KEGG   ORTHOLOGY: K00512
Entry
K00512                      KO                                     
Symbol
CYP17A
Name
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map04917  Prolactin signaling pathway
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Reaction
R02211  progesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R03783  pregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R04852  11beta-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R04853  20alpha-hydroxycholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R08517  17alpha-hydroxypregnenolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
R08518  17alpha-hydroxyprogesterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
R13212  5alpha-pregnane-3,20-dione,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R13213  allopregnanolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R13218  5alpha-pregnane-3alpha,17alpha-diol-20-one,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
R13460  21-deoxycortisol,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
Disease
H00216  Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Other DBs
GO: 0004508 0047442
Genes
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
PPS: 100989182(CYP17A1)
GGO: 101152080
PON: 100439753
PPYG: 129006765
NLE: 100596228
HMH: 116484149
SSYN: 129466716
MCC: 678693(CYP17A1)
MCF: 102133235(CYP17A1)
MTHB: 126962752
MNI: 105478336
CSAB: 103216445(CYP17A1)
CATY: 105581896
PANU: 101026704
TGE: 112630974
MLEU: 105537798
RRO: 104656530
RBB: 108515083
TFN: 117067514
PTEH: 111538851
CANG: 105522771
CJC: 100400572(CYP17A1)
SBQ: 101048584
CIMI: 108306253(CYP17A1)
ANAN: 105708253(CYP17A1)
CSYR: 103251416
MMUR: 105874387
LCAT: 123650072
ERUF: 138376364(CYP17A1)
PCOQ: 105824322
OGA: 100959209
MMU: 13074(Cyp17a1)
MCAL: 110285327
MPAH: 110334801
RNO: 25146(Cyp17a1)
MCOC: 116101357
ANU: 117722327
ASYL: 127676349
MUN: 110556807
CGE: 100758683
MAUA: 101831170(Cyp17a1)
PROB: 127233418
PLEU: 114696710
MORG: 121453907
MFOT: 126504210
AAMP: 119802303
NGI: 103744072
HGL: 101726496
CPOC: 100729670
CCAN: 109691327
DORD: 105986673
DSP: 122115926
DMER: 138807803(Cyp17a1)
PLOP: 125346105
NCAR: 124985398
MMMA: 107149847
ITI: 101970767
OCU: 100346394
OPI: 101532918
OCZ: 121164190 121166347
TUP: 102472543
GVR: 103596172
CFA: 477807(CYP17A1)
CLUD: 112672259
VVP: 112917782
VLG: 121485837
NPO: 129493641
AML: 100476785
UMR: 103681600
UAH: 113251880
UAR: 123795915
ELK: 111145221
LLV: 125084794
MPUF: 101671806
MNP: 132015377
MLK: 131828491
NVS: 122901070
ORO: 101384623
EJU: 114205173
ZCA: 113923407
MLX: 118025661
MANO: 123846812
NSU: 110589350
LWW: 102745940
FCA: 493967(CYP17A1)
PYU: 121037171
PCOO: 112854651
PBG: 122493194
PVIV: 125147397
LRUF: 124507106
LGF: 123577016
AJU: 106966901
PTG: 102966057
PPAD: 109272832
PUC: 125932918
PLEZ: 122202542
HHV: 120239617
CCRU: 144218486(CYP17A1)
BTA: 112444495 132342070 281739(CYP17A1)
BOM: 102270241(CYP17A1) 102270532
BIU: 109553214 109579081
BBUB: 102412624 112581551
BKE: 129636640 129636818
BBIS: 105002787
CHX: 102182376 102182663(CYP17A1A)
OAS: 105601846(CYP17) 493968(CYP17A1)
BTAX: 128067746 128071173
CSUM: 138070286 138070289(CYP17A1)
ODA: 120873501
CCAD: 122445953 122446740
MREE: 136158297 136158298 136158299
OVR: 110139799(CYP17A1)
MBEZ: 129555394 129555959
SSC: 403330(CYP17A1)
CFR: 102519078
CBAI: 105081696
CDK: 105095024
VPC: 102528385
BACU: 103007900
BMUS: 118882672
LVE: 103081477
OOR: 101283719
LALB: 132507156
GMF: 115858009(CYP17A1)
DDP: 132439311(CYP17A1)
DLE: 111172355
PCAD: 102989171
PSIU: 116741612
PPHC: 136136698(CYP17A1)
