KEGG ORTHOLOGY: K00489

KEGG

ORTHOLOGY: K00489

Entry

K00489                      KO

Symbol

CYP7A1

Name

cholesterol 7alpha-monooxygenase [EC:1.14.14.23]

Pathway

Primary bile acid biosynthesis

Steroid hormone biosynthesis

Metabolic pathways

PPAR signaling pathway

Bile secretion

Cholesterol metabolism

Module

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

Reaction

cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)

cholest-5-ene-3beta,26-diol,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)

dehydroepiandrosterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
   00140 Steroid hormone biosynthesis
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
  09154 Digestive system
   04976 Bile secretion
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
   04979 Cholesterol metabolism
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00489  CYP7A1; cholesterol 7alpha-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.23  cholesterol 7alpha-monooxygenase
     K00489  CYP7A1; cholesterol 7alpha-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP7 family
   K00489  CYP7A1; cholesterol 7alpha-monooxygenase

Other DBs

GO:

Genes

HSA:	1581(CYP7A1)

PTR:	464191(CYP7A1)

PPS:	100991402(CYP7A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	698127(CYP7A1)

MCF:	102132452(CYP7A1)

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100399021(CYP7A1)

SBQ:

CIMI:

108317247(CYP7A1)

ANAN:

105724883(CYP7A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13122(Cyp7a1)

MCAL:

MPAH:

RNO:	25428(Cyp7a1)

MCOC:

ANU:

MUN:

CGE:	100689275(Cyp7a1)

MAUA:

101824665(Cyp7a1)

PROB:

PLEU:

114686695 114699453

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

100337633(Cyp7a1)

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100328551(CYP7A1)

OPI:

TUP:

GVR:

CFA:	486962(CYP7A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101099612(CYP7A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	510507(CYP7A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	448985(CYP7A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100022261(CYP7A1)

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	414834(CYP7A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106039033(CYP7A1)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136368950(CYP7A1)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CLV:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102573271(CYP7A1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108695305(cyp7a1.S) 108718803(cyp7a1.L)

XTR:	100488670(cyp7a1)

NPR:

RTEM:

BBUF:

BGAR:

122938779 122939024 122939329

MUO:	115460373 115477690

GSH:

DRE:	394148(cyp7a1) 559097(cyp7a1b)

SRX:	107718110 107722516 107730123

SANH:

107691428 107693703 107698673

SGH:	107559847 107586715 107589909

CCAR:

109056383 109057064 109057066

CAUA:

113040546 113045841 113106318

CGIB:

127950474 127961200 128027733

PTET:

122349354 122355329

LROH:

127168270 127175112

OMC:	131526563 131544743

PPRM:

120480128 120483094

RKG:	130070953 130106289

MAMB:

125251471 125265875

CIDE:

127496167 127516385 127525483

CERY:

137003090(cyp7a1) 137030136(cyp7a1b)

MASI:

127427182 127440520 127442624 127454199

TROS:

130554717 130555678

TDW:	130417339 130418385

MANU:

129442332 129452914

IPU:	108267573 108278029

IFU:	128609893 128621219

PHYP:

113539292 113540421

SMEO:

124388006 124394123

TFD:	113647919 113657587

TVC:	132848476 132858364

TRN:	134312243 134334409

AMEX:

103040934 103044953

CMAO:

118804749 118825453

EEE:	113579320 113588311

CHAR:

105893799 105894732 105894733

TRU:

TFS:

TNG:	GSTEN00033663G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

119209795 119209821

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

119010555 119010568

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

133452283 133458623

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

106569008(CP7A1) 106599162

STRU:

115156828 115169870

OTW:	112227027 112261098

OMY:	110508825 110530204

OGO:	124009846 124040961

ONE:	115103177 115113922

OKI:	109872341 109875009

OKE:	118394577 118402211

SALP:

111956365 111979725

SNH:	120020428 120055841

CCLU:

121535121 121580836

ELS:

SFM:	108929603 108929630 108937652

PKI:	111847244 111852535

AANG:

118224694 118233129

LOC:	102694683 102694877 102695076

PSPA:

121309455 121313448 121313830

ARUT:

117399510 117399809 117972377

PSEX:

120530238 120530239

LCM:	102352060 102354799 102364376

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116941481 116942568 116951536

LRJ:	133344327 133349197

BFO:

BBEL:

109465361 109486986

CIN:	100175980 100176228

SCLV:

HRO:	HELRODRAFT_188864

LGI:	LOTGIDRAFT_234414

PVUL:

PCAN:

112572137 112572563 112572564 112572567 112572778

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111110307 111110573

OED:

MYI:

PMAX:

DPOL:

127832277 127881121

MAEA:

128211178 128212428

OBI:

OSN:

LJP:

LAK:

LLON:

Reference

Authors

Noshiro M, Okuda K

Title

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

Journal

FEBS Lett 268:137-40 (1990)
DOI:10.1016/0014-5793(90)80992-R

Sequence

[hsa:1581]

Reference

Authors

Norlin M, Wikvall K

Title

Enzymes in the conversion of cholesterol into bile acids.

Journal

Curr Mol Med 7:199-218 (2007)
DOI:10.2174/156652407780059168

LinkDB

DBGET integrated database retrieval system