KEGG   ORTHOLOGY: K01136
Entry
K01136                      KO                                     
Symbol
IDS
Name
iduronate 2-sulfatase [EC:3.1.6.13]
Pathway
map00531  Glycosaminoglycan degradation
map01100  Metabolic pathways
map04142  Lysosome
Module
M00076  Dermatan sulfate degradation
M00078  Heparan sulfate degradation
Disease
H00129  Mucopolysaccharidosis type II
H00421  Mucopolysaccharidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    K01136  IDS; iduronate 2-sulfatase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01136  IDS; iduronate 2-sulfatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.13  iduronate-2-sulfatase
     K01136  IDS; iduronate 2-sulfatase
Other DBs
RN: R07812 R07821
GO: 0004423
Genes
HSA: 3423(IDS)
PTR: 465896(IDS)
PPS: 100981796(IDS)
GGO: 101148217(IDS)
PON: 100435640(IDS)
NLE: 100581849(IDS)
MCC: 700892(IDS)
MCF: 102137236(IDS)
CSAB: 103232717(IDS)
CATY: 105595595(IDS)
PANU: 101008279(IDS)
TGE: 112615029(IDS)
RRO: 104657812(IDS)
RBB: 108539780(IDS)
TFN: 117078229(IDS)
PTEH: 111536373(IDS)
CJC: 100415225(IDS)
SBQ: 101027610(IDS)
CSYR: 103274999(IDS)
MMUR: 105857531(IDS)
OGA: 100962027(IDS)
MMU: 15931(Ids)
MCAL: 110286776(Ids)
MPAH: 110313631(Ids)
RNO: 363513(Ids)
MCOC: 116085689(Ids)
MUN: 110540175(Ids)
CGE: 100763345(Ids)
PLEU: 114688017(Ids)
NGI: 103737443(Ids)
HGL: 101710577(Ids)
CPOC: 100717247(Ids)
CCAN: 109695031(Ids)
DORD: 105992884(Ids)
DSP: 122108468(Ids)
OCU: 100356659(IDS)
OPI: 101532056(IDS)
TUP: 102483402(IDS)
CFA: 492194(IDS)
VVP: 112927657(IDS)
VLG: 121482887(IDS)
AML: 100469837(IDS)
UMR: 103662556(IDS)
UAH: 113241894(IDS)
UAR: 123786528(IDS)
ELK: 111158976
LLV: 125091730
MPUF: 101690645(IDS)
ORO: 101382674(IDS)
EJU: 114199013(IDS) 114202770
ZCA: 113930544(IDS)
MLX: 118008400(IDS)
FCA: 101081450(IDS)
PYU: 121025133(IDS)
PBG: 122477618(IDS)
PTG: 102968319(IDS)
PPAD: 109258697(IDS)
AJU: 106988547(IDS)
HHV: 120227028(IDS)
BTA: 541272(IDS)
BOM: 102286693(IDS)
BIU: 109554785(IDS)
BBUB: 102410975(IDS)
CHX: 102189563(IDS)
OAS: 101116540(IDS)
ODA: 120881766(IDS)
CCAD: 122434594(IDS)
SSC: 100512880(IDS)
CFR: 102510249(IDS)
CBAI: 105064973(IDS)
CDK: 105104103(IDS)
VPC: 102525480(IDS)
BACU: 103018480(IDS)
LVE: 103078281(IDS)
OOR: 101289790(IDS)
DLE: 111167853(IDS)
PCAD: 102983735
PSIU: 116747351(IDS)
ECB: 111771607(IDS)
EPZ: 103540044(IDS)
EAI: 106842534(IDS)
MYB: 102251234(IDS)
MYD: 102771465(IDS)
MMYO: 118653914(IDS)
MLF: 102440269(IDS)
MNA: 107530067(IDS)
PKL: 118716954(IDS)
HAI: 109388991(IDS)
DRO: 112296325(IDS)
SHON: 118996043(IDS)
AJM: 119051673(IDS)
PDIC: 114505161(IDS)
PHAS: 123807068(IDS)
MMF: 118635949(IDS)
RFQ: 117023447(IDS)
PALE: 102893087(IDS)
PGIG: 120608677(IDS)
PVP: 105309494(IDS)
MJV: 108405651(IDS)
TOD: 119245842(IDS)
SARA: 101538521(IDS)
LAV: 100668951(IDS)
TMU: 101348522
DNM: 101426784(IDS)
MDO: 100025173(IDS)
GAS: 123253324(IDS)
SHR: 100932918(IDS)