NASI: 112393002
ECB: 100034232(CYP17A1)
EPZ: 103558137(CYP17A1)
EAI: 106838161
MYB: 102259343
MYD: 102761363
MMYO: 118670308
MLF: 102417518
MDT: 132214301
MYUM: 139021764(CYP17A1)
PKL: 118718912
EFUS: 103288524
MNA: 107542528
DRO: 112300189
SHON: 118999460
AJM: 119059642
PDIC: 114497592
PHAS: 123828947
MMF: 118631983
PPAM: 129077302
HAI: 109379659
RFQ: 117036161
PALE: 102884618
PGIG: 120609141
PVP: 105309652
RAY: 107515566
MJV: 108410298(CYP17A1)
TOD: 119234280 119234908 119253889
SARA: 101555669
SFUM: 130029832
SETR: 126033429 126033430 126033432
LAV: 100660963
TMU: 101354636
ETF: 101641397
DNM: 101441314
MDO: 100028896
GAS: 123234242
SHR: 100915970
AFZ: 127551531
PCW: 110194957
TVP: 118828459
PBRV: 138169419(CYP17A1)
MLAO: 141521337(CYP17A1)
OAA: 100080906
TACU: 119938334
GGA: 425056(CYP17A1)
PCOC: 116231659
MGP: 100540331
CJO: 107316091
TPAI: 128077760
LMUT: 125694083
NMEL: 110399428
APLA: 101792920
AACU: 137859354(CYP17A1)
OJA: 118169027
ACYG: 106031836(CYP17A1)
CATA: 118248702
AFUL: 116491607
TGU: 100218933
LSR: 110473583(CYP17A1)
VMC: 128810585
VCHA: 128791327
AIB: 137478238(CYP17A1)
SCAN: 103813852
PMOA: 120502140
OTC: 121341799
PRUF: 121350302
ATRC: 139599131(CYP17A1)
MATE: 118688347
GFR: 102038147
FAB: 101821194
OMA: 130254684
PHI: 102104333
PMAJ: 107206790
CCAE: 111931270
CCW: 104695563
CBRC: 103624562
ACOE: 138112855(CYP17A1)
ETL: 114071768
ZAB: 102070509
ZLE: 135449587
ACHL: 103809385
SVG: 106857584
MMEA: 130581524
HRT: 120755804
SATI: 136364505(CYP17A1)
CFAI: 136293648(CYP17A1)
CCIC: 134046257
FPG: 101910363
FCH: 102054501
CCRI: 104161242
NNT: 104400042
SHAB: 115608953
ACUN: 113481735
ANOC: 141961495(CYP17A1)
SURA: 141945658(CYP17A1)
TALA: 104366646
ACHC: 115348606
HALD: 104314833
HLE: 104830098
AGEN: 126042899
HHAR: 128147507
BBUT: 142030684(CYP17A1)
GCL: 127017763
CSTI: 104553046
LDI: 104355067
MNB: 103779364
DPUB: 104307099
PPUS: 135175976
IIN: 128968107
AVIT: 104273742
BRHI: 104495232
EGZ: 104125602
NNI: 104022305
PARX: 142063824(CYP17A1)
PADL: 103916301
AFOR: 103897707
FGA: 104083220
CBOR: 142084625(CYP17A1)
GSTE: 104261700
CBOY: 140655735(CYP17A1)
MAME: 142410890(CYP17A1)
CLV: 102093575
CNIC: 135990797
MUI: 104536211
PGUU: 104461069
PLET: 104618241
EHS: 104508633
CMAC: 104485256
CUCA: 104059767
TEO: 104377577
BREG: 104634307
GAME: 129208836
OHA: 104336177
ACAR: 104518499
CPEA: 104390883
CVF: 104283370
RTD: 128911280
CRID: 134517161
LMIC: 141744802(CYP17A1)
NARQ: 141472202(CYP17A1)
AAM: 106494668
AROW: 112967993
NPD: 112957074
TGT: 104565299
DNE: 112989287
SCAM: 104138131
ASN: 102372221
AMJ: 102567971(CYP17A1)
CPOO: 109323822
GGN: 109287570
PSS: 102457785
CIZ: 142015943(CYP17A1) 142015945
CMY: 102945773
CCAY: 125640071
LKP: 140915391(CYP17A1)
NDS: 141991736(CYP17A1)
DCC: 119858827
CPIC: 101933089
TST: 117880996
CABI: 116817103
MRV: 120408966
ACS: 100553634 100553834
ASAO: 132769882
PVT: 110077624
SUND: 121925460
PBI: 103063631
PMUR: 107290855
CTIG: 120316288
TSR: 106541312
PGUT: 117678655
PCAE: 139317913 139318110(CYP17A1)
APRI: 131200733
PTEX: 113439073
NSS: 113410986
VKO: 123024050
PMUA: 114597528
PRAF: 128414286
HCG: 128349368
GJA: 107117909
STOW: 125437989
EMC: 129332683
XLA: 100036774(cyp17a1.L)
XTR: 100145650(cyp17a1)
NPR: 108784547 108784564
RTEM: 120946990
ACAT: 141105925(CYP17A1)
PADS: 140339367 140339377 140339480
BBUF: 121004269 121005522
BGAR: 122942304
DTC: 141059675(CYP17A1)
PWL: 138300299(CYP17A1)
MUO: 115469991
GSH: 117358874
DRE: 399692(cyp17a1) 796487(cyp17a2)
SRX: 107707716 107750198
SANH: 107673162 107695149
SGH: 107574436 107588661
CCAR: 109076732 109111078
