Entry
Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:
R04081 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:
C04656 ]
Product
GDP [CPD:
C00035 ];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC
2.4.1.344 ). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K00718 galactoside 2-L-fucosyltransferase 1/2
K12245 bifunctional glycosyltransferase PgtA
Genes
HSA : 2523(FUT1) 2524(FUT2)
PTR : 104001169 468944(FUT2) 468947(FUT1)
PPS : 100990363(FUT1) 100991035 103785330
GGO : 101131113(FUT1) 101146871
NLE : 100589182 100589750(FUT2) 100592672(FUT1)
MCC : 718252(FUT1) 718794 722582
MCF : 102121228 102121606 102125198(FUT1)
CSAB : 103234986 103234988 103234996(FUT1)
CATY : 105595250 105595251 105595255(FUT1)
PANU : 101013578 101015696(FUT2)
TGE : 112612788 112613043(FUT1) 112613472
RRO : 104666550(FUT1) 104666555 104666558
RBB : 108523627 108523645(FUT2) 108523649(FUT1)
TFN : 117091518 117091519 117091525(FUT1)
PTEH : 111520070 111520123(FUT2) 111520144(FUT1)
CJC : 100389529(FUT1) 100896666(FUT2)
SBQ : 101047116 101047433 101048065(FUT1)
CSYR : 103250047(FUT2) 103250056 103250472(FUT1)
MMUR : 105865666 105865678(FUT1) 105865687(FUT2) 105870481
OGA : 100948058(FUT1) 100948992 100959714(FUT2)
MMU : 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL : 110298382 110298509(Fut2) 110299147(Fut1)
MPAH : 110334098(Fut1) 110334752(Fut2) 110335813
RNO : 308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC : 116100499(Fut1) 116102215(Fut2) 116102218
MUN : 110550459 110550494 110550500(Fut1)
CGE : 100751185(Fut2) 100757047(Fut1) 113836307
PLEU : 114684672 114684692(Fut1) 114684704(Fut2)
NGI : 103743624 103743625 103743628(Fut1)
HGL : 101709834(Fut1) 101710190(Fut2)
CPOC : 100728677(Fut1) 100729517 100732186(Fut2)
CCAN : 109682667(Fut2) 109682669(Fut1) 109682676
DORD : 105994138 105994139 105994140 105994357 105994359 105994380(Fut1)
DSP : 122125587 122125760(Fut1) 122125806 122125807 122125827 122125850
NCAR : 124966644 124967481
OCU : 100009290(RFT-II) 100009291(FUT1) 100349124
OPI : 101528747(FUT2) 101533603(FUT1) 101534586
TUP : 102471780 102474609(FUT1)
CFA : 102151792 484396(FUT1) 484398(FUT2)
VVP : 112931221(FUT1) 112931228(FUT2)
VLG : 121484100 121485417(FUT1) 121485419(FUT2)
AML : 100472596 100478397(FUT1) 100478902(FUT2)
UMR : 103657100(FUT1) 103657240 103657242
UAH : 113243333(FUT1) 113243338(FUT2) 113243340
UAR : 123776277(FUT1) 123776296(FUT2) 123776330
ELK : 111160712 111160713 111160721
LLV : 125088646 125088954 125088957
MPUF : 101671692(FUT2) 101671981 101692582(FUT1)
ORO : 101374079(FUT1) 101374953(FUT2) 101375248
EJU : 114199504(FUT2) 114199506 114199624(FUT1)
ZCA : 113935287(FUT2) 113936331 113936763(FUT1)
MLX : 117998045(FUT2) 117998229 117998234(FUT1)
FCA : 101080847(FUT1) 101085847
PYU : 121018729(FUT2) 121018738(FUT1) 121026260
PBG : 122494860(FUT1) 122494868(FUT2) 122494869
PTG : 102962287(FUT2) 102969895(FUT1)
PPAD : 109253109(FUT1) 109253122(FUT2)
AJU : 106988654 106988710(FUT1) 113593452
HHV : 120240643(FUT2) 120240672 120243441(FUT1)
BTA : 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM : 102282547(FUT1) 102283305(FUT2) 102283588
BIU : 109572956 109573030(FUT2) 109573041(FUT1)
BBUB : 102393140 102395162(FUT1) 102410181
CHX : 102178850 102185028 102185596(FUT1)
OAS : 101107465 101108248(FUT1) 105608435
ODA : 120872177(FUT1) 120872179(FUT2) 120872184
CCAD : 122420846 122420957(FUT1) 122421650(FUT2)
SSC : 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
CFR : 102521344(FUT1) 102522076(FUT2) 102522586 116661616
CBAI : 105062593 105062594 105062601(FUT1)
CDK : 105090616 105102900(FUT1) 105102904 105102922
VPC : 102530733 102531228 107033936(FUT1)
LVE : 103080875(FUT2) 103081703(FUT1)
OOR : 101289320(FUT1) 101289561(FUT2)
DLE : 111180647(FUT1) 111180654(FUT2) 111180655
PCAD : 102973479(FUT1) 102996473(FUT2) 102996580
PSIU : 116744079 116744335(FUT1) 116744531(FUT2)
ECB : 100054216 100054259 100054308 100054499(FUT1)
EPZ : 103544534 103553324(FUT1) 103553326(FUT2)
EAI : 106838254(FUT2) 106838255 106838257(FUT1)
MYB : 102257351(FUT1) 102259445(FUT2)
MYD : 102760565(FUT2) 102767518 102768655(FUT1)
MMYO : 118655350 118655402(FUT2) 118655429(FUT1)
MLF : 102425138 102430088(FUT1) 102433448 102433757
MNA : 107531808(FUT2) 107531852(FUT1)
PKL : 118712167(FUT2) 118712169(FUT1) 118712177
HAI : 109391063(FUT2) 109391098(FUT1)
DRO : 112310077(FUT2) 112310079(FUT1)
AJM : 119043799(FUT1) 119044277(FUT2) 119059557
PDIC : 114511479 114511480 114511482(FUT1)
PHAS : 123830209(FUT1) 123830244 123830310(FUT2)
MMF : 118638875(FUT1) 118639085(FUT2) 118639300
RFQ : 117034335(FUT1) 117035221(FUT2)
PALE : 102885708(FUT1) 102886704(FUT2)
PGIG : 120606939(FUT1) 120606992(FUT2)
PVP : 105301801(FUT1) 105301804(FUT2)
RAY : 107498802(FUT2) 107498851(FUT1)
MJV : 108393134 108393209 108400331(FUT1)
TOD : 119249527 119249528 119249532(FUT1)
LAV : 100662459 100674697(FUT1) 100675832(FUT2)
TMU : 101356480 101358508 101359037
DNM : 101422926 101443440(FUT1) 101444337(FUT2)