PCW: 110199816(IDS)
OAA: 100081812(IDS)
GGA: 422392(IDS)
PCOC: 116234854(IDS)
MGP: 100548552(IDS)
CJO: 107312964(IDS)
NMEL: 110403286(IDS)
APLA: 101805206(IDS)
ACYG: 106037727(IDS)
AFUL: 116494372(IDS)
TGU: 100231299(IDS)
LSR: 110480065(IDS)
SCAN: 103816359(IDS)
PMOA: 120506191(IDS)
OTC: 121331886(IDS)
PRUF: 121363238(IDS)
GFR: 102044849(IDS)
FAB: 101817405(IDS)
PHI: 102102287(IDS)
PMAJ: 107204060(IDS)
CCAE: 111928496(IDS)
CCW: 104691675(IDS)
ETL: 114056735(IDS)
ZAB: 102065825(IDS)
FPG: 101917991(IDS)
FCH: 102056477(IDS)
CLV: 102095548(IDS)
EGZ: 104124077(IDS)
NNI: 104019072(IDS)
ACUN: 113480248(IDS)
TALA: 104365536(IDS)
PADL: 103922912(IDS)
ACHC: 115333540(IDS)
AAM: 106487578(IDS)
AROW: 112972805(IDS)
NPD: 112947092(IDS)
DNE: 112986845(IDS)
ASN: 102375700(IDS)
AMJ: 102571433(IDS)
CPOO: 109313625(IDS)
GGN: 109300820(IDS)
PSS: 102447899(IDS)
CMY: 102931008(IDS)
CPIC: 101944748(IDS)
TST: 117883182(IDS)
CABI: 116824492(IDS)
MRV: 120372584(IDS)
ACS: 100565846(ids)
PVT: 110082990(IDS)
SUND: 121937360(IDS)
PBI: 103053966(IDS)
PMUR: 107291666(IDS)
TSR: 106549285(IDS)
PGUT: 117677977(IDS)
VKO: 123022088(IDS)
PMUA: 114589233(IDS)
ZVI: 118084337(IDS)
GJA: 107107996(IDS)
XLA: 108698425(ids.L)
XTR: 100135738(ids)
NPR: 108783898(IDS)
RTEM: 120913664(IDS)
BBUF: 120977745(IDS)
BGAR: 122946435(IDS)
DRE: 559959(ids)
SANH: 107703646
SGH: 107588358
CCAR: 109108298(ids)
CAUA: 113113609(ids)
IPU: 108268807(ids)
PHYP: 113542945(ids)
SMEO: 124386343(ids)
AMEX: 103032782(ids)
EEE: 113572503(ids)
LCO: 104932265(ids)
NCC: 104948380(ids)
CGOB: 115014997(ids)
ELY: 117260683(ids)
PLEP: 121947925(ids)
SLUC: 116036600(ids)
ECRA: 117951985(ids)
PFLV: 114562652(ids)
GAT: 120817090(ids)
PPUG: 119210911(ids)
MSAM: 119888202(ids)
CUD: 121516852(ids)
MZE: 101484170(ids)
ONL: 100701301(ids)
OAU: 116328130(ids)
OLA: 101158287(ids)
OML: 112153796(ids)
XMA: 102223507(ids)
XCO: 114139558(ids)
XHE: 116714780(ids)
PRET: 103471071(ids)
PFOR: 103149292(ids)
PLAI: 106957966(ids)
PMEI: 106928927(ids)
GAF: 122837431
CVG: 107093837(ids)
CTUL: 119797269(ids)
GMU: 124860357(ids)
NFU: 107382373(ids)
KMR: 108240015(ids)
ALIM: 106533195(ids)
AOCE: 111582599(ids)
CSEM: 103391272(ids)
POV: 109627356(ids)
SSEN: 122761367 122778945(ids)
HHIP: 117769232(ids)
LCF: 108878945(ids)
SDU: 111226708(ids)
SLAL: 111646415(ids)
XGL: 120785469(ids)
HCQ: 109524284(ids)
BPEC: 110172172(ids)
MALB: 109957582(ids)
SASA: 106611990(ids)
OTW: 112256025(ids)
OMY: 110504761(ids)
OGO: 124010384(ids)
ONE: 115129288(ids)
SALP: 111965339 112070437(ids)
SNH: 120062503
ELS: 105027395(ids)
SFM: 108922862(ids)
PKI: 111848144(ids)
AANG: 118223704(ids)
LOC: 102691141(ids)
PSPA: 121318966(ids)
ARUT: 117412437
LCM: 102348043(IDS)
CMK: 103178266(ids)
RTP: 109937925
BFO: 118419919
BBEL: 109467966
CIN: 100185385
SCLV: 120336576
DME: Dmel_CG12014(Ids)
DER: 6546473
DSE: 6610634
DSI: Dsimw501_GD13763(Dsim_GD13763)