CAUA: 113041336 113056832 113074379 113085111
CGIB: 127970183 128012018
PTET: 122334561 122356746
LROH: 127161931 127174815
GRF: 141325889 141325890(cyp17a1)
OMC: 131532047 131552199
PPRM: 120479844 120484073 120484098
RKG: 130071743 130072784
MAMB: 125260617 125276970 125276972
CIDE: 127504550 127525002
CERY: 137008823(cyp17a2) 137020080(cyp17a1) 137020081
MASI: 127413875 127418618
TROS: 130545059 130559140
TDW: 130408901 130432033
MANU: 129416856(cyp17a1) 129431020(cyp17a2)
PDAB: 135750302(cyp17a2) 135786981(cyp17a1)
IPU: 100313515(cyp17) 108275468
IFU: 128605687 128619575
PHYP: 113530739 113542020
SMEO: 124396975 124398983
TFD: 113636291 113641757
TVC: 132847358 132862061
CGAR: 128510449 128529254
NGRA: 132888873 132896641
TRN: 134314252 134333162
AMEX: 103036160 111194069
CMAO: 118810050 118822544
EEE: 113570353 113585465
CHAR: 105891434 105911586
SPIL: 134059918 134063690
ASAD: 121684920 121690350
TRU: 100125766(cyp17a2) 100125798(cyp17a1) 115249663
TFS: 130522769 130533807
LCO: 104935158 104936651
NCC: 104957534
TBEN: 117480807 117483604
CGOB: 115019922
PGEO: 117459816(cyp17a1)
GACU: 117532575 117561641
EMAC: 134858547 134876176
ELY: 117248465 117272651
EFO: 125883749 125904031
PLEP: 121954365 121962489
SLUC: 116034661 116053620
ECRA: 117935140 117960349
ESP: 116686493
PFLV: 114546162 114571983
GAT: 100192329(cyp17a2) 100192330(cyp17a1)
PPUG: 119214573 119222944
AFB: 129091901 129093054
CLUM: 117743904 117747918
PSWI: 130207004 130212104
CANA: 137792044(cyp17a2) 137801920(cyp17a1)
CVE: 137874409(cyp17a2) 137885460(cyp17a1)
MSAM: 119912282 119917252
SCHU: 122870149 122883929
EARM: 139294476(cyp17a1) 139305572(cyp17a2)
CUD: 121504405 121510915
SPUL: 138588211(cyp17a1) 138600683(cyp17a2)
LMIX: 132958106 132975763
HTC: 141795442(cyp17a1) 141811218(cyp17a2)
ALAT: 119026703 119033497
ASTR: 137590379(cyp17a2) 137603815(cyp17a1)
PKLU: 139210524(cyp17a1) 139223298(cyp17a2)
MZE: 101475441(cyp17a2) 101477086(cyp17a1)
ONL: 100702216(cyp17a2) 100703469(cyp17)
OAU: 116332169 116335890
OLA: 100125816(cyp17) 101170547(cyp17a2)
OML: 112156384 112161529
CSAI: 133452414 133463668
XMA: 102221767 102238057
XCO: 114138338 114157614
XHE: 116712776 116732588 116732589
PRET: 103476526 103480951
PFOR: 103149115 103155787
PLAI: 106934850 106958972
PMEI: 106916522 106928572
GAF: 122820816 122842871
PPRL: 129355868 129360155 129376685
CVG: 107083007 107099069
CTUL: 119773762 119787729
GMU: 124858740 124881307
NFU: 107375507 107396730
KMR: 108239115 108251556
ALIM: 106511002 106515325
NWH: 119417878 119430866
AOCE: 111563640 111579695
EJA: 138213560(cyp17a1) 138214162(cyp17a2)
BFRE: 138614574(cyp17a1) 138636408(cyp17a2)
MCEP: 125009171 125018366
CSEM: 103387725 103389439
POV: 109634757 109639880
SSEN: 122766283 122781515
SSOE: 131456340 131473509
HHIP: 117751868 117775903
HSP: 118102904 118119196
PPLT: 128429949 128453430
SMAU: 118283790 118320091
LCF: 108892361 108895342
SDU: 111233121 111239202
SLAL: 111661066 111669513
XGL: 120796819 120797261
HCQ: 109516617 109523214
SSCV: 125978579(cyp17a1) 125992396(cyp17a2)
SBIA: 133494674 133509358
PEE: 133397560 133409947
PTAO: 133472952 133485558
BPEC: 110156961 110160276
ENY: 140351335(cyp17a1) 140371453(cyp17a2)
MALB: 109972947 109973668
BSPL: 114841926 114851252
SJO: 128372655 128384087
SSCO: 133991854 134006120
TTY: 137174939(cyp17a2) 137196576(cyp17a1)
GMH: 115529578 115559780
SASA: 106576693 106592366
STRU: 115193858 115198019
OTW: 112238453 112252939
OMY: 100137017(cyp17a1) 110509408
OGO: 124013898 124040788
ONE: 115136350
OKI: 109882966 109889877
OKE: 118369634 127906903
OMM: 135510002 135515542
