KEGG   ORTHOLOGY: K01116
Entry
K01116                      KO                                     
Symbol
PLCG1
Name
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04070  Phosphatidylinositol signaling system
map04072  Phospholipase D signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04919  Thyroid hormone signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05012  Parkinson disease
map05022  Pathways of neurodegeneration - multiple diseases
map05110  Vibrio cholerae infection
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05135  Yersinia infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Reaction
R03332  1-phosphatidyl-D-myo-inositol inositolphosphohydrolase
R03435  1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
R10952  1-phosphatidyl-1D-myo-inositol-4-phosphate inositolbisphosphohydrolase
Disease
H02792  Immune dysregulation, autoimmunity, and autoinflammation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04072 Phospholipase D signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04658 Th1 and Th2 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04659 Th17 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04062 Chemokine signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09158 Development and regeneration
   04360 Axon guidance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05231 Choline metabolism in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05171 Coronavirus disease - COVID-19
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05131 Shigellosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05135 Yersinia infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05022 Pathways of neurodegeneration - multiple diseases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Other DBs
GO: 0004435
Genes
HSA: 5335(PLCG1)
PTR: 458253(PLCG1)
PPS: 100995010(PLCG1)
GGO: 101135199(PLCG1)
PON: 100450941(PLCG1)
PPYG: 129021640(PLCG1)
NLE: 100591458(PLCG1)
HMH: 116461010(PLCG1)
SSYN: 129474522(PLCG1)
MCC: 697069(PLCG1)
MCF: 102138726(PLCG1)
MTHB: 126963902
MNI: 105496357(PLCG1)
CSAB: 103245987(PLCG1)
CATY: 105588401(PLCG1)
PANU: 101012165(PLCG1)
TGE: 112632711(PLCG1)
MLEU: 105535768(PLCG1)
RRO: 104672220(PLCG1)
RBB: 108519825(PLCG1)
TFN: 117068778(PLCG1)
PTEH: 111553217(PLCG1)
CANG: 105502491(PLCG1)
CJC: 100397497(PLCG1)
SBQ: 101046976(PLCG1)
CIMI: 108291487(PLCG1)
ANAN: 105719128(PLCG1)
CSYR: 103262907(PLCG1)
MMUR: 105865830(PLCG1)
LCAT: 123622735(PLCG1)
PCOQ: 105816581(PLCG1)
OGA: 100948398(PLCG1)
MMU: 18803(Plcg1)
MCAL: 110290454(Plcg1)
MPAH: 110319649(Plcg1)
RNO: 25738(Plcg1)
MCOC: 116091317(Plcg1)
ANU: 117703352(Plcg1)
MUN: 110552794(Plcg1)
CGE: 100769697(Plcg1)
MAUA: 101824564(Plcg1)
PROB: 127224331(Plcg1)
PLEU: 114692579(Plcg1)
MORG: 121460138(Plcg1)
MFOT: 126506998
AAMP: 119814207(Plcg1)
NGI: 103747244(Plcg1)
HGL: 101705192(Plcg1)
CPOC: 100716986(Plcg1)
CCAN: 109683399(Plcg1)
DORD: 105981663(Plcg1)
DSP: 122120202(Plcg1)
PLOP: 125353663(Plcg1)
NCAR: 124977089
MMMA: 107138082(Plcg1)
OCU: 100349958
OPI: 101520175(PLCG1)
TUP: 102469651(PLCG1)
GVR: 103606318(PLCG1)
CFA: 485874(PLCG1)
CLUD: 112673956(PLCG1)
VVP: 112928123(PLCG1)
VLG: 121477887(PLCG1)
NPO: 129493567(PLCG1)
AML: 100480586(PLCG1)
UMR: 103669754(PLCG1)
UAH: 113258609(PLCG1)
UAR: 123796994(PLCG1)
ELK: 111141423
LLV: 125109927
MPUF: 101685356(PLCG1)
MNP: 132021927(PLCG1)
MLK: 131807620(PLCG1)
NVS: 122916074(PLCG1)
ORO: 101380728(PLCG1)
EJU: 114223136(PLCG1)
ZCA: 113938304(PLCG1)
MLX: 118011488(PLCG1)
NSU: 110579324(PLCG1)
LWW: 102727444
FCA: 101092925(PLCG1)
