KEGG   ORTHOLOGY: K00718
Entry
K00718                      KO                                     
Symbol
FUT1_2
Name
galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
Pathway
map00601  Glycosphingolipid biosynthesis - lacto and neolacto series
map00603  Glycosphingolipid biosynthesis - globo and isoglobo series
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.69  type 1 galactoside alpha-(1,2)-fucosyltransferase
     K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Glycosyltransferases [BR:ko01003]
 Glycan extension
  ABO blood group
   K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Others
   Fucosyltransferase
    K00718  FUT1_2; galactoside 2-L-fucosyltransferase 1/2
Other DBs
RN: R05968 R06024 R06027 R06031 R06035 R06041 R06085 R06086 R06089 R06090 R06156 R06170
GO: 0008107
CAZy: GT11
Genes
HSA: 2523(FUT1) 2524(FUT2)
PTR: 104001169 468944(FUT2) 468947(FUT1)
PPS: 100990363(FUT1) 100991035 103785330
GGO: 101131113(FUT1) 101146871
PON: 100445051(FUT2)
NLE: 100589182 100589750(FUT2) 100592672(FUT1)
MCC: 718252(FUT1) 718794 722582
MCF: 102121228 102121606 102125198(FUT1)
CSAB: 103234986 103234988 103234996(FUT1)
CATY: 105595250 105595251 105595255(FUT1)
PANU: 101013578 101015696(FUT2)
RBB: 108523627 108523645(FUT2) 108523649(FUT1)
PTEH: 111520070 111520123(FUT2) 111520144(FUT1)
CJC: 100389529(FUT1) 100896666(FUT2)
CSYR: 103250047(FUT2) 103250056 103250472(FUT1)
OGA: 100948058(FUT1) 100948992 100959714(FUT2)
MMU: 14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL: 110298382 110298509(Fut2) 110299147(Fut1)
MPAH: 110334098(Fut1) 110334752(Fut2) 110335813
RNO: 308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC: 116100499(Fut1) 116102215(Fut2) 116102218
CGE: 100751185(Fut2) 100757047(Fut1) 113836307
PLEU: 114684672 114684692(Fut1) 114684704(Fut2)
HGL: 101709834(Fut1) 101710190(Fut2)
CPOC: 100728677(Fut1) 100729517 100732186(Fut2)
CCAN: 109682667(Fut2) 109682669(Fut1) 109682676
OCU: 100009290(RFT-II) 100009291(FUT1) 100349124
OPI: 101528747(FUT2) 101533603(FUT1) 101534586
TUP: 102471780 102474609(FUT1)
CFA: 102151792 484396(FUT1) 484398(FUT2)
VVP: 112931221(FUT1) 112931228(FUT2)
VLG: 121484100 121485417(FUT1) 121485419(FUT2)
AML: 100472596 100478397(FUT1) 100478902(FUT2)
UAH: 113243333(FUT1) 113243338(FUT2) 113243340
UAR: 123776277(FUT1) 123776296(FUT2) 123776330
MPUF: 101671692(FUT2) 101671981 101692582(FUT1)
ORO: 101374079(FUT1) 101374953(FUT2) 101375248
EJU: 114199504(FUT2) 114199506 114199624(FUT1)
ZCA: 113935287(FUT2) 113936331 113936763(FUT1)
MLX: 117998045(FUT2) 117998229 117998234(FUT1)
FCA: 101080847(FUT1) 101085847
PYU: 121018729(FUT2) 121018738(FUT1) 121026260
PBG: 122494860(FUT1) 122494868(FUT2) 122494869