OCLA: 139379260 139411130
SALP: 111951662 112078788
SNH: 120017914
SFON: 129836264
CCLU: 121553719 121559195
ELS: 105006241 105008018
OEP: 134009684 134022276
SFM: 108926160 108933747
PKI: 111836781 111859263
AANG: 118218511 118231945
AROT: 135245089 135260072
CCOG: 133118035 133135907
LOC: 102683310 102696373
PSPA: 121321480 121326245
ARUT: 117409034 117415544
PSEX: 120514450
LCM: 102350866 102365866
CMK: 103177103
RTP: 109937010
CPLA: 122561334
CPUN: 140463316(cyp17a1)
HOC: 132826540
SCAU: 119950696
LERI: 129704116
HAKA: 140715053(cyp17a1)
PMRN: 116939743 116941468
LRJ: 133345432 133345701 133346921
BFO: 118425323 118425478
BBEL: 109475258 109487130
LPIC: 129281073
LVG: 121405585 121430712 121431603 121431604 121432065
AJJ: 139958664 139973573 139974391
ARUN: 117299790 117304840
AAMU: 139949021 139952058
AFIL: 140138450 140166127
PFLL: 139117201 139133185 139140889
DSV: 119442568
DALB: 135909649 135909662 135910800 135916011
RSAN: 119377837
RMP: 119159398
LSAX: 138946723 138946734 138946789 138946821 138946829 138946908 138955339 138956560 138966363 138980018 138980034
BARL: 143280532 143299619 143299816 143301818 143302046 143302056
BGT: 106073674
HRJ: 124264060 124275507
HCRA: 139480494
CRG: 105337314
CANU: 128160771 128161280 128167344 128185043
CVN: 111101403 111101451 111135334
OED: 125646576 125646578 125646588 125663947 125675636
PMAX: 117327584
AIRR: 138334403
YBA: 132548700 132548711 132549536 132552681
MMER: 123555172 123558347
RPHI: 132715500
OSN: 115223139
LJP: 135477652 135481844
ATEN: 116286226 116287483 116289234 116292213 116292286 116300224 116300467 116304432 116305619 116307262 116308086 116309069
MCAZ: 138023625 138025282 138025283 138025288 138026600 138026601 138028760 138028773 138033165 138038150 138050324 138050325 138051725 138051731 138055303
MFOO: 137973445 137979306 137979307 137991048 137991049 137994981 137994983 137994984 137994985 137997619 138003697
XEN: 124452194 124452197 124452291 124455834
HSY: 130614135 130614136 130630581 130634454 130645371 130648549
RES: 135685504 135686448 135687123 135689501 135689767 135689768 135690225 135694397 135694459 135695166 135695610 135696563
CCLM: 134179378 134184129 134184132
AG: AAG02227(CYP17A1)
 » show all
Reference
PMID:3025870 (CYP17A1)
  Authors
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL
  Title
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
  Journal
Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407
  Sequence
[hsa:1586]
Reference
PMID:17569754 (CYP17A2)
  Authors
Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y
  Title
A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney.
  Journal
Endocrinology 148:4282-91 (2007)
DOI:10.1210/en.2007-0487
  Sequence
[ola:101170547]
LinkDB

KEGG   ENZYME: 1.14.14.19
Entry
EC 1.14.14.19               Enzyme                                 
Name
steroid 17alpha-monooxygenase;
steroid 17alpha-hydroxylase;
cytochrome P-450 17alpha;
cytochrome P-450 (P-450 17alpha,lyase);
17alpha-hydroxylase-C17,20 lyase;
CYP17;
CYP17A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
steroid,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
Reaction(IUBMB)
a C21-steroid + [reduced NADPH---hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02131]
Reaction(KEGG)
R02131 > R02211 R03783 R04852 R04853 R13212 R13213
Substrate
C21-steroid;
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
17alpha-hydroxy-C21-steroid;
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17alpha-hydroxyprogesterone deacetylase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.