PYU: 121012188(PLCG1)
PCOO: 112869500(PLCG1)
PBG: 122496268(PLCG1)
PVIV: 125161716(PLCG1)
LRUF: 124503060
PTG: 102952137(PLCG1)
PPAD: 109272437(PLCG1)
PUC: 125936595
AJU: 106974495
HHV: 120228585(PLCG1)
BTA: 281987(PLCG1)
BOM: 102265099(PLCG1)
BIU: 109567698(PLCG1)
BBUB: 102400354(PLCG1)
BBIS: 104980493(PLCG1)
CHX: 102181878(PLCG1)
OAS: 101103341(PLCG1)
BTAX: 128058189(PLCG1)
ODA: 120869330(PLCG1)
CCAD: 122448704(PLCG1)
MBEZ: 129563552(PLCG1)
SSC: 100152497(PLCG1)
CFR: 102524452(PLCG1)
CBAI: 105071939(PLCG1)
CDK: 105085024(PLCG1)
VPC: 102542680(PLCG1)
BACU: 103016663(PLCG1)
BMUS: 118881019(PLCG1)
LVE: 103068930(PLCG1)
OOR: 101281412(PLCG1)
DLE: 111184170(PLCG1)
PCAD: 102992700(PLCG1)
PSIU: 116740089(PLCG1)
NASI: 112398380(PLCG1)
ECB: 100070545(PLCG1)
EPZ: 103562208(PLCG1)
EAI: 106834358(PLCG1)
MYB: 102248243(PLCG1)
MYD: 102756475(PLCG1)
MMYO: 118662889(PLCG1)
MLF: 102421330(PLCG1)
MDT: 132239948(PLCG1)
PKL: 118708113(PLCG1)
EFUS: 103303954(PLCG1)
MNA: 107542131(PLCG1)
DRO: 112303845(PLCG1)
SHON: 118985484(PLCG1)
AJM: 119063199(PLCG1)
PDIC: 114506303(PLCG1)
PHAS: 123814793(PLCG1)
MMF: 118618299(PLCG1)
PPAM: 129070698(PLCG1)
HAI: 109379925(PLCG1)
RFQ: 117015909(PLCG1)
PALE: 102896228(PLCG1)
PGIG: 120603668(PLCG1)
PVP: 105296521(PLCG1)
RAY: 107506741(PLCG1)
MJV: 108407248
TOD: 119235450(PLCG1)
SARA: 101545860(PLCG1)
SETR: 126017276(PLCG1)
LAV: 100677739(PLCG1)
TMU: 101359597
ETF: 101651012(PLCG1)
DNM: 101411498(PLCG1)
MDO: 100032696(PLCG1)
GAS: 123237416(PLCG1)
SHR: 100923119(PLCG1)
AFZ: 127550395
PCW: 110216705(PLCG1)
TVP: 118840765(PLCG1)
OAA: 100078757(PLCG1)
GGA: 419175(PLCG1) 776273
PCOC: 116227799 116235162(PLCG1)
MGP: 100542272 100548670(PLCG1)
CJO: 107310620 107322901(PLCG1)
TPAI: 128081205(PLCG1) 128091181
LMUT: 125690472 125701080(PLCG1)
NMEL: 110393955 110408143(PLCG1)
APLA: 101792010 101798692
ACYG: 106042207 106043486(PLCG1)
CATA: 118248780(PLCG1) 118257917
AFUL: 116486200 116495680(PLCG1)
TGU: 100220070(PLCG1) 115494036
LSR: 110469274(PLCG1) 110475168
SCAN: 103818789(PLCG1) 103826392
PMOA: 120504669 120511282(PLCG1)
OTC: 121333386 121343724(PLCG1)
PRUF: 121349284 121359593(PLCG1)
GFR: 102032882(PLCG1) 102038983
FAB: 101806517(PLCG1) 101820005
OMA: 130249586 130261233(PLCG1)
PHI: 102100949 102114427(PLCG1)
PMAJ: 107200506 107213300(PLCG1)
CCAE: 111925206 111938259(PLCG1)
CCW: 104687887(PLCG1) 104692596
CBRC: 103617003(PLCG1) 103623879
ETL: 114058083(PLCG1) 114070992 114072166
ZAB: 102063253(PLCG1) 102070810
ZLE: 135444705 135456391(PLCG1)
ACHL: 103803401(PLCG1) 103810886
SVG: 106855621 106857738(PLCG1)
MMEA: 130580710(PLCG1) 130584375
HRT: 120750365 120760230(PLCG1)
SATI: 136368406(PLCG1) 136372409
FPG: 101912447(PLCG1) 101918282
FCH: 102046961 102057302(PLCG1)
CCRI: 104161711(PLCG1) 104168845
NNT: 104405992 104412289
SHAB: 115613957 115615084(PLCG1)
ACUN: 113477170 113487655(PLCG1)
TALA: 104359757 104360894(PLCG1) 122152703
ACHC: 115339114(PLCG1) 115340577
HALD: 104323025 104325684
HLE: 104842031(PLCG1) 104842119
AGEN: 126045429 126049489
GCL: 127013317 127023298
LDI: 104342512(PLCG1) 104345319
DPUB: 104299399 104307576(PLCG1)
AVIT: 104273395 104278062
BRHI: 104489615(PLCG1) 104494933
EGZ: 104128859 104132170(PLCG1)
NNI: 104009589(PLCG1) 104020599
PCRI: 104034184 104036285
PCAO: 104044798(PLCG1)
PADL: 103912439(PLCG1) 103925979
AFOR: 103895832(PLCG1) 103901296
FGA: 104073699 104077745(PLCG1)
GSTE: 104254945(PLCG1) 104263331
CLV: 102098341(PLCG1) 102098590
MUI: 104539252 104547382
PGUU: 104465604 104465741
PLET: 104618654 104619556
EHS: 104506056(PLCG1) 104512680
CMAC: 104477730 104480418(PLCG1)
