KEGG   ORTHOLOGY: K01283
Entry
K01283                      KO                                     
Symbol
ACE, CD143
Name
peptidyl-dipeptidase A [EC:3.4.15.1]
Pathway
map04614  Renin-angiotensin system
map04924  Renin secretion
map05142  Chagas disease
map05171  Coronavirus disease
map05410  Hypertrophic cardiomyopathy
map05415  Diabetic cardiomyopathy
Disease
H00083  Allograft rejection
H00575  Renal tubular dysgenesis
H01456  Diabetic nephropathy
H01457  Diabetic retinopathy
H02559  Microvascular complications of diabetes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    K01283  ACE, CD143; peptidyl-dipeptidase A
   04614 Renin-angiotensin system
    K01283  ACE, CD143; peptidyl-dipeptidase A
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K01283  ACE, CD143; peptidyl-dipeptidase A
   05415 Diabetic cardiomyopathy
    K01283  ACE, CD143; peptidyl-dipeptidase A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01283  ACE, CD143; peptidyl-dipeptidase A
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01283  ACE, CD143; peptidyl-dipeptidase A
   04090 CD molecules
    K01283  ACE, CD143; peptidyl-dipeptidase A
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.15  Peptidyl-dipeptidases
    3.4.15.1  peptidyl-dipeptidase A
     K01283  ACE, CD143; peptidyl-dipeptidase A
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M2
   K01283  ACE, CD143; peptidyl-dipeptidase A
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01283  ACE, CD143; peptidyl-dipeptidase A
CD molecules [BR:ko04090]
 Proteins
  K01283  CD143, ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Genes
HSA: 1636(ACE)
PTR: 449567(ACE)
PPS: 100980711(ACE)
GGO: 101145787
PON: 100453403(ACE) 100453767
PPYG: 129017614 129017934(ACE)
NLE: 100592115 105737894
HMH: 116458382 116458677
SSYN: 129469664 129470104(ACE)
MCC: 100428661(ACE)
MCF: 102127700 102128376(ACE)
CATY: 105590725(ACE)
PANU: 101020307
TGE: 112609814(ACE)
TFN: 117067444
CANG: 105515963(ACE)
CJC: 100408147(ACE) 100408518
SBQ: 101052117(ACE)
CIMI: 108318275
CSYR: 103265660
MMUR: 105861642(ACE) 105861733
LCAT: 123620584(ACE) 123621200
ERUF: 138391693(ACE) 138392401
MMU: 11421(Ace) 217246(Ace3)
MCAL: 110304805(Ace) 110305195
MPAH: 110331687(Ace) 110332456
RNO: 24310(Ace) 498012(Ace3)
MCOC: 116077933(Ace) 116078573
MMIU: 308425242(LOC308425242) 308425640(ACE)
CGE: 100753209(Ace3) 103158533(Ace)
PROB: 127218024(Ace) 127218040
PMAV: 102913648 102928060(Ace)
MORG: 121436287 121436320(Ace)
MFOT: 126487553
HGL: 101701835(Ace) 101703133
DORD: 105998512(Ace) 105998551
DMER: 138830531 138830865(Ace)
PLOP: 125365757(Ace) 125366292
SVUL: 306657239(ACX6B4_019671) 306657241(ACX6B4_019673)
SCIL: 308637026(LOC308637026)
MAVE: 308274460(ACE) 308275746(LOC308275746)
OCU: 100009274(ACE) 103351595
OPI: 101533604(ACE) 101534995
GVR: 103589236(ACE)
CFA: 100856208 610668(ACE)
MNP: 132003318 132004477(ACE)
MMAQ: 308357684(LOC308357684) 308357685(LOC308357685)
NSU: 110570363 110570385(ACE)
FCA: 101083124 101094061(ACE)
PYU: 121015249(ACE) 121015251
PBG: 122485753(ACE) 122485756
LGF: 123603907(ACE)
PLEZ: 122205834(ACE) 122205836
CCRU: 144245040(ACE) 144245041
BTA: 100295485(ACE3) 509484(ACE)
BOM: 102266786(ACE) 102273543
BJV: 133232619(ACE) 133232622
BBIS: 105000614(ACE)
OAS: 105613829 554335(ACE)
OCAN: 138415289(ACE) 138415290
BTAX: 128064606(ACE) 128065386
CSUM: 138083371(ACE) 138083668
MBEZ: 129544531(ACE) 129544532
SSC: 100515049 613133(ACE)
VPC: 102532894
