Entry
Name
leucine dehydrogenase;
L-leucine dehydrogenase;
L-leucine:NAD+ oxidoreductase, deaminating;
LeuDH
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-leucine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ [RN:
R01088 ]
Reaction(KEGG)
Substrate
Product
Comment
Also acts on isoleucine, valine, norvaline and norleucine.
History
EC 1.4.1.9 created 1972
Pathway
ec00280 Valine, leucine and isoleucine degradation
ec00290 Valine, leucine and isoleucine biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
XPH : XppCFBP6546_04670(XppCFBP6546P_04670)
PRE : PCA10_42250(ldh) PCA10_47390(ldh)
PFUW : KF707C_13910 KF707C_47090
PALC : A0T30_06840 A0T30_14845
PPRC : PFLCHA0_c09910(yqiT)
PMUD : NCTC8068_00974(ldh)
PFW : PF1751_v1c09880(ldh)
PPSY : AOC04_13560 AOC04_15895
PSET : THL1_4272 THL1_4748
PALL : UYA_15265 UYA_17100
POJ : PtoMrB4_41490(ldh_1) PtoMrB4_46580(ldh_2)
PPSH : G5J76_19780 G5J76_22425
PLAL : FXN65_20595 FXN65_22810
PSEJ : HNQ25_08415 HNQ25_10225
PKH : JLK41_14525 JLK41_16520
PTY : JWV26_01315 JWV26_03320
PMAO : PMYSY11_0918(ldh) PMYSY11_3133(ldh)
PWZ : J7655_06490 J7655_08095
PTW : TUM18999_42130(ldh_1) TUM18999_50530(ldh_2)
PTAE : NCTC10697_03144(ldh_1) NCTC10697_03593(ldh_2)
PHF : NLY38_08550 NLY38_19000
PSOA : PSm6_03170(ldh_1) PSm6_10390(ldh_2)
PCHE : QYM18_00800 QYM18_22950
PSLP : BHQ29_05915 BHQ29_07875
PZD : KQ248_00065 KQ248_22350
SCAA : TUM17387_23300(ldh)
KIM : G3T16_03500 G3T16_14340
CEY : CleRT_04440 CleRT_05880
ALG : AQULUS_16550(ldh_1) AQULUS_19950(ldh_2)
LLG : 44548918_01841(gdhA)
LJR : NCTC11533_01986(gdhA)
LCJ : NCTC11976_01351(ldh)
LWA : SAMEA4504053_2513(gdhA_2)
LSS : NCTC12082_00031(gdhA)
LADL : NCTC12735_01295(ldh)
MARS : A8C75_17205 A8C75_20465
MSEC : LN244_00965 LN244_03770
MRZ : KDW95_18465 KDW95_21715
BSAN : CHH28_08985 CHH28_12080
NCU : F0U83_06065 F0U83_13230
NJP : NEJAP_2297 NEJAP_2985
AJP : AMJAP_0344 AMJAP_2751
REH : H16_B0449(h16_B0449)
REU : Reut_B5816 Reut_C6219
CBW : RR42_m2084 RR42_s0423
PLG : NCTC10937_04329(ldh)
THAG : CKCBHOJB_00662(ldh)
LABR : CHH27_16120 CHH27_16580
LABP : FJ695_07140 FJ695_10130
ACUT : MRB58_17020 MRB58_24365
TSV : DSM104635_01267(ldh)
PPIC : PhaeoP14_01857(ldh)
RMM : ROSMUCSMR3_02235(ldh)
RID : RIdsm_00787(ldh_1) RIdsm_03966(ldh_2)
HNE : HNE_1615(ldh1) HNE_2735(ldh2)
NOV : TQ38_012850 TQ38_019680 TQ38_019975
NOG : GKE62_13835 GKE62_14900 GKE62_14915 GKE62_17290
SPHK : SKP52_12340(ldh1) SKP52_15415(ldh2)
SPHP : LH20_07375 LH20_07755
SMAG : AN936_03740 AN936_11630 AN936_12440
SMAZ : LH19_12770 LH19_13720
STER : AOA14_17450 AOA14_17950
SGI : SGRAN_2658(ldh) SGRAN_3000(ldh2)