CUCA: 104057059(PLCG1) 104063945
TEO: 104381212(PLCG1) 104383879
BREG: 104637705 104642587
OHA: 104335904 104336875(PLCG1)
ACAR: 104519064 104524108(PLCG1)
CPEA: 104389760(PLCG1) 104392718
CVF: 104283994 104285207(PLCG1)
RTD: 128904950 128916476(PLCG1)
AAM: 106488145(PLCG1) 106494802
AROW: 112967901 112971424(PLCG1)
NPD: 112949622(PLCG1) 112954009
TGT: 104568547(PLCG1) 104580375
DNE: 112979055(PLCG1) 112991307
SCAM: 104141709(PLCG1) 104142512
ASN: 102368895 102369875(PLCG1)
AMJ: 102563626(PLCG1) 102574067
CPOO: 109313182(PLCG1) 109322589
GGN: 109292397(PLCG1) 109305247
PSS: 102459944(PLCG1) 102461099
CMY: 102944142(PLCG1) 102946940
CCAY: 125622273(PLCG1) 125632911
DCC: 119841778(PLCG1) 119851292
CPIC: 101930905 101935550(PLCG1)
TST: 117873861 117885831(PLCG1)
CABI: 116815149 116817342(PLCG1)
MRV: 120380808(PLCG1) 120395123 120398927
ACS: 100559347(plcg1) 100566976
ASAO: 132773206(PLCG1) 132775158
PVT: 110070157 110076765(PLCG1)
SUND: 121929364(PLCG1) 121929490
PBI: 103062888 103064933(PLCG1)
PMUR: 107287257(PLCG1) 107298984
CTIG: 120311643(PLCG1) 120319640
TSR: 106549424(PLCG1)
PGUT: 117663635(PLCG1) 117666979
APRI: 131195068(PLCG1) 131196239
PTEX: 113434416(PLCG1) 113452797
NSS: 113410470(PLCG1)
VKO: 123028453(PLCG1) 123035300
PMUA: 114599554(PLCG1) 114600186
PRAF: 128416370(PLCG1) 128416997
ZVI: 118088856(PLCG1) 118089856
HCG: 128324958 128325331(PLCG1)
GJA: 107109685(PLCG1) 107121439
STOW: 125432882(PLCG1)
EMC: 129330101(PLCG1) 129333103
XLA: 108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR: 100496658 100496674(plcg1)
NPR: 108786812(PLCG1) 108789042
RTEM: 120918704(PLCG1) 120939772
BBUF: 121000970 121003186(PLCG1)
BGAR: 122940991(PLCG1)
MUO: 115475841(PLCG1) 115480882
GSH: 117355378 117369283(PLCG1)
DRE: 373867(plcg1)
SRX: 107713547 107723006 107747732
SANH: 107663201(plcg1) 107703619
SGH: 107557477 107562619
CCAR: 109066470 109071906(plcg1)
CAUA: 113040970(plcg1) 113068656
CGIB: 127944687 128011400
PTET: 122328825(plcg1)
LROH: 127154337(plcg1)
OMC: 131531605(plcg1)
PPRM: 120491887
RKG: 130077783(plcg1)
MAMB: 125260147(plcg1)
CIDE: 127504476
CERY: 137009720(plcg1)
MASI: 127418877 127419780
TROS: 130545503(plcg1)
TDW: 130409758(plcg1)
MANU: 129431516(plcg1)
IPU: 108275796
IFU: 128619938(plcg1)
PHYP: 113545570(plcg1)
SMEO: 124399277(plcg1)
TFD: 113651828(plcg1)
TVC: 132861800(plcg1)
TRN: 134333574(plcg1)
AMEX: 103023099(plcg1)
CMAO: 118822100(plcg1)
EEE: 113588884(plcg1)
CHAR: 105904288(plcg1) 122130602
TRU: 101065481 101069039(plcg1)
TFS: 130529254 130530364(plcg1)
TNG: GSTEN00006212G001 GSTEN00011828G001
LCO: 104925092(plcg1) 104927718
NCC: 104954784 104964925(plcg1)
TBEN: 117479579(plcg1) 117495768
CGOB: 115006734 115011301(plcg1)
PGEO: 117445233 117450000(plcg1)
GACU: 117540673(plcg1) 117560594
EMAC: 134863657(plcg1) 134869081
ELY: 117253479 117258827(plcg1)
EFO: 125891327(plcg1) 125895319
PLEP: 121946685(plcg1) 121963117
SLUC: 116038103 116062265(plcg1)
ECRA: 117947430(plcg1) 117949908
ESP: 116692557(plcg1) 116695236
PFLV: 114558144(plcg1) 114561436
GAT: 120823912(plcg1)
PPUG: 119216496 119223301(plcg1)
AFB: 129094102 129100358(plcg1)
CLUM: 117729444 117733717(plcg1)
PSWI: 130193629 130199481(plcg1)
MSAM: 119900255 119905411(plcg1)
SCHU: 122878068 122883778(plcg1)
CUD: 121511686 121517235(plcg1)
ALAT: 119022912(plcg1) 119029127
MZE: 101470576(plcg1) 101473405
ONL: 100704581(plcg1) 100711065
OAU: 116332045 116334564(plcg1)
OLA: 101163005(plcg1) 101167946
OML: 112150370 112158781(plcg1)
CSAI: 133457101(plcg1) 133458677
XMA: 102217766(plcg1) 102229810