History
EC 1.14.14.19 created 1961 as EC 1.99.1.9, transferred 1965 to EC 1.14.1.7, transferred 1972 to EC 1.14.99.9, modified 2013, transferred 2015 to EC 1.14.14.19
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Genes
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
PPS: 100989182(CYP17A1)
GGO: 101152080
PON: 100439753
PPYG: 129006765
NLE: 100596228
HMH: 116484149
SSYN: 129466716
MCC: 678693(CYP17A1)
MCF: 102133235(CYP17A1)
MTHB: 126962752
MNI: 105478336
CSAB: 103216445(CYP17A1)
CATY: 105581896
PANU: 101026704
TGE: 112630974
MLEU: 105537798
RRO: 104656530
RBB: 108515083
TFN: 117067514
PTEH: 111538851
CANG: 105522771
CJC: 100400572(CYP17A1)
SBQ: 101048584
CIMI: 108306253(CYP17A1)
ANAN: 105708253(CYP17A1)
CSYR: 103251416
MMUR: 105874387
LCAT: 123650072
ERUF: 138376364(CYP17A1)
PCOQ: 105824322
OGA: 100959209
MMU: 13074(Cyp17a1)
MCAL: 110285327
MPAH: 110334801
RNO: 25146(Cyp17a1)
MCOC: 116101357
ANU: 117722327
ASYL: 127676349
MUN: 110556807
CGE: 100758683
MAUA: 101831170(Cyp17a1)
PROB: 127233418
PLEU: 114696710
MORG: 121453907
MFOT: 126504210
AAMP: 119802303
NGI: 103744072
HGL: 101726496
CPOC: 100729670
CCAN: 109691327
DORD: 105986673
DSP: 122115926
DMER: 138807803(Cyp17a1)
PLOP: 125346105
NCAR: 124985398
MMMA: 107149847
ITI: 101970767
OCU: 100346394
OPI: 101532918
OCZ: 121164190 121166347
TUP: 102472543
GVR: 103596172
CFA: 477807(CYP17A1)
CLUD: 112672259
VVP: 112917782
VLG: 121485837
NPO: 129493641
AML: 100476785
UMR: 103681600
UAH: 113251880
UAR: 123795915
ELK: 111145221
LLV: 125084794
MPUF: 101671806
MNP: 132015377
MLK: 131828491
NVS: 122901070
ORO: 101384623
EJU: 114205173
ZCA: 113923407
MLX: 118025661
MANO: 123846812
NSU: 110589350
LWW: 102745940
FCA: 493967(CYP17A1)
PYU: 121037171
PCOO: 112854651
PBG: 122493194
PVIV: 125147397
LRUF: 124507106
LGF: 123577016
AJU: 106966901
PTG: 102966057
PPAD: 109272832
PUC: 125932918
PLEZ: 122202542
HHV: 120239617
CCRU: 144218486(CYP17A1)
BTA: 112444495 132342070 281739(CYP17A1)
BOM: 102270241(CYP17A1) 102270532
BIU: 109553214 109579081
BBUB: 102412624 112581551
BKE: 129636640 129636818
BBIS: 105002787
CHX: 102182376 102182663(CYP17A1A)
OAS: 105601846(CYP17) 493968(CYP17A1)
BTAX: 128067746 128071173
CSUM: 138070286 138070289(CYP17A1)
ODA: 120873501
CCAD: 122445953 122446740
MREE: 136158297 136158298 136158299
OVR: 110139799(CYP17A1)
MBEZ: 129555394 129555959
SSC: 403330(CYP17A1)
CFR: 102519078
CBAI: 105081696
CDK: 105095024
VPC: 102528385
BACU: 103007900
BMUS: 118882672
LVE: 103081477
OOR: 101283719
LALB: 132507156
GMF: 115858009(CYP17A1)
DDP: 132439311(CYP17A1)
DLE: 111172355
PCAD: 102989171
PSIU: 116741612
PPHC: 136136698(CYP17A1)
NASI: 112393002
ECB: 100034232(CYP17A1)
EPZ: 103558137(CYP17A1)
EAI: 106838161
MYB: 102259343
MYD: 102761363
MMYO: 118670308
MLF: 102417518
MDT: 132214301
MYUM: 139021764(CYP17A1)
PKL: 118718912
EFUS: 103288524
MNA: 107542528
DRO: 112300189
SHON: 118999460
AJM: 119059642
PDIC: 114497592
PHAS: 123828947
MMF: 118631983
PPAM: 129077302
HAI: 109379659
RFQ: 117036161
PALE: 102884618
PGIG: 120609141
PVP: 105309652
RAY: 107515566
MJV: 108410298(CYP17A1)
TOD: 119234280 119234908 119253889
SARA: 101555669
SFUM: 130029832
SETR: 126033429 126033430 126033432
LAV: 100660963
TMU: 101354636
ETF: 101641397
DNM: 101441314
MDO: 100028896
GAS: 123234242
SHR: 100915970
AFZ: 127551531
PCW: 110194957
TVP: 118828459
PBRV: 138169419(CYP17A1)
MLAO: 141521337(CYP17A1)
OAA: 100080906
TACU: 119938334
GGA: 425056(CYP17A1)
PCOC: 116231659
MGP: 100540331
CJO: 107316091
TPAI: 128077760
LMUT: 125694083
NMEL: 110399428
