KEGG   ORTHOLOGY: K00844
Entry
K00844                      KO                                     
Symbol
HK
Name
hexokinase [EC:2.7.1.1]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00051  Fructose and mannose metabolism
map00052  Galactose metabolism
map00500  Starch and sucrose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map00521  Streptomycin biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01250  Biosynthesis of nucleotide sugars
map04066  HIF-1 signaling pathway
map04910  Insulin signaling pathway
map04930  Type II diabetes mellitus
map04973  Carbohydrate digestion and absorption
map05131  Shigellosis
map05230  Central carbon metabolism in cancer
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
M00892  UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc
Reaction
R00299  ATP:D-glucose 6-phosphotransferase
R00760  ATP:D-fructose 6-phosphotransferase
R00867  ATP:D-fructose 6-phosphotransferase
R01326  ATP:D-mannose 6-phosphotransferase
R01600  ATP:beta-D-glucose 6-phosphotransferase
R01786  ATP:alpha-D-glucose 6-phosphotransferase
R01961  ATP:D-glucosamine 6-phosphotransferase
R03920  ATP:D-fructose 6-phosphotransferase
Disease
H00527  Retinitis pigmentosa
H00664  Anemia due to disorders of glycolytic enzymes
H02470  Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00844  HK; hexokinase
   00051 Fructose and mannose metabolism
    K00844  HK; hexokinase
   00052 Galactose metabolism
    K00844  HK; hexokinase
   00500 Starch and sucrose metabolism
    K00844  HK; hexokinase
   00520 Amino sugar and nucleotide sugar metabolism
    K00844  HK; hexokinase
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K00844  HK; hexokinase
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K00844  HK; hexokinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K00844  HK; hexokinase
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K00844  HK; hexokinase
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K00844  HK; hexokinase
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K00844  HK; hexokinase
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K00844  HK; hexokinase
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K00844  HK; hexokinase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00844  HK; hexokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     K00844  HK; hexokinase
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    K00844  HK; hexokinase
Other DBs
GO: 0004396
Genes
HSA: 3098(HK1) 3099(HK2) 3101(HK3) 80201(HKDC1)
PTR: 100614100 450504(HKDC1) 450505(HK1) 462298(HK3) 741291(HK2)
PPS: 100969639(HKDC1) 100969975(HK1) 100983149(HK2) 100990081(HK3) 100993163
GGO: 101125395(HK2) 101127052(HKDC1) 101131029(HK1) 101146050(HK3)
PON: 100172246(HK1) 100433183(HKDC1) 100458288(HK3) 100460834(HK2)
PPYG: 129006684(HK1) 129006686(HKDC1) 129024134 129030047(HK2) 129037450(HK3)
NLE: 100591401(HK3) 100593006(HK2) 100595352(HKDC1) 100595917(HK1)
HMH: 116458837(HKDC1) 116458853(HK1) 116471905(HK3) 116483233(HK2)
SSYN: 129461764(HK2) 129475469 129480585(HKDC1) 129480586(HK1) 129485964(HK3)
MCC: 698120(HK3) 710479(HK2) 711922(HK1) 711995(HKDC1)
MCF: 102121518(HK2) 102145864(HK1) 102147228(HKDC1) 107126374(HK3)
MNI: 105465311(HK2) 105466097(HK1) 105466098(HKDC1) 105484072(HK3)
CSAB: 103216074(HK1) 103216076(HKDC1) 103220012(HK2) 103245036(HK3)
CATY: 105581709(HK3) 105596876(HK2) 105597256(HKDC1) 105597257(HK1)
PANU: 101022816(HK3) 101024623(HK2) 101025527(HK1) 101026703(HKDC1)
TGE: 112604885(HK2) 112626931(HK3) 112631174(HK1) 112631439(HKDC1)
MLEU: 105544742(HK2) 105546723(HK3) 105547434(HKDC1) 105547435(HK1)
RRO: 104661961(HKDC1) 104661963(HK1) 104674833(HK2) 104680441(HK3)
RBB: 108530364(HK1) 108530366(HKDC1) 108531690(HK2) 108544799(HK3)
TFN: 117062074(HK2) 117065352(HK3) 117082732(HKDC1) 117082733(HK1) 117099756