XCO: 114146805(plcg1) 114151085
XHE: 116725415 116728103(plcg1)
PRET: 103463411 103467475(plcg1)
PFOR: 103129695 103141866(plcg1)
PLAI: 106937578 106940345(plcg1)
PMEI: 106909447(plcg1) 106919104
GAF: 122828386(plcg1) 122838256
PPRL: 129370252(plcg1) 129371997
CVG: 107083024 107087598(plcg1)
CTUL: 119774047(plcg1) 119787619
GMU: 124869858(plcg1) 124873539
NFU: 107391021(plcg1) 107393039
KMR: 108235263(plcg1) 108248356
ALIM: 106523657(plcg1) 106526007
NWH: 119417581(plcg1) 119430403
AOCE: 111576272(plcg1) 111582127
MCEP: 125009887 125021358(plcg1)
CSEM: 103385539(plcg1) 103399890
POV: 109635039 109635202(plcg1) 109644530
SSEN: 122777504(plcg1) 122781292
HHIP: 117759796 117764528(plcg1)
HSP: 118110564(plcg1) 118121605
PPLT: 128442866(plcg1)
SMAU: 118316467(plcg1) 118317716
LCF: 108877896 108879537
SDU: 111219324(plcg1) 111227542
SLAL: 111668916(plcg1) 111671648
XGL: 120790483 120803745(plcg1)
HCQ: 109514977(plcg1) 109524567
SSCV: 125989228
SBIA: 133496357(plcg1)
PEE: 133413447(plcg1)
PTAO: 133467099(plcg1)
BPEC: 110164633(plcg1) 110172233
MALB: 109961232 109964670(plcg1)
BSPL: 114854549 114858475(plcg1)
SJO: 128357219(plcg1) 128361401
SASA: 106560399 106566556(plcg1)
STRU: 115158661 115168907(plcg1)
OTW: 112222319(plcg1) 112251330
OMY: 110492526(plcg1) 110523019
OGO: 123996699 124045594(plcg1)
ONE: 115101998(plcg1) 115108766
OKI: 109882317 109884808(plcg1)
OKE: 118371157(plcg1) 118372761
SALP: 111975516 111976591(plcg1)
SNH: 120054971 120061431(plcg1)
CCLU: 121533863 121546104(plcg1)
ELS: 105011953 105013964(plcg1)
SFM: 108926447 108932661 108936962(plcg1)
PKI: 111835929 111837114(plcg1) 111837772
AANG: 118208555(plcg1) 118225935
LOC: 102684678(plcg1) 102696192
PSPA: 121297987(plcg1) 121307815 121312797 121314271
ARUT: 117394730 117399853 117420443 117430821
PSEX: 120515081(plcg1) 120529699
LCM: 102352804 102362442(PLCG1)
CMK: 103186275(plcg1)
RTP: 109912305 109939029
CPLA: 122548917 122560240(plcg1)
HOC: 132815071 132822984(plcg1)
LERI: 129696002 129707265(plcg1)
PMRN: 116945727 116954188 116957023
LRJ: 133340300 133355776 133362993
BFO: 118417806
BBEL: 109473767
CIN: 100178711
SCLV: 120340574 120341030
SPU: 579102 583807
LPIC: 129269143
APLC: 110980002
ARUN: 117288789
AJC: 117113118
SKO: 100377901
DME: Dmel_CG4200(sl)
DER: 6550553
DSE: 116801966
DSI: Dsimw501_GD17281(Dsim_GD17281)
DYA: Dyak_GE17264
DAN: 6501908
DSR: 110181712
DPO: 4814530
DPE: 6599358
DMN: 108156056
DWI: 6648777
DGR: 6564826
DMO: Dmoj_GI14457
DAZ: 108617824
DNV: 108655465
DHE: 111594077
DVI: 6631556
CCAT: 101461358
BOD: 106621926
BDR: 105224228
RZE: 108371557 108379535
AOQ: 129236818
TDA: 119670291 119670487
MDE: 101900328
SCAC: 106084315
LCQ: 111684567
LSQ: 119613272
GFS: 119632489
ECOE: 129948041
CLON: 129606649
HIS: 119654686
AGA: 1270776
ACOZ: 120956548
AARA: 120899719
AMER: 121598261
ASTE: 118504266
AFUN: 125768498
AMOU: 128303280
AALI: 118466377
AAG: 5564766
AALB: 109411979 109424555
ASUA: 134227555
CQU: CpipJ_CPIJ008193
CPII: 120423157
BCOO: 119078713
AME: 551709
ACER: 108004149
ALAB: 122711003
ADR: 102673857
AFLR: 100867745
BIM: 100748682
BBIF: 117208499
BVK: 117242996
BVAN: 117164972
BTER: 100647687
BAFF: 126923331
BPYO: 122574589
BPAS: 132913090
FVI: 122530135
CCAL: 108629199
OBB: 114871263
OLG: 117604406
MGEN: 117219131
NMEA: 116428997
CGIG: 122397090
SOC: 105196430
MPHA: 105833149
AEC: 105144421
ACEP: 105624086
PBAR: 105431231
VEM: 105560673
HST: 105188458
DQU: 106743174
CFO: 105257806
FEX: 115235984
LHU: 105673001(sl)
PGC: 109852947
OBO: 105286217
PCF: 106786441
PFUC: 122519752
VPS: 122630398
VCRB: 124424037
VVE: 124950382