APLA: 101792920
AACU: 137859354(CYP17A1)
OJA: 118169027
ACYG: 106031836(CYP17A1)
CATA: 118248702
AFUL: 116491607
TGU: 100218933
LSR: 110473583(CYP17A1)
VMC: 128810585
VCHA: 128791327
AIB: 137478238(CYP17A1)
SCAN: 103813852
PMOA: 120502140
OTC: 121341799
PRUF: 121350302
ATRC: 139599131(CYP17A1)
MATE: 118688347
GFR: 102038147
FAB: 101821194
OMA: 130254684
PHI: 102104333
PMAJ: 107206790
CCAE: 111931270
CCW: 104695563
CBRC: 103624562
ACOE: 138112855(CYP17A1)
ETL: 114071768
ZAB: 102070509
ZLE: 135449587
ACHL: 103809385
SVG: 106857584
MMEA: 130581524
HRT: 120755804
SATI: 136364505(CYP17A1)
CFAI: 136293648(CYP17A1)
CCIC: 134046257
FPG: 101910363
FCH: 102054501
CCRI: 104161242
NNT: 104400042
SHAB: 115608953
ACUN: 113481735
ANOC: 141961495(CYP17A1)
SURA: 141945658(CYP17A1)
TALA: 104366646
ACHC: 115348606
HALD: 104314833
HLE: 104830098
AGEN: 126042899
HHAR: 128147507
BBUT: 142030684(CYP17A1)
GCL: 127017763
CSTI: 104553046
LDI: 104355067
MNB: 103779364
DPUB: 104307099
PPUS: 135175976
IIN: 128968107
AVIT: 104273742
BRHI: 104495232
EGZ: 104125602
NNI: 104022305
PARX: 142063824(CYP17A1)
PADL: 103916301
AFOR: 103897707
FGA: 104083220
CBOR: 142084625(CYP17A1)
GSTE: 104261700
CBOY: 140655735(CYP17A1)
MAME: 142410890(CYP17A1)
CLV: 102093575
CNIC: 135990797
MUI: 104536211
PGUU: 104461069
PLET: 104618241
EHS: 104508633
CMAC: 104485256
CUCA: 104059767
TEO: 104377577
BREG: 104634307
GAME: 129208836
OHA: 104336177
ACAR: 104518499
CPEA: 104390883
CVF: 104283370
RTD: 128911280
CRID: 134517161
LMIC: 141744802(CYP17A1)
NARQ: 141472202(CYP17A1)
AAM: 106494668
AROW: 112967993
NPD: 112957074
TGT: 104565299
DNE: 112989287
SCAM: 104138131
ASN: 102372221
AMJ: 102567971(CYP17A1)
CPOO: 109323822
GGN: 109287570
PSS: 102457785
CIZ: 142015943(CYP17A1) 142015945
CMY: 102945773
CCAY: 125640071
LKP: 140915391(CYP17A1)
NDS: 141991736(CYP17A1)
DCC: 119858827
CPIC: 101933089
TST: 117880996
CABI: 116817103
MRV: 120408966
ACS: 100553634 100553834
ASAO: 132769882
PVT: 110077624
SUND: 121925460
PBI: 103063631
PMUR: 107290855
CTIG: 120316288
TSR: 106541312
PGUT: 117678655
PCAE: 139317913 139318110(CYP17A1)
APRI: 131200733
PTEX: 113439073
NSS: 113410986
VKO: 123024050
PMUA: 114597528
PRAF: 128414286
HCG: 128349368
GJA: 107117909
STOW: 125437989
EMC: 129332683
XLA: 100036774(cyp17a1.L)
XTR: 100145650(cyp17a1)
NPR: 108784547 108784564
RTEM: 120946990
ACAT: 141105925(CYP17A1)
PADS: 140339367 140339377 140339480
BBUF: 121004269 121005522
BGAR: 122942304
DTC: 141059675(CYP17A1)
PWL: 138300299(CYP17A1)
MUO: 115469991
GSH: 117358874
DRE: 399692(cyp17a1) 796487(cyp17a2)
SRX: 107707716 107750198
SANH: 107673162 107695149
SGH: 107574436 107588661
CCAR: 109076732 109111078
CAUA: 113041336 113056832 113074379 113085111
CGIB: 127970183 128012018
PTET: 122334561 122356746
LROH: 127161931 127174815
GRF: 141325889 141325890(cyp17a1)
OMC: 131532047 131552199
PPRM: 120479844 120484073 120484098
RKG: 130071743 130072784
MAMB: 125260617 125276970 125276972
CIDE: 127504550 127525002
CERY: 137008823(cyp17a2) 137020080(cyp17a1) 137020081
MASI: 127413875 127418618
TROS: 130545059 130559140
TDW: 130408901 130432033
MANU: 129416856(cyp17a1) 129431020(cyp17a2)
PDAB: 135750302(cyp17a2) 135786981(cyp17a1)
IPU: 100313515(cyp17) 108275468
IFU: 128605687 128619575
PHYP: 113530739 113542020
SMEO: 124396975 124398983
TFD: 113636291 113641757
TVC: 132847358 132862061
CGAR: 128510449 128529254
NGRA: 132888873 132896641
TRN: 134314252 134333162
AMEX: 103036160 111194069
CMAO: 118810050 118822544
EEE: 113570353 113585465
CHAR: 105891434 105911586
SPIL: 134059918 134063690