DAN: 6506843
DSR: 110177559
DPE: 6601698
DMN: 108152850
DWI: 6645875
DGR: 6558002
DAZ: 108614650
DNV: 108650413
DHE: 111601084
DVI: 6623790
CCAT: 101450281
BOD: 106624196
MDE: 101896463
SCAC: 106089515
LCQ: 111690708
ACOZ: 120952744
AARA: 120906700
AAG: 5572289
AALB: 109431614
CPII: 120423600
CNS: 116345890
AME: 724550
ACER: 108003103
ALAB: 122719407
BIM: 100747349
BBIF: 117217264
BVK: 117243015
BVAN: 117155222
BTER: 100647993
BPYO: 122575014
CCAL: 108622260
MGEN: 117226330
NMEA: 116427173
CGIG: 122400255
SOC: 105193763
MPHA: 105837418
AEC: 105147376
ACEP: 105624958
PBAR: 105426620
VEM: 105557423
HST: 105185301
DQU: 106749424
CFO: 105253432
FEX: 115235396
LHU: 105673528
PGC: 109860994
OBO: 105283280
PCF: 106787197
PFUC: 122516811
VPS: 122630918
NVI: 100119376
CSOL: 105365576
TPRE: 106650519
MDL: 103570322
CGLO: 123263273
FAS: 105263507
DAM: 107036955
AGIF: 122858749
CCIN: 107268146
TCA: 655669
DPA: 109540804
SOY: 115874731
ATD: 109598542
AGB: 108911873
NVL: 108560267
APLN: 108738006
PPYR: 116169867
OTU: 111415433
BMOR: 101744799
BMAN: 114241742
MSEX: 115451146
BANY: 112046670
PMAC: 106715653
PPOT: 106105684
PXU: 106113405
PRAP: 111001403
ZCE: 119833535
HAW: 110370991
TNL: 113507089
OFU: 114364068
BTAB: 109038066
CLEC: 106670417
HHAL: 106680034
FOC: 113209995
ZNE: 110832438
CSEC: 111870513
PVM: 113824470
PJA: 122242148
HAME: 121871886
PCLA: 123772446
PTRU: 123515495
HAZT: 108680906
EAF: 111699044
RMP: 119169964
CSCU: 111634598
BGT: 106063888
CRG: 105329839
MYI: 110456562
OBI: 106871045
OSN: 115216752
NVE: 5506756
EPA: 110243498
ATEN: 116295503
ADF: 107340223
AMIL: 114970454
SPIS: 111326384
NGD: NGA_0701900(IDS)
PAT: Patl_0891
SPHU: SPPYR_0445
SSAN: NX02_06250
ADO: A6F68_00793(betC_2) A6F68_01095(betC_7)
PIR: VN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RUL: UC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
LCRE: Pla8534_31970(betC_9) Pla8534_37420 Pla8534_62290(betC_14)
RLC: K227x_60000(betC_18)
AMUC: Pan181_24280(betC_2) Pan181_35480
PEH: Spb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PLS: VT03_16380(betC_4) VT03_26185(betC_5)
GMR: GmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
GPN: Pan110_26060 Pan110_31690(betC_5) Pan110_33350(betC_6) Pan110_37530 Pan110_50420(betC_9) Pan110_52270(betC_11) Pan110_54560(betC_12) Pan110_57880(betC_13) Pan110_58100(betC_14)
PLON: Pla110_26770(betC_3) Pla110_45380(betC_7)
FTJ: FTUN_0511
ALUS: STSP2_00836(betC_2)
VBL: L21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
ABAC: LuPra_00139(betC_1)
BVU: BVU_1771
PSAC: PSM36_3070
BACC: BRDCF_p1883(betC)
SDJ: NCTC13534_02722(betC_2)
DFE: Dfer_2051
MARM: YQ22_02090
ZGA: ZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
TJE: TJEJU_2924(idsA)
 » show all
Reference
  Authors
Coronado-Pons I, Novials A, Casas S, Clark A, Gomis R
  Title
Identification of iduronate-2-sulfatase in mouse pancreatic islets.
