193266)
PCUBJR316_0007953
MPRMPER_11639
MRRMoror_7029
MOREE1B28_007330
SCMSCHCO_01121912(SCHCODRAFT_01121912) SCHCO_02619321(SCHCODRAFT_02619321)
CPUTCONPUDRAFT_138512
SLASERLADRAFT_416883
WSEWALSEDRAFT_61402(sts1)
WICJ056_001933
UMAUMAG_01498
PFPPFL1_05816
MGLMGL_2410
MRTMRET_3238
MSYMMSY001_1748
PGRPGTG_05048 PGTG_17808
MLRMELLADRAFT_73573
MBRMONBRDRAFT_37477
AAFAURANDRAFT_59487
TCR506577.120 507709.90
LMALMJF_33_0680
LIFLINJ_33_0730
LDOLDBPK_330730
LMILMXM_32_0680
LBZLBRM_33_0720
LPANLPMP_330730
NGRNAEGRDRAFT_29477 NAEGRDRAFT_81757
CBUCBU_1206
CBSCOXBURSA331_A1354
CBDCBUD_1293
CBGCbuG_0804
CBCCbuK_1070
 » show all
Reference
1  [PMID:14922]
  Authors
Neal WD, Parks LW.
  Title
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.
  Journal
J Bacteriol 129:1375-8 (1977)
DOI:10.1128/JB.129.3.1375-1378.1977
Reference
2  [PMID:10722850]
  Authors
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
  Title
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
  Journal
FEBS Lett 470:83-7 (2000)
DOI:10.1016/S0014-5793(00)01290-4
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.71
IUBMB Enzyme Nomenclature: 1.3.1.71
ExPASy - ENZYME nomenclature database: 1.3.1.71
BRENDA, the Enzyme Database: 1.3.1.71
LinkDB

KEGG   REACTION: R05641
Entry
R05641                      Reaction                               
Name
ergosterol:NADP+ Delta24(24(1))-oxidoreductase
Definition
Ergosterol + NADP+ <=> Ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00237  C01694_C05440
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Orthology
K00223  Delta24(24(1))-sterol reductase [EC:1.3.1.71]
Other DBs
RHEA: 18504
LinkDB

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