KEGG ORTHOLOGY: K00562

ORTHOLOGY: K00562

Entry

K00562                      KO

Symbol

INMT, TEMT

Name

methyltransferase [EC:2.1.1.49 2.1.1.96]

Pathway

map00380

Tryptophan metabolism

map00450

Selenocompound metabolism

map01100

Metabolic pathways

Reaction

R02174

S-adenosyl-L-methionine:amine N-methyltransferase

R02910

S-adenosyl-L-methionine:amine N-methyltransferase

R09370

S-adenosyl-L-methionine:dimethyl-selenide Se-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00562  INMT, TEMT; methyltransferase
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    K00562  INMT, TEMT; methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.49  amine N-methyltransferase
     K00562  INMT, TEMT; methyltransferase
    2.1.1.96  thioether S-methyltransferase
     K00562  INMT, TEMT; methyltransferase

Other DBs

GO:	0030748 0004790

Genes

HSA:	11185(INMT)

PTR:	463912(INMT)

PPS:	100986665(INMT)

GGO:	101143120(INMT)

PON:	100171421(INMT)

PPYG:

129040473(INMT)

NLE:	100603670(INMT)

HMH:	116812596(INMT)

SSYN:

129490076(INMT)

MCC:	694969(INMT)

MCF:	102139220(INMT)

MTHB:

126950079

MNI:	105475814(INMT)

CSAB:

103226272(INMT)

CATY:

105596176(INMT)

PANU:

100998123(INMT)

TGE:	112620035(INMT)

MLEU:

105533692(INMT)

RRO:	104663737(INMT)

RBB:	108532381(INMT)

PTEH:

111522205(INMT)

CJC:	100387750(INMT)

SBQ:	101035075(INMT)

CIMI:

108303319(INMT)

ANAN:

105732855(INMT)

CSYR:

103254460(INMT)

MMUR:

105855099(INMT)

LCAT:

123646987(INMT)

ERUF:

138376962(INMT)

OGA:	100957733(INMT)

MMU:	21743(Inmt)

MCAL:

110296762(Inmt)

MPAH:

110317265(Inmt)

RNO:	368066(Inmt)

MCOC:

116098126(Inmt)

ANU:	117720797(Inmt)

ASYL:

127677462(Inmt)

MUN:	110555148(Inmt)

CGE:	100773805(Inmt)

MAUA:

101835859(Inmt)

PROB:

127235715(Inmt)

PLEU:

114689706(Inmt)

MORG:

121439573(Inmt)

MFOT:

126509501

AAMP:

119806657(Inmt)

NGI:	103729450(Inmt)

HGL:	101710622(Inmt) 106008943

CPOC:

100724009

NCAR:

124991696

MMMA:

107146148(Inmt)

ITI:	101963869(Inmt)

OCU:	100008695(INMT) 100338404

OPI:	101526879 101531959

OCZ:	121145759 121145857(INMT)

TUP:	102502473(INMT)

ORO:	105758206(INMT)

BTA:	527922(INMT)

BOM:	102270640(INMT)

BIU:	109557473(INMT)

BBUB:

102411712(INMT)

BBIS:

104980483(INMT)

CHX:

102186084

OAS:

101123289

BTAX:

128047032(INMT)

CSUM:

138080361

ODA:	120877395(INMT)

CCAD:

122438422(INMT)

MREE:

136171146(INMT)

OVR:	110142474(INMT)

MBEZ:

129552077(INMT)

SSC:	100512997(INMT)

CFR:	102503927 102504745

CBAI:

105081898(INMT) 105082129

CDK:	105095849 105106408 116154033

VPC:	102537199(INMT)

BACU:

103019292

BMUS:

118900898(INMT)

LVE:

103070876

OOR:	101284322(INMT)

LALB:

132524198(INMT)

GMF:	115853526(INMT)

DDP:	132430684(INMT)

DLE:	111180005(INMT)

PCAD:

102980842(INMT)

PSIU:

116759859(INMT)

PPHC:

136128583(INMT)

NASI:

112406305(INMT)

ECB:

100055070

EPZ:	103541247(INMT)

EAI:	106830978 106831065(INMT)

MNA:	107544372(INMT)

MJV:	108403655(INMT)

TOD:	119244139 119249740

SARA:

101538793(INMT) 101539242

SFUM:

130027518 130027664

SETR:

126025505 126025529

LAV:	100671921(INMT)

TMU:

101350596

ETF:	101652383(INMT)

DNM:	101412422(INMT)

OAA:	100081148(INMT)

TACU:

119936256(INMT)

ACS:

100553677

ASAO:

132782581 132782593 132782794

XLA:	108696501 108696502 108697004 108697006 108699501 379432(nnmt.L) 399013(inmt.L)