  Journal
Am J Physiol Endocrinol Metab 287:E983-90 (2004)
DOI:10.1152/ajpendo.00528.2003
  Sequence
[mmu:15931]
LinkDB

KEGG   ENZYME: 3.1.6.13
Entry
EC 3.1.6.13                 Enzyme                                 
Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
History
EC 3.1.6.13 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01136  iduronate 2-sulfatase
Genes
HSA3423(IDS)
PTR465896(IDS)
PPS100981796(IDS)
GGO101148217(IDS)
PON100435640(IDS)
NLE100581849(IDS)
MCC700892(IDS)
MCF102137236(IDS)
CSAB103232717(IDS)
CATY105595595(IDS)
PANU101008279(IDS)
TGE112615029(IDS)
RRO104657812(IDS)
RBB108539780(IDS)
TFN117078229(IDS)
PTEH111536373(IDS)
CJC100415225(IDS)
SBQ101027610(IDS)
CSYR103274999(IDS)
MMUR105857531(IDS)
OGA100962027(IDS)
MMU15931(Ids)
MCAL110286776(Ids)
MPAH110313631(Ids)
RNO363513(Ids)
MCOC116085689(Ids)
MUN110540175(Ids)
CGE100763345(Ids)
PLEU114688017(Ids)
NGI103737443(Ids)
HGL101710577(Ids)
CPOC100717247(Ids)
CCAN109695031(Ids)
DORD105992884(Ids)
DSP122108468(Ids)
OCU100356659(IDS)
OPI101532056(IDS)
TUP102483402(IDS)
CFA492194(IDS)
VVP112927657(IDS)
VLG121482887(IDS)
AML100469837(IDS)
UMR103662556(IDS)
UAH113241894(IDS)
UAR123786528(IDS)
ELK111158976
LLV125091730
MPUF101690645(IDS)
ORO101382674(IDS)
EJU114199013(IDS) 114202770
ZCA113930544(IDS)
MLX118008400(IDS)
FCA101081450(IDS)
PYU121025133(IDS)
PBG122477618(IDS)
PTG102968319(IDS)
PPAD109258697(IDS)
AJU106988547(IDS)
HHV120227028(IDS)
BTA541272(IDS)
BOM102286693(IDS)
BIU109554785(IDS)
BBUB102410975(IDS)
CHX102189563(IDS)
OAS101116540(IDS)
ODA120881766(IDS)
CCAD122434594(IDS)
SSC100512880(IDS)
CFR102510249(IDS)
CBAI105064973(IDS)
CDK105104103(IDS)
VPC102525480(IDS)
BACU103018480(IDS)
LVE103078281(IDS)
OOR101289790(IDS)
DLE111167853(IDS)
PCAD102983735
PSIU116747351(IDS)
ECB111771607(IDS)
EPZ103540044(IDS)
EAI106842534(IDS)
MYB102251234(IDS)
MYD102771465(IDS)
MMYO118653914(IDS)
MLF102440269(IDS)
MNA107530067(IDS)
PKL118716954(IDS)
HAI109388991(IDS)
DRO112296325(IDS)
SHON118996043(IDS)
AJM119051673(IDS)
PDIC114505161(IDS)
PHAS123807068(IDS)
MMF118635949(IDS)
RFQ117023447(IDS)
PALE102893087(IDS)
PGIG120608677(IDS)
PVP105309494(IDS)
RAY107502397 107502399(IDS) 107506382 107507519 107507961
MJV108405651(IDS)
TOD119245842(IDS)
SARA101538521(IDS)
LAV100668951(IDS)
TMU101348522
DNM101426784(IDS)
MDO100025173(IDS)
GAS123253324(IDS)
SHR100932918(IDS)
PCW110199816(IDS)
OAA100081812(IDS)
GGA422392(IDS)
PCOC116234854(IDS)
MGP100548552(IDS)
CJO107312964(IDS)
NMEL110403286(IDS)
APLA101805206(IDS)
ACYG106037727(IDS)
AFUL116494372(IDS)
TGU100231299(IDS)
LSR110480065(IDS)
SCAN103816359(IDS)
PMOA120506191(IDS)
OTC121331886(IDS)
PRUF121363238(IDS)
GFR102044849(IDS)
FAB101817405(IDS)
PHI102102287(IDS)
PMAJ107204060(IDS)
CCAE111928496(IDS)
CCW104691675(IDS)
ETL114056735(IDS)
ZAB102065825(IDS)
FPG101917991(IDS)
FCH102056477(IDS)
CLV102095548(IDS)
EGZ104124077(IDS)
NNI104019072(IDS)
ACUN113480248(IDS)
TALA104365536(IDS)
PADL103922912(IDS)
ACHC115333540(IDS)
AAM106487578(IDS)
AROW112972805(IDS)
NPD112947092(IDS)
