Entry
Name
tyrosine transaminase;
tyrosine aminotransferase;
glutamic-hydroxyphenylpyruvic transaminase;
glutamic phenylpyruvic aminotransferase;
L-phenylalanine 2-oxoglutarate aminotransferase;
L-tyrosine aminotransferase;
phenylalanine aminotransferase;
phenylalanine transaminase;
phenylalanine-alpha-ketoglutarate transaminase;
phenylpyruvate transaminase;
phenylpyruvic acid transaminase;
tyrosine-alpha-ketoglutarate aminotransferase;
tyrosine-alpha-ketoglutarate transaminase;
tyrosine-2-ketoglutarate aminotransferase;
TyrAT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tyrosine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate [RN:
R00734 ]
Reaction(KEGG)
Substrate
Product
4-hydroxyphenylpyruvate [CPD:
C01179 ];
L-glutamate [CPD:
C00025 ]
Comment
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC
2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC
3.4.22.32 (stem bromelain) and EC
3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].
History
EC 2.6.1.5 created 1961
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec00270 Cysteine and methionine metabolism
ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
ec00950 Isoquinoline alkaloid biosynthesis
ec00960 Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00815 tyrosine aminotransferase
K00838 aromatic amino acid aminotransferase I / 2-aminoadipate transaminase
Genes
AJM : 119063105(TAT) 119065886
DNM : 101421111 101447466(TAT)
XLA : 108714054(tat.L) 443707(tat.S)
SRX : 107722456 107738398(tat)
SANH : 107666226 107684657
CGIB : 127934260 127977307
MASI : 127417269 127455909
SASA : 106560893 106573680
STRU : 115151894 115196871
OTW : 112218477 112252299(tat)
SALP : 111952487 111962314
SNH : 120053861(tat) 120066208
CCLU : 121531815 121576697
PSPA : 121296569 121325490
ARUT : 117424131 117425437(tat)
DSI : Dsimw501_GD17166(Dsim_GD17166)
AALB : 109410125 109427406
ASUA : 134205871 134211034
BCOO : 119069568 119070594
MSEX : 115451923 115451927
SLIU : 111362089 111362092
ATRA : 106143580 106143667
GMW : 113516969 128199984 128200384
CFEL : 113372367 113373478 113373480
CSCU : 111614404 111626752
PTEP : 107440345 107445588
ABRU : 129971349 129972343
LPOL : 106461800 106465145
CEL : CELE_F42D1.2(tatn-1)
CBR : CBG_07591(Cbr-tatn-1)
MAEA : 128243255 128243295
AMIL : 114953265 114954204
XEN : 124436093 124436602 124437500 124437501 124448997 124449634
TAD : TRIADDRAFT_33190 TRIADDRAFT_35383
ATH : AT2G24850(TAT3) AT4G23590 AT4G28410 AT4G28420 AT5G36160 AT5G53970(TAT7)
ALY : 110226039 9302085 9305575 9305843 9306540 9314873
CRB : 17875917 17877612 17879828 17880212 17880420 17880995
CSAT : 104707597 104716905 104716943 104717364 104717365 104720487 104722058 104722059 104722060 104725917 104729122 104730504 104730505 104731110 104732579 104737296 104761425 104785743
EUS : EUTSA_v10000170mg EUTSA_v10000482mg EUTSA_v10000548mg EUTSA_v10000557mg EUTSA_v10002017mg EUTSA_v10004290mg EUTSA_v10013642mg EUTSA_v10025166mg EUTSA_v10025195mg EUTSA_v10025293mg EUTSA_v10026801mg
BRP : 103842224 103842591 103852000 103854450 103858362 103861413 103861830 103868301