PTEH: 111521608(HK3) 111523396(HK2) 111537778(HKDC1) 111537910(HK1)
CANG: 105501274(HKDC1) 105501286(HK1) 105514615(HK2) 105515118(HK3)
CJC: 100385141(HKDC1) 100396473(HK2) 100404624 100413117(HK1) 100415061(HK3)
SBQ: 101029285(HK3) 101047051(HK1) 101047634(HK2) 101049162(HKDC1)
CIMI: 108289332(HK2) 108292142(HK3) 108318125(HK1) 108318126(HKDC1)
ANAN: 105707132(HK3) 105716673(HK1) 105716693(HKDC1) 105717137(HK2)
CSYR: 103265048(HK3) 103267272(HK2) 103275697(HK1) 103275707(HKDC1)
MMUR: 105870209(HK1) 105870210(HKDC1) 105883841(HK3) 105884567(HK2)
LCAT: 123623473(HK3) 123637096(HK2) 123650431(HKDC1) 123650433(HK1)
PCOQ: 105821686(HK1) 105821696(HKDC1) 105823514(HK3) 105826871(HK2)
OGA: 100947200(HKDC1) 100959804(HK3) 100963430(HK2) 105886409(HK1)
MMU: 15275(Hk1) 15277(Hk2) 212032(Hk3) 216019(Hkdc1)
MCAL: 110296267(Hk2) 110302692(Hk1) 110303354(Hkdc1) 110307543(Hk3)
MPAH: 110314383(Hk2) 110326557(Hkdc1) 110326866(Hk1) 110334200(Hk3)
RNO: 100364027(Hkdc1) 25058(Hk1) 25059(Hk2) 25060(Hk3)
MCOC: 116074509(Hkdc1) 116075501(Hk1) 116081619(Hk3) 116099117(Hk2)
ANU: 117713920(Hk3) 117715071(Hk2) 117724458(Hkdc1) 117724695(Hk1)
MUN: 110549757(Hk3) 110561607(Hk2) 110563779(Hk1) 110563780(Hkdc1)
CGE: 100765413(Hk1) 100765703(Hkdc1) 100765901(Hk3) 100772205(Hk2)
MAUA: 101825158(Hk3) 101831511(Hk2) 101839646(Hkdc1) 101839911(Hk1)
PROB: 127224002(Hk1) 127224033(Hkdc1) 127229204(Hk3) 127235467(Hk2)
PLEU: 114689452(Hk3) 114694430(Hk2) 114704759(Hk1) 114704760(Hkdc1)
MORG: 121435398(Hk2) 121450606(Hk1) 121450966(Hkdc1) 121453383(Hk3)
AAMP: 119806784(Hk2) 119817811(Hk3) 119822689(Hk1) 119822980(Hkdc1)
NGI: 103726981(Hk2) 103729731(Hk1) 103729733(Hkdc1) 103745389(Hk3)
HGL: 101706410(Hk3) 101708521(Hkdc1) 101709130(Hk1) 101722401(Hk2)
CPOC: 100725134(Hk3) 100729828(Hkdc1) 100730936(Hk1) 100732658(Hk2)
CCAN: 109684938(Hkdc1) 109685239(Hk1) 109685772(Hk3) 109697922(Hk2)
DORD: 105985481(Hk3) 105986246(Hkdc1) 105986324(Hk1) 105999561(Hk2)
DSP: 122096516(Hk3) 122098737 122122251(Hk1) 122122283(Hkdc1) 122125146(Hk2)
PLOP: 125341869(Hk3) 125346404(Hkdc1) 125346406(Hk1) 125356388(Hk2)
MMMA: 107144712(Hk3) 107154239(Hk2) 107154825(Hk1) 107154826(Hkdc1)
OPI: 101516172(HK1) 101517233(HKDC1) 101518316(HK2) 101524409(HK3)
TUP: 102479777(HK3) 102493365(HK1) 102494607(HKDC1) 102499175(HK2)
GVR: 103593106(HK3) 103603194(HK1) 103603195(HKDC1) 103606289(HK2)
CFA: 100856448(HK2) 479234(HK1) 489019(HKDC1) 489096(HK3)
CLUD: 112651170(HK3) 112651623(HKDC1) 112651928(HK1) 112664264(HK2)
VVP: 112916701(HK2) 112923912(HKDC1) 112923920(HK1) 112925741(HK3)
VLG: 121486269(HKDC1) 121486645(HK3) 121486953(HK1) 121491114(HK2)
NPO: 129501364(HK2) 129509465(HK3) 129509549(HK1) 129509769(HKDC1) 129518136
AML: 100470774(HK2) 100475939(HKDC1) 100483014(HK3) 100483319(HK1)
UMR: 103664456(HK3) 103667783(HKDC1) 103668004(HK1) 103671429(HK2)
UAH: 113243430(HK2) 113259127(HKDC1) 113259128(HK1) 113264133(HK3)
UAR: 123782848(HK1) 123783032(HKDC1) 123786093(HK2) 123793926(HK3)
MPUF: 101671479(HK1) 101671950(HK3) 101672779(HKDC1) 101685139(HK2)
MNP: 132015224(HKDC1) 132016372(HK1) 132021415(HK2) 132028459(HK3)
MLK: 131828882(HK1) 131828884(HKDC1) 131831957(HK3) 131840346(HK2)
NVS: 122892422(HK3) 122900744(HKDC1) 122900745(HK1) 122915030(HK2)
ORO: 101373969(HK1) 101374267(HKDC1) 101383196(HK3) 101384043(HK2)
EJU: 114208634(HK3) 114214114(HK1) 114214160(HKDC1) 114218963(HK2)
ZCA: 113923473(HK1) 113923888(HKDC1) 113929631(HK3) 113937263(HK2)
NSU: 110588350(HK3) 110588874(HK2) 110589230(HKDC1) 110589652(HK1)
FCA: 101080358(HK3) 101089344(HK2) 101094295(HKDC1) 101098403(HK1)
PYU: 121011516(HK3) 121019208(HK2) 121036725(HK1) 121036727(HKDC1)
PCOO: 112854256(HKDC1) 112854661(HK1) 112860292(HK3) 112869712(HK2)
PBG: 122491733(HK3) 122492835(HK1) 122492836(HKDC1) 122497068(HK2)
PVIV: 125147781(HK1) 125147923(HKDC1) 125148831(HK3) 125162625(HK2)
PTG: 102952730(HK3) 102955671(HK1) 102956632(HKDC1) 102962533(HK2)