PTG: 102962287(FUT2) 102969895(FUT1)
PPAD: 109253109(FUT1) 109253122(FUT2)
HHV: 120240643(FUT2) 120240672 120243441(FUT1)
BTA: 281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM: 102282547(FUT1) 102283305(FUT2) 102283588
BIU: 109572956 109573030(FUT2) 109573041(FUT1)
ODA: 120872177(FUT1) 120872179(FUT2) 120872184
CCAD: 122420846 122420957(FUT1) 122421650(FUT2)
SSC: 100524201(FUT2A) 397138(FUT1) 397139(FUT2)
BACU: 103015344(FUT1)
LVE: 103080875(FUT2) 103081703(FUT1)
OOR: 101289320(FUT1) 101289561(FUT2)
DLE: 111180647(FUT1) 111180654(FUT2) 111180655
PCAD: 102973479(FUT1) 102996473(FUT2) 102996580
PSIU: 116744079 116744335(FUT1) 116744531(FUT2)
EPZ: 103544534 103553324(FUT1) 103553326(FUT2)
EAI: 106838254(FUT2) 106838255 106838257(FUT1)
MYB: 102257351(FUT1) 102259445(FUT2)
MYD: 102760565(FUT2) 102767518 102768655(FUT1)
MMYO: 118655350 118655402(FUT2) 118655429(FUT1)
MNA: 107531808(FUT2) 107531852(FUT1)
PKL: 118712167(FUT2) 118712169(FUT1) 118712177
HAI: 109391063(FUT2) 109391098(FUT1)
DRO: 112310077(FUT2) 112310079(FUT1)
AJM: 119043799(FUT1) 119044277(FUT2) 119059557
PHAS: 123830209(FUT1) 123830244 123830310(FUT2)
MMF: 118638875(FUT1) 118639085(FUT2) 118639300
RFQ: 117034335(FUT1) 117035221(FUT2)
PALE: 102885708(FUT1) 102886704(FUT2)
PGIG: 120606939(FUT1) 120606992(FUT2)
PVP: 105301801(FUT1) 105301804(FUT2)
RAY: 107498802(FUT2) 107498851(FUT1)
SARA: 101558921(FUT1)
LAV: 100662459 100674697(FUT1) 100675832(FUT2)
DNM: 101422926 101443440(FUT1) 101444337(FUT2)
SHR: 100930940 100931578(FUT1)
CPOO: 109320810
ACS: 100561462(fut2)
PVT: 110078544(FUT2)
SUND: 121934331(FUT2)
PBI: 103053688(FUT2)
PMUR: 107282448(FUT2)
TSR: 106538382(FUT2)
PGUT: 117669071(FUT2)
VKO: 123032081(FUT2)
GJA: 107122202(FUT2)
XLA: 108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
LCM: 102356194 102357968(FUT1)
AARA: 120893372
CPII: 120417762
AME: 726095
ACER: 107996340
ALAB: 122712867
BIM: 100743109
BBIF: 117205737
BVK: 117230790
BVAN: 117166399
BTER: 100642421
BPYO: 122575423
CCAL: 108630635
OBB: 114874445
MGEN: 117229000
NMEA: 116431575
CGIG: 122405371
SOC: 105199316
MPHA: 105835366
AEC: 105148166
ACEP: 105624787
PBAR: 105431936
VEM: 105564089
HST: 105188950
DQU: 106741823
CFO: 105255117
FEX: 115240039
LHU: 105672546
PGC: 109852313
OBO: 105284978
PCF: 106790045
PFUC: 122518204
VPS: 122627880
NVI: 100116336
MDL: 103570941
CGLO: 123263839
FAS: 105263616
DAM: 107042564
AGIF: 122849782
CCIN: 107270440
TCA: 655912
SOY: 115885653
CSET: 123319092
AGB: 108917833
LDC: 111505639
NVL: 108559505
OTU: 111421329
FOC: 113208685
DMK: 116929405
SDM: 118190819
 » show all
Reference
PMID:2118655
  Authors
Larsen RD, Ernst LK, Nair RP, Lowe JB
  Title
Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.