BNA : 106363727 106368591 106373574 106374529 106381241 106384874 106388375 106390270 106390999 106399847 106407706 106407707 106413506 106438398 106440999 111197947 125605521
BOE : 106292912 106296601 106306456 106307600 106310556 106327911 106332189
RSZ : 108807388 108810163 108813278 108818723 108820767 108835078 108836108 108839484 108841903 108846081 108852514 108853702 108854582 130502282 130508120
THJ : 104799934 104811878 104824693
CPAP : 110808937 110811978
CIT : 102611153 102612119 102612421 102612722 102617885 102619270
CIC : CICLE_v10008448mg CICLE_v10015280mg CICLE_v10015303mg CICLE_v10015356mg CICLE_v10015358mg CICLE_v10015371mg CICLE_v10017643mg
PVY : 116108241 116109455 116110061 116110346 116113296 116113302 116113319 116113368 116113370 116116910 116124917
MINC : 123195565 123195581 123195582 123195583 123195584 123200913 123219249
TCC : 18594061 18608750 18608751 18608756
GRA : 105782332 105784054 105794853 105794854
GHI : 107886791 107886792 107894135 107895254 107909272 107918502 107920617
GAB : 108461332 108461540 108474596 108474854
HSYR : 120121410 120122656 120144747 120149632 120159342 120163769 120164566 120175650
DZI : 111275860 111286878 111290950 111290961 111290976 111298478
EGR : 104440927 104448486 120288938
GMX : 100784392 100785132 100800830 732650
GSJ : 114374634 114378581 114416821 114416822
PVU : PHAVU_005G101300g PHAVU_011G157500g
CCAJ : 109788742 109817239
ADU : 107462233 107463070 107478096 107478521
AIP : 107613484 107613564 107629831 107630223
AHF : 112707148 112707762 112737703 112737991 112771508 112772365 112789831 112790135
LANG : 109325989 109353397
PCIN : 129312317 129312928 129313792 129314505
QSA : O6P43_000995 O6P43_000996 O6P43_028834 O6P43_029136
FVE : 101295974 101305385 101306248
RCN : 112168180 112188947 112188948 112189602
PPER : 18765981 18766018 18780545
PMUM : 103325999 103328397
PDUL : 117613186 117623311 117624312
MDM : 103405636 103448720 114824039
MSYL : 126588827 126610961 126610962 126614344
PXB : 103932694 103945451 103945452
ZJU : 107417315 107417411 107417412 107432580
MNT : 21393604 21393606 21395381
CSAV : 115698185 115698780 115699415 115699416
BHJ : 120087057 120089218 120089352
MCHA : 111010585 111017967 111017981
CMAX : 111469691 111469693 111469736 111469919 111480434
CMOS : 111446697 111451024 111451743 111451744 111451745
CPEP : 111789322 111794585 111794734 111795278 111795279
RCU : 8263465 8269138 8269139
MEAN : 126655006 126656123 126656124 126656192 126670685
JCU : 105637437 105646901 105646902
HBR : 110636295 110642734 110655282 110665423 110665424
MESC : 110611399 110612621 110627904 110629029 110629311
POP : 18106787 18106789 18106790 18106791 7459961 7462312
PEU : 105128901 105128906 105128909 105128910 105129245 105141957 105141958
PALZ : 118038355 118049844 118049846 118049847 118059576 118059577
JRE : 108988048 109007996 109007998 109012863 109017789
CILL : 122281928 122307496 122307497 122307847 122307879
CAVE : 132175586 132180545 132180547 132181414 132181756 132182777
QSU : 112000093 112000313 112001678 112012602 112013265 112013270
QLO : 115955637 115957610 115957997 115958534 115973365
