KEGG   ORTHOLOGY: K01127
Entry
K01127                      KO                                     
Symbol
GPLD1
Name
glycosylphosphatidylinositol phospholipase D [EC:3.1.4.50]
Pathway
map00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
    K01127  GPLD1; glycosylphosphatidylinositol phospholipase D
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.50  glycosylphosphatidylinositol phospholipase D
     K01127  GPLD1; glycosylphosphatidylinositol phospholipase D
Other DBs
RN: R06623
GO: 0004621
Genes
HSA: 2822(GPLD1)
PTR: 462473(GPLD1)
PPS: 100973223(GPLD1)
GGO: 101146393(GPLD1)
PON: 100455517(GPLD1)
NLE: 100598329(GPLD1)
MCC: 707782(GPLD1)
MCF: 102125729(GPLD1)
CSAB: 103222053(GPLD1)
CATY: 105572618(GPLD1)
PANU: 101001857(GPLD1)
TGE: 112622303(GPLD1)
RRO: 104663891(GPLD1)
RBB: 108533667(GPLD1)
TFN: 117086801(GPLD1)
PTEH: 111541103(GPLD1)
CJC: 100385911(GPLD1)
SBQ: 101035773(GPLD1)
CSYR: 103251843(GPLD1)
MMUR: 105865209(GPLD1)
LCAT: 123638333(GPLD1)
OGA: 100943003(GPLD1)
MMU: 14756(Gpld1)
MCAL: 110307663(Gpld1)
MPAH: 110333811(Gpld1)
RNO: 291132(Gpld1)
MCOC: 116081596(Gpld1)
MUN: 110551065(Gpld1)
CGE: 100759513(Gpld1)
MAUA: 101825977(Gpld1)
PLEU: 114700916(Gpld1)
MORG: 121434002(Gpld1)
AAMP: 119817603(Gpld1)
NGI: 103745185(Gpld1)
HGL: 101724062(Gpld1)
CPOC: 100734898(Gpld1)
CCAN: 109688371(Gpld1)
DORD: 106000038(Gpld1)
DSP: 122111059(Gpld1)
NCAR: 124988281
OCU: 100351916(GPLD1)
OPI: 101523140(GPLD1)
TUP: 102501907(GPLD1)
CFA: 478735(GPLD1)
VVP: 112920498(GPLD1)
VLG: 121499732(GPLD1)
AML: 100484842(GPLD1)
UMR: 103665176(GPLD1)
UAH: 113264336(GPLD1)
UAR: 123794261(GPLD1)
ELK: 111138612
LLV: 125101848
MPUF: 101688496(GPLD1)
ORO: 101370230(GPLD1)
EJU: 114212585(GPLD1)
ZCA: 113926556(GPLD1)
MLX: 118027226(GPLD1)
FCA: 101088486(GPLD1)
PYU: 121020624(GPLD1)
PBG: 122489168(GPLD1)
PTG: 102964289(GPLD1)
PPAD: 109252710(GPLD1)
AJU: 106968449(GPLD1)
HHV: 120219837(GPLD1)
BTA: 287025(GPLD1)
BOM: 102286788(GPLD1)
BIU: 109577315(GPLD1)
BBUB: 102389512(GPLD1)
CHX: 102169718(GPLD1)
OAS: 101119000(GPLD1)
ODA: 120870310(GPLD1)
CCAD: 122429730(GPLD1)
SSC: 100157497(GPLD1)
CFR: 102518271(GPLD1)
CBAI: 105061677(GPLD1)
CDK: 105089129(GPLD1)
VPC: 102538547(GPLD1)
BACU: 103003582(GPLD1)
LVE: 103088629(GPLD1)
OOR: 101288738(GPLD1)
DLE: 111168561(GPLD1)
PCAD: 102975868(GPLD1)
PSIU: 116761576(GPLD1)
ECB: 100067517(GPLD1)
EPZ: 103546694(GPLD1)
EAI: 106822357(GPLD1)
MYB: 102260484(GPLD1)
MYD: 102753404(GPLD1)
MMYO: 118672726(GPLD1)
MNA: 107539689(GPLD1)
PKL: 118727102(GPLD1)
HAI: 109396397(GPLD1)
DRO: 112313946(GPLD1)
SHON: 118990658(GPLD1)
AJM: 119054900(GPLD1)
PDIC: 114489512(GPLD1)
PHAS: 123833507(GPLD1)