  Journal
Proc Natl Acad Sci U S A 87:6674-8 (1990)
DOI:10.1073/pnas.87.17.6674
  Sequence
[hsa:2523]
Reference
PMID:7876235
  Authors
Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB
  Title
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
  Journal
J Biol Chem 270:4640-9 (1995)
DOI:10.1074/jbc.270.9.4640
  Sequence
[hsa:2524]
LinkDB

KEGG   ENZYME: 2.4.1.69
Entry
EC 2.4.1.69                 Enzyme                                 
Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R04081]
Reaction(KEGG)
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04656]
Product
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00718  galactoside 2-L-fucosyltransferase 1/2
K12245  bifunctional glycosyltransferase PgtA
Genes
HSA2523(FUT1) 2524(FUT2)
PTR104001169 468944(FUT2) 468947(FUT1)
PPS100990363(FUT1) 100991035 103785330
GGO101131113(FUT1) 101146871
PON100445051(FUT2)
NLE100589182 100589750(FUT2) 100592672(FUT1)
MCC718252(FUT1) 718794 722582
MCF102121228 102121606 102125198(FUT1)
CSAB103234986 103234988 103234996(FUT1)
CATY105595250 105595251 105595255(FUT1)
PANU101013578 101015696(FUT2)
TGE112612788 112613043(FUT1) 112613472
RRO104666550(FUT1) 104666555 104666558
RBB108523627 108523645(FUT2) 108523649(FUT1)
TFN117091518 117091519 117091525(FUT1)
PTEH111520070 111520123(FUT2) 111520144(FUT1)
CJC100389529(FUT1) 100896666(FUT2)
SBQ101047116 101047433 101048065(FUT1)
CSYR103250047(FUT2) 103250056 103250472(FUT1)
MMUR105865666 105865678(FUT1) 105865687(FUT2) 105870481
OGA100948058(FUT1) 100948992 100959714(FUT2)
MMU14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL110298382 110298509(Fut2) 110299147(Fut1)
MPAH110334098(Fut1) 110334752(Fut2) 110335813
RNO308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC116100499(Fut1) 116102215(Fut2) 116102218
MUN110550459 110550494 110550500(Fut1)
CGE100751185(Fut2) 100757047(Fut1) 113836307
PLEU114684672 114684692(Fut1) 114684704(Fut2)
NGI103743624 103743625 103743628(Fut1)
HGL101709834(Fut1) 101710190(Fut2)
CPOC100728677(Fut1) 100729517 100732186(Fut2)
CCAN109682667(Fut2) 109682669(Fut1) 109682676
DORD105994138 105994139 105994140 105994357 105994359 105994380(Fut1)
DSP122125587 122125760(Fut1) 122125806 122125807 122125827 122125850
NCAR124966644 124967481
OCU100009290(RFT-II) 100009291(FUT1) 100349124
OPI101528747(FUT2) 101533603(FUT1) 101534586
TUP102471780 102474609(FUT1)
CFA102151792 484396(FUT1) 484398(FUT2)
VVP112931221(FUT1) 112931228(FUT2)
VLG121484100 121485417(FUT1) 121485419(FUT2)
AML100472596 100478397(FUT1) 100478902(FUT2)
UMR103657100(FUT1) 103657240 103657242
UAH113243333(FUT1) 113243338(FUT2) 113243340
UAR123776277(FUT1) 123776296(FUT2) 123776330
ELK111160712 111160713 111160721
LLV125088646 125088954 125088957
MPUF101671692(FUT2) 101671981 101692582(FUT1)
ORO101374079(FUT1) 101374953(FUT2) 101375248
EJU114199504(FUT2) 114199506 114199624(FUT1)
ZCA113935287(FUT2) 113936331 113936763(FUT1)
MLX117998045(FUT2) 117998229 117998234(FUT1)
FCA101080847(FUT1) 101085847
PYU121018729(FUT2) 121018738(FUT1) 121026260
PBG122494860(FUT1) 122494868(FUT2) 122494869
PTG102962287(FUT2) 102969895(FUT1)
PPAD109253109(FUT1) 109253122(FUT2)
AJU106988654 106988710(FUT1) 113593452
HHV120240643(FUT2) 120240672 120243441(FUT1)
BTA281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM102282547(FUT1) 102283305(FUT2) 102283588
BIU109572956 109573030(FUT2) 109573041(FUT1)
BBUB102393140 102395162(FUT1) 102410181
CHX102178850 102185028 102185596(FUT1)
OAS101107465 101108248(FUT1) 105608435
ODA120872177(FUT1) 120872179(FUT2) 120872184
CCAD122420846 122420957(FUT1) 122421650(FUT2)
SSC100524201(FUT2A) 397138(FUT1) 397139(FUT2)
CFR102521344(FUT1) 102522076(FUT2) 102522586 116661616
CBAI105062593 105062594 105062601(FUT1)
CDK105090616 105102900(FUT1) 105102904 105102922
VPC102530733 102531228 107033936(FUT1)
BACU103015344(FUT1)
LVE103080875(FUT2) 103081703(FUT1)
OOR101289320(FUT1) 101289561(FUT2)
DLE111180647(FUT1) 111180654(FUT2) 111180655