TWL : 119981760 119982006 119990119 120004586
VVI : 100241782 100242005 100253895 100259032
VRI : 117909455 117927179 117927375 117927376 117927377
SLY : 101249935 101250231 101252470 101260030 101264863 101266674
SPEN : 107005550 107006026 107026348 107026415 107031866 107032620
SOT : 102578536 102584172 102586039 102586777 102590152 102594104 102606206
SSTN : 125862376 125862455 125866014 125866237 125875915 125875916 125875917 125877185
SDUL : 129876270 129877595 129882273 129889761 129892011 129892349
CANN : 107845345 107848959 107849753 107851104 107866734 107878340 107878341 107878342
LBB : 132602514 132614388 132617657 132617934 132618165 132618985 132627334 132628881
NTA : 107776772 107788787 107789747 107804312 107804314 107806169 107819268 107819272 107823705 107826261
NSY : 104211944 104211945 104213958 104228182 104241947
NTO : 104104119 104104136 104104148 104108282 104119618
NAU : 109221888 109223541 109227275 109227276 109230869 109239085 109240631
INI : 109188066 109188259 109188345
ITR : 116009845 116010592 116011470
SIND : 105165816 105178558
OEU : 111367454 111368893 111395464
SSPL : 121740889 121756020 121756428 121758245 121772289 121805018 121808555 121810483 121810810
SMIL : 131009242 131009243 131009245 131009249 131012426
SHIS : 125187248 125187295 125187371 125187372 125187373 125187852 125191168 125191380 125193857 125197065 125207629
APAN : 127247807 127248078 127266152 127266153
HAN : 110885705 110897482 110922226 110925732
ECAD : 122581868 122584673 122584674 122594339 122595461 122598211 122599611 122610911
LSV : 111884400 111906702 111906715 111906716 111906717 111916900 111919969
CCAV : 112500435 112500443 112516515 112524102 112524103 112524531 112524713 112525004 112525719 112527364
DCR : 108205473 108216623 108224044 108224339
CSIN : 114259507 114262236 114269984 114307352
RVL : 131323362 131324882 131324883 131329096
AEW : 130751012 130751420 130761651 130763007 130773880 130790158 130790620
BVG : 104883286 104883287 104891474 104893267
SOE : 110779131 110782785 110782786 110791586
CQI : 110683880 110686958 110700147 110700148 110732609
ATRI : 130801494 130809475 130821414
NNU : 104592560 104599456 104599457 104608160
MING : 122080293 122083545 122084327
TSS : 122640844 122651932 122651933 122651934 122651936
PSOM : 113287557 113308110 113318550 113334119 113335631 113335775 113341707 113341807 113348796 113350549 113352867 113353418
OSA : 4329098 4329101 4340970 4350712 4351017
OBR : 102710536 102714105 102717663 102721243
OGL : 127753960 127754893 127761245 127761539 127777133
BDI : 100822209 100825535 100828620 100841166
ATS : 109736601 109746718 109749918 109779912 109785695
TDC : 119285752 119295535 119316485 119318133 119322784 119323644 119331696 119335162 119363173
TAES : 123058708 123085991 123091579 123091651 123097263 123109698 123128624 123132659 123136751 123138505 123144236 123145756 123147760 123162344 123165172 123167180
TUA : 125514922 125517634 125523452 125546608 125546788 125548742 125551544 125554731
LPER : 127295420 127305733 127313798 127317529