SPHQ : BWQ93_01290 BWQ93_08310
SPHO : C3E99_05710 C3E99_10370
SPHX : E5675_06140 E5675_13265
SINA : KNJ79_12305 KNJ79_16800
SPHU : SPPYR_0813(ldh) SPPYR_1057(ldh)
SPHI : TS85_08180 TS85_11675
SPLK : AV944_05985 AV944_16480
SPHA : D3Y57_02645 D3Y57_06430
SPAU : DRN02_009905 DRN02_017880
SPAP : H3Z74_07150 H3Z74_14985
SCHY : GVO57_02900 GVO57_08535
SSUA : FPZ54_04555 FPZ54_19235
SSAG : KV697_08035 KV697_17205
SFLA : SPHFLASMR4Y_01279(ldh)
BLAS : BSY18_22 BSY18_2937
SPZR : G5C33_05980 G5C33_05990 G5C33_14930 G5C33_18175
AMX : AM2010_116 AM2010_742
PMAS : NCF86_06290 NCF86_10415
CMAN : A9D14_08080 A9D14_16915
CCRO : CMC5_007100 CMC5_032400
PCAY : FRD00_21620 FRD00_23530
GJF : M493_12170 M493_12345
PARG : PspKH34_11530(yqiT_1)
BLEN : NCTC4824_01775(bcd)
SDP : NCTC12225_00433(dhlE)
SSTE : SAMEA4384403_1260(dhlE)
BAYD : BSPP4475_11535(gdhA)
PSAB : PSAB_04665 PSAB_13610
PBJ : VN24_08750 VN24_17500
PRI : PRIO_1162(ldh1) PRIO_3732(ldh5)
PXL : BS614_01600 BS614_05430
PBAC : HUB98_15735 HUB98_19080 HUB98_22790
PSOP : KP014_08180 KP014_18685
PMAH : PTQ21_03785 PTQ21_07170
PAMY : P9222_03210 P9222_06810
PPAB : KET34_01975 KET34_32805
ALIC : GI364_12700 GI364_13075
DAI : Desaci_3322 Desaci_4535
FWA : DCMF_16555 DCMF_18320
AACX : DEACI_0616 DEACI_2774
ACAE : HYG86_16045 HYG86_16060
THEP : DYI95_005740 DYI95_005745
TTE : TTE2202(GdhA3) TTE2203(GdhA4)
DBC : MFMK1_000453 MFMK1_001174
BACG : D2962_05325 D2962_12775
HOR : Hore_06730 Hore_06750
AFT : BBF96_08650 BBF96_08665
KME : H0A61_02459(ldh_1) H0A61_02772(ldh_2)
FCZ : IMF26_02230 IMF26_02245
SRW : TUE45_pSRc_0492(ldh)
AMAU : DSM26151_22690(ldh)
AMAV : GCM10025877_07270(ldh_2)
ACYN : ORV05_03990 ORV05_13020
ASIC : Q0Z83_002840 Q0Z83_029200
BALA : DSM104299_04803(ldh_1) DSM104299_05636(ldh_2)
CWO : Cwoe_1545 Cwoe_2247 Cwoe_4384
SBAE : DSM104329_04601(ldh_2)
RIV : Riv7116_1653 Riv7116_1899
NSPH : BDGGKGIB_00537(ldh)
SNG : SNE_A05300(ldh-A) SNE_A22050(ldh-B)
SNEP : Enr13x_22040(ldh_2)
AMUC : Pan181_29100(ldh_1)
PBAP : Pla133_08250(ldh_1) Pla133_19950(ldh_2)
SDJ : NCTC13534_04154(ldh)
STHA : NCTC11429_04949(ldh)
FOK : KK2020170_16900(vdh)
PHG : KCTC32516_02251(ldh)
KOS : KORDIASMS9_03834(ldh)
PTAN : CRYO30217_01447(ldh)
» show all
Taxonomy
Reference
Authors
SANWAL BD, ZINK MW.
Title
L-Leucine dehydrogenase of Bacillus cereus.
Journal
Reference
2
Authors
Zink MW, Sanwal BD.
Title
The distribution and substrate specificity of L-leucine dehydrogenase.
Journal
Arch Biochem Biophys 99:72-77 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.9
ExPASy - ENZYME nomenclature database: 1.4.1.9
BRENDA, the Enzyme Database: 1.4.1.9
LinkDB
All DBs