MMF: 118637507(GPLD1)
RFQ: 117015438(GPLD1)
PALE: 102896882(GPLD1)
PGIG: 120607804(GPLD1)
PVP: 105306900(GPLD1)
RAY: 107508879(GPLD1)
MJV: 108399074(GPLD1)
TOD: 119230328 119251689(GPLD1)
SARA: 101538377(GPLD1)
LAV: 100677378(GPLD1)
TMU: 101344243
DNM: 101430948(GPLD1)
MDO: 100024296(GPLD1)
GAS: 123240054(GPLD1)
SHR: 100931811(GPLD1)
PCW: 110208720(GPLD1)
OAA: 100092985(GPLD1)
GGA: 420819(GPLD1)
PCOC: 116239798(GPLD1)
MGP: 100546397(GPLD1)
CJO: 107309738(GPLD1)
NMEL: 110394624(GPLD1)
APLA: 101792700(GPLD1)
ACYG: 106038351(GPLD1)
AFUL: 116485918(GPLD1)
TGU: 100230775(GPLD1)
LSR: 110483464(GPLD1)
SCAN: 103819395(GPLD1)
PMOA: 120503505(GPLD1)
OTC: 121347820(GPLD1)
PRUF: 121357795(GPLD1)
GFR: 102032214(GPLD1)
FAB: 101816045(GPLD1)
PHI: 102114237(GPLD1)
PMAJ: 107200258(GPLD1)
CCAE: 111923724(GPLD1)
CCW: 104691444(GPLD1)
ETL: 114069829(GPLD1)
ZAB: 102066942(GPLD1)
FPG: 101912228(GPLD1)
FCH: 102052413(GPLD1)
CLV: 102090900(GPLD1)
EGZ: 104125477(GPLD1)
NNI: 104021793(GPLD1)
PLET: 104618061(GPLD1)
ACUN: 113476037(GPLD1)
TALA: 104368490(GPLD1)
PADL: 103919061(GPLD1)
ACHC: 115353059(GPLD1)
AAM: 106483272(GPLD1)
AROW: 112972795(GPLD1)
DNE: 112992496(GPLD1)
ASN: 102375814(GPLD1)
AMJ: 102574726(GPLD1)
CPOO: 109316301(GPLD1)
GGN: 109302143(GPLD1)
PSS: 102448848(GPLD1)
CMY: 102944962(GPLD1)
CPIC: 101945760(GPLD1)
TST: 117873259(GPLD1)
CABI: 116836102(GPLD1)
MRV: 120396443(GPLD1)
ACS: 100567850(gpld1)
PVT: 110072878(GPLD1)
SUND: 121927761(GPLD1)
PBI: 103063314(GPLD1)
PMUR: 107289603(GPLD1)
PGUT: 117672545(GPLD1)
VKO: 123021649(GPLD1)
PMUA: 114600839(GPLD1)
ZVI: 118090549(GPLD1)
GJA: 107113400(GPLD1)
STOW: 125439160(GPLD1)
XLA: 108718535
XTR: 116411679(gpld1)
NPR: 108792898(GPLD1)
RTEM: 120940771(GPLD1)
BBUF: 121001703(GPLD1)
BGAR: 122939268(GPLD1)
LCM: 102345190(GPLD1)
BFO: 118405295
BBEL: 109466135
APLC: 110975439
SKO: 102801774
EAF: 111713084
PCAN: 112573356
BGT: 106061229
GAE: 121374135
HRF: 124113065
HRJ: 124288674
MYI: 110456981
LAK: 106165615
NVE: 5525170
EPA: 110241955
ATEN: 116291696
ADF: 107355065
PDAM: 113678713
SPIS: 111330701
DGT: 114523470
XEN: 124446939
SCE: YJL132W
NCS: NCAS_0A09790(NCAS0A09790)
NDI: NDAI_0G06190(NDAI0G06190)
TBL: TBLA_0D05660(TBLA0D05660)
TDL: TDEL_0H01030(TDEL0H01030)
KNG: KNAG_0C02670(KNAG0C02670)
DDI: DDB_G0276919(pldG)
DFA: DFA_04808(pldG)
 » show all
Reference
  Authors
Schofield JN, Rademacher TW
  Title
Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.
  Journal
Biochim Biophys Acta 1494:189-94 (2000)
DOI:10.1016/S0167-4781(00)00194-9
  Sequence
[hsa:2822]
Reference
PMID:3422494
  Authors
Low MG, Prasad AR
  Title
A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.