LRD : 124664043 124685390 124685425 124688665 124693351 124698943 124702608 124703070
SBI : 110435496 110435653 8055490 8058608 8059342 8078226
ZMA : 100191816 100279205 100279999
MFLO : 136454772 136482254 136484153 136484309 136485218 136485557 136486179 136490086
SITA : 101755781 101758101 101769783 101770190 101771219 101782097 101785339
SVS : 117833356 117833371 117845643 117853535 117853884 117854015 117861201
PVIR : 120644669 120644672 120645152 120651530 120666035 120683289 120685027 120686869 120690745 120699231 120699299
PHAI : 112885573 112901542 112902250 112903204
PDA : 103698735 103702474 103719690
EGU : 105040940 105059924 105059989
MUS : 103977045 103978985 103999327
ZOF : 121982140 121986016 122032086 122034755
DCT : 110097323 110105401 110109169
AOF : 109822122 109823294 109829210 109829667 109840566 109840572
MSIN : 131241143 131245251 131245252 131245253
MPP : MICPUCDRAFT_25369(TAT)
CME : CYME_CMC034C CYME_CMT533C
GSL : Gasu_04500 Gasu_21880 Gasu_47920 Gasu_56640
AGO : AGOS_AFR548C AGOS_AGR167W
KLA : KLLA0_A04906g KLLA0_F10021g
KMX : KLMA_20259(ARO8) KLMA_50151(ARO8)
LTH : KLTH0E07678g KLTH0G02002g
NCS : NCAS_0E00670(NCAS0E00670)
NDI : NDAI_0I02830(NDAI0I02830)
TPF : TPHA_0D03370(TPHA0D03370)
TDL : TDEL_0D05790(TDEL0D05790)
KAF : KAFR_0D01420(KAFR0D01420)
KNG : KNAG_0B00660(KNAG0B00660)
ZMK : HG535_0B02410 HG535_0F03900
SLUD : SCDLUD_001488 SCDLUD_002357
PGU : PGUG_02078 PGUG_04621
LBG : 92209718(LODBEIA_P45220)
CAL : CAALFM_C200340CA(ARO8)
PKZ : C5L36_0A12110 C5L36_0E01100
BNN : FOA43_000076 FOA43_002087
BBRX : BRETT_001037 BRETT_003919
OPA : HPODL_01516 HPODL_01574
YLI : 2911847(YALI2_E01347g)
SMP : 10802715(SMAC4_04612)
PBEL : QC761_109500(ARO8_2)
PPSD : QC762_109500(ARO8_2)
PPSP : QC763_109500(ARO8_2)
PPSA : QC764_109500(ARO8_2)
FVR : FVEG_01416 FVEG_03489
FOX : FOXG_00100 FOXG_05640 FOXG_09911
NHE : NECHADRAFT_50127 NECHADRAFT_51829 NECHADRAFT_74483 NECHADRAFT_94787
FFC : NCS54_00056900 NCS54_00456400 NCS54_00907800 NCS54_01236800
FKR : NCS57_00055100 NCS57_00461400 NCS57_01226300 NCS57_01313200
FMU : J7337_000607 J7337_003508
TRE : TRIREDRAFT_105978 TRIREDRAFT_57322
TRR : M419DRAFT_7300 M419DRAFT_99227
TATV : 25776020(TrAtP1_002168) 25781476(TrAtP1_003907) 25784654(TrAtP1_010359)
TASP : 36607505(TrAFT101_000440) 36609378(TrAFT101_010894) 36611538(TrAFT101_003401)
AMUS : LMH87_008267 LMH87_012115
PLJ : 28885438(PLICBS_006998)
PTKZ : JDV02_001737(ARO8_1)
CFJ : CFIO01_05667 CFIO01_06036 CFIO01_12021
CLUP : CLUP02_05332 CLUP02_15557
SAPO : SAPIO_CDS0338 SAPIO_CDS3624
PFY : PFICI_00876 PFICI_05473 PFICI_07657 PFICI_08638
BFU : BCIN_07g04780(Bcaro8)
ANI : ANIA_04156 ANIA_06338
AOR : AO090020000444 AO090026000245
ANG : An02g00030 An02g05540
AFV : AFLA_006053 AFLA_006709 AFLA_010210
ALUC : AKAW2_21160S(ARO8_1) AKAW2_21604S
ACHE : ACHE_50803A(ARO8_2)
APUU : APUU_51301A(ARO8_2)
POU : POX_a00237 POX_a01329
TRG : TRUGW13939_05336 TRUGW13939_11796
PTRR : 6345839(PtrM4_141250) 6350080(PtrM4_056030)
FFU : CLAFUR5_06006 CLAFUR5_08181
NPA : UCRNP2_4527 UCRNP2_8015
SPO : 2538779(SPOM_SPCC569.07) 2540092(SPOM_SPBC1773.13) 2543350(SPOM_SPAC56E4.03)
SOM : SOMG_00046 SOMG_01863