DNE112986845(IDS)
ASN102375700(IDS)
AMJ102571433(IDS)
CPOO109313625(IDS)
GGN109300820(IDS)
PSS102447899(IDS)
CMY102931008(IDS)
CPIC101944748(IDS)
TST117883182(IDS)
CABI116824492(IDS)
MRV120372584(IDS)
ACS100565846(ids)
PVT110082990(IDS)
SUND121937360(IDS)
PBI103053966(IDS)
PMUR107291666(IDS)
TSR106549285(IDS)
PGUT117677977(IDS)
VKO123022088(IDS)
PMUA114589233(IDS)
ZVI118084337(IDS)
GJA107107996(IDS)
XLA108698425(ids.L)
XTR100135738(ids)
NPR108783898(IDS)
RTEM120913664(IDS)
BBUF120977745(IDS)
BGAR122946435(IDS)
DRE559959(ids)
SRX107742636 107754550
SANH107703646
SGH107588358
CCAR109108298(ids)
CAUA113113609(ids)
IPU108268807(ids)
PHYP113542945(ids)
SMEO124386343(ids)
AMEX103032782(ids)
EEE113572503(ids)
TRU101066362 115252486
TNGGSTEN00010710G001
LCO104932265(ids)
NCC104948380(ids)
CGOB115014997(ids)
ELY117260683(ids)
PLEP121947925(ids)
SLUC116036600(ids)
ECRA117951985(ids)
PFLV114562652(ids)
GAT120817090(ids)
PPUG119210911(ids)
MSAM119888202(ids)
CUD121516852(ids)
MZE101484170(ids)
ONL100701301(ids)
OAU116328130(ids)
OLA101158287(ids)
OML112153796(ids)
XMA102223507(ids)
XCO114139558(ids)
XHE116714780(ids)
PRET103471071(ids)
PFOR103149292(ids)
PLAI106957966(ids)
PMEI106928927(ids)
GAF122837431
CVG107093837(ids)
CTUL119797269(ids)
GMU124860357(ids)
NFU107382373(ids)
KMR108240015(ids)
ALIM106533195(ids)
AOCE111582599(ids)
CSEM103391272(ids)
POV109627356(ids)
SSEN122761367 122778945(ids)
HHIP117769232(ids)
LCF108878945(ids)
SDU111226708(ids)
SLAL111646415(ids)
XGL120785469(ids)
HCQ109524284(ids)
BPEC110172172(ids)
MALB109957582(ids)
SASA106611990(ids)
OTW112256025(ids)
OMY110504761(ids)
OGO124010384(ids)
ONE115129288(ids)
SALP111965339 112070437(ids)
SNH120062503
ELS105027395(ids)
SFM108922862(ids)
PKI111848144(ids)
AANG118223704(ids)
LOC102691141(ids)
PSPA121318966(ids)
ARUT117412437
LCM102348043(IDS)
CMK103178266(ids)
RTP109937925
BFO118419919
BBEL109467966
CIN100185385
SCLV120336576
SPU100892602 100892667 115918435 115922305 579992 584730 587680 588607 588631
APLC110983712 110983804
SKO100370796 100374826
DMEDmel_CG12014(Ids)
DER6546473
DSE6610634
DSIDsimw501_GD13763(Dsim_GD13763)
DYADyak_GE21364
DAN6506843
DSR110177559
DPODpse_GA11337
DPE6601698
DMN108152850
DWI6645875
DGR6558002
DMODmoj_GI12380
DAZ108614650
DNV108650413
DHE111601084
DVI6623790
CCAT101450281
BOD106624196
MDE101896463
SCAC106089515
LCQ111690708
AGAAgaP_AGAP005778
ACOZ120952744
AARA120906700
AAG5572289
AALB109431614
CQUCpipJ_CPIJ004938
CPII120423600
CNS116345890
AME724550
ACER108003103
ALAB122719407
BIM100747349
BBIF117217264
BVK117243015
BVAN117155222
BTER100647993
BPYO122575014
CCAL108622260
OBB114873358 114873437
MGEN117226330
NMEA116427173
CGIG122400255
SOC105193763
MPHA105837418
AEC105147376
ACEP105624958
PBAR105426620
VEM105557423
HST105185301
DQU106749424
CFO105253432
FEX115235396
LHU105673528
PGC109860994
OBO105283280
PCF106787197
PFUC122516811
VPS122630918
NVI100119376
CSOL105365576
TPRE106650519
MDL103570322
CGLO123263273
FAS105263507
DAM107036955
AGIF122858749
CCIN107268146
TCA655669
DPA109540804