PPAD: 109263394(HK2) 109264349(HK1) 109264350(HKDC1) 109267563(HK3)
HHV: 120232483(HK1) 120232497(HKDC1) 120236784(HK3) 120237003(HK2)
BTA: 280817(HK1) 614824(HKDC1) 788926(HK2)
BOM: 102268099(HKDC1) 102270322(HK1) 102274810(HK2) 102275095(HK3)
BBUB: 102406489(HK1) 102407034(HKDC1) 102408948(HK3) 102414046(HK2)
BBIS: 104980872(HK2) 104997458(HKDC1) 104997459(HK1)
CHX: 102168356(HK2) 102182403(HK3) 102189736(HKDC1) 102190759(HK1)
OAS: 100036759(HK1) 101107690(HK2) 101107841(HKDC1) 101119209(HK3)
BTAX: 128047716(HKDC1) 128048870(HK1) 128055232(HK2)
ODA: 120851230(HK2) 120863872(HK3) 120865186(HK1) 120865189(HKDC1)
CCAD: 122440049(HK3) 122441464(HK2) 122446471(HK1) 122446730(HKDC1)
MBEZ: 129539870(HK2) 129555765(HK1) 129555768(HKDC1)
SSC: 100152344(HK1) 100153520(HKDC1) 100522855(HK3) 494561(HK2)
CFR: 102509660(HK1) 102509897(HKDC1) 102511221(HK3) 102518387(HK2)
CBAI: 105062047(HK3) 105066353(HK1) 105066355(HKDC1) 105067752(HK2)
CDK: 105085304(HK2) 105099579(HK3) 105099882(HK1) 105099884(HKDC1)
VPC: 102530131(HK1) 102532150(HK3) 102538146(HK2) 102539927(HKDC1)
BACU: 103000123(HK1) 103000583(HKDC1) 103005558(HK2) 103011120(HK3)
BMUS: 118882499(HK1) 118883066(HKDC1) 118906046(HK2)
LVE: 103077114(HK3) 103078924(HK2) 103085238(HK1) 103085507(HKDC1)
OOR: 101271458(HK1) 101271708(HKDC1) 101278255(HK2) 101281461(HK3)
DLE: 111169081(HK2) 111169843(HK3) 111183455(HKDC1) 111183456(HK1)
PSIU: 116741742(HK1) 116741744(HKDC1) 116750935(HK3) 116764077(HK2)
NASI: 112397869(HK3) 112403280(HK2) 112413526(HK1) 112413527(HKDC1)
ECB: 100009677(HK2) 100068725(HK3) 100072686(HKDC1) 100072687(HK1)
EPZ: 103549373(HK1) 103549388(HKDC1) 103557323(HK3) 103557674(HK2)
EAI: 106821924(HK3) 106835132(HK2) 106845014(HKDC1) 106845016(HK1)
MYB: 102243213(HK1) 102246049(HK2) 102259488(HK3) 102263651(HKDC1)
MYD: 102760926(HK3) 102762722(HKDC1) 102763004(HK1) 102767710(HK2)
MMYO: 118658712(HK3) 118668817(HK2) 118670089(HK1) 118670090(HKDC1)
MLF: 102417861(HK3) 102425498(HK2) 102426995(HKDC1) 102441041(HK1)
MDT: 132213166(HK2) 132214882(HK1) 132214883(HKDC1) 132235583(HK3)
PKL: 118711850(HK3) 118717581(HK2) 118719161(HKDC1) 118719162(HK1)
EFUS: 103287205(HK3) 103289509(HK1) 103289510(HKDC1) 103291385(HK2)
MNA: 107525054(HK3) 107526031(HK1) 107526078(HKDC1) 107529247(HK2)
DRO: 112302963(HK2) 112305499(HK1) 112305506(HKDC1) 112320357(HK3)
SHON: 118975417(HK1) 118975418(HKDC1) 118999734(HK3) 119000113(HK2)
AJM: 119038115(HK1) 119038131(HKDC1) 119038386(HK2) 119062960(HK3)
PDIC: 114496129(HK1) 114496733(HKDC1) 114499758(HK2) 114509614(HK3)
PHAS: 123810029(HK3) 123811416(HK2) 123820909(HK1) 123820910(HKDC1)
MMF: 118630629(HK2) 118632470(HKDC1) 118632471(HK1) 118644012(HK3)
PPAM: 129066336(HK3) 129069782(HKDC1) 129069925(HK1) 129086805(HK2)
HAI: 109371220(HK2) 109372136(HKDC1) 109372148(HK1) 109389785(HK3)
RFQ: 117016808(HK3) 117033209(HK2) 117035717(HKDC1) 117036227(HK1)
PALE: 102878115(HK3) 102892478(HK2) 102894665(HKDC1) 102898766(HK1)
PGIG: 120594630(HK2) 120609468(HKDC1) 120609469(HK1) 120616551(HK3)
PVP: 105290772(HK2) 105293519(HK3) 105300108(HKDC1) 105300133
RAY: 107502916(HK2) 107504088(HK1) 107504095(HKDC1) 107517523(HK3)
MJV: 108388525(HKDC1) 108389977(HK2) 108395133(HK1) 108402203(HK3)
TOD: 119234296(HKDC1) 119234535(HK1) 119236182(HK3) 119259107(HK2)
SARA: 101539958(HK3) 101546234(HKDC1) 101546493(HK1) 101547331(HK2)
SETR: 125994999(HKDC1) 126011928(HK3) 126024783(HK2) 126033517(HK1)
LAV: 100660114(HK2) 100661681(HK3) 100669094(HK1) 100677445(HKDC1)
DNM: 101420683(HK2) 101422567(HK3) 101429566 101440515(HKDC1)
MDO: 100015984(HKDC1) 100031311(HK1) 100031793(HK3) 100032849(HK2)
GAS: 123233019(HK1) 123234410 123235495(HK3) 123236995(HK2)
SHR: 100919294(HK3) 100926799(HK1) 100930478 116421983(HKDC1)
PCW: 110200049(HK1) 110200090(HKDC1) 110207611(HK2) 110216727(HK3)
TVP: 118828463(HK1) 118829452(HKDC1) 118843394(HK2) 118843921(HK3)
