KEGG ORTHOLOGY: K00497

ORTHOLOGY: K00497

Entry

K00497                      KO

Symbol

CYP11B1

Name

steroid 11beta-monooxygenase [EC:1.14.15.4]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Reaction

R02218

progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02725

androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02843

steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03329

steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03851

11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R04850

17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)

R08949

11-deoxycorticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta,18-hydroxylating)

Disease

H00216

Congenital adrenal hyperplasia

H00602

Glucocorticoid-remediable aldosteronism (GRA)

H01603

Primary aldosteronism

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; steroid 11beta-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K00497  CYP11B1; steroid 11beta-monooxygenase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00497  CYP11B1; steroid 11beta-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00497  CYP11B1; steroid 11beta-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; steroid 11beta-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K00497  CYP11B1; steroid 11beta-monooxygenase

Other DBs

GO:

0004507

Genes

HSA:	1584(CYP11B1)

PTR:	464437(CYP11B1)

PPS:	100971586(CYP11B1)

GGO:

PON:

PPYG:

NLE:

HMH:	116465197 116465198

SSYN:

129486883

MCC:	695793(CYP11B1)

MCF:	102136659(CYP11B1)

MTHB:

126961618

MNI:

105488429

CSAB:

103237546(CYP11B1)

CATY:

105581188

PANU:

101002490 116276421

TGE:	112630213 112630247

MLEU:

105536287

RRO:

104679773

RBB:

108536535

TFN:	117079172 117079174

PTEH:

111535654

CANG:

105509013

CJC:	100415667(CYP11B1)

SBQ:

101048076

CIMI:

108291253(CYP11B1)

ANAN:

105728099(CYP11B1)

CSYR:

103276447

ERUF:

138381591 138381592

OGA:

100948075

MMU:	110115(Cyp11b1) 13072(Cyp11b2)

MCAL:

110310257 110310258

MPAH:

110334511 110335023

RNO:	120093683(Cyp11b2l1) 24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)

MCOC:

116073894 116082436

ANU:	117719036 117719092

ASYL:

127667342 127667824

MUN:	110544545 110562757

CGE:	100771648 107977023

MAUA:

101823339 101823606

PROB:

127225603 127225649 127225650

PLEU:

PMAV:

MORG:

MFOT:

AAMP:

CNL:

NGI:	103748431 103748432

HGL:

CPOC:

CCAN:

DORD:

DSP:	122125332 122125344

PLOP:

125360501 125361022

NCAR:

124991075 124991346

MMMA:

107142805 107143071

ITI:	101963849 101968373

OCU:	100328543(CYP11B2) 100342863

OPI:

101518686

OCZ:	121163853 121163854

TUP:	102471986 102492986

CFA:	482071(CYP11B2)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:	125281062 125281076

UAR:	123779294 123796461

ELK:

111146729

LLV:	125098158 125099244

MNP:

132013308

MLK:	131827767 131827768

NVS:	122905498 122905499

ORO:

101364874

EJU:	114204069 114204070

ZCA:	113911085 118356903

MLX:

MANO:

NSU:

LWW:

FCA:	101097790(CYP11B1)

PYU:	121024468 121043245

PCOO:

112859405

PBG:	122496110 122496111

PVIV:

125156496

LRUF:

124507499 124507515

LGF:	123586547 123586550

AJU:	106989683 128312793

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

BTA:	282422(CYP11B1) 787628

BOM:

102272939

BIU:	109568177 109568372 109568377

BBUB:

112577757 112579063

BKE:	129627167 129627169

BBIS:

104997957

CHX:	102188238 102188517

OAS:	101102377 767576(CYP11B1)

BTAX:

CSUM:

ODA:

CCAD:

MREE:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:

DDP:

DLE:

PCAD:

PSIU:

PPHC:

NASI:

ECB:	100063612 100063645

EPZ:	103543718 103544682

EAI:	106827552 123275604

MYD:

MMYO:

MDT:

MYUM:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:	105302023 105310134

RAY:

107507877

MJV:	108400067(CYP11B2)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138155881(CYP11B2)

OAA:

TACU:

AACU:

TGU:

LSR:

ATRC:

PHI:

ACOE:

CCIC:

FPG:

FCH:

BBUT:

PPUS:

CBOY:

140646799(SCRT1)

CNIC:

135985062

AROW:

112976664

ASN:

102375758

AMJ:	102575737(CYP11B1)

CPOO:

CIZ:

CMY:

CCAY:

LKP:

NDS:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

APRI:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:

XTR:

RTEM:

PADS:

BBUF:

BGAR:

DTC:

PWL:

MUO:

GSH:

DRE:	791124(cyp11c1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141342427(cyp11c1)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TDW:

MANU:

129448943(cyp11c1)

PDAB:

135752178(cyp11c1)

IPU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00015374G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

117460921(cyp11c1)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

AFB:

CLUM:

PSWI:

CANA:

137780999(cyp11c1)

CVE:	137891513(cyp11c1)

MSAM:

119897544

SCHU:

122881607

EARM:

139289734(cyp11c1)

CUD:

121514148

SPUL:

138584179(cyp11c1)

LMIX:

132983189

HTC:	141800409(cyp11c1)

ALAT:

119006071

ASTR:

137601281(cyp11c1)

PKLU:

139204982(cyp11c1)

MZE:	101463871(cyp11c1)

ONL:	100533461(cyp11b)

OAU:

116320943

OLA:	100125822(cyp11b)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

EJA:	138192094(cyp11c1)

BFRE:

138619392(cyp11c1)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140374293(cyp11c1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137191355(cyp11c1)

GMH:

115553949

SASA:

100136945

OTW:

121840636

OMY:	100135891(cyp11b) 110534298

OGO:	123998350 124004644

ONE:

115122985

OKI:

109881262

OKE:	118373241 127915287

OMM:	135519772 135523001

OCLA:

SALP:

SNH:

SFON:

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CPUN:

HAKA:

Reference

PMID:2592361

Authors

Mornet E, Dupont J, Vitek A, White PC

Title

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Journal

J Biol Chem 264:20961-7 (1989)

Sequence

[hsa:1584]

Reference

PMID:3485096

Authors

Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P

Title

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

Journal

J Biol Chem 261:3556-62 (1986)

LinkDB

ORTHOLOGY: K07433

Entry

K07433                      KO

Symbol

CYP11B2

Name

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04925

Aldosterone synthesis and secretion

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

Reaction

R02218

progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02725

androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02843

steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03262

corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)

R03263

R03329

steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03851

11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R04850

17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)

Disease

H00258

Aldosterone synthase deficiency

H00602

Glucocorticoid-remediable aldosteronism (GRA)

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
    1.14.15.5  corticosterone 18-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase

Other DBs

GO:	0004507 0047783

Genes

HSA:	1585(CYP11B2)

PTR:	745937(CYP11B2)

PPS:	100971238(CYP11B2)

GGO:

PON:

PPYG:

NLE:

SSYN:

MCC:	695914(CYP11B2)

MCF:	102137301(CYP11B2)

MTHB:

126961020 126961026

MNI:	105483796 105488428

CSAB:

103237547(CYP11B2)

CATY:

PANU:

MLEU:

RRO:

RBB:

TFN:

CANG:

CJC:	100415304(CYP11B2)

CIMI:

108291254(CYP11B2)

ANAN:

105728086(CYP11B2)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:	100948396 100958146

HGL:

101700701

CPOC:

100379213(Cyp11b2) 100727186

GVR:	103599088 103604864 103604866

» show all

Reference

PMID:2592361

Authors

Mornet E, Dupont J, Vitek A, White PC

Title

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Journal

J Biol Chem 264:20961-7 (1989)

Sequence

[hsa:1585]

Reference

PMID:12452430

Authors

Bureik M, Lisurek M, Bernhardt R

Title

The human steroid hydroxylases CYP1B1 and CYP11B2.

Journal

Biol Chem 383:1537-51 (2002)
DOI:10.1515/BC.2002.174

LinkDB

ENZYME: 1.14.15.4

Entry

EC 1.14.15.4                Enzyme

Name

steroid 11beta-monooxygenase;
steroid 11beta-hydroxylase;
steroid 11beta/18-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating)

Reaction(IUBMB)

a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O [RN:R02726]

Reaction(KEGG)

R02726 > R02725;
(other) R02218 R02843 R03262 R03263 R03329 R03851 R04850 R08949

Substrate

steroid [CPD:C00377];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

11beta-hydroxysteroid [CPD:C01058];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]

Comment

A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.

