Entry
Name
(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase;
ganglioside GM2 synthase;
ganglioside GM3 acetylgalactosaminyltransferase;
GM2 synthase;
UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase;
GM2/GD2-synthase;
beta-1,4N-acetylgalactosaminyltransferase;
asialo-GM2 synthase;
GalNAc-T;
UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide [RN:
R04584 R05939 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:
C00203 ];
O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide
Product
UDP [CPD:
C00015 ];
O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide
Comment
This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 [3] and lactosylceramide [2] are also substrates, but glycoproteins and oligosaccharides are not substrates.
History
EC 2.4.1.92 created 1976, modified 2006
Pathway
ec00604 Glycosphingolipid biosynthesis - ganglio series
Orthology
K00725 (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
Genes
PPYG : 129009866(B4GALNT1)
SSYN : 129465668(B4GALNT1)
CSAB : 103238575(B4GALNT1)
CATY : 105587249(B4GALNT1)
PANU : 101005418(B4GALNT1)
MLEU : 105545605(B4GALNT1)
PTEH : 111541797(B4GALNT1)
CANG : 105500499(B4GALNT1)
CIMI : 108309735(B4GALNT1)
ANAN : 105729103(B4GALNT1)
CSYR : 103263166(B4GALNT1)
MMUR : 105877987(B4GALNT1)
LCAT : 123639596(B4GALNT1)
PCOQ : 105818113(B4GALNT1)
MCAL : 110302844(B4galnt1)
MPAH : 110326328(B4galnt1)
MCOC : 116075819(B4galnt1)
MAUA : 101833950(B4galnt1)
PROB : 127215677(B4galnt1)
PLEU : 114704807(B4galnt1)
MORG : 121457348(B4galnt1)
AAMP : 119803561(B4galnt1)
CPOC : 100719351(B4galnt1)
CCAN : 109686096(B4galnt1)
DORD : 105988581(B4galnt1)
PLOP : 125362144(B4galnt1)
MMMA : 107140121(B4galnt1)
CLUD : 112677966(B4GALNT1)
MPUF : 101692331(B4GALNT1)
PCOO : 112863779(B4GALNT1)
PVIV : 125170476(B4GALNT1)
PPAD : 109270387(B4GALNT1)
BBUB : 102409613(B4GALNT1)
BBIS : 104988128(B4GALNT1)
BTAX : 128047491(B4GALNT1)
CSUM : 138077861(B4GALNT1)
CCAD : 122427339(B4GALNT1)
MREE : 136167284(B4GALNT1)
MBEZ : 129536857(B4GALNT1)
CBAI : 105062135(B4GALNT1)
BACU : 103016988(B4GALNT1)
BMUS : 118902610(B4GALNT1)
PCAD : 102983599(B4GALNT1)
PSIU : 116760689(B4GALNT1)
NASI : 112394238(B4GALNT1)
MMYO : 118651334(B4GALNT1)
EFUS : 103292474(B4GALNT1)
SHON : 118975962(B4GALNT1)
PDIC : 114513768(B4GALNT1)
PHAS : 123812944(B4GALNT1)
PPAM : 129076029(B4GALNT1)
PALE : 102880239(B4GALNT1)
PGIG : 120604959(B4GALNT1)
SARA : 101557033(B4GALNT1)
SETR : 126022225(B4GALNT1)
PBRV : 138155188(B4GALNT1)
PMOA : 120499532(B4GALNT1)
PRUF : 121356353(B4GALNT1)
SATI : 136372705(B4GALNT1)
TALA : 116959221 122153816
CUCA : 128849472(B4GALNT1)
AROW : 112961595(B4GALNT1)
CPOO : 109324403(B4GALNT1)
CCAY : 125627745(B4GALNT1)
CPIC : 101945852(B4GALNT1)
CABI : 116818857(B4GALNT1)
ASAO : 132767715(B4GALNT1)
SUND : 121921249(B4GALNT1)
PMUR : 107294728(B4GALNT1)
CTIG : 120303310(B4GALNT1)
PGUT : 117666505(B4GALNT1)
APRI : 131190792(B4GALNT1)
PTEX : 113444822(B4GALNT1)
PMUA : 114592946(B4GALNT1)
PRAF : 128404881(B4GALNT1)
STOW : 125428050(B4GALNT1)
XLA : 108709867(b4galnt1.S) 379299(b4galnt1.L)
RTEM : 120929452(B4GALNT1)
BBUF : 120996074(B4GALNT1)
BGAR : 122932266(B4GALNT1)
DRE : 558684(b4galnt1a) 793635(b4galnt1b)
SRX : 107708855 107711068 107716216 107717192 107733607
SANH : 107667298 107667748 107673615 107681939 107695798
SGH : 107570598 107582708 107582953 107585207 107586541
CCAR : 109047493 109056959 109062280 109062741 109064114 109076424