CNE : CNB03000 CNB03180 CNF04620
CNB : CNBB2510 CNBB2710 CNBF0280
CNG : CNAG_03808 CNAG_03828 CNAG_05676 CNAG_06555
KMG : 30161020(I203_105390) 30164958(I203_108254) 30165767(I203_103244) 30166570(I203_100709)
KNE : 92177578(IAR55_000318) 92177622(IAR55_000362) 92181465(IAR55_004207) 92183232(IAR55_005974) 92184350(IAR55_007092)
TMS : TREMEDRAFT_64754 TREMEDRAFT_68672 TREMEDRAFT_71644
TASA : A1Q1_00184 A1Q1_05529 A1Q1_06907 A1Q1_07720
CCAC : CcaHIS019_0701480(CcaverHIS019_0701480) CcaHIS019_0705380(CcaverHIS019_0705380)
TVS : TRAVEDRAFT_133162 TRAVEDRAFT_56842
DSQ : DICSQDRAFT_135879 DICSQDRAFT_181832
PCO : PHACADRAFT_250454 PHACADRAFT_28172
SHS : STEHIDRAFT_120086 STEHIDRAFT_152122 STEHIDRAFT_170511 STEHIDRAFT_60514 STEHIDRAFT_80491
PSQ : PUNSTDRAFT_104522 PUNSTDRAFT_125467 PUNSTDRAFT_53871
ADL : AURDEDRAFT_114554 AURDEDRAFT_116968 AURDEDRAFT_130695 AURDEDRAFT_147363 AURDEDRAFT_54486 AURDEDRAFT_75410 AURDEDRAFT_93142
FME : FOMMEDRAFT_169725 FOMMEDRAFT_61360
GTR : GLOTRDRAFT_71756 GLOTRDRAFT_98301
ABP : AGABI1DRAFT113513(AGABI1DRAFT_113513)
ABV : AGABI2DRAFT191838(AGABI2DRAFT_191838)
MRR : Moror_12963 Moror_17465
SCM : SCHCO_02482695(SCHCODRAFT_02482695) SCHCO_02623001(SCHCODRAFT_02623001) SCHCO_02626718(SCHCODRAFT_02626718) SCHCO_02681983(SCHCODRAFT_02681983)
SLA : SERLADRAFT_356993(amt1) SERLADRAFT_414134 SERLADRAFT_475830
TET : TTHERM_00046180 TTHERM_00554320 TTHERM_00683360
PTM : GSPATT00000348001 GSPATT00003669001 GSPATT00006392001 GSPATT00009705001 PTMB.175c
FCY : FRACYDRAFT_250461(TAT1)
PSOJ : PHYSODRAFT_321944 PHYSODRAFT_537941
TCR : 508535.50 510187.20 510187.30 510187.40 510187.50 510187.70 510795.10 511461.20
LMAT : 92510407(LSCM1_00243) 92510409(LSCM1_00245) 92510410(LSCM1_00246)
» show all
Taxonomy
Reference
Authors
CANELLAKIS ZN, COHEN PP.
Title
Purification studies of tyrosine-alpha-ketoglutaric acid transaminase.
Journal
J Biol Chem 222:53-62 (1956)
Reference
Authors
CANELLAKIS ZN, COHEN PP.
Title
Kinetic and substrate specificity study of tyrosine-alpha-ketoglutaric acid transaminase.
Journal
J Biol Chem 222:63-71 (1956)
Reference
Authors
JACOBY GA, LADU BN.
Title
STUDIES ON THE SPECIFICITY OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE.
Journal
J Biol Chem 239:419-24 (1964)
Reference
Authors
KENNEY FT.
Title
Properties of partially purified tyrosine-alpha-ketoglutarate transaminase from rat liver.
Journal
J Biol Chem 234:2707-12 (1959)
Reference
Authors
Miller JE, Litwack G.
Title
Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase.
Journal
J Biol Chem 246:3234-40 (1971)
Reference
Authors
ROWSELL EV.
Title
Transaminations with L-glutamate and alpha-oxoglutarate in fresh extracts of animal tissues.
Journal
Reference
Authors
SENTHESHANMUGANATHAN S.
Title
The purification and properties of the tyrosine-2-oxoglutarate transaminase of Saccharomyces cerevisiae.
Journal
Reference
Authors
Heilbronn J, Wilson J, Berger BJ
Title
Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.5
ExPASy - ENZYME nomenclature database: 2.6.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.6.1.5
BRENDA, the Enzyme Database: 2.6.1.5
LinkDB
All DBs