OAA: 100074718(HK2) 100079843(HK3) 100085443(HK1) 100088018(HKDC1)
GGA: 373889(HK1) 374044(HK2) 423698(HKDC1) 768421(HK3)
TPAI: 128076272 128078104(HK1) 128081670(HK3)
SCAN: 103817507(HK3) 103822724 103823724(HKDC1) 103823725(HK1)
GFR: 102031971(HK1) 102032137(HKDC1) 102042831(HK2) 102044178(HK3)
FAB: 101810322(HK2) 101813440(HK3) 101814475(HKDC1) 101814878(HK1)
CBRC: 103611551(HK3) 103622612(HK2) 103623619(HK1) 103623620
ZAB: 102066731(HKDC1) 102066912(HK1) 102067471(HK3) 102075049
ACHL: 103802944 103806257(HKDC1)
SATI: 136364418(HK1) 136364421 136367566(HK3) 136372452(HK2)
FPG: 101917382(HK3) 101918504(HK1) 101918678(HKDC1) 101919932(HK2)
FCH: 102055063(HK1) 102055236(HKDC1) 102055764(HK3) 102056548
CCRI: 104158540(HKDC1) 104167699(HK2) 104169031(HK1) 104169489
TALA: 104357108(HK3) 104360392(HKDC1) 104365546(HK1) 104368811
HALD: 104317561(HK1) 104319946(HKDC1) 104320094(HK2)
HLE: 104828909(GCK) 104839105(HK3) 104839582(HK1) 104839583(HKDC1)
LDI: 104341308(HK1) 104343957(HKDC1) 104343979(HK2) 104348088
MNB: 103770268 103773641(HK2) 103774854(HK1)
DPUB: 104298688(HK1) 104298689(HKDC1) 104303992(HK3) 104309449(HK2)
AVIT: 104272019(HK1) 104280046(HKDC1) 104281200
BRHI: 104493166(HK2) 104495701(HKDC1) 104499385(HK1)
EGZ: 104124621(HK1) 104124622(HKDC1) 104128868(HK3) 104130346(HK2)
NNI: 104013489(HKDC1) 104013490(HK1) 104017587(HK2) 104018992(HK3)
PCRI: 104023941(HK2) 104034122(HK1) 104035667(HKDC1)
PCAO: 104042146(HK1) 104046345 104049902(HKDC1)
PADL: 103918476(HK1) 103918477(HKDC1) 103918816(HK3) 103919658(HK2)
GSTE: 104255278(HK1) 104259983 104260732(HKDC1)
MUI: 104540648(HKDC1) 104541185(HK1) 104548379
PLET: 104620301 104621577(HKDC1) 104628395(HK1)
CMAC: 104474054(HK1) 104478710(HKDC1)
CUCA: 104063104 104063105(HK1) 104065319(HK2) 104065601(HK3)
BREG: 104634208 104636348(HK1) 104638278(HK2) 104643053(HKDC1)
OHA: 104331282 104338396(HKDC1) 104338397(HK1)
ACAR: 104524158 104528495(HKDC1) 104529267(HK1)
CPEA: 104386284(HKDC1) 104386305(HK1) 104390242(HK2) 104392672(HK3)
CVF: 104293464(HK2) 104294082(HK3) 104294237(HK1) 104294247(HKDC1)
DNE: 112986873(HK1) 112986876(HKDC1) 112990014 112996892(HK3)
SCAM: 104140560(HK2) 104144614(HK1) 104144624(HKDC1)
CPOO: 109310239(HK3) 109312472(HKDC1) 109312473(HK1) 109317350(HK2)
GGN: 109289823(HK3) 109290990(HK1) 109290991(HKDC1) 109295498(HK2)
CMY: 102930728(HK3) 102933769(HKDC1) 102934001 102942097(HK2)
CCAY: 125626497(HK2) 125639752(HK1) 125639753 125641257(HK3)
CPIC: 101931154(HK1) 101931432(HKDC1) 101943345 101948904(HK3)
TST: 117872900(HK2) 117880821(HKDC1) 117880822(HK1)
MRV: 120370352(HK3) 120397750 120409247(HK1) 120409248(HKDC1)
ACS: 100560089(hk3) 100564618 100566564(hkdc1) 100566756(hk1)
SUND: 121924101(HK3) 121925397 121925398(HKDC1) 121935123(HK2)
VKO: 123016795 123018408(HK1) 123018409(HKDC1)
PRAF: 128408053(HK3) 128413922(HK1) 128413925 128420069(HK2)
XLA: 100036846(hk2.L) 108696205 108697444 108710242 108711534(hkdc1.L) 108712774(hkdc1.S) 108713229(hk2.S) 394323(hk1.L)
DRE: 321224(hkdc1) 406339(hk2) 406791(hk1)
PTET: 122345156(hk2) 122356180(hkdc1) 122356181(hk1)
LROH: 127165050(hk2) 127174940(hkdc1) 127174942(hk1)
OMC: 131540510(hk2) 131552290(hkdc1) 131552291(hk1)
PPRM: 120469620(hk2) 120479693(hkdc1) 120479694(hk1)
RKG: 130088083(hk2) 130089706(hkdc1) 130089708(hk1)
MAMB: 125267357(hk2) 125276845(hkdc1) 125276846(hk1)
CERY: 137020512(hkdc1) 137020513(hk1) 137034924(hk2)
TROS: 130558884(hkdc1) 130558885(hk1) 130568615(hk2)
TDW: 130419046(hk2) 130431787(hkdc1) 130431788(hk1)
MANU: 129415414(hkdc1) 129415416(hk1) 129439740(hk2)
IFU: 128605926(hk1) 128605927 128625495(hk2)
SMEO: 124375821(hk1) 124375835(hkdc1) 124380564(hk2)
TFD: 113657219(hk2) 113661028(hkdc1) 113661029(hk1)
TVC: 132847514(hk1) 132847516(hkdc1) 132854367(hk2)
TRN: 134307771 134315254(hkdc1) 134335670(hk2)
AMEX: 103028521(hk1) 103036666(hk2) 103047009(hkdc1)
