KEGG   ORTHOLOGY: K00270
Entry
K00270                      KO                                     
Symbol
pdh
Name
phenylalanine dehydrogenase [EC:1.4.1.20]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R00688  L-phenylalanine:NAD+ oxidoreductase (deaminating)
R09830  L-tyrosine:NAD+ oxidoreductase (deaminating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00360 Phenylalanine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K00270  pdh; phenylalanine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.20  phenylalanine dehydrogenase
     K00270  pdh; phenylalanine dehydrogenase
Other DBs
GO: 0050175
Genes
BTD: BTI_5242
BUU: WS70_19890
BSAV: WS86_20905
BUD: AQ610_28820
BUL: BW21_4864
BIF: N288_11510
BFD: NCTC4823_03400(pdh_2)
BSHI: LGQ02_06840
BACO: OXB_2922
BHAI: KJK41_02300
BACF: AM500_11745
BHAM: ABN702_08225
BHK: B4U37_11725
BCOH: BC6307_11155
BEO: BEH_00940
PKS: IE339_04020
BHA: BH0218(pdh)
SHUA: PQ477_12595
BON: A361_12115
BKO: CKF48_14850
CFIR: NAF01_10810
CSOA: LIS82_12725
CPSS: M5V91_09330
BDA: FSZ17_10715
CSUA: IM538_12510
OIH: OB2878
VIG: BKP57_13055
VPN: A21D_01988(pdh)
VPT: KBP50_02890
VSS: PD280_04145
PASA: BAOM_4375(pdh)
PSYH: D0S48_01850
PSYO: PB01_19085
POF: GS400_11785
PCHU: QNI29_12975
PONA: IMZ31_11400
NMK: CHR53_20485
NCM: QNK12_10370
MSEE: WCV65_02090
BVQ: FHE72_02655
RMF: D5E69_02585
RAZ: U9J35_02335
ROD: P8596_02360
ROSS: V2W31_02360
BVJ: I5776_15075
BOU: I5818_18765
HSPO: JGZ69_00650
CTHU: HUR95_03565
MJO: FOF60_09435
FHL: OE105_09610
FAF: OE104_01100
SFOR: QNH23_12685
ALKL: MM271_04395
ALKG: MOJ78_04400
DOM: RRU94_00830
BBAD: K7T73_17795
FPN: ABE65_003865
FAR: ABE41_003915
FEC: QNH15_05240
PHJ: LC071_15225
GKA: GK2031(pdh)
GTE: GTCCBUS3UF5_23040
GTK: GT3570_09480
GTM: GT3921_09425
GLI: GLN3_03090
BCAL: CWI35_00265
GTN: GTNG_1916
GYC: GYMC61_2857
GYA: GYMC52_1987
GMC: GY4MC1_1502
GGH: GHH_c20750(pdh)
GJF: M493_10405
GEJ: A0V43_07810
GZA: IC807_06150
GTH: Geoth_1594
PTL: AOT13_14870
PTB: DER53_14730
PARG: PspKH34_14350(yqiT_2)
PCAL: BV455_03379(pdh)
ANM: GFC28_427(pdh)
ANL: GFC29_1197(pdh)
AND: GRQ40_10590
ACAI: ISX45_08215
AAMY: GFC30_1772(pdh)
HYI: K2M58_06305
SBAH: RQP18_12135
ESI: Exig_0386
EAN: Eab7_0362(pdh)
EXM: U719_01985
EXU: ESP131_04430
EACE: KKI46_02245
EXI: A0126_01910
EXH: HNY42_03435
PELG: ACJ7K1_06300
AFX: JZ786_20650
ACUR: JZ785_24655
TUM: CBW65_09705
TAB: CIG75_18085
JEO: JMA_35970
SPSY: AZE41_14025
STHO: QNH10_13700
SOW: QWT69_13630
SPOH: GGGNBK_09445(gdhA)
RST: ATY39_01260
PANC: E2636_08200
LFB: C1X05_13650
TVU: AB849_007145
KPUL: GXN76_03225
KEB: GXN75_03355
PABS: JIR001_05320(ldh)
TMR: Tmar_1152
THEF: E1B22_09430
TCP: Q5761_05700
SCOA: QU709_30935
AACD: LWP59_32015
AMYS: CVV72_20625
LED: BBK82_09900
AG: BAA08816(pdh)
 » show all
Reference
PMID:8535000
  Authors
Yamada A, Dairi T, Ohno Y, Huang XL, Asano Y
  Title
Nucleotide sequencing of phenylalanine dehydrogenase gene from Bacillus badius IAM 11059.
  Journal
Biosci Biotechnol Biochem 59:1994-5 (1995)
DOI:10.1271/bbb.59.1994
  Sequence
[ag:BAA08816]
Reference
PMID:3311741
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x
LinkDB