ASAD: 121684920 121690350
TRU: 100125766(cyp17a2) 100125798(cyp17a1) 115249663
TFS: 130522769 130533807
LCO: 104935158 104936651
NCC: 104957534
TBEN: 117480807 117483604
CGOB: 115019922
PGEO: 117459816(cyp17a1)
GACU: 117532575 117561641
EMAC: 134858547 134876176
ELY: 117248465 117272651
EFO: 125883749 125904031
PLEP: 121954365 121962489
SLUC: 116034661 116053620
ECRA: 117935140 117960349
ESP: 116686493
PFLV: 114546162 114571983
GAT: 100192329(cyp17a2) 100192330(cyp17a1)
PPUG: 119214573 119222944
AFB: 129091901 129093054
CLUM: 117743904 117747918
PSWI: 130207004 130212104
CANA: 137792044(cyp17a2) 137801920(cyp17a1)
CVE: 137874409(cyp17a2) 137885460(cyp17a1)
MSAM: 119912282 119917252
SCHU: 122870149 122883929
EARM: 139294476(cyp17a1) 139305572(cyp17a2)
CUD: 121504405 121510915
SPUL: 138588211(cyp17a1) 138600683(cyp17a2)
LMIX: 132958106 132975763
HTC: 141795442(cyp17a1) 141811218(cyp17a2)
ALAT: 119026703 119033497
ASTR: 137590379(cyp17a2) 137603815(cyp17a1)
PKLU: 139210524(cyp17a1) 139223298(cyp17a2)
MZE: 101475441(cyp17a2) 101477086(cyp17a1)
ONL: 100702216(cyp17a2) 100703469(cyp17)
OAU: 116332169 116335890
OLA: 100125816(cyp17) 101170547(cyp17a2)
OML: 112156384 112161529
CSAI: 133452414 133463668
XMA: 102221767 102238057
XCO: 114138338 114157614
XHE: 116712776 116732588 116732589
PRET: 103476526 103480951
PFOR: 103149115 103155787
PLAI: 106934850 106958972
PMEI: 106916522 106928572
GAF: 122820816 122842871
PPRL: 129355868 129360155 129376685
CVG: 107083007 107099069
CTUL: 119773762 119787729
GMU: 124858740 124881307
NFU: 107375507 107396730
KMR: 108239115 108251556
ALIM: 106511002 106515325
NWH: 119417878 119430866
AOCE: 111563640 111579695
EJA: 138213560(cyp17a1) 138214162(cyp17a2)
BFRE: 138614574(cyp17a1) 138636408(cyp17a2)
MCEP: 125009171 125018366
CSEM: 103387725 103389439
POV: 109634757 109639880
SSEN: 122766283 122781515
SSOE: 131456340 131473509
HHIP: 117751868 117775903
HSP: 118102904 118119196
PPLT: 128429949 128453430
SMAU: 118283790 118320091
LCF: 108892361 108895342
SDU: 111233121 111239202
SLAL: 111661066 111669513
XGL: 120796819 120797261
HCQ: 109516617 109523214
SSCV: 125978579(cyp17a1) 125992396(cyp17a2)
SBIA: 133494674 133509358
PEE: 133397560 133409947
PTAO: 133472952 133485558
BPEC: 110156961 110160276
ENY: 140351335(cyp17a1) 140371453(cyp17a2)
MALB: 109972947 109973668
BSPL: 114841926 114851252
SJO: 128372655 128384087
SSCO: 133991854 134006120
TTY: 137174939(cyp17a2) 137196576(cyp17a1)
GMH: 115529578 115559780
SASA: 106576693 106592366
STRU: 115193858 115198019
OTW: 112238453 112252939
OMY: 100137017(cyp17a1) 110509408
OGO: 124013898 124040788
ONE: 115136350
OKI: 109882966 109889877
OKE: 118369634 127906903
OMM: 135510002 135515542
OCLA: 139379260 139411130
SALP: 111951662 112078788
SNH: 120017914
SFON: 129836264
CCLU: 121553719 121559195
ELS: 105006241 105008018
OEP: 134009684 134022276
SFM: 108926160 108933747
PKI: 111836781 111859263
AANG: 118218511 118231945
AROT: 135245089 135260072
CCOG: 133118035 133135907
LOC: 102683310 102696373
PSPA: 121321480 121326245
ARUT: 117409034 117415544
PSEX: 120514450
LCM: 102350866 102365866
CMK: 103177103
RTP: 109937010
CPLA: 122561334
CPUN: 140463316(cyp17a1)
HOC: 132826540
SCAU: 119950696
LERI: 129704116
HAKA: 140715053(cyp17a1)
PMRN: 116939743 116941468
LRJ: 133345432 133345701 133346921
BFO: 118425323 118425478
BBEL: 109475258 109487130
LPIC: 129281073
LVG: 121405585 121430712 121431603 121431604 121432065
AJJ: 139958664 139973573 139974391
ARUN: 117299790 117304840
AAMU: 139949021 139952058