CAUA : 113046700 113046702 113047614 113050355 113066542 113085425 113094168
CGIB : 127960243 128015731
PTET : 122329311(b4galnt1a) 122347215(b4galnt1b)
LROH : 127154383(b4galnt1a) 127167364(b4galnt1b)
OMC : 131531907(b4galnt1a) 131542433(b4galnt1b)
PPRM : 120463589(b4galnt1a) 120491381(b4galnt1b)
RKG : 130073611(b4galnt1a) 130087557(b4galnt1b)
MAMB : 125259537(b4galnt1a) 125273705(b4galnt1b)
CIDE : 127505109 127514749
CERY : 137009737(b4galnt1a) 137010688(b4galnt1b)
MASI : 127420175 127446676 127448647
TROS : 130556534(b4galnt1b) 130571996(b4galnt1a)
TDW : 130409795(b4galnt1a) 130425150(b4galnt1b)
MANU : 129431030(b4galnt1a) 129450290(b4galnt1b)
IPU : 108272210(b4galnt1b) 108276385 108276386 108276500
IFU : 128614781(b4galnt1b) 128619252 128619300
PHYP : 113530618 113530674 113530881 113545817(b4galnt1)
SMEO : 124390265(b4galnt1b)
TFD : 113658252(b4galnt1a) 113660538(b4galnt1b)
TVC : 132844148(b4galnt1b) 132862228(b4galnt1a)
TRN : 134316624(b4galnt1b) 134333845(b4galnt1a)
AMEX : 103039726(b4galnt1b) 103043708(b4galnt1a)
CMAO : 118808252(b4galnt1b) 118822707(b4galnt1a)
EEE : 113567787(b4galnt1) 113589183
CHAR : 105897319(b4galnt1a)
TRU : 101063785 101064428(b4galnt1)
TFS : 130524298(b4galnt1b) 130530174(b4galnt1a)
TNG : GSTEN00027252G001 GSTEN00027254G001 GSTEN00028095G001
LCO : 104931956(b4galnt1) 104932572
TBEN : 117490021(b4galnt1b) 117494271(b4galnt1a)
CGOB : 115008865(b4galnt1) 115010627
PGEO : 117447391(b4galnt1b) 117449311(b4galnt1a)
GACU : 117541879(b4galnt1a) 117551053(b4galnt1b)
EMAC : 134871250(b4galnt1a) 134882602(b4galnt1b)
ELY : 117257558(b4galnt1b) 117258938(b4galnt1a)
EFO : 125889274(b4galnt1b) 125891661(b4galnt1a)
PLEP : 121939030 121946469(b4galnt1a) 121950679(b4galnt1b)
SLUC : 116039006(b4galnt1a) 116041660(b4galnt1b)
ECRA : 117943914(b4galnt1b) 117947769(b4galnt1a)
ESP : 116688378(b4galnt1) 116692690
PFLV : 114554065(b4galnt1) 114559465
GAT : 120829097(b4galnt1a) 120835599(b4galnt1b)
PPUG : 119223254 119229857(b4galnt1b)
AFB : 129099881(b4galnt1a) 129105782(b4galnt1b)
CLUM : 117731019(b4galnt1b) 117734202(b4galnt1a)
PSWI : 130199399(b4galnt1a) 130208867(b4galnt1b)
CANA : 137796651(b4galnt1b) 137800435(b4galnt1a)
CVE : 137879584(b4galnt1b) 137889692(b4galnt1a)
MSAM : 119886148(b4galnt1b) 119905488(b4galnt1a)
SCHU : 122867054(b4galnt1b) 122883091(b4galnt1a)
CUD : 121504305 121506149(b4galnt1b) 121518213(b4galnt1a)
ALAT : 119020492(b4galnt1b) 119023434(b4galnt1a)
ASTR : 137594919(b4galnt1b) 137602895(b4galnt1a)
MZE : 101478170 101483501 112434815
ONL : 100701263(b4galnt1) 100705425
OAU : 116325820(b4galnt1a) 116333850(b4galnt1b)
OLA : 101155420(b4galnt1) 101171003
OML : 112145405(b4galnt1b) 112159647(b4galnt1a)
CSAI : 133448753(b4galnt1b) 133457191(b4galnt1a)
XMA : 102222577 102228614 102235034
XCO : 114135118 114135952 114148900
XHE : 116710988 116710989 116727168
PRET : 103465386(b4galnt1) 103467344
PFOR : 103132481 103133123 103141140 103147665
PLAI : 106939363 106941044 106950804
PMEI : 106908770 106909689 106920821 106920822
GAF : 122832697(b4galnt1a) 122834697 122834726(b4galnt1b)
PPRL : 129357775(b4galnt1b) 129372481(b4galnt1a)
CVG : 107082147(b4galnt1) 107086793
CTUL : 119776671(b4galnt1b) 119782168
GMU : 124856483(b4galnt1b) 124861330(b4galnt1a)
NFU : 107385684(b4galnt1) 107390873
KMR : 108228644(b4galnt1a) 108235553(b4galnt1b)
ALIM : 106518031(b4galnt1) 106524945
NWH : 119412559(b4galnt1b) 119416969(b4galnt1a)
AOCE : 111566651(b4galnt1) 111587243