NVI: 100123217
CSOL: 105368048
TPRE: 106659590
LHT: 122501490
LBD: 127279858
MDL: 103577678
CGLO: 123270370
FAS: 105272066
DAM: 107038623
AGIF: 122855397 122858738
CINS: 118071016
VCAN: 122417062
CCIN: 107265921
DSM: 124405392 124406033
NPT: 124213005 124213441
NFB: 124176538 124176747
NLO: 107225561 107226599
NVG: 124298827 124299153
AROA: 105687144 105688758
TCA: 660210
DPA: 109537047
SOY: 115878143
AGRG: 126733559
ATD: 109597552
CSET: 123307246
AGB: 108906346 108906363
LDC: 111503416
DVV: 126891888
NVL: 108561344
APLN: 108742977
PPYR: 116173773
OTU: 111426782
BMOR: 100329155(PLCg)
BMAN: 114250026
MSEX: 115455765
DPL: KGM_207160
MJU: 123880687
NIQ: 126780358
VCD: 124543019
MCIX: 123668610
PMAC: 106717301
PPOT: 106104480
PXU: 106126231
PRAP: 110998146
PBX: 123718383
PNAP: 125062203
ZCE: 119835662
CCRC: 123705175
LSIN: 126978841
AAGE: 121738739
HAW: 110374501
HZE: 124645395
TNL: 113505041
SLIU: 111360524
OFU: 114359335
ATRA: 106133856
GMW: 113519965
PXY: 105381166
PGW: 126380025
LGLY: 125241844
CFEL: 113362973 113362975
CCRN: 123296721
API: 100166969
DNX: 107163682
AGS: 114120080
RMD: 113553363
ACOO: 126840281
DVT: 126905320
BTAB: 109035929
DCI: 103520225
CLEC: 106662403
HHAL: 106680176(sl)
NLU: 111051096
HVI: 124358584
MQU: 128993901 129005459
PHU: Phum_PHUM019460
FOC: 113206987
TPAL: 117648362
ZNE: 110834677
CSEC: 111866231
SGRE: 126268133
BROR: 134538235
IEL: 124159594
FCD: 110851828
DPX: DAPPUDRAFT_204745
DMK: 116922163 116931053 123475793
DPZ: 124316127 124326988
PVM: 113828575
PJA: 122251600
PCHN: 125045593
PMOO: 119584399
HAME: 121879670
PCLA: 123755966
CQD: 128704018
PTRU: 123498080
ESN: 126998501
MNZ: 135220808
HAZT: 108675741
EAF: 111694868
LSM: 121129012
TCF: 131879266
PPOI: 119093830 119093993
ISC: 8024678
DSV: 119466610
RSAN: 119376389
RMP: 119176473
VDE: 111246565
VJA: 111264790
TUT: 107359684
DPTE: 113789230 113794163
DFR: 124492301 124497852
CSCU: 111628132
CVS: 136990835(sl)
PTEP: 107452539
ABRU: 129960925 129987760
UDV: 129230395 129230397
SDM: 118198563
LPOL: 106465601
PMEO: 129580735 129580738 129600127
CEL: CELE_T01E8.3(plc-3)
CBR: CBG_18715(Cbr-plc-3)
CRQ: GCK72_004247
NAI: NECAME_11673
LOA: LOAG_00547
TSP: Tsp_10563
HRO: HELRODRAFT_88112
LGI: LOTGIDRAFT_234838
PVUL: 126815318 126815319
PCAN: 112576695 112576761
BGT: 106062205
GAE: 121388527 121388579 121391162
HRF: 124138588 124138590
HRJ: 124256072 124256074
CRG: 105340725
CANU: 128187187
CVN: 111132178
OED: 125648918
MYI: 110450840
PMAX: 117337032
MCAF: 127702963
MMER: 123550511
RPHI: 132728555
DPOL: 127846015 127846016
MAEA: 128243701 128243840
OBI: 106874041
OSN: 115220856
LJP: 135475240
LAK: 106152397
LLON: 135496404
NVE: 5506289 5513427
EPA: 110244579
ATEN: 116296605
ADF: 107357605
AMIL: 114966528
PDAM: 113679030
SPIS: 111332971
DGT: 114516528 114516606
XEN: 124436486 124436558 124436580
HMG: 100212273
HSY: 130614374
RES: 135691366
AQU: 100633163
MBR: MONBRDRAFT_23046
SRE: PTSG_03830
 » show all
Reference
PMID:18593525
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
Reference
PMID:10579907
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671
Reference
PMID:2167438
  Authors
Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M
  Title
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
  Journal
Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770
  Sequence
[hsa:5335]
LinkDB

KEGG   ORTHOLOGY: K05859
Entry
K05859                      KO                                     
Symbol
PLCG2
Name
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04020  Calcium signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04070  Phosphatidylinositol signaling system
