Entry |
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Name |
valine dehydrogenase (NAD+)
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Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
L-valine:NAD+ oxidoreductase (deaminating)
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Reaction(IUBMB) |
L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN: R01434]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
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History |
EC 1.4.1.23 created 2012
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Pathway |
ec00280 | Valine, leucine and isoleucine degradation |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K00271 | valine dehydrogenase (NAD+) |
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Genes |
MHEV: | MHEL_32040 MHEL_42550 |
NAD: | NCTC11293_05547(vdh_2) |
RPY: | Y013_11145 Y013_15265 |
RKO: | JWS14_08325 JWS14_42330 |
SLE: | sle_37550(sle_37550) |
SGM: | GCM10017557_39900(vdh) |
SKA: | CP970_01500 CP970_22610 |
SSPB: | CP982_04260 CP982_20750 |
STUI: | GCM10017668_33070(vdh) |
SDUR: | M4V62_22555 M4V62_41915 |
SXT: | KPP03845_104041(vdh) |
GEW: | MF406_12530 MF406_18520 |
NAQU: | ENKNEFLB_00649(vdh) |
AEZ: | C3E78_00975 C3E78_01905 |
BBRG: | U6N30_26720 U6N30_26725 |
AMQ: | AMETH_5418(gdhA1) AMETH_5508 |
AMYC: | CU254_28145 CU254_42095 |
AAB: | A4R43_37595 A4R43_38030 |
AMYY: | YIM_40015(vdh2) YIM_40475(pdh) |
ATHM: | L1857_30080 L1857_34545 |
VMA: | VAB18032_05395 VAB18032_12700 |
VER: | HUT12_00950 HUT12_01655 |
ACTR: | Asp14428_45710 Asp14428_76480 |
AOU: | ACTOB_000127 ACTOB_004620 |
» show all
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Reference |
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Authors |
Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V. |
Title |
Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens. |
Journal |
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Reference |
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Authors |
Navarrete RM, Vara JA, Hutchinson CR |
Title |
Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.4.1.23 |
ExPASy - ENZYME nomenclature database: | 1.4.1.23 |
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LinkDB |
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