SOY115874731
ATD109598542
AGB108911873
NVL108560267
APLN108738006
PPYR116169867
OTU111415433
BMOR101744799
BMAN114241742
MSEX115451146
DPLKGM_202663
BANY112046670
PMAC106715653
PPOT106105684
PXU106113405
PRAP111001403
ZCE119833535
HAW110370991
TNL113507089
OFU114364068
PXY105382488 105389116
BTAB109038066
CLEC106670417
HHAL106680034
NLU111046525 111061142 120355108 120355801 120356024
PHUPhum_PHUM557360
FOC113209995
ZNE110832438
CSEC111870513
PVM113824470
PJA122242148
HAME121871886
PCLA123772446
PTRU123515495
HAZT108680906
EAF111699044
ISCIscW_ISCW002030
DSV119449692 119449694
RMP119169964
CSCU111634598
PTEP107436780 107441331
SDM118181385 118189191
LGILOTGIDRAFT_104488 LOTGIDRAFT_123341 LOTGIDRAFT_153520 LOTGIDRAFT_165917 LOTGIDRAFT_182753
PCAN112559502 112559503 112559504 112559583 112559713
BGT106063888
GAE121374686 121377054 121378631 121378632 121378634 121378635
HRF124112807 124112980 124112981 124113001 124113003 124118457 124118983 124118984 124122656 124122658 124122659 124122660 124122661 124122662 124125297 124125298 124125299 124125300 124125301 124125302 124132900 124147513 124149615 124149618 124152520 124152521 124152523 124152524 124152526 124152528 124152530 124152531 124152532 124152533 124152534 124152535 124152538 124152539
HRJ124253119 124262409 124265030 124269853 124269854 124269855 124270479 124270480 124270816 124272583 124274728 124286941 124286945 124287446 124287447 124287449 124287451 124287452 124287453 124287454 124287455 124287457 124287483 124287488 124287489 124290992 124292414 124292415 124292417 124292418
CRG105329839
MYI110456562
MMER123541840 123542263 123545463 123546109 123546157 123556889 123558400 123562141 123562143
OBI106871045
OSN115216752
LAK106169855 106178049
NVE5506756
EPA110243498
ATEN116295503
ADF107340223
AMIL114970454
PDAM113686490 113686493
SPIS111326384
AQU100632261 100634409 100635941 100636070 100637425 100637941 100638175 100638304 105312205 109584014 109584015 109587233
MBRMONBRDRAFT_22994 MONBRDRAFT_25248 MONBRDRAFT_27026 MONBRDRAFT_27633 MONBRDRAFT_28811 MONBRDRAFT_30487 MONBRDRAFT_32660
SREPTSG_08138 PTSG_08989
NGDNGA_0701900(IDS)
AAFAURANDRAFT_24889(ITS3) AURANDRAFT_63017(ITS1) AURANDRAFT_67199(ITS2)
EHXEMIHUDRAFT_103111 EMIHUDRAFT_103855 EMIHUDRAFT_112105 EMIHUDRAFT_122517 EMIHUDRAFT_194249 EMIHUDRAFT_209682 EMIHUDRAFT_212280 EMIHUDRAFT_217387 EMIHUDRAFT_219397 EMIHUDRAFT_224019 EMIHUDRAFT_226946 EMIHUDRAFT_236119 EMIHUDRAFT_241437 EMIHUDRAFT_250748 EMIHUDRAFT_251085 EMIHUDRAFT_254050 EMIHUDRAFT_449285 EMIHUDRAFT_462481 EMIHUDRAFT_470309 EMIHUDRAFT_98819
VAFD1115_15455
VASGT360_18225
CPSCPS_2358 CPS_2375 CPS_2381
THTE2K93_07360
PATPatl_0891
CATEC2869_03515 C2869_06890 C2869_07510 C2869_07615
HALCEY643_10695
SPHKSKP52_01945
SPHXE5675_04665
SPHUSPPYR_0445
SSANNX02_06250
SKRBRX40_12300
SPLMBXU08_07020
SHYDCJD35_08000
ANHA6F65_00907
ADOA6F68_00793(betC_2) A6F68_01095(betC_7)
OACOscil6304_3690
VBHCMV30_08140
ROOG5S37_04965 G5S37_05100 G5S37_06235 G5S37_09990 G5S37_28180
LUOHHL09_01145 HHL09_01155 HHL09_08160