  Journal
Proc Natl Acad Sci U S A 85:980-4 (1988)
DOI:10.1073/pnas.85.4.980
LinkDB

KEGG   ENZYME: 3.1.4.50
Entry
EC 3.1.4.50                 Enzyme                                 
Name
glycosylphosphatidylinositol phospholipase D;
GPI-PLD;
glycoprotein phospholipase D;
phosphatidylinositol phospholipase D;
phosphatidylinositol-specific phospholipase D
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
glycoprotein-phosphatidylinositol phosphatidohydrolase
Reaction(IUBMB)
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate [RN:R06623]
Reaction(KEGG)
R06623(G);
(other) R04149 R07398
Substrate
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:C04248];
H2O [CPD:C00001]
Product
6-(alpha-D-glucosaminyl)-1D-myo-inositol [CPD:C15658];
3-sn-phosphatidate [CPD:C00416]
Comment
This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
History
EC 3.1.4.50 created 1990, modified 2002
Pathway
ec00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ec01100  Metabolic pathways
Orthology
K01127  glycosylphosphatidylinositol phospholipase D
Genes
HSA2822(GPLD1)
PTR462473(GPLD1)
PPS100973223(GPLD1)
GGO101146393(GPLD1)
PON100455517(GPLD1)
NLE100598329(GPLD1)
MCC707782(GPLD1)
MCF102125729(GPLD1)
CSAB103222053(GPLD1)
CATY105572618(GPLD1)
PANU101001857(GPLD1)
TGE112622303(GPLD1)
RRO104663891(GPLD1)
RBB108533667(GPLD1)
TFN117086801(GPLD1)
PTEH111541103(GPLD1)
CJC100385911(GPLD1)
SBQ101035773(GPLD1)
CSYR103251843(GPLD1)
MMUR105865209(GPLD1)
LCAT123638333(GPLD1)
OGA100943003(GPLD1)
MMU14756(Gpld1)
MCAL110307663(Gpld1)
MPAH110333811(Gpld1)
RNO291132(Gpld1)
MCOC116081596(Gpld1)
MUN110551065(Gpld1)
CGE100759513(Gpld1)
MAUA101825977(Gpld1)
PLEU114700916(Gpld1)
MORG121434002(Gpld1)
AAMP119817603(Gpld1)
NGI103745185(Gpld1)
HGL101724062(Gpld1)
CPOC100734898(Gpld1)
CCAN109688371(Gpld1)
DORD106000038(Gpld1)
DSP122111059(Gpld1)
NCAR124988281
OCU100351916(GPLD1)
OPI101523140(GPLD1)
TUP102501907(GPLD1)
CFA478735(GPLD1)
VVP112920498(GPLD1)
VLG121499732(GPLD1)
AML100484842(GPLD1)
UMR103665176(GPLD1)
UAH113264336(GPLD1)
UAR123794261(GPLD1)
ELK111138612
LLV125101848
MPUF101688496(GPLD1)
ORO101370230(GPLD1)
EJU114212585(GPLD1)
ZCA113926556(GPLD1)
MLX118027226(GPLD1)
FCA101088486(GPLD1)
PYU121020624(GPLD1)
PBG122489168(GPLD1)
PTG102964289(GPLD1)
PPAD109252710(GPLD1)
AJU106968449(GPLD1)
HHV120219837(GPLD1)
BTA287025(GPLD1)
BOM102286788(GPLD1)
BIU109577315(GPLD1)
BBUB102389512(GPLD1)
CHX102169718(GPLD1)
OAS101119000(GPLD1)
ODA120870310(GPLD1)
CCAD122429730(GPLD1)
SSC100157497(GPLD1)
CFR102518271(GPLD1)
CBAI105061677(GPLD1)
CDK105089129(GPLD1)
VPC102538547(GPLD1)
BACU103003582(GPLD1)
LVE103088629(GPLD1)
OOR101288738(GPLD1)
DLE111168561(GPLD1)
PCAD102975868(GPLD1)
PSIU116761576(GPLD1)
ECB100067517(GPLD1)
EPZ103546694(GPLD1)
EAI106822357(GPLD1)
MYB102260484(GPLD1)
MYD102753404(GPLD1)
MMYO118672726(GPLD1)
MNA107539689(GPLD1)
PKL118727102(GPLD1)
HAI109396397(GPLD1)
DRO112313946(GPLD1)
SHON118990658(GPLD1)
AJM119054900(GPLD1)
PDIC114489512(GPLD1)
PHAS123833507(GPLD1)
MMF118637507(GPLD1)
RFQ117015438(GPLD1)
PALE102896882(GPLD1)
PGIG120607804(GPLD1)
PVP105306900(GPLD1)
RAY107508879(GPLD1)
MJV108399074(GPLD1)
TOD119230328 119251689(GPLD1)
SARA101538377(GPLD1)
LAV100677378(GPLD1)
TMU101344243
DNM101430948(GPLD1)
MDO100024296(GPLD1)
GAS123240054(GPLD1)
SHR100931811(GPLD1)
PCW110208720(GPLD1)
OAA100092985(GPLD1)
GGA420819(GPLD1)
PCOC116239798(GPLD1)
MGP100546397(GPLD1)
CJO107309738(GPLD1)
NMEL110394624(GPLD1)
APLA101792700(GPLD1)
ACYG106038351(GPLD1)