MDO : 100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242
GAS : 123232152 123232153 123239882 123243077 123243086 123243105 123256126
SHR : 100930940 100931578(FUT1)
PCW : 110196105 110196106 110219782(FUT1)
OAA : 100080706 100085980 100681084
AMJ : 102565316 102575664(FUT2) 102577364
PSS : 102452892 102460361 102460609 106732458
CMY : 102930615 102930836 102941010
CPIC : 101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396
TST : 117888428 117888432 117888709 117888950 117888951
CABI : 116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142
MRV : 120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326
PMUA : 114583227 114583228 114583229 114583232 114583233 114583234
ZVI : 118078806 118095493 118095494 118095495 118095498 118095499
XLA : 108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR : 100487812 100493351(fut2) 100497569 447958(fut1)
NPR : 108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082
RTEM : 120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086
BBUF : 120986925 120998931 120999020 121002347 121002358
BGAR : 122926147 122926616 122926697 122926698 122926699
ARUT : 117411838 117414304 117414310 117414311 117414321 117962737 117971578
LCM : 102356194 102357968(FUT1)
CMK : 103173436 103183767 103183768 103183770
DPA : 109540163 109540165 109542888 109542896
APLN : 108734594 108734595 108734597 108744520
PPYR : 116173637 116173643 116174628
CSEC : 111866362 111869870
PVM : 113801332 113803224 113816156 113816158 113820062
PJA : 122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313
PCHN : 125040729 125041424 125041464 125041465 125042669 125047484
HAME : 121857928 121859712 121865565 121873191 121876429 121878319
PCLA : 123745380 123745839 123745855 123747543 123749803 123756248 123760817 123761082 123761209 123761439 123764310 123764311 123768844 123769133 123772508
PTRU : 123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469
HAZT : 108666313 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691
EAF : 111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736
CSCU : 111616725 111635294 111635298 111635299 111635300 111639905 111639907
PTEP : 107436408 107453824 107453825
HRO : HELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656
LGI : LOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229
PCAN : 112553292 112553375 112554855 112556519 112556940 112558077 112558225 112560251 112561425 112561426 112561558 112561583 112561593 112561915 112561979 112562553 112562695 112562762 112563041 112563042 112563043 112563185 112563308 112565210 112565435 112577325
BGT : 106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165
GAE : 121367132 121367171 121367798 121373000 121373417 121373567 121376740 121377211 121377523 121377693 121377714 121378014 121378114 121378115 121379170 121379733 121382570 121383128 121383519 121383834 121383835 121383836 121383936 121387311 121388888 121389756 121389757 121390104 121390458
HRF : 124112513 124117187 124117189 124117190 124117210 124119771 124119773 124121954 124121955 124121957 124121965 124124420 124127806 124128463 124131613 124132907 124133896 124133906 124140790 124140806 124140821 124143464 124145593 124145594 124145595 124145597 124145598 124145599 124149229 124152669 124152705 124152706
HRJ : 124254082 124256146 124257211 124257612 124257618 124257620 124258423 124258424 124258425 124260176 124261672 124264378 124264381 124264592 124267335 124268944 124268946 124268947 124270264 124273041 124273428 124273664 124273700 124282283 124284979 124285128 124292343
CRG : 105324924 105324936 105324937 105325455 105325959 105326082 105326310 105327892 105327909 105330520 105332175 105332210 105332678 105336015 109617642 109618315 109618713 117682678 117682679 117689798
MYI : 110441722 110443797 110446355 110446386 110447282 110447822 110450057 110450361 110452484 110452526 110452548 110452860 110453471 110455288 110460015 110464228 110464242 110464244 110466462 110466463 110466972
PMAX : 117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595
MMER : 123523565 123523771 123527929 123527930 123539602 123541860 123542355 123542382 123542599 123549943 123551987 123557094 123565920 123566230
OBI : 106868790 106869239 106871940 106875849 106877689
OSN : 115211963 115222189 115223466 115223552 115232568
LAK : 106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472
» show all
Taxonomy
Reference
Authors
Beyer TA, Hill RL.
Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5373-9 (1980)
Reference
Authors
Beyer TA, Sadler JE, Hill RL.
Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
Journal
J Biol Chem 255:5364-72 (1980)
Reference
Authors
Kumazaki T, Yoshida A
Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
Journal
Reference
Authors
Koda Y, Soejima M, Wang B, Kimura H
Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
Journal
Reference
Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
LinkDB
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