History

EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K00497

steroid 11beta-monooxygenase

K07433

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase

Genes

HSA:	1584(CYP11B1) 1585(CYP11B2)

PTR:	464437(CYP11B1) 745937(CYP11B2)

PPS:	100971238(CYP11B2) 100971586(CYP11B1)

GGO:	101142418 115930159

PON:	100459910 100461139

PPYG:

129042626 129042640

NLE:	100605657 115830633

HMH:	116465197 116465198

SSYN:

129486882 129486883

MCC:	695793(CYP11B1) 695914(CYP11B2)

MCF:	102136659(CYP11B1) 102137301(CYP11B2)

MTHB:

126961020 126961026 126961618

MNI:	105483796 105488428 105488429

CSAB:

103237546(CYP11B1) 103237547(CYP11B2)

CATY:

105581188 105581294

PANU:

101002490 101002842 116276421

TGE:	112630213 112630247

MLEU:

105536287 105536288

RRO:	104679773 104679775

RBB:	108536535 108536550

TFN:	117078861 117079172 117079174

PTEH:

111535654

CANG:

105509012 105509013

CJC:	100415304(CYP11B2) 100415667(CYP11B1)

SBQ:

101048076

CIMI:

108291253(CYP11B1) 108291254(CYP11B2)

ANAN:

105728086(CYP11B2) 105728099(CYP11B1)

CSYR:

103276447 103276450

MMUR:

105867373 105867374

LCAT:

123644516 123644520

ERUF:

138381591 138381592

PCOQ:

105813307 105813360

OGA:	100948075 100948396 100958146

MMU:	110115(Cyp11b1) 13072(Cyp11b2)

MCAL:

110310257 110310258

MPAH:

110334511 110335023

RNO:	120093683(Cyp11b2l1) 24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)

MCOC:

116073894 116082436

ANU:	117719036 117719092

ASYL:

127667342 127667824

MUN:	110544545 110562757

CGE:	100771648 107977023

MAUA:

101823339 101823606

PROB:

127225603 127225649 127225650

PLEU:

114684742 114684743

PMAV:

102924048

MORG:

121461414 121461416

MFOT:

126503589 126503590

AAMP:

119823440 119823447

CNL:

130888950

NGI:	103748431 103748432

HGL:	101700701 101701311

CPOC:

100379213(Cyp11b2) 100727186 111755182

CCAN:

109681807 109681816

DORD:

105992320 106002066

DSP:	122125332 122125344

PLOP:

125360501 125361022

NCAR:

124991075 124991346

MMMA:

107142805 107143071

ITI:	101963849 101968373

OCU:	100328543(CYP11B2) 100342863

OPI:

101518686

OCZ:	121163853 121163854

TUP:	102471986 102492986

GVR:	103599088 103604864 103604866

CFA:	482071(CYP11B2)

CLUD:

112662131

VVP:

112911200

VLG:

121499022

NPO:

129502591

AML:

100478197

UMR:

103680551

UAH:	125281062 125281076

UAR:	123779294 123796461

ELK:

111146729

LLV:	125098158 125099244

MNP:

132013308

MLK:	131827767 131827768

NVS:	122905498 122905499

ORO:

101364874

EJU:	114204069 114204070

ZCA:	113911085 118356903

MLX:

118015252

MANO:

123858670

NSU:

110578976

LWW:

102732818

FCA:	101097790(CYP11B1)

PYU:	121024468 121043245

PCOO:

112859405

PBG:	122496110 122496111

PVIV:

125156496

LRUF:

124507499 124507515

LGF:	123586547 123586550

AJU:	106989683 128312793

PTG:

102972244

PPAD:

109258417

PUC:

125924912

PLEZ:

122210855

HHV:

120227687

CCRU:

144226680

BTA:	282422(CYP11B1) 787628

BOM:

102272939

BIU:	109568177 109568372 109568377

BBUB:

112577757 112579063

BKE:	129627167 129627169

BBIS:

104997957

CHX:	102188238 102188517

OAS:	101102377 767576(CYP11B1)

BTAX:

128059464 128059476

CSUM:

138088413 138088750

ODA:

120859420

CCAD:

122451091

MREE:

136144977

MBEZ:

129560226

SSC:

110260194

CFR:

102517728

CBAI:

105077899

CDK:

105106427

VPC:

102532708

BACU:

103009357

BMUS:

118883237

LVE:

103089121

OOR:

101286768

LALB:

132507857

GMF:

115863290

DDP:

132440410

DLE:

111165107

PCAD:

102988484

PSIU:

116742421

PPHC:

136136821

NASI:

112397123

ECB:	100063612 100063645

EPZ:	103543718 103544682

EAI:	106827552 123275604

MYD:

102752229

MMYO:

118670722

MDT:

132219835

MYUM:

138993306

PKL:

118718613

EFUS:

103302673

MNA:

107542744

DRO:

112315587

SHON:

118988945

AJM:

119064760

PDIC:

114514446

PHAS:

123833011

MMF:

118643316

PPAM:

129084099

HAI:

109390820

RFQ:

117033759

PALE:

102881458

PGIG:

120588772

PVP:	105302023 105310134

RAY:

107507877

MJV:	108400067(CYP11B2)

TOD:

119232024

SARA:

101544036

SFUM:

130033610

SETR:

126008743

LAV:

100654178

TMU:

101354125

ETF:

101664498

DNM:

101424711

MDO:

100032885

GAS:

123255806

SHR:

100930767

AFZ:

127544520

PCW:

110214194

TVP:

118833874

PBRV:

138155881(CYP11B2)

OAA:

100082065

TACU:

119939998

AACU:

137849090

TGU:

116807520

LSR:

110479458

ATRC:

139587191

PHI:

102113159

ACOE:

138101691

CCIC:

134057549

FPG:

101918505

FCH:

102046275

BBUT:

142028520

PPUS:

135181278

CBOY:

140646799(SCRT1)

CNIC:

135985062

AROW:

112976664

ASN:

102375758

AMJ:	102575737(CYP11B1)

CPOO:

109310774

CIZ:

142009015

CMY:

102933677

CCAY:

125630881

LKP:

140905827

NDS:

141981237

DCC:

119851557

CPIC:

101950678

TST:

117873891

CABI:

116833743

MRV:

120396417

ACS:

100560890

ASAO:

132773556

PVT:

110084842

SUND:

121929727

PBI:

103058342

PMUR:

107300041

CTIG:

120298053

TSR:

106545562

PGUT:

117666942

PCAE:

139314526

APRI:

131196363

VKO:

123035256

PMUA:

114600140

PRAF:

128416955

ZVI:

118089700

HCG:

128322106

GJA:

107116366

STOW:

125425154

EMC:

129333751

XLA:

108718624

XTR:

101731070

RTEM:

120921857

PADS:

140330394

BBUF:

121001585

BGAR:

122938238

DTC:

141060323

PWL:

138274973

MUO:

115481511

GSH:

117353600

DRE:	791124(cyp11c1)

SRX:

107745157

SANH:

107698185

SGH:

107570796

CCAR:

109110857

CAUA:

113059430

CGIB:

128030261

PTET:

122357920

LROH:

127178203

GRF:	141342427(cyp11c1)

OMC:

131521331

PPRM:

120491104

RKG:

130103912

MAMB:

125243223

CIDE:

127497506

CERY:

137002098

MASI:

127453357

TDW:

130432709

MANU:

129448943(cyp11c1)

PDAB:

135752178(cyp11c1)

IPU:

108263488

PHYP:

113525473

SMEO:

124384380

TFD:

113647799

TVC:

132846065

CGAR:

128520287

NGRA:

132886340

TRN:

134310851

AMEX:

103026652

CMAO:

118813895

EEE:

113574779

CHAR:

105912980

SPIL:

134082421

ASAD:

121720838

TRU:

101075863

TFS:

130532956

TNG:	GSTEN00015374G001

LCO:

104920541

NCC:

104944920

TBEN:

117480465

CGOB:

115021232

PGEO:

117460921(cyp11c1)

GACU:

117541005

EMAC:

134861593

ELY:

117265363

EFO:

125893014

PLEP:

121945728

SLUC:

116049596

ECRA:

117946724

ESP:

116691100

PFLV:

114556971

GAT:

120810783

AFB:

129110285

CLUM:

117745803

PSWI:

130213196

CANA:

137780999(cyp11c1)

CVE:	137891513(cyp11c1)

MSAM:

119897544

SCHU:

122881607

EARM:

139289734(cyp11c1)

CUD:

121514148

SPUL:

138584179(cyp11c1)