EJA : 138193256(b4galnt1a) 138201361(b4galnt1b)
MCEP : 124996938(b4galnt1a) 125007198(b4galnt1b)
CSEM : 103385079 103385954(b4galnt1)
POV : 109629415(b4galnt1) 109630534
SSEN : 122768416(b4galnt1b) 122777098(b4galnt1a)
HHIP : 117761296(b4galnt1b) 117765024(b4galnt1a)
HSP : 118105510(b4galnt1b) 118111613(b4galnt1a)
PPLT : 128441744(b4galnt1a) 128452214(b4galnt1b)
SMAU : 118308945(b4galnt1b) 118316827(b4galnt1a)
LCF : 108876488(b4galnt1a) 108881464(b4galnt1b)
SDU : 111219289 111221963(b4galnt1)
SLAL : 111667834(b4galnt1) 111668982
XGL : 120783424(b4galnt1b) 120804023(b4galnt1a)
HCQ : 109522137(b4galnt1) 109531384
SSCV : 125976677(b4galnt1b) 125988023(b4galnt1a)
SBIA : 133505580(b4galnt1a) 133507139(b4galnt1b)
PEE : 133402341(b4galnt1a) 133409129(b4galnt1b)
PTAO : 133478538(b4galnt1a) 133483763(b4galnt1b)
BPEC : 110164780 110168375(b4galnt1)
MALB : 109968366 109972083
BSPL : 114856333(b4galnt1b) 114859002(b4galnt1a)
SJO : 128356009(b4galnt1b) 128357945(b4galnt1a)
SASA : 100306792(b4gn1) 106565528 106572659
STRU : 115150577 115165495 115207831
OTW : 112216357 112217564(b4galnt1b) 112254603
OMY : 110494320 110528114(b4galnt1b) 110532694
OGO : 124003500 124019822(b4galnt1b) 124032285
ONE : 115125666 115139823 115143172
OKI : 109891138 109904750 109907071
OKE : 118376214 118388567 118400293(b4galnt1b)
SALP : 111966771 111966811 111970082(b4galnt1)
SNH : 120058804 120061253 120065186
CCLU : 121537887 121575259 121577619
ELS : 105005742 105013542 105017218(b4galnt1)
SFM : 108918587(b4galnt1) 108939037
PKI : 111851086 111854415(b4galnt1) 111860628
AANG : 118207800 118211247(b4galnt1b)
PSPA : 121308998(b4galnt1b)
ARUT : 117401004 117967072
PSEX : 120524830(b4galnt1b)
LCM : 102353417 102354362(B4GALNT1)
CPLA : 122543394 122543431
LERI : 129714719 129714721(b4galnt1b)
PMRN : 116944255 116946880 116946891 116951224
LRJ : 133344966 133344967 133345076
BFO : 118403673 118404274 118409104 118410769 118413253 118413880 118413881 118416384 118420990 118423730 118424548 118427545 118429972 118431016 118431239
BBEL : 109462277 109467557 109468930 109469051 109469639 109470355 109471463 109472103 109472932 109473331 109474378 109474463 109475330 109478673 109482281 109484300 109486291
SKO : 100366571 100366802 100367188 100367258 100367410 100367566 100368131 100369117 100369900 100372465 100374186 100377850 100377910 100378876 102804391
» show all
Taxonomy
Reference
Authors
Dicesare JL, Dain JA.
Title
The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain.
Journal
Reference
Authors
Pohlentz G, Klein D, Schwarzmann G, Schmitz D, Sandhoff K.
Title
Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver.
Journal
Reference
Authors
Hidari JK, Ichikawa S, Furukawa K, Yamasaki M, Hirabayashi Y
Title
beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F.
Journal
Sequence
Reference
Authors
Hashimoto Y, Sekine M, Iwasaki K, Suzuki A.
Title
Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver.
Journal
J Biol Chem 268:25857-64 (1993)
Reference
Authors
Nagai K, Ishizuka I.
Title
Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain.
Journal
Reference
Authors
Furukawa K, Takamiya K, Furukawa K.
Title
Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides.
Journal
Reference
Authors
Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL.
Title
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.92
ExPASy - ENZYME nomenclature database: 2.4.1.92
LinkDB
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