VBAIMCC26134_05065 IMCC26134_14340 IMCC26134_14360
VBSEGM51_05040 EGM51_06095 EGM51_06440
RBARB10612 RB110 RB11127(ids) RB12089 RB2085(betC) RB2254 RB2707 RB5424 RB763
PSLPsta_0190 Psta_1325 Psta_4390
PIRVN12_09385 VN12_21255(betC_6) VN12_22170(betC_7)
RULUC8_11930 UC8_17290(betC_4) UC8_25850 UC8_36630(betC_8) UC8_53680(betC_12)
MFFMFFC18_08440(betC_1) MFFC18_24440(betC_5) MFFC18_27880(betC_6) MFFC18_28310 MFFC18_48110
ROLCA51_00570(betC_1) CA51_05180 CA51_09680 CA51_13020(betC_3) CA51_15580(betC_4) CA51_27610 CA51_27790(betC_7)
AHELQ31a_06790(betC_2) Q31a_18220 Q31a_38050 Q31a_39670 Q31a_40250(betC_12) Q31a_49120 Q31a_52450 Q31a_62100(betC_14)
LCREPla8534_31970(betC_9) Pla8534_37420 Pla8534_62290(betC_14)
AAGGETAA8_12620 ETAA8_19150(betC_4) ETAA8_29880 ETAA8_34290(betC_7) ETAA8_40770
BVOPan97_01350(betC_1) Pan97_04460(betC_3) Pan97_04520 Pan97_05370 Pan97_10250(betC_7) Pan97_11360 Pan97_28910
RLCK227x_60000(betC_18)
TTFTHTE_1564 THTE_3218 THTE_3574
LPAVPLANPX_2904
AMUCPan181_24280(betC_2) Pan181_35480
PNDPla175_08790(betC_3) Pla175_16280(betC_7) Pla175_17960 Pla175_22610(betC_9) Pla175_23090 Pla175_29660(betC_16) Pla175_30230(betC_17) Pla175_30620(betC_18) Pla175_34340(betC_19) Pla175_43580(betC_21) Pla175_44060
PLMPlim_0651 Plim_3206 Plim_3468
PEHSpb1_00530(betC_1) Spb1_14370(betC_2) Spb1_39310(betC_6)
PBSPlabr_1704 Plabr_1705 Plabr_2092 Plabr_3173 Plabr_3214 Plabr_3306 Plabr_3888 Plabr_3983
PLSVT03_16380(betC_4) VT03_26185(betC_5)
FMRFuma_00103 Fuma_00319 Fuma_00869(betC_3) Fuma_03662(betC_8) Fuma_05561 Fuma_05572
GMRGmarT_16040(betC_3) GmarT_33550(betC_6) GmarT_39170(betC_9) GmarT_51320(betC_11) GmarT_52750(betC_12) GmarT_56780(betC_15) GmarT_56970(betC_16)
GIMF1728_16070 F1728_16135 F1728_17540 F1728_18375 F1728_20155 F1728_26680 F1728_28935 F1728_29645
GPNPan110_26060 Pan110_31690(betC_5) Pan110_33350(betC_6) Pan110_37530 Pan110_50420(betC_9) Pan110_52270(betC_11) Pan110_54560(betC_12) Pan110_57880(betC_13) Pan110_58100(betC_14)
MRIMal4_02780(betC_2) Mal4_02830 Mal4_11450(betC_3) Mal4_23560 Mal4_25490(betC_10) Mal4_25920 Mal4_38510 Mal4_38980(betC_16) Mal4_43080(betC_18) Mal4_52730
SDYNMal52_09100(betC_4) Mal52_09280 Mal52_20470(betC_5) Mal52_23390
PLONPla110_26770(betC_3) Pla110_45380(betC_7)
TIMGMBLW1_10970
LRSPX52LOC_01054 PX52LOC_03291
FTJFTUN_0511
ULIETAA1_29150 ETAA1_30410(betC_3) ETAA1_30420 ETAA1_48310(betC_4)
SACISinac_2390 Sinac_5994
PBPSTSP1_02381
PBASSMSP2_00670 SMSP2_00786
ALUSSTSP2_00836(betC_2)
HBSIPV69_00480 IPV69_05370 IPV69_05465 IPV69_06155 IPV69_07740 IPV69_17595
VBLL21SP4_00397(betC_1) L21SP4_01487 L21SP4_01919(betC_8)
TSAAciPR4_1572
ABACLuPra_00139(betC_1)
BZGC4H11_09370
BHFC3V43_10380
BVUBVU_1771
BDOEL88_19490
BDHGV66_08985
PSACPSM36_3070
PARYA4V02_08150
ACOUA5CBH24_04400
BACCBRDCF_p1883(betC)
DRCG0Q07_14495
MCOSGM418_07545 GM418_10580 GM418_11520 GM418_11530 GM418_15485 GM418_18720 GM418_22600 GM418_24840 GM418_25460
ASXCDL62_09655
MBASALGA_0045 ALGA_2234
CHITFW415_14010 FW415_21965
NIAA8C56_23685
PGINFRZ67_01245 FRZ67_01250
PHEPhep_2247 Phep_3489