KEGG   ENZYME: 1.4.1.20
Entry
EC 1.4.1.20                 Enzyme                                 
Name
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ [RN:R00688]
Reaction(KEGG)
R00688;
(other) R00145 R00146 R09830
Substrate
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
History
EC 1.4.1.20 created 1989
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00270  phenylalanine dehydrogenase
Genes
BTD: BTI_5242
BUU: WS70_19890
BSAV: WS86_20905
BUD: AQ610_28820
BUL: BW21_4864
BIF: N288_11510
BFD: NCTC4823_03400(pdh_2)
BSHI: LGQ02_06840
BACO: OXB_2922
BHAI: KJK41_02300
BACF: AM500_11745
BHAM: ABN702_08225
BHK: B4U37_11725
BCOH: BC6307_11155
BEO: BEH_00940
PKS: IE339_04020
BHA: BH0218(pdh)
SHUA: PQ477_12595
BON: A361_12115
BKO: CKF48_14850
CFIR: NAF01_10810
CSOA: LIS82_12725
CPSS: M5V91_09330
BDA: FSZ17_10715
CSUA: IM538_12510
OIH: OB2878
VIG: BKP57_13055
VPN: A21D_01988(pdh)
VPT: KBP50_02890
VSS: PD280_04145
PASA: BAOM_4375(pdh)
PSYH: D0S48_01850
PSYO: PB01_19085
POF: GS400_11785
PCHU: QNI29_12975
PONA: IMZ31_11400
NMK: CHR53_20485
NCM: QNK12_10370
MSEE: WCV65_02090
BVQ: FHE72_02655
RMF: D5E69_02585
RAZ: U9J35_02335
ROD: P8596_02360
ROSS: V2W31_02360
BVJ: I5776_15075
BOU: I5818_18765
HSPO: JGZ69_00650
CTHU: HUR95_03565
MJO: FOF60_09435
FHL: OE105_09610
FAF: OE104_01100
SFOR: QNH23_12685
ALKL: MM271_04395
ALKG: MOJ78_04400
DOM: RRU94_00830
BBAD: K7T73_17795
FPN: ABE65_003865
FAR: ABE41_003915
FEC: QNH15_05240
PHJ: LC071_15225
GKA: GK2031(pdh)
GTE: GTCCBUS3UF5_23040
GTK: GT3570_09480
GTM: GT3921_09425
GLI: GLN3_03090
BCAL: CWI35_00265
GTN: GTNG_1916
GYC: GYMC61_2857
GYA: GYMC52_1987
GMC: GY4MC1_1502
GGH: GHH_c20750(pdh)
GJF: M493_10405
GEJ: A0V43_07810
GZA: IC807_06150
GTH: Geoth_1594
PTL: AOT13_14870
PTB: DER53_14730
PARG: PspKH34_14350(yqiT_2)
PCAL: BV455_03379(pdh)
ANM: GFC28_427(pdh)
ANL: GFC29_1197(pdh)
AND: GRQ40_10590
ACAI: ISX45_08215
AAMY: GFC30_1772(pdh)
HYI: K2M58_06305
SBAH: RQP18_12135
ESI: Exig_0386
EAN: Eab7_0362(pdh)
EXM: U719_01985
EXU: ESP131_04430
EACE: KKI46_02245
EXI: A0126_01910
EXH: HNY42_03435
PELG: ACJ7K1_06300
AFX: JZ786_20650
ACUR: JZ785_24655
TUM: CBW65_09705
TAB: CIG75_18085
JEO: JMA_35970
SPSY: AZE41_14025
STHO: QNH10_13700
SOW: QWT69_13630
SPOH: GGGNBK_09445(gdhA)
RST: ATY39_01260
PANC: E2636_08200
LFB: C1X05_13650
TVU: AB849_007145
KPUL: GXN76_03225
KEB: GXN75_03355
PABS: JIR001_05320(ldh)
TMR: Tmar_1152
THEF: E1B22_09430
TCP: Q5761_05700
SCOA: QU709_30935
AACD: LWP59_32015
AMYS: CVV72_20625
LED: BBK82_09900
 » show all
Reference
1  [PMID:3112142]
  Authors
Asano Y, Nakazawa A, Endo K.
  Title
Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization.
  Journal
J Biol Chem 262:10346-54 (1987)
Reference
2  [PMID:3311741]
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.20
IUBMB Enzyme Nomenclature: 1.4.1.20
ExPASy - ENZYME nomenclature database: 1.4.1.20
BRENDA, the Enzyme Database: 1.4.1.20
CAS: 69403-12-9
LinkDB

KEGG   REACTION: R00688
Entry
R00688                      Reaction                               
Name
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Definition
L-Phenylalanine + H2O + NAD+ <=> Phenylpyruvate + Ammonia + NADH + H+
Equation
C00079 + C00001 + C00003 <=> C00166 + C00014 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00006  C00079_C00166
Enzyme
1.4.1.20
Pathway
rn00360  Phenylalanine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.20
     R00688  L-Phenylalanine + H2O + NAD+ <=> Phenylpyruvate + Ammonia + NADH + H+
Orthology
K00270  phenylalanine dehydrogenase [EC:1.4.1.20]
Other DBs
RHEA: 21411
LinkDB

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