AFIL: 140138450 140166127
PFLL: 139117201 139133185 139140889
DSV: 119442568
DALB: 135909649 135909662 135910800 135916011
RSAN: 119377837
RMP: 119159398
LSAX: 138946723 138946734 138946789 138946821 138946829 138946908 138955339 138956560 138966363 138980018 138980034
BARL: 143280532 143299619 143299816 143301818 143302046 143302056
BGT: 106073674
HRJ: 124264060 124275507
HCRA: 139480494
CRG: 105337314
CANU: 128160771 128161280 128167344 128185043
CVN: 111101403 111101451 111135334
OED: 125646576 125646578 125646588 125663947 125675636
PMAX: 117327584
AIRR: 138334403
YBA: 132548700 132548711 132549536 132552681
MMER: 123555172 123558347
RPHI: 132715500
OSN: 115223139
LJP: 135477652 135481844
ATEN: 116286226 116287483 116289234 116292213 116292286 116300224 116300467 116304432 116305619 116307262 116308086 116309069
MCAZ: 138023625 138025282 138025283 138025288 138026600 138026601 138028760 138028773 138033165 138038150 138050324 138050325 138051725 138051731 138055303
MFOO: 137973445 137979306 137979307 137991048 137991049 137994981 137994983 137994984 137994985 137997619 138003697
XEN: 124452194 124452197 124452291 124455834
HSY: 130614135 130614136 130630581 130634454 130645371 130648549
RES: 135685504 135686448 135687123 135689501 135689767 135689768 135690225 135694397 135694459 135695166 135695610 135696563
CCLM: 134179378 134184129 134184132
 » show all
Reference
1  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
2  [PMID:6966286]
  Authors
Yoshida KI, Oshima H, Troen P
  Title
Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17 alpha-hydroxylation.
  Journal
J Clin Endocrinol Metab 50:895-9 (1980)
DOI:10.1210/jcem-50-5-895
Reference
3  [PMID:12693981]
  Authors
Gilep AA, Estabrook RW, Usanov SA
  Title
Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
  Journal
Biochemistry (Mosc) 68:86-98 (2003)
DOI:10.1023/a:1022101703670
  Sequence
[oas:493968] [chx:102182663] [ag:AAG02227]
Reference
4  [PMID:17386955]
  Authors
Kolar NW, Swart AC, Mason JI, Swart P
  Title
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris.
  Journal
J Biotechnol 129:635-44 (2007)
DOI:10.1016/j.jbiotec.2007.02.003
Reference
5  [PMID:18707589]
  Authors
Pechurskaya TA, Lukashevich OP, Gilep AA, Usanov SA
  Title
Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization.
  Journal
Biochemistry (Mosc) 73:806-11 (2008)
DOI:10.1134/s0006297908070092
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.19
IUBMB Enzyme Nomenclature: 1.14.14.19
ExPASy - ENZYME nomenclature database: 1.14.14.19
BRENDA, the Enzyme Database: 1.14.14.19
CAS: 9029-67-8
LinkDB

KEGG   REACTION: R13212
Entry
R13212                      Reaction                               
Name
5alpha-pregnane-3,20-dione,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
Definition
5alpha-Pregnane-3,20-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5alpha-Pregnan-17alpha-ol-3,20-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C03681 + C03024 + C00007 <=> C22831 + C03161 + C00001
Reaction class
RC00660  C03681_C22831
Enzyme
1.14.14.19
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19
     R13212  5alpha-Pregnane-3,20-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5alpha-Pregnan-17alpha-ol-3,20-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.19
   R02131  Steroid <=> 17alpha-Hydroxysteroid
    R13212  5alpha-Pregnane-3,20-dione <=> 5alpha-Pregnan-17alpha-ol-3,20-dione
Orthology
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
LinkDB

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