LMIX:

132983189

HTC:	141800409(cyp11c1)

ALAT:

119006071

ASTR:

137601281(cyp11c1)

PKLU:

139204982(cyp11c1)

MZE:	101463871(cyp11c1)

ONL:	100533461(cyp11b)

OAU:

116320943

OLA:	100125822(cyp11b)

OML:

112143274

CSAI:

133432964

XMA:

102236274

XCO:

114139300

XHE:

116715552

PRET:

103478110

PFOR:

103136813

PLAI:

106957061

PMEI:

106922010

GAF:

122830567

PPRL:

129371107

CVG:

107088793

CTUL:

119783082

GMU:

124865602

NFU:

107379700

KMR:

108235361

ALIM:

106515094

NWH:

119410002

EJA:	138192094(cyp11c1)

BFRE:

138619392(cyp11c1)

MCEP:

125015727

CSEM:

103388284

POV:

109633048

SSEN:

122774868

SSOE:

131471413

HHIP:

117777191

HSP:

118113534

PPLT:

128449257

SMAU:

118299793

LCF:

108885901

SDU:

111230014

SLAL:

111652162

XGL:

120784322

HCQ:

109522775

SSCV:

125975714

SBIA:

133500663

PEE:

133401343

PTAO:

133479217

BPEC:

110163163

ENY:	140374293(cyp11c1)

MALB:

109970182

BSPL:

114842551

SJO:

128366469

SSCO:

133982928

TTY:	137191355(cyp11c1)

GMH:

115553949

SASA:

100136945

OTW:

121840636

OMY:	100135891(cyp11b) 110534298

OGO:	123998350 124004644

ONE:

115122985

OKI:

109881262

OKE:	118373241 127915287

OMM:	135519772 135523001

OCLA:

139379416 139405974

SALP:

112074060

SNH:

120047273

SFON:

129841898

CCLU:

121543144 123481512

ELS:

105018961

OEP:

134023661

SFM:

108925533

PKI:

111853322

AANG:

118210794

AROT:

135233515

CCOG:

133133540

LOC:

102683152

PSPA:

121306922

ARUT:

117395226 117969833

PSEX:

120518870

LCM:

102345423

CPUN:

140453886

HAKA:

140736351

» show all

Reference

1 [PMID:13276417]

Authors

GRANT JK, BROWNIE AC.

Title

The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation.

Journal

Biochim Biophys Acta 18:433-4 (1955)
DOI:10.1016/0006-3002(55)90111-6

Reference

2 [PMID:13211659]

Authors

HAYANO M, DORFMAN RI.

Title

On the mechanism of the C11 beta-hydroxylation of steroids.

Journal

J Biol Chem 211:227-35 (1954)

Reference

3 [PMID:13426185]

Authors

TOMKINS GM, MICHAEL PJ, CURRAN JF.

Title

Studies on the nature of steroid 11-beta hydroxylation.

Journal

Biochim Biophys Acta 23:655-6 (1957)
DOI:10.1016/0006-3002(57)90396-7

Reference

4 [PMID:3485096]

Authors

Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P

Title

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

Journal

J Biol Chem 261:3556-62 (1986)

Reference

5 [PMID:4967077]

Authors

Zuidweg MH.

Title

Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata.

Journal

Biochim Biophys Acta 152:144-58 (1968)
DOI:10.1016/0005-2760(68)90016-7

Other DBs

ExplorEnz - The Enzyme Database:

1.14.15.4

IUBMB Enzyme Nomenclature:

1.14.15.4

ExPASy - ENZYME nomenclature database:

1.14.15.4

BRENDA, the Enzyme Database:

1.14.15.4

CAS:

9029-66-7

LinkDB

REACTION: R02843

Entry

R02843                      Reaction

Name

steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

Definition

11-Deoxycortisol + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Cortisol + 2 Oxidized ferredoxin + H2O

Equation

C05488 + 2 C00138 + C00007 + 2 C00080 <=> C00735 + 2 C00139 + C00001

Reaction class

RC00661

C00735_C05488

Enzyme

1.14.15.4

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R02843  11-Deoxycortisol + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Cortisol + 2 Oxidized ferredoxin + H2O

Orthology

K00497

steroid 11beta-monooxygenase [EC:1.14.15.4]

K07433

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

LinkDB

DBGET integrated database retrieval system