map04072  Phospholipase D signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04380  Osteoclast differentiation
map04611  Platelet activation
map04613  Neutrophil extracellular trap formation
map04625  C-type lectin receptor signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04919  Thyroid hormone signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map05110  Vibrio cholerae infection
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Reaction
R03332  1-phosphatidyl-D-myo-inositol inositolphosphohydrolase
R03435  1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
R10952  1-phosphatidyl-1D-myo-inositol-4-phosphate inositolbisphosphohydrolase
Disease
H01743  Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04613 Neutrophil extracellular trap formation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04625 C-type lectin receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04062 Chemokine signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09158 Development and regeneration
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05171 Coronavirus disease - COVID-19
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05131 Shigellosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Other DBs
GO: 0004435
Genes
HSA: 5336(PLCG2)
PTR: 454268(PLCG2)
PPS: 100984694(PLCG2)
GGO: 101133643(PLCG2)
PON: 100457650(PLCG2)
PPYG: 129015232(PLCG2)
NLE: 100604145(PLCG2)
HMH: 116470775(PLCG2)
SSYN: 129493473(PLCG2)
MCC: 714173(PLCG2)
MCF: 102117471(PLCG2)
MTHB: 126943961
MNI: 105491204(PLCG2)
CSAB: 103233371(PLCG2)
CATY: 105589398(PLCG2)
PANU: 101004091(PLCG2)
TGE: 112614034(PLCG2)
MLEU: 105546817(PLCG2)
RRO: 104671624(PLCG2)
RBB: 108539491(PLCG2)
TFN: 117088112(PLCG2)
PTEH: 111552578(PLCG2)
CANG: 105511970(PLCG2)
CJC: 100390347(PLCG2)
SBQ: 101030999(PLCG2)
CIMI: 108313460(PLCG2)
ANAN: 105726497(PLCG2)
CSYR: 103267377(PLCG2)
MMUR: 105859475(PLCG2)
LCAT: 123625473(PLCG2)
PCOQ: 105813491(PLCG2)
OGA: 100948829(PLCG2)
MMU: 234779(Plcg2)
MCAL: 110300336(Plcg2)
MPAH: 110337392(Plcg2)
RNO: 29337(Plcg2)
MCOC: 116070251(Plcg2)
ANU: 117723064(Plcg2)
MUN: 110550263(Plcg2)
CGE: 100752475(Plcg2)
MAUA: 101831758(Plcg2)
PROB: 127234658(Plcg2)
PLEU: 114697457(Plcg2)
MORG: 121447066(Plcg2)
MFOT: 126502936
AAMP: 119801950(Plcg2)
NGI: 103725694 103748739
HGL: 101715321(Plcg2)
CPOC: 100726796(Plcg2)
CCAN: 109696649(Plcg2)
DORD: 105982979(Plcg2)
PLOP: 125357867(Plcg2)
NCAR: 124966613
MMMA: 107150868(Plcg2)
OCU: 100340139
OPI: 101526399(PLCG2)
TUP: 102483786(PLCG2)
GVR: 103591521(PLCG2)
CFA: 489692(PLCG2)
CLUD: 112646723(PLCG2)
VVP: 112911890 112912331
VLG: 121500177(PLCG2)
NPO: 129497753(PLCG2)
AML: 100481994(PLCG2)
UMR: 103662093(PLCG2)
UAH: 113252535(PLCG2)
UAR: 123791349(PLCG2)
ELK: 111152978
LLV: 125089755
MPUF: 101670617(PLCG2)
MNP: 132005665(PLCG2)
MLK: 131818792(PLCG2)
NVS: 122911198(PLCG2)
ORO: 101378505(PLCG2)
EJU: 114202334(PLCG2)
ZCA: 113936075(PLCG2)
MLX: 118023528(PLCG2)
NSU: 110593864(PLCG2)
FCA: 101080675(PLCG2)
PYU: 121009974(PLCG2)
PCOO: 112857487(PLCG2)
PBG: 122494519(PLCG2)
PVIV: 125152537(PLCG2)
LRUF: 124511524
PTG: 102963653(PLCG2)
PPAD: 109245637(PLCG2)
PUC: 125916347
AJU: 106984018
HHV: 120228197(PLCG2)
BTA: 100337091(PLCG2)
BOM: 102285300(PLCG2)
BIU: 109572707(PLCG2)
BBUB: 102396307(PLCG2)
BBIS: 104996518(PLCG2)
CHX: 102180337(PLCG2)
OAS: 101122126(PLCG2)
BTAX: 128063111(PLCG2)
ODA: 120873247(PLCG2)
CCAD: 122420118(PLCG2)
MBEZ: 129547229(PLCG2)
SSC: 100518663(PLCG2)
CFR: 102514470(PLCG2)