CMAO: 118810584(hk1) 118810585(hkdc1) 118826948(hk2)
PPRL: 129363995(hkdc1) 129363996(hk1) 129370572 129373065(hk2)
LCM: 102359026(HK3) 102363536(HK2) 102364429(HKDC1) 102364683(HK1)
LERI: 129704285 129704286(hk1) 129713428(hk2)
BFO: 118414727
BBEL: 109463192
AJC: 117102288
DME: Dmel_CG3001(Hex-A) Dmel_CG32849(Hex-t2) Dmel_CG33102(Hex-t1) Dmel_CG8094(Hex-C)
DSI: Dsimw501_GD21281(Dsim_Hex-t1) Dsimw501_GD21282(Dsim_Hex-t2) Dsimw501_GD24777(Dsim_GD24777) Dsimw501_GD25630(Dsim_GD25630)
DYA: Dyak_GE12255(Dyak_Hex-C) Dyak_GE17799(Dyak_Hex-A) Dyak_GE23668(Dyak_Hex-t1) Dyak_GE23669(Dyak_Hex-t2)
HIS: 119654823
AGA: 1270715
ACOZ: 120960075
AARA: 120905053
AMER: 121599173
ASTE: 118508206
AFUN: 125770021
AMOU: 128299361
AALI: 118467672
AAG: 5571932
ASUA: 134224442
CPII: 120423256
OBB: 114872100
OLG: 117603672
NMEA: 116432316
LHU: 105670888(Hex-A) 105671942
NVI: 100121683
CSOL: 105368881
TPRE: 106648956
FAS: 105274295
LDC: 111507602
DVV: 114343821
NVL: 108565519
APLN: 108740588
PPYR: 116162765
NIQ: 126772132
PPOT: 106103043
PBX: 123712986
PNAP: 125063007
CCRC: 123696913
CCRN: 123301681
CLEC: 106661784
BROR: 134539237
PCHN: 125027999
DFR: 124498523
PMEO: 129587747
CEL: CELE_F14B4.2(hxk-1)
CBR: CBG_19465
BMY: BM_BM12811(Bma-hxk-1.1)
TSP: Tsp_08386
LLON: 135494974
NVE: 5515074
EPA: 110238574
ATEN: 116303537
ADF: 107330418
AMIL: 114975924
DGT: 114516190
XEN: 124445024
HMG: 100212254
HSY: 130645631
RES: 135695943
AQU: 100639704
ATH: AT1G47840(HXK3) AT1G50460(HKL1) AT2G19860(HXK2) AT3G20040(ATHXK4) AT4G29130(HXK1) AT4G37840(HKL3)
SLY: 101249034 101256649 543638(Hxk2) 543779(hxk1) 778210(HXK3) 778211(HXK4)
OSA: 107275630(HXK10) 4324666(HXK5) 4326516(HXK3) 4326547(HXK2) 4326776(HXK4) 4338010(HXK6) 4339361(HXK5) 4339420(HXK2) 4342654(HXK4) 4343113(HXK1)
VCN: VOLCADRAFT_67129(hxk1)
APRO: F751_3201
SCE: YCL040W(GLK1) YDR516C(EMI2) YFR053C(HXK1) YGL253W(HXK2) YLR446W(NGK1)
KMX: KLMA_10051(GLK1) KLMA_60412(RAG5)
CGR: 2886356(GVI51_A04631) 2886595(GVI51_B00583) 2887872(GLK1) 2888498(HXK2) 2891598(GVI51_M00583)
NCS: NCAS_0A00340(NCAS0A00340) NCAS_0B08930(NCAS0B08930) NCAS_0E00180(NCAS0E00180) NCAS_0F04080(NCAS0F04080)
NDI: NDAI_0A00320(NDAI0A00320) NDAI_0B06350(NDAI0B06350) NDAI_0F04460(NDAI0F04460) NDAI_0I03320(NDAI0I03320) NDAI_0J02790(NDAI0J02790)
TPF: TPHA_0B01640(TPHA0B01640) TPHA_0B04850(TPHA0B04850) TPHA_0E03770(TPHA0E03770) TPHA_0G03730(TPHA0G03730)
TBL: TBLA_0A05050(TBLA0A05050) TBLA_0A07540(TBLA0A07540) TBLA_0B06320(TBLA0B06320) TBLA_0E00110(TBLA0E00110) TBLA_0I03540(TBLA0I03540)
TDL: TDEL_0C06700(TDEL0C06700) TDEL_0D06490(TDEL0D06490)
KAF: KAFR_0D00310(KAFR0D00310) KAFR_0E04210(KAFR0E04210) KAFR_0G01260(KAFR0G01260) KAFR_0J00110(KAFR0J00110) KAFR_0J02970(KAFR0J02970)
KNG: KNAG_0B06640(KNAG0B06640) KNAG_0C00400(KNAG0C00400) KNAG_0D03030(KNAG0D03030) KNAG_0F00230(KNAG0F00230) KNAG_0I00140(KNAG0I00140)
PIC: PICST_32526(NAG5) PICST_73701(GLK1) PICST_85453(HXK1)
LEL: PVL30_002616(HXK2) PVL30_002803(GLK1) PVL30_003153(NAG5)
LBG: 92206448(LODBEIA_P12520) 92206802(LODBEIA_P16060) 92206877(LODBEIA_P16810)
CTEN: 18246540(hxk1) 18246667(GLK1) 18250686(NAG5)
YLI: 2911808(YALI2_E00408g) 2912006(YALI2_E00309g)
SLB: AWJ20_2590(HXK2) AWJ20_361(GLK1) AWJ20_4024(HXK2)
NTE: NEUTE1DRAFT119084(NEUTE1DRAFT_119084) NEUTE1DRAFT126829(NEUTE1DRAFT_126829) NEUTE1DRAFT87040(NEUTE1DRAFT_87040)
SMP: 10803659(SMAC4_05818) 10805170(SMAC4_03834)
PBEL: QC761_106760(hxk1) QC761_115110(GLK1) QC761_408700(NAG5)
PPSD: QC762_106760(hxk1) QC762_115110(GLK1) QC762_408700(NAG5)
PPSP: QC763_106760(hxk1) QC763_115110(GLK1) QC763_408700(NAG5)
PPSA: QC764_106760(hxk1) QC764_115110(GLK1) QC764_408700(NAG5)
TATV: 25778004(TrAtP1_008775) 25779136(TrAtP1_012482) 25781055(TrAtP1_000777)
TASP: 36607648(TrAFT101_002662) 36612307(TrAFT101_010243) 36613471(TrAFT101_001631)
MAW: 19247286(hxk1_1) 19247807(NAG5_1) 90962753(hxk1_3) 90963836(J3458_019820)