XTR:	100491548 496676(nnmt) 548447 594924(inmt)

NPR:	108799420 108799728 108799731

RTEM:

120915490 120915491 120915505 120915524 120926873 120926876

ACAT:

141111100 141111101 141111104 141111106 141111112 141127126 141127130 141128269 141128270

PADS:

140340415 140341099 140341289

BBUF:

120996795 120996849 120999241

BGAR:

122926837 122928942

DTC:	141075050 141097825 141097826 141098058

PWL:	138258044 138260410 138283319 138283321 138284995 138284997

MUO:	115481614 115481769 115481991

GSH:	117347473 117347493 117347584 117347883

BBEL:

109468493 109478432 109485111

SKO:

100367711

PFLL:

139117498 139117508 139122677 139130901 139131236 139131719 139131720 139138501 139139525 139144953 139144955

PCHN:

DSV:

CSCU:

CVS:

SDM:	118188870 118205359

NAI:	NECAME_02876

PVUL:

126812400

GAE:	121366614 121378382 121378383 121378452 121379017 121379235

HRF:

124145666

HRJ:	124258498 124265701 124265717

HASI:

137264908 137264909 137265153 137265915 137294335

HCRA:

139453049 139477855

MYI:

110462853

PMAX:

117341599

LAK:	106157416 106157421 106157433 106157912 106157913 106157914 106162346 106165307 106170527 106180314 106181959

LLON:

ADF:

AMIL:

MCAZ:

PDAM:

CCLM:

134189236 134194057 134194095

PBW:	D172_003270

» show all

Reference

PMID:10552930

Authors

Thompson MA, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM

Title

Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization.

Journal

Genomics 61:285-97 (1999)
DOI:10.1006/geno.1999.5960

Sequence

[hsa:11185]

LinkDB

ENZYME: 2.1.1.49

Entry

EC 2.1.1.49                 Enzyme

Name

amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:amine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:R02808]

Reaction(KEGG)

R02808 > R02174 R02910;
(other) R08537

Substrate

S-adenosyl-L-methionine [CPD:C00019];
amine [CPD:C00706]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
methylated amine [CPD:C02436]

Comment

An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.

History

EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)

Pathway

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K00562

methyltransferase

Genes

HSA:	11185(INMT)

PTR:	463912(INMT)

PPS:	100986665(INMT)

GGO:	101143120(INMT)

PON:	100171421(INMT)

PPYG:

129040473(INMT)

NLE:	100603670(INMT)

HMH:	116812596(INMT)

SSYN:

129490076(INMT)

MCC:	694969(INMT)

MCF:	102139220(INMT)

MTHB:

126950079

MNI:	105475814(INMT)

CSAB:

103226272(INMT)

CATY:

105596176(INMT)

PANU:

100998123(INMT)

TGE:	112620035(INMT)

MLEU:

105533692(INMT)

RRO:	104663737(INMT)

RBB:	108532381(INMT)

PTEH:

111522205(INMT)

CJC:	100387750(INMT)

SBQ:	101035075(INMT)

CIMI:

108303319(INMT)

ANAN:

105732855(INMT)

CSYR:

103254460(INMT)

MMUR:

105855099(INMT)

LCAT:

123646987(INMT)

ERUF:

138376962(INMT)

OGA:	100957733(INMT)

MMU:	21743(Inmt)

MCAL:

110296762(Inmt)

MPAH:

110317265(Inmt)

RNO:	368066(Inmt)

MCOC:

116098126(Inmt)

ANU:	117720797(Inmt)

ASYL:

127677462(Inmt)

MUN:	110555148(Inmt)

CGE:	100773805(Inmt)

MAUA:

101835859(Inmt)

PROB:

127235715(Inmt)

PLEU:

114689706(Inmt)

MORG:

121439573(Inmt)

MFOT:

126509501

AAMP:

119806657(Inmt)

NGI:	103729450(Inmt)

HGL:	101710622(Inmt) 106008943

CPOC:

100724009

NCAR:

124991696

MMMA:

107146148(Inmt)

ITI:	101963869(Inmt)

OCU:	100008695(INMT) 100338404

OPI:	101526879 101531959

OCZ:	121145759 121145857(INMT)

TUP:	102502473(INMT)

ORO:	105758206(INMT)

BTA:	527922(INMT)

BOM:	102270640(INMT)

BIU:	109557473(INMT)

BBUB:

102411712(INMT)

BBIS:

104980483(INMT)

CHX:

102186084

OAS:

101123289

BTAX:

128047032(INMT)

CSUM:

138080361

ODA:	120877395(INMT)

CCAD:

122438422(INMT)

MREE:

136171146(INMT)

