Entry
Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:
R04631 R05941 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:
C00015 ];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
History
EC 2.4.1.62 created 1972, modified 2013
Pathway
ec00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ec00604 Glycosphingolipid biosynthesis - ganglio series
Orthology
K00715 ganglioside galactosyltransferase
K02175 beta-1,3-galactosyltransferase / beta-1,3-N-acetylglucosaminyltransferase
Genes
SHR : 100932392 105750445(B3GALT4)
ACS : 103280835 103280836 103281647
ASAO : 132766300(B3GALT4) 132766301 132766303 132780113
CTIG : 120318402 120318403
APRI : 131192785 131192788 131192789 131192792
PTEX : 113450372 113452891 113455095
PRAF : 128409556(B3GALT4) 128409557
STOW : 125424808 125424812
XLA : 108698545(b3galt4.L)
DRE : 101883911 101886595(b3galt4)
CCAR : 109078046 109078053 109078403
BPEC : 110156371 110158064(b3galt4)
STRU : 115166337 115168435(b3galt4)
OTW : 112215736 112222246(b3galt4)
OMY : 110492437(b3galt4) 110531971
OKE : 118361425 118370697(b3galt4)
SALP : 111966177 111977194
SNH : 120058757 120061656(b3galt4)
CCLU : 121537296 121545378(b3galt4)
SCLV : 120330808 120332862
DSI : Dsimw501_GD16669(Dsim_GD16669)
AALB : 109411046 115256312
ASUA : 134203214 134219275
CSET : 123317488 123317489
APLN : 108733038 112904194
MCIX : 123656879 123665532
PRAP : 110996374 110997620 110998479
LSIN : 126969642 126969804
SLIU : 111351040 111359277 111359853
FCD : 110845484 110845485 110846305 110856195 110862185
DMK : 116922454 123471529 123471540
PCHN : 125032776 125042967
PTRU : 123503416 123515942
PPOI : 119108919 119108920 119108923
DSV : 119432928 119448348 119455931
RSAN : 119378880 119404949
RMP : 119162043 119162045 119172723 119187537
VDE : 111247359 111249037 111249712 111252487
VJA : 111263934 111266965 111273729
CBR : CBG_06216(Cbr-bre-5)
BMY : BM_BM5757(Bma-bre-5)
CRG : 105322782 105331369 105332568 105334278 109620855 117684906 117692837
CANU : 128167023 128167578 128168344 128174851 128176387 128184818 128189687 128189818 128190103
CVN : 111118220 111134324 111135186
OED : 125648428 125651108 125655361 125655380 125665301 125669998 125671241 125683699
MYI : 110440246 110440864 110443682 110443698 110444412 110445052 110445909 110449420 110449421 110451039 110451742 110451752 110451782 110452065 110452229 110452234 110452238 110453247 110453258 110456350 110456822 110457161 110457668 110457671 110458134 110459672 110461148 110461707 110464579
PMAX : 117314790 117315091 117315382 117315401 117315822 117317336 117319939 117321246 117322795 117323873 117325181 117325182 117325183 117326096 117329749 117332397 117332555 117332783 117337888 117339598 117339809 117340743 117342078 117342795
SMM : Smp_014260 Smp_014280 Smp_151210
SHX : MS3_00007254(B3GALT1_3) MS3_00007265
OVI : T265_07747 T265_08677 T265_14897
LLON : 135498597 135498632 135501690 135503124
» show all
Taxonomy
Reference
Authors
Basu S, Kaufman B, Roseman S.
Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
Journal
J Biol Chem 240:4115-7 (1965)
Reference
Authors
Yip GB, Dain JA.
Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
Journal
Reference
Authors
Yip MC, Dain JA.
Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
LinkDB
All DBs