MBRN: 26239789(hxkA_1) 26240607(hxkA_2) 26243007(glkA)
PLJ: 28882347(PLICBS_001616) 28884888(PLICBS_006086) 28887185(PLICBS_002458) 28892572(PLICBS_006402)
CDET: 87939487(CDEST_02984) 87940773(CDEST_04270) 87944313(CDEST_07810) 87945294(CDEST_08791)
PTRR: 6343656(PtrM4_110660) 6344528(PtrM4_047360) 6346435(PtrM4_151150) 6349764(PtrM4_001450)
SPO: 2542634(hxk1) 2543607(hxk2)
SOM: SOMG_02076(hxk1) SOMG_03633(hxk2)
CDEP: 91084683(L203_100467) 91086639(L203_102427)
KMG: 30162479(I203_101028) 30164981(I203_108277)
KNE: 92177582(IAR55_000322) 92179344(IAR55_002085)
CCAC: CcaHIS019_0302050(hxk1) CcaHIS019_0402390(CcaverHIS019_0402390)
ABP: AGABI1DRAFT114620(AGABI1DRAFT_114620) AGABI1DRAFT57808(AGABI1DRAFT_57808)
ABV: AGABI2DRAFT184646(AGABI2DRAFT_184646) AGABI2DRAFT194802(AGABI2DRAFT_194802)
SCM: SCHCO_02616310(SCHCODRAFT_02616310) SCHCO_02624360(SCHCODRAFT_02624360)
MGL: MGL_1289
MRT: MRET_2854
EHI: EHI_098290(77.t00021) EHI_098560(19.t00020)
PLAG: 39740855(PADL01_0622100)
PBRS: 92371820(MKS88_003733)
PREL: PRELSG_1124300(HK)
CPV: cgd6_3800
LMAT: 92514616(LSCM1_04603)
LOI: 92361600(LSCM4_05734) 92361601(LSCM4_05736)
LENR: 94173344(CUR178_06160) 94173345(CUR178_06161)
LEIN: 94188871(JIQ42_05233) 94188872(JIQ42_05234)
PHET: 94291046(JKF63_04999)
SCL: sce6033(hxk)
CCE: Ccel_3221
DRM: Dred_1810
DAE: Dtox_3946
HMO: HM1_0763
MHG: MHY_04720
PUF: UFO1_4440
PFT: JBW_00035
SOVA: SOV_37160
TPA: TP_0505
TPP: TPASS_0505(hxk)
TPB: TPFB_0505
TDE: TDE_2469
TPAA: TPLL2_0505
TPED: TPE_0072
BTH: BT_2430
BFR: BF2523
BXY: BXY_18040
PDI: BDI_1250
DORI: FH5T_05565
ANF: AQPE_4485
 » show all
Reference
  Authors
Kawai S, Mukai T, Mori S, Mikami B, Murata K
  Title
Hypothesis: structures, evolution, and ancestor of glucose kinases in the hexokinase family.
  Journal
J Biosci Bioeng 99:320-30 (2005)
DOI:10.1263/jbb.99.320
Reference
PMID:3207429
  Authors
Nishi S, Seino S, Bell GI
  Title
Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.
  Journal
Biochem Biophys Res Commun 157:937-43 (1988)
DOI:10.1016/s0006-291x(88)80964-1
  Sequence
[hsa:3098]
LinkDB

KEGG   ORTHOLOGY: K12407
Entry
K12407                      KO                                     
Symbol
GCK
Name
glucokinase [EC:2.7.1.2]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00052  Galactose metabolism
map00500  Starch and sucrose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map00521  Streptomycin biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01250  Biosynthesis of nucleotide sugars
map04910  Insulin signaling pathway
map04911  Insulin secretion
map04917  Prolactin signaling pathway
map04922  Glucagon signaling pathway
map04930  Type II diabetes mellitus
map04950  Maturity onset diabetes of the young
map05230  Central carbon metabolism in cancer
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
M00892  UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc
Reaction
R00299  ATP:D-glucose 6-phosphotransferase
R01600  ATP:beta-D-glucose 6-phosphotransferase
R01786  ATP:alpha-D-glucose 6-phosphotransferase
Disease
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
H01267  Familial hyperinsulinemic hypoglycemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12407  GCK; glucokinase
   00052 Galactose metabolism
    K12407  GCK; glucokinase
   00500 Starch and sucrose metabolism
    K12407  GCK; glucokinase
   00520 Amino sugar and nucleotide sugar metabolism
    K12407  GCK; glucokinase
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K12407  GCK; glucokinase
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K12407  GCK; glucokinase
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K12407  GCK; glucokinase
   04910 Insulin signaling pathway
    K12407  GCK; glucokinase
   04922 Glucagon signaling pathway
    K12407  GCK; glucokinase
   04917 Prolactin signaling pathway
    K12407  GCK; glucokinase