AFUL116485918(GPLD1)
TGU100230775(GPLD1)
LSR110483464(GPLD1)
SCAN103819395(GPLD1)
PMOA120503505(GPLD1)
OTC121347820(GPLD1)
PRUF121357795(GPLD1)
GFR102032214(GPLD1)
FAB101816045(GPLD1)
PHI102114237(GPLD1)
PMAJ107200258(GPLD1)
CCAE111923724(GPLD1)
CCW104691444(GPLD1)
ETL114069829(GPLD1)
ZAB102066942(GPLD1)
FPG101912228(GPLD1)
FCH102052413(GPLD1)
CLV102090900(GPLD1)
EGZ104125477(GPLD1)
NNI104021793(GPLD1)
PLET104618061(GPLD1)
ACUN113476037(GPLD1)
TALA104368490(GPLD1)
PADL103919061(GPLD1)
ACHC115353059(GPLD1)
AAM106483272(GPLD1)
AROW112972795(GPLD1)
NPD112958299 112958300
DNE112992496(GPLD1)
ASN102375814(GPLD1)
AMJ102574726(GPLD1)
CPOO109316301(GPLD1)
GGN109302143(GPLD1)
PSS102448848(GPLD1)
CMY102944962(GPLD1)
CPIC101945760(GPLD1)
TST117873259(GPLD1)
CABI116836102(GPLD1)
MRV120396443(GPLD1)
ACS100567850(gpld1)
PVT110072878(GPLD1)
SUND121927761(GPLD1)
PBI103063314(GPLD1)
PMUR107289603(GPLD1)
PGUT117672545(GPLD1)
VKO123021649(GPLD1)
PMUA114600839(GPLD1)
ZVI118090549(GPLD1)
GJA107113400(GPLD1)
STOW125439160(GPLD1)
XLA108718535
XTR116411679(gpld1)
NPR108792898(GPLD1)
RTEM120940771(GPLD1)
BBUF121001703(GPLD1)
BGAR122939268(GPLD1)
LCM102345190(GPLD1)
BFO118405295
BBEL109466135
SPU115926364 590298
APLC110975439
SKO102801774
EAF111713084
PCAN112573356
BGT106061229
GAE121374135
HRF124113065
HRJ124288674
CRG105347431 105347449 105347450
MYI110456981
PMAX117326416 117326417
LAK106165615
NVE5525170
EPA110241955
ATEN116291696
ADF107355065
PDAM113678713
SPIS111330701
DGT114523470
XEN124446939
SCEYJL132W
SPAOSPAR_J00780
KLAKLLA0_E15401g
KMXKLMA_60039
LTHKLTH0F05830g
ZROZYRO0D03256g
CGRCAGL0L05720g
NCSNCAS_0A09790(NCAS0A09790)
NDINDAI_0G06190(NDAI0G06190)
TBLTBLA_0D05660(TBLA0D05660)
TDLTDEL_0H01030(TDEL0H01030)
TGBHG536_0F01060
KNGKNAG_0C02670(KNAG0C02670)
ZMKHG535_0C00920
PPAPAS_chr4_0595
YLIYALI0B15972g
SLBAWJ20_2030
PKZC5L36_0C01010
BNNFOA43_004168
OPAHPODL_01688
TMLGSTUM_00002772001
SREPTSG_02129
DDIDDB_G0276919(pldG)
DPPDICPUDRAFT_96554
DFADFA_04808(pldG)
ACANACA1_147710
 » show all
Reference
1  [PMID:3422494]
  Authors
Low MG, Prasad AR
  Title
A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.
  Journal
Proc Natl Acad Sci U S A 85:980-4 (1988)
DOI:10.1073/pnas.85.4.980
Reference
2  [PMID:3028377]
  Authors
Malik AS, Low MG.
  Title
Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases.
  Journal
Biochem J 240:519-27 (1986)
DOI:10.1042/bj2400519
Reference
3  [PMID:7961859]
  Authors
Li JY, Hollfelder K, Huang KS, Low MG.
  Title
Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies.
  Journal
J Biol Chem 269:28963-71 (1994)
Reference
4  [PMID:11254757]
  Authors
Deeg MA, Bierman EL, Cheung MC.
  Title
GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex.
  Journal
J Lipid Res 42:442-51 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.50
IUBMB Enzyme Nomenclature: 3.1.4.50
ExPASy - ENZYME nomenclature database: 3.1.4.50
BRENDA, the Enzyme Database: 3.1.4.50
CAS: 113756-14-2
LinkDB

KEGG   REACTION: R06623
Entry
R06623                      Reaction                               
Name
glycoprotein-phosphatidylinositol phosphatidohydrolase
Definition
G00144 + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + Phosphatidate
Equation
Remark
Same as: R07398
Enzyme
Pathway
rn00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
rn01100  Metabolic pathways
Orthology
K01127  glycosylphosphatidylinositol phospholipase D [EC:3.1.4.50]
LinkDB

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