CBAI: 105078942(PLCG2)
CDK: 105089440(PLCG2)
VPC: 102540897(PLCG2)
BACU: 103014764(PLCG2)
BMUS: 118885802(PLCG2)
LVE: 103070997(PLCG2)
OOR: 101285216(PLCG2)
DLE: 111179463(PLCG2)
PCAD: 102983230(PLCG2)
PSIU: 116744707(PLCG2)
NASI: 112393390(PLCG2)
ECB: 100055670(PLCG2)
EPZ: 103558212(PLCG2)
EAI: 106832855
MYB: 102261553(PLCG2)
MYD: 102773476(PLCG2)
MMYO: 118674206(PLCG2)
MLF: 102420000(PLCG2)
MDT: 132217215(PLCG2)
PKL: 118720533(PLCG2)
EFUS: 103284403(PLCG2)
MNA: 107524904(PLCG2)
DRO: 112300725(PLCG2)
SHON: 118983037(PLCG2)
AJM: 119047103(PLCG2)
PDIC: 114488244(PLCG2)
PHAS: 123805718(PLCG2)
MMF: 118639621(PLCG2)
PPAM: 129075160(PLCG2)
HAI: 109378365(PLCG2)
RFQ: 117034806(PLCG2)
PALE: 102883128(PLCG2)
PGIG: 120622970(PLCG2)
PVP: 105289863(PLCG2)
RAY: 107521319(PLCG2)
MJV: 108400464(PLCG2)
TOD: 119249121(PLCG2)
SARA: 101554088(PLCG2)
SETR: 126027269(PLCG2)
LAV: 100658990(PLCG2)
TMU: 101346393
ETF: 101644253(PLCG2)
DNM: 101428386(PLCG2)
MDO: 100027579(PLCG2)
GAS: 123237042(PLCG2)
SHR: 100919206(PLCG2)
AFZ: 127548673
PCW: 110212621(PLCG2)
TVP: 118843532(PLCG2)
OAA: 100076776(PLCG2)
GGA: 415805(PLCG2)
PCOC: 116243922(PLCG2)
MGP: 100549684(PLCG2)
CJO: 107319403(PLCG2)
TPAI: 128082052(PLCG2)
LMUT: 125699039(PLCG2)
NMEL: 110404260(PLCG2)
APLA: 101799246(PLCG2)
ACYG: 106044837(PLCG2)
CATA: 118246617(PLCG2)
AFUL: 116494152(PLCG2)
TGU: 100219388(PLCG2)
LSR: 110476350(PLCG2)
SCAN: 103816730(PLCG2)
PMOA: 120508082(PLCG2)
OTC: 121334040(PLCG2)
PRUF: 121348913(PLCG2)
GFR: 102039725(PLCG2)
FAB: 101811465(PLCG2)
OMA: 130257856(PLCG2)
PHI: 102103443(PLCG2)
PMAJ: 107209788(PLCG2)
CCAE: 111934454(PLCG2)
CCW: 104691823(PLCG2)
CBRC: 103620109(PLCG2)
ETL: 114066562(PLCG2)
ZAB: 102064935(PLCG2)
ZLE: 135452876(PLCG2)
ACHL: 103803834
SVG: 106852067(PLCG2)
MMEA: 130577280(PLCG2)
HRT: 120757825(PLCG2)
SATI: 136366473(PLCG2)
FPG: 101914329(PLCG2)
FCH: 102058636(PLCG2)
CCRI: 104164322(PLCG2)
NNT: 104402843(PLCG2)
SHAB: 115619893(PLCG2)
ACUN: 113484485(PLCG2)
TALA: 104357329(PLCG2)
ACHC: 115345998(PLCG2)
HALD: 104325196(PLCG2)
HLE: 104839384(PLCG2)
AGEN: 126040423
GCL: 127021030
CSTI: 104563586(PLCG2)
LDI: 104352535(PLCG2)
MNB: 103772869(PLCG2)
DPUB: 104300823(PLCG2)
AVIT: 104281388(PLCG2)
BRHI: 104496950(PLCG2)
EGZ: 104133768(PLCG2)
NNI: 104014569(PLCG2)
PCRI: 104033730(PLCG2)
PCAO: 104048375(PLCG2)
PADL: 103923865(PLCG2)
AFOR: 103897308(PLCG2)
FGA: 104079549(PLCG2)
GSTE: 104250779(PLCG2)
CLV: 102095823(PLCG2)
MUI: 104543108(PLCG2)
PGUU: 104460935(PLCG2)
PLET: 104617540(PLCG2)
EHS: 104505877(PLCG2)
CMAC: 104486418(PLCG2)
CUCA: 104059381(PLCG2)
TEO: 104381078(PLCG2)
BREG: 104638899(PLCG2)
OHA: 104339197(PLCG2)
ACAR: 104522667(PLCG2)
CPEA: 104396358(PLCG2)
CVF: 104291180(PLCG2)
RTD: 128908577(PLCG2)
AAM: 106483269(PLCG2)
AROW: 112962495(PLCG2)
NPD: 112949908(PLCG2)
TGT: 104567312(PLCG2)
DNE: 112978838(PLCG2)
SCAM: 104149338(PLCG2)
ASN: 102378303(PLCG2)
AMJ: 106736910(PLCG2)
CPOO: 109310651(PLCG2)
GGN: 109289467(PLCG2)
PSS: 102454220(PLCG2)
CMY: 102930635(PLCG2)
CCAY: 125645320(PLCG2)
DCC: 119840995(PLCG2)
CPIC: 101932685(PLCG2)
TST: 117886777(PLCG2)
CABI: 116816699(PLCG2)
MRV: 120384432(PLCG2)
ACS: 100566814(plcg2)
ASAO: 132783040(PLCG2)
PVT: 110085508(PLCG2)
SUND: 121914835(PLCG2)
PBI: 103052396(PLCG2)
PMUR: 107292601(PLCG2)
CTIG: 120312591(PLCG2)
TSR: 106539149(PLCG2)
PGUT: 117670361(PLCG2)
APRI: 131184325(PLCG2)
PTEX: 113445120(PLCG2)
NSS: 113414939(PLCG2)
VKO: 123025316(PLCG2)
PMUA: 114601931(PLCG2)
PRAF: 128419153(PLCG2)
ZVI: 118087873(PLCG2)
HCG: 128334301(PLCG2)
GJA: 107105783(PLCG2)
STOW: 125443848(PLCG2)
EMC: 129343968(PLCG2)