OVR:	110142474(INMT)

MBEZ:

129552077(INMT)

SSC:	100512997(INMT)

CFR:	102503927 102504745

CBAI:

105081898(INMT) 105082129

CDK:	105095849 105106408 116154033

VPC:	102537199(INMT)

BACU:

103019292

BMUS:

118900898(INMT)

LVE:

103070876

OOR:	101284322(INMT)

LALB:

132524198(INMT)

GMF:	115853526(INMT)

DDP:	132430684(INMT)

DLE:	111180005(INMT)

PCAD:

102980842(INMT)

PSIU:

116759859(INMT)

PPHC:

136128583(INMT)

NASI:

112406305(INMT)

ECB:

100055070

EPZ:	103541247(INMT)

EAI:	106830978 106831065(INMT)

MNA:	107544372(INMT)

MJV:	108403655(INMT)

TOD:	119244139 119249740

SARA:

101538793(INMT) 101539242

SFUM:

130027518 130027664

SETR:

126025505 126025529

LAV:	100671921(INMT)

TMU:

101350596

ETF:	101652383(INMT)

DNM:	101412422(INMT)

OAA:	100081148(INMT)

TACU:

119936256(INMT)

ACS:

100553677

ASAO:

132782581 132782593 132782794

XLA:	108696501 108696502 108697004 108697006 108699501 379432(nnmt.L) 399013(inmt.L)

XTR:	100491548 496676(nnmt) 548447 594924(inmt)

NPR:	108799420 108799728 108799731

RTEM:

120915490 120915491 120915505 120915524 120926873 120926876

ACAT:

141111100 141111101 141111104 141111106 141111112 141127126 141127130 141128269 141128270

PADS:

140340415 140341099 140341289

BBUF:

120996795 120996849 120999241

BGAR:

122926837 122928942

DTC:	141075050 141097825 141097826 141098058

PWL:	138258044 138260410 138283319 138283321 138284995 138284997

MUO:	115481614 115481769 115481991

GSH:	117347473 117347493 117347584 117347883

BBEL:

109468493 109478432 109485111

SKO:

100367711

PFLL:

139117498 139117508 139122677 139130901 139131236 139131719 139131720 139138501 139139525 139144953 139144955

PCHN:

125036405

DSV:

119434542

CSCU:

111615693 111641734

CVS:

136987502

SDM:	118188870 118205359

NAI:	NECAME_02876

PVUL:

126812400

GAE:	121366614 121378382 121378383 121378452 121379017 121379235

HRF:

124145666

HRJ:	124258498 124265701 124265717

HASI:

137264908 137264909 137265153 137265915 137294335

HCRA:

139453049 139477855

MYI:

110462853

PMAX:

117341599

LAK:	106157416 106157421 106157433 106157912 106157913 106157914 106162346 106165307 106170527 106180314 106181959

LLON:

135483514

ADF:

107342266

AMIL:

114946916

MCAZ:

138049885

PDAM:

113682356

CCLM:

134189236 134194057 134194095

PBW:	D172_003270

» show all

Reference

1 [PMID:3949799]

Authors

Ansher SS, Jakoby WB.

Title

Amine N-methyltransferases from rabbit liver.

Journal

J Biol Chem 261:3996-4001 (1986)

Reference

2 [PMID:3377829]

Authors

Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.

Title

Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.

Journal

Biochem Pharmacol 37:1673-7 (1988)
DOI:10.1016/0006-2952(88)90426-1

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.49

IUBMB Enzyme Nomenclature:

2.1.1.49

ExPASy - ENZYME nomenclature database:

2.1.1.49

BRENDA, the Enzyme Database:

2.1.1.49

CAS:	51377-47-0 111694-10-1

LinkDB

REACTION: R02174

Entry

R02174                      Reaction

Name

S-adenosyl-L-methionine:amine N-methyltransferase

Definition

S-Adenosyl-L-methionine + Tryptamine <=> S-Adenosyl-L-homocysteine + N-Methyltryptamine

Equation

C00019 + C00398 <=> C00021 + C06213

Reaction class

RC00003

C00019_C00021

RC00060

C00398_C06213

Enzyme

2.1.1.49

Pathway

rn00380

Tryptophan metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.49
     R02174  S-Adenosyl-L-methionine + Tryptamine <=> S-Adenosyl-L-homocysteine + N-Methyltryptamine
IUBMB reaction hierarchy [BR:br08202]
2. Transferase reactions
  2.1.1.49
   R02808  Amine <=> Methylated amine
    R02174  Tryptamine <=> N-Methyltryptamine

Orthology

K00562

methyltransferase [EC:2.1.1.49 2.1.1.96]

LinkDB

DBGET integrated database retrieval system