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K12407  GCK; glucokinase
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K12407  GCK; glucokinase
   04950 Maturity onset diabetes of the young
    K12407  GCK; glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.2  glucokinase
     K12407  GCK; glucokinase
Other DBs
GO: 0004340
Genes
HSA: 2645(GCK)
PTR: 737923(GCK)
PPS: 100979621(GCK)
GGO: 101138839(GCK)
PON: 100459152(GCK)
PPYG: 129040338(GCK)
NLE: 100591653(GCK)
HMH: 116812491(GCK)
SSYN: 129489968(GCK)
MCC: 699728(GCK)
MCF: 102127599(GCK)
MTHB: 126950167
MNI: 105494211(GCK)
CSAB: 103226145(GCK)
CATY: 105596912(GCK)
PANU: 101010803(GCK)
TGE: 112620869(GCK)
MLEU: 105541943(GCK)
RRO: 104671144(GCK)
RBB: 108544024(GCK)
TFN: 117073299(GCK)
PTEH: 111552288(GCK)
CANG: 105515056(GCK)
CJC: 100409392(GCK)
SBQ: 101027980(GCK)
CIMI: 108293813(GCK)
ANAN: 105708075(GCK)
CSYR: 103259589(GCK)
MMUR: 105858409(GCK)
LCAT: 123647605(GCK)
PCOQ: 105812466(GCK)
OGA: 100954843(GCK)
MMU: 103988(Gck)
MCAL: 110305090(Gck)
MPAH: 110330598(Gck)
RNO: 24385(Gck)
MCOC: 116068614(Gck)
ANU: 117712800(Gck)
MUN: 110546096(Gck)
CGE: 100763110(Gck)
MAUA: 101839629(Gck)
PROB: 127233921(Gck)
PLEU: 114693980(Gck)
MORG: 121459576(Gck)
MFOT: 126500978
AAMP: 119820164(Gck)
NGI: 103734982(Gck)
HGL: 101721664(Gck)
CPOC: 100717630(Gck)
CCAN: 109685901(Gck)
DORD: 105998283(Gck)
DSP: 122128065(Gck)
PLOP: 125345524(Gck)
NCAR: 124990937
MMMA: 107146217(Gck)
OCU: 100341946
OPI: 101521696(GCK)
TUP: 102492140(GCK)
GVR: 103592964(GCK)
CFA: 606490(GCK)
CLUD: 112650698(GCK)
VVP: 112911707(GCK)
VLG: 121489105(GCK)
NPO: 129515614(GCK)
AML: 100475738(GCK)
UMR: 103674684(GCK)
UAH: 113257909(GCK)
UAR: 123789458(GCK)
LLV: 125081245
MPUF: 101680613(GCK)
MNP: 132016358(GCK)
NVS: 122905382(GCK)
ORO: 101383256(GCK)
EJU: 114202278(GCK)
ZCA: 113911462(GCK)
MLX: 118024577(GCK)
NSU: 110592634(GCK)
LWW: 102732079(GCK)
FCA: 100037406(GCK)
PYU: 121016941(GCK)
PBG: 122487627(GCK)
PVIV: 125153345(GCK)
LRUF: 124524269
PTG: 102965436(GCK)
PPAD: 109267871(GCK)
PUC: 125929733
AJU: 106968236
HHV: 120238910(GCK)
BTA: 616576(GCK)
BOM: 102277785(GCK)
BIU: 109557544(GCK)
BBUB: 102398970(GCK)
BBIS: 104980380(GCK)
CHX: 102185429(GCK)
OAS: 101117412(GCK)
BTAX: 128046290(GCK)
ODA: 120877500(GCK)
CCAD: 122438530(GCK)
MBEZ: 129552565(GCK)
SSC: 100514142(GCK)
CFR: 102506850(GCK)
CBAI: 105080693(GCK)
CDK: 105092330(GCK)
VPC: 102535882(GCK)
BACU: 103004735(GCK)
BMUS: 118901272(GCK)
LVE: 103074175(GCK)
OOR: 101286839(GCK)
DLE: 111184513(GCK)
PCAD: 102974757(GCK)
PSIU: 116759611(GCK)
NASI: 112401344(GCK)
ECB: 100051836
EPZ: 103554943(GCK)
EAI: 106822865
MYB: 102261259(GCK)
MYD: 102757162(GCK)
MMYO: 118665862(GCK)
MLF: 102436756(GCK)
MDT: 132211242(GCK)
PKL: 118717989(GCK)
EFUS: 103303605(GCK)
MNA: 107542054(GCK)
DRO: 112306978(GCK)
SHON: 118983459(GCK)
AJM: 119052877
PDIC: 114490225(GCK)
PHAS: 123811692(GCK)
MMF: 118619794(GCK)
PPAM: 129068867(GCK)
HAI: 109373004(GCK)
RFQ: 117012405(GCK)
PALE: 102884319(GCK)
PGIG: 120589556(GCK)
PVP: 105308746(GCK)
RAY: 107512383(GCK)
MJV: 108394025(GCK)
TOD: 119253142(GCK)
SARA: 101537755(GCK)
SETR: 126031378(GCK)
LAV: 100658238(GCK)
TMU: 101346854
ETF: 101638924
DNM: 101429195(GCK)
MDO: 100030125(GCK)
GAS: 123235027(GCK)
SHR: 100918168(GCK)
AFZ: 127548834
PCW: 110206409(GCK)
TVP: 118843668(GCK)
GGA: 430370(GCK)
PCOC: 116231330(GCK)
MGP: 100546168(GCK)
CJO: 107323664(GCK)
TPAI: 128090214(GCK)
LMUT: 125685174(GCK)
NMEL: 110387119(GCK)
APLA: 119715227(GCK)
ACYG: 125180994(GCK)
CATA: 118260953(GCK)
TGU: 100222236(GCK)
LSR: 110478293(GCK)
SCAN: 108963196(GCK)
PMOA: 120504999(GCK)
OTC: 121346673(GCK)
PRUF: 121359823(GCK)
GFR: 102040748(GCK)
FAB: 101821944(GCK)
OMA: 130261867(GCK)
PHI: 102105464(GCK)
PMAJ: 107213875(GCK)
CCAE: 111938902(GCK)
CCW: 104683184(GCK)
CBRC: 103620169(GCK)
ETL: 114071694(GCK)
ZAB: 102060530
ZLE: 135457029(GCK)
ACHL: 103801984(GCK)