PCAD102973479(FUT1) 102996473(FUT2) 102996580
PSIU116744079 116744335(FUT1) 116744531(FUT2)
ECB100054216 100054259 100054308 100054499(FUT1)
EPZ103544534 103553324(FUT1) 103553326(FUT2)
EAI106838254(FUT2) 106838255 106838257(FUT1)
MYB102257351(FUT1) 102259445(FUT2)
MYD102760565(FUT2) 102767518 102768655(FUT1)
MMYO118655350 118655402(FUT2) 118655429(FUT1)
MLF102425138 102430088(FUT1) 102433448 102433757
MNA107531808(FUT2) 107531852(FUT1)
PKL118712167(FUT2) 118712169(FUT1) 118712177
HAI109391063(FUT2) 109391098(FUT1)
DRO112310077(FUT2) 112310079(FUT1)
AJM119043799(FUT1) 119044277(FUT2) 119059557
PDIC114511479 114511480 114511482(FUT1)
PHAS123830209(FUT1) 123830244 123830310(FUT2)
MMF118638875(FUT1) 118639085(FUT2) 118639300
RFQ117034335(FUT1) 117035221(FUT2)
PALE102885708(FUT1) 102886704(FUT2)
PGIG120606939(FUT1) 120606992(FUT2)
PVP105301801(FUT1) 105301804(FUT2)
RAY107498802(FUT2) 107498851(FUT1)
MJV108393134 108393209 108400331(FUT1)
TOD119249527 119249528 119249532(FUT1)
SARA101558921(FUT1)
LAV100662459 100674697(FUT1) 100675832(FUT2)
TMU101356480 101358508 101359037
DNM101422926 101443440(FUT1) 101444337(FUT2)
MDO100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242
GAS123232152 123232153 123239882 123243077 123243086 123243105 123256126
SHR100930940 100931578(FUT1)
PCW110196105 110196106 110219782(FUT1)
OAA100080706 100085980 100681084
ASN102379237 102387217
AMJ102565316 102575664(FUT2) 102577364
CPOO109320810
PSS102452892 102460361 102460609 106732458
CMY102930615 102930836 102941010
CPIC101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396
TST117888428 117888432 117888709 117888950 117888951
CABI116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142
MRV120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326
ACS100561462(fut2)
PVT110078544(FUT2)
SUND121934331(FUT2)
PBI103053688(FUT2)
PMUR107282448(FUT2)
TSR106538382(FUT2)
PGUT117669071(FUT2)
VKO123032081(FUT2)
PMUA114583227 114583228 114583229 114583232 114583233 114583234
ZVI118078806 118095493 118095494 118095495 118095498 118095499
GJA107122202(FUT2)
XLA108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR100487812 100493351(fut2) 100497569 447958(fut1)
NPR108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082
RTEM120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086
BBUF120986925 120998931 120999020 121002347 121002358
BGAR122926147 122926616 122926697 122926698 122926699
ARUT117411838 117414304 117414310 117414311 117414321 117962737 117971578
LCM102356194 102357968(FUT1)
CMK103173436 103183767 103183768 103183770
RTP109912480 109915920
AARA120893372
CPII120417762
AME726095
ACER107996340
ALAB122712867
BIM100743109
BBIF117205737
BVK117230790
BVAN117166399
BTER100642421
BPYO122575423
CCAL108630635
OBB114874445
MGEN117229000
NMEA116431575
CGIG122405371
SOC105199316
MPHA105835366
AEC105148166
ACEP105624787
PBAR105431936
VEM105564089
HST105188950
DQU106741823
CFO105255117
FEX115240039
LHU105672546
PGC109852313
OBO105284978
PCF106790045
PFUC122518204
VPS122627880
NVI100116336
MDL103570941
CGLO123263839
FAS105263616
DAM107042564
AGIF122849782
CCIN107270440
TCA655912
DPA109540163 109540165 109542888 109542896
SOY115885653
ATD109606225 109609698
CSET123319092
AGB108917833
LDC111505639
NVL108559505
APLN108734594 108734595 108734597 108744520
PPYR116173637 116173643 116174628
OTU111421329
DCI103507867 103522072
PHUPhum_PHUM354220
FOC113208685
ZNE110826935 110834024
CSEC111866362 111869870
DPXDAPPUDRAFT_307215
DMK116929405
PVM113801332 113803224 113816156 113816158 113820062
PJA122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313
PCHN125040729 125041424 125041464 125041465 125042669 125047484
HAME121857928 121859712 121865565 121873191 121876429 121878319
PCLA123745380 123745839 123745855 123747543 123749803 123756248 123760817 123761082 123761209 123761439 123764310 123764311 123768844 123769133 123772508
PTRU123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469