SHGSph21_4218 Sph21_5173
SMIZ4412673_01943
SPHZE3D81_15590
SDJNCTC13534_02722(betC_2)
MMABHQ865_20705
AGDFRZ59_08605 FRZ59_09485
OLIFKG96_18495 FKG96_21210 FKG96_23435
CMRCycma_0852 Cycma_3754 Cycma_3797 Cycma_3901
CAMUCA2015_0736 CA2015_3688 CA2015_3725
EVIEchvi_0936 Echvi_3776
ESTDN752_02210 DN752_10940 DN752_23000 DN752_23410
ECHIFKX85_04685 FKX85_17770
ALMAO498_15650
DFEDfer_2051
FIBA6C57_05995
ALSDJ013_02320 DJ013_04270 DJ013_06750
FLMMY04_5044 MY04_5052 MY04_5157 MY04_5164
FLLEI427_16845 EI427_21685 EI427_21720
FYAKMW28_27690 KMW28_27725 KMW28_28200
FKAKM029_23090 KM029_26055
FBTD770_14535
FFAFFWV33_10655 FFWV33_14845 FFWV33_15050 FFWV33_17845
FNKE1750_01020 E1750_01035 E1750_17170 E1750_17200
FBCFB2170_01941 FB2170_06815
MARMYQ22_02090
MAREEJ994_10160 EJ994_10220 EJ994_10435
CAOCelal_0430 Celal_0431
CLYCelly_1791 Celly_1796
CLHIX49_08840 IX49_08865
CBALM667_18145 M667_19620
CBATM666_18145 M666_19535
ZGAZOBELLIA_181(idsA1) ZOBELLIA_2730(idsA2) ZOBELLIA_3146(idsA3) ZOBELLIA_3526(idsA4)
SPONHME9304_00667
POLABXQ17_09695 BXQ17_09710 BXQ17_09750 BXQ17_09845
PHALH9I45_05880 H9I45_05905 H9I45_05950 H9I45_05955
WIJBWZ20_07955
SZEAW14_08895 AW14_08920 AW14_08960 AW14_13205 AW14_13220 AW14_13235 AW14_13405 AW14_13435
AHZAPS56_04555 APS56_05910 APS56_09900
TJETJEJU_2924(idsA)
WFUAXE80_00055 AXE80_06065 AXE80_06125 AXE80_06140 AXE80_07595 AXE80_10200 AXE80_10210 AXE80_10620 AXE80_12690 AXE80_12995
FOHFORMA_02030 FORMA_02150 FORMA_02410 FORMA_02490 FORMA_02510 FORMA_07140 FORMA_07310
FOPFNB79_04820 FNB79_14610
SALTAO058_17590
SEONBWZ22_10495 BWZ22_10535 BWZ22_10550 BWZ22_11745
AALGAREALGSMS7_01173 AREALGSMS7_01304
TAJC1A40_08420 C1A40_08455 C1A40_13045 C1A40_13085 C1A40_13100
KANIMCC3317_46410 IMCC3317_46440
EMARD1013_16565
GAAHX109_03365 HX109_13995
FBUUJ101_00816 UJ101_00822(GNS)
FBEFF125_02310 FF125_03865 FF125_12590 FF125_15540
ORHOrnrh_1056
ORIQ785_05885
 » show all
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim Biophys Acta 708:134-40 (1982)
DOI:10.1016/0167-4838(82)90213-8
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc Natl Acad Sci U S A 70:2134-8 (1973)
DOI:10.1073/pnas.70.7.2134
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim Biophys Acta 661:106-11 (1981)
DOI:10.1016/0005-2744(81)90088-7
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J Biochem (Tokyo) 91:433-41 (1982)
DOI:10.1093/oxfordjournals.jbchem.a133715
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.13
IUBMB Enzyme Nomenclature: 3.1.6.13
ExPASy - ENZYME nomenclature database: 3.1.6.13
BRENDA, the Enzyme Database: 3.1.6.13
CAS: 50936-59-9
LinkDB

KEGG   REACTION: R07821
Entry
R07821                      Reaction                               
Name
L-iduronate-2-sulfate 2-sulfohydrolase
Definition
G13041 + H2O <=> G13042 + Sulfate
Equation
Enzyme
Pathway
rn00531  Glycosaminoglycan degradation
rn01100  Metabolic pathways
Module
M00076  Dermatan sulfate degradation
Orthology
K01136  iduronate 2-sulfatase [EC:3.1.6.13]
LinkDB

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