XLA: 108714087(plcg2.L)
XTR: 100496686(plcg2)
NPR: 108786572(PLCG2)
RTEM: 120917948(PLCG2)
BBUF: 120981059(PLCG2)
MUO: 115470901(PLCG2)
GSH: 117359058(PLCG2)
DRE: 561747(plcg2)
SRX: 107722471 107738392
SANH: 107666218 107666222(plcg2) 107684680
SGH: 107559804(plcg2) 107587040 107587041
CCAR: 109047939 109057498
CAUA: 113061559 113061561 113118238
CGIB: 127934627 127977584
PTET: 122362774(plcg2)
LROH: 127181164(plcg2)
OMC: 131524740(plcg2)
PPRM: 120462011(plcg2)
RKG: 130094821(plcg2)
MAMB: 125253968(plcg2)
CIDE: 127500215
CERY: 137023276(plcg2)
MASI: 127417260 127455887
TROS: 130562479(plcg2)
TDW: 130436032
MANU: 129419762(plcg2) 129419763 129419764
IPU: 108264222
IFU: 128606925(plcg2)
PHYP: 113534527(plcg2)
SMEO: 124395716(plcg2)
TFD: 113652640(plcg2)
TVC: 132851365(plcg2)
TRN: 134322873(plcg2)
AMEX: 103036277(plcg2)
CMAO: 118818167(plcg2)
EEE: 113577174(plcg2)
CHAR: 105900725 105904657(plcg2)
TRU: 101072923(plcg2)
TFS: 130536386(plcg2)
TNG: GSTEN00016798G001
LCO: 104932460(plcg2)
TBEN: 117484411(plcg2)
CGOB: 115009314(plcg2)
PGEO: 117450121(plcg2)
GACU: 117553219(plcg2)
EMAC: 134876246(plcg2)
ELY: 117250944 117262733(plcg2)
EFO: 125887137(plcg2)
PLEP: 121949768(plcg2)
SLUC: 116040257(plcg2)
ECRA: 117948801(plcg2)
ESP: 116693373 116693374
PFLV: 114560248(plcg2)
GAT: 120808617(plcg2)
PPUG: 119196016(plcg2)
AFB: 129107826(plcg2)
CLUM: 117731905(plcg2)
PSWI: 130195679(plcg2)
MSAM: 119893498
SCHU: 122874454
CUD: 121514969
ALAT: 119024782(plcg2)
MZE: 101479429(plcg2)
ONL: 100697485(plcg2)
OAU: 116318822(plcg2)
OLA: 101157053(plcg2)
OML: 112152461(plcg2)
CSAI: 133443937(plcg2)
XMA: 102220131(plcg2)
XCO: 114137117(plcg2)
XHE: 116708435(plcg2)
PRET: 103466833(plcg2)
PFOR: 103129264(plcg2)
PLAI: 106936613(plcg2)
PMEI: 106911768(plcg2)
GAF: 122835085(plcg2)
PPRL: 129359838(plcg2)
CVG: 107084318(plcg2)
CTUL: 119789164(plcg2)
GMU: 124860019(plcg2)
NFU: 107389305(plcg2)
KMR: 108237447(plcg2)
ALIM: 106536649(plcg2)
NWH: 119415540(plcg2)
AOCE: 111563111(plcg2)
MCEP: 125015418(plcg2)
CSEM: 103379748(plcg2)
POV: 109641214(plcg2)
HHIP: 117763823(plcg2)
HSP: 118109207(plcg2)
PPLT: 128444206(plcg2)
SMAU: 118315330(plcg2)
LCF: 108902239
SDU: 111229657(plcg2)
SLAL: 111647676(plcg2)
XGL: 120793769
HCQ: 109513068(plcg2)
SSCV: 125970551
SBIA: 133502019(plcg2)
PEE: 133402913(plcg2)
PTAO: 133477573(plcg2)
BPEC: 110169397(plcg2)
MALB: 109967271(plcg2)
BSPL: 114857550 114857551
SJO: 128358370(plcg2)
SASA: 106573684(plcg2)
STRU: 115151896(plcg2)
OTW: 112252303(plcg2)
OMY: 100136053(plcg2)
OGO: 124000074(plcg2)
ONE: 115109334(plcg2)
OKI: 109889294(plcg2)
OKE: 118401316(plcg2)
SALP: 111952198(plcg2)
SNH: 120053864(plcg2)
CCLU: 121576695(plcg2)
ELS: 105018577(plcg2)
SFM: 108926548 108926652(plcg2)
PKI: 111851875(plcg2)
AANG: 118228424(plcg2)
LOC: 102696681(plcg2)
PSPA: 121295981 121296706 121325734
ARUT: 117424336 117424596 117425617
PSEX: 120535553(plcg2)
LCM: 102358132(PLCG2)
CMK: 103175953(plcg2)
RTP: 109928136(plcg2)
CPLA: 122558270(plcg2)
HOC: 132823890(plcg2)
LERI: 129705387(plcg2)
API: 100161327
TCF: 131881317
BGT: 106070801
 » show all
Reference
PMID:2849563
  Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
  Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
  Journal
FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7
  Sequence
[hsa:5336]
Reference
PMID:23555801
  Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
  Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
  Journal
PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842
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