HAZT108666313 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691
EAF111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736
CSCU111616725 111635294 111635298 111635299 111635300 111639905 111639907
PTEP107436408 107453824 107453825
SDM118190819
HROHELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656
LGILOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229
PCAN112553292 112553375 112554855 112556519 112556940 112558077 112558225 112560251 112561425 112561426 112561558 112561583 112561593 112561915 112561979 112562553 112562695 112562762 112563041 112563042 112563043 112563185 112563308 112565210 112565435 112577325
BGT106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165
GAE121367132 121367171 121367798 121373000 121373417 121373567 121376740 121377211 121377523 121377693 121377714 121378014 121378114 121378115 121379170 121379733 121382570 121383128 121383519 121383834 121383835 121383836 121383936 121387311 121388888 121389756 121389757 121390104 121390458
HRF124112513 124117187 124117189 124117190 124117210 124119771 124119773 124121954 124121955 124121957 124121965 124124420 124127806 124128463 124131613 124132907 124133896 124133906 124140790 124140806 124140821 124143464 124145593 124145594 124145595 124145597 124145598 124145599 124149229 124152669 124152705 124152706
HRJ124254082 124256146 124257211 124257612 124257618 124257620 124258423 124258424 124258425 124260176 124261672 124264378 124264381 124264592 124267335 124268944 124268946 124268947 124270264 124273041 124273428 124273664 124273700 124282283 124284979 124285128 124292343
CRG105324924 105324936 105324937 105325455 105325959 105326082 105326310 105327892 105327909 105330520 105332175 105332210 105332678 105336015 109617642 109618315 109618713 117682678 117682679 117689798
MYI110441722 110443797 110446355 110446386 110447282 110447822 110450057 110450361 110452484 110452526 110452548 110452860 110453471 110455288 110460015 110464228 110464242 110464244 110466462 110466463 110466972
PMAX117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595
MMER123523565 123523771 123527929 123527930 123539602 123541860 123542355 123542382 123542599 123549943 123551987 123557094 123565920 123566230
OBI106868790 106869239 106871940 106875849 106877689
OSN115211963 115222189 115223466 115223552 115232568
LAK106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472
DDIDDB_G0283761(pgtA)
DPPDICPUDRAFT_159362
DFADFA_01805(pgtA)
 » show all
Reference
1  [PMID:7372640]
  Authors
Beyer TA, Hill RL.
  Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5373-9 (1980)
Reference
2  [PMID:6246105]
  Authors
Beyer TA, Sadler JE, Hill RL.
  Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5364-72 (1980)
Reference
3  [PMID:6588382]
  Authors
Kumazaki T, Yoshida A
  Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
  Journal
Proc Natl Acad Sci U S A 81:4193-7 (1984)
DOI:10.1073/pnas.81.13.4193
Reference
4  [PMID:9219535]
  Authors
Koda Y, Soejima M, Wang B, Kimura H
  Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
  Journal
Eur J Biochem 246:750-5 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00750.x
Reference
5  [PMID:10589734]
  Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
  Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
  Journal
Microbiology 145 ( Pt 11):3245-53 (1999)
DOI:10.1099/00221287-145-11-3245
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
IUBMB Enzyme Nomenclature: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
BRENDA, the Enzyme Database: 2.4.1.69
CAS: 56093-23-3
LinkDB

KEGG   REACTION: R06027
Entry
R06027                      Reaction                               
Definition
GDP-L-fucose + nLc5Cer <=> GDP + Type II B antigen
Equation
Enzyme
2.4.1.-
Pathway
rn00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rn01100  Metabolic pathways
Orthology
K00718  galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
LinkDB

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