SVG: 106862426(GCK)
MMEA: 130585276(GCK)
HRT: 120764125(GCK)
SATI: 136372457(GCK)
FPG: 101920472(GCK)
FCH: 102058018(GCK)
CCRI: 104166344(GCK)
SHAB: 115618479(GCK)
TALA: 104368397(GCK)
ACHC: 115349907(GCK)
AGEN: 126051542
GCL: 127028242
DPUB: 104305272(GCK)
EGZ: 104122939(GCK)
NNI: 104022603(GCK)
AFOR: 103904193(GCK)
CLV: 102084067(GCK)
PLET: 104626588(GCK)
CUCA: 104067003(GCK)
CPEA: 104391564(GCK)
CVF: 104285069(GCK)
RTD: 128919625(GCK)
AAM: 106494575(GCK)
AROW: 112971124(GCK)
NPD: 112950360(GCK)
TGT: 104576790(GCK)
DNE: 112995687(GCK)
SCAM: 104148918(GCK)
ASN: 102373336(GCK)
AMJ: 102558588(GCK)
PSS: 102457711(GCK)
CMY: 102932759(GCK)
CCAY: 125626430(GCK)
DCC: 119848667(GCK)
CPIC: 101935155(GCK)
TST: 117872865(GCK)
CABI: 116815260(GCK)
MRV: 120399219(GCK)
ACS: 100554306(gck)
ASAO: 132782762(GCK)
PVT: 110084342(GCK)
SUND: 121934329(GCK)
PBI: 103062255(GCK)
PMUR: 107286239(GCK)
CTIG: 120313940(GCK)
TSR: 106547695(GCK)
PGUT: 117677051(GCK)
APRI: 131203815(GCK)
PTEX: 113447689(GCK)
NSS: 113414477(GCK)
VKO: 123027051(GCK)
PMUA: 114585937(GCK)
PRAF: 128403174(GCK)
ZVI: 118096834(GCK)
HCG: 128333931(GCK)
GJA: 107117392(GCK)
STOW: 125442282(GCK)
EMC: 129342642(GCK)
XLA: 108712732(gck.S) 378602(gck.L)
XTR: 100124905(gck)
NPR: 108796074(GCK)
RTEM: 120933060(GCK)
BBUF: 120986169(GCK)
BGAR: 122929466(GCK)
MUO: 115469274(GCK)
GSH: 117362228(GCK)
DRE: 751668(gck)
PTET: 122350055(gck)
LROH: 127169121(gck)
PPRM: 120473515(gck)
RKG: 130081876(gck)
MAMB: 125280380(gck)
CIDE: 127518029
CERY: 137026559(gck)
TROS: 130567946(gck)
TDW: 130440187(gck)
MANU: 129414448(gck)
IPU: 108265751
IFU: 128607372(gck)
PHYP: 113546126(gck)
SMEO: 124399852(gck)
TFD: 113645911(gck)
TVC: 132853816(gck)
TRN: 134318454(gck)
AMEX: 103039737(gck)
CMAO: 118813216(gck)
EEE: 113588677(gck)
CHAR: 105903589(gck)
TRU: 101063910(gck)
TFS: 130525356(gck)
LCO: 104922970(gck)
NCC: 104956790(gck)
TBEN: 117472657(gck)
CGOB: 115013132(gck)
PGEO: 117452731(gck)
GACU: 117560230(gck)
EMAC: 134873291(gck)
ELY: 117252119(gck)
EFO: 125890055(gck)
PLEP: 121944522(gck)
SLUC: 116054258(gck)
ECRA: 117945488(gck)
ESP: 116689629(gck)
PFLV: 114555604(gck)
GAT: 120830946(gck)
PPUG: 119225324(gck)
AFB: 129101072(gck)
CLUM: 117736413
PSWI: 130197289(gck)
MSAM: 119891486(gck)
SCHU: 122876290(gck)
ALAT: 119019390(gck)
ASTR: 137592740(gck)
MZE: 101465626(gck)
ONL: 100695414(gck)
OAU: 116310976(gck)
OLA: 101168372(gck)
OML: 112148443(gck)
CSAI: 133450701(gck)
XMA: 102229323(gck)
XCO: 114154034(gck)
XHE: 116729225(gck)
PRET: 103470005(gck)
PFOR: 103145883(gck)
PLAI: 106962841(gck)
PMEI: 106929044(gck)
GAF: 122828774(gck)
PPRL: 129365946(gck)
CVG: 107089653(gck)
CTUL: 119778162(gck)
GMU: 124878136(gck)
NFU: 107394278(gck)
KMR: 108233647(gck)
ALIM: 106519906(gck)
NWH: 119413856(gck)
AOCE: 111567820(gck)
MCEP: 125012328(gck)
CSEM: 103397747(gck)
POV: 109637065(gck)
SSEN: 122769013(gck)
HHIP: 117767207(gck)
HSP: 118115140(gck)
PPLT: 128438522(gck)
SMAU: 118313627(gck)
LCF: 108881204
SDU: 111236443(gck)
SLAL: 111654902(gck)
XGL: 120805335(gck)
HCQ: 109526325(gck)
SSCV: 125994079
SBIA: 133498866(gck)
PEE: 133400604(gck)
PTAO: 133475114(gck)
BPEC: 110153979(gck)
MALB: 109956568(gck)
BSPL: 114862260(gck)
SJO: 128365387(gck)
SASA: 106580581(gk) 106585167
SALP: 111957731 111974003(gck)
ELS: 105014407(gck)
SFM: 108932222 108940338(gck)
PKI: 111861171(gck)
AANG: 118206764(gck) 118212896
LOC: 102694132(gck)
ARUT: 117397918(gck)
PSEX: 120538964(gck)
LCM: 102364718(GCK)
CMK: 103187782(gck)
RTP: 109932925(gck)
CPLA: 122543099(gck)
HOC: 132836906(gck)
LERI: 129713266(gck)
PMRN: 116940633(GCK)
LRJ: 133343469(GCK)
TDA: 119677820
ECOE: 129949262
API: 103310688
 » show all
Reference
  Authors
Iynedjian PB
  Title
Molecular physiology of mammalian glucokinase.
  Journal
Cell Mol Life Sci 66:27-42 (2009)
DOI:10.1007/s00018-008-8322-9
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