BMUS: 118886312 118886658(ACE)
LVE: 103087287
LALB: 132510692(ACE) 132511931
DDP: 132414817 132414942(ACE)
SCOO: 307177036(ACYUVP_002309)
PCRS: 137211640(ACE) 137211677(LOC137211677)
DLE: 111182603(ACE)
PCAD: 102985025(ACE) 102985307
PSIU: 116745506(ACE)
HAMP: 307068509(ACE)
ECB: 100064777 100064801(ACE)
MYB: 102243978(ACE)
MYD: 102756093(ACE)
MMYO: 118671818(ACE)
MLF: 102417726(ACE)
MDT: 132218560(ACE)
MYUM: 138994668(ACE)
PKL: 118726627
EFUS: 103293154(ACE)
POTS: 308252493(ACE)
MNA: 107531049(ACE)
DRO: 112316275(ACE)
SHON: 119003488(ACE)
AJM: 119036302(ACE)
PDIC: 114502602(ACE)
PHAS: 123817563(ACE)
MMF: 118634520(ACE)
PPAM: 129071531(ACE)
HAI: 109380275 109380308(ACE)
RFQ: 117012687 117012768(ACE)
RHII: 308488089(ACE) 308488090(LOC308488090)
PALE: 102880255 102890071(ACE)
RAY: 107501813(ACE) 107502259
MJV: 108400809 108401348(ACE)
TOD: 119230616(ACE) 119232510
SFUM: 130035098 130035425(ACE)
MDO: 100025797(ACE)
AFZ: 127560404
MLAO: 141514017
OAA: 114815136(ACE)
TACU: 119934111(ACE)
GGA: 419953(ACE)
PCOC: 116233814(ACE)
MGP: 100542100(ACE)
CJO: 107325232(ACE)
TPAI: 128088718(ACE)
LMUT: 125684637(ACE)
NMEL: 110388589(ACE)
APLA: 101802065(ACE)
AACU: 137844522(ACE)
OJA: 118158395(ACE)
BCLA: 308453040(ACE)
ACYG: 106045989(ACE)
ABRC: 308181622(ACE)
CATA: 118258897(ACE)
AFUL: 116498500(ACE)
TGU: 100217841(ACE)
LSR: 110474830(ACE)
VMC: 128819977(ACE)
VCHA: 128800099(ACE)
AIB: 137486493(ACE)
SCAN: 103821656(ACE)
PMOA: 120498197(ACE)
OTC: 121347708(ACE)
PRUF: 121352461(ACE)
ATRC: 139601788(ACE)
MATE: 118696727(ACE)
MAEN: 136567285(ACE)
GFR: 102032473(ACE)
FAB: 101819593(ACE)
OMA: 130264134(ACE)
PHI: 102111483(ACE)
PMAJ: 107215323(ACE)
CCAE: 111940103(ACE)
CCW: 104698643(ACE)
CBRC: 103619910(ACE)
ACOE: 138099413(ACE)
ETL: 114066935(ACE)
ZAB: 102065179(ACE)
ZLE: 135458614(ACE)
ACHL: 103811065(ACE)
SVG: 106861214(ACE)
MMEA: 130582460(ACE)
LCAI: 146426809(ACE)
HRT: 120763794(ACE)
SATI: 136372380(ACE)
CFAI: 136301843(ACE)
CCIC: 134053146(ACE)
NNT: 104405844(ACE)
SHAB: 115617938(ACE)
POCC: 134166965(ACE)
PECH: 308229379(ACE)
FPG: 101924109(ACE)
FCH: 102048145(ACE)
FRS: 119158816(ACE)
CCRI: 104157279(ACE)
ACUN: 113489137(ACE)
ANOC: 141970354(ACE)
SURA: 141953579(ACE)
TALA: 104369510(ACE)
ACHC: 115345056(ACE)
HALD: 104313802(ACE)
HLE: 104827978(ACE)
AGEN: 126038709
HHAR: 128140809(ACE)
BBUT: 142034646(ACE)
GCL: 127026523
CSTI: 104557834(ACE)
LDI: 104344268(ACE)
DPUB: 104309240(ACE)
PPUS: 135191870(ACE)
IIN: 128978473(ACE)
AVIT: 104273835(ACE)
BRHI: 104502331(ACE)
EGZ: 104134883(ACE)
NNI: 104009894(ACE)
PLEC: 309599808(ACE)
PCRI: 104038703(ACE)
PCAO: 104051561(ACE)
PARX: 142068049(ACE)
PADL: 103913868(ACE)
AFOR: 103906062(ACE)
FGA: 104076621(ACE)
CBOR: 142092122(ACE)
GSTE: 104264711(ACE)
CBOY: 140662435(ACE)
MAME: 142419701(ACE)
CLV: 102083877(ACE)
CNIC: 135998057(ACE)
NMAY: 308049906(ACE)
MUI: 104545390(ACE)
PGUU: 104469594(ACE)
PLET: 104618579(ACE)
EHS: 104513983(ACE)
CMAC: 104476826(ACE)
CUCA: 104054375(ACE)
PCUR: 138731070(ACE)
TEO: 104377133(ACE)
BREG: 104639029(ACE)
GAME: 129195317(ACE)
OHA: 104338713(ACE)
ACAR: 104530793(ACE)
CEUR: 306728858(ACE)
CPEA: 104390241(ACE)
HEK: 139788384(ACE)
CVF: 104285377(ACE)
RTD: 128919418(ACE)
CRID: 134524586(ACE)
LMIC: 141732719(ACE)
NARQ: 141474856(ACE)
AAM: 106497416(ACE)
AROW: 112962781(ACE)
NPD: 112960180(ACE)
TGT: 104564873(ACE)
DNE: 112982806(ACE)
SCAM: 104144771(ACE)
ASN: 102374457(ACE)
AMJ: 102573284(ACE)
CPOO: 109318963(ACE)
GGN: 109302091(ACE)
PSS: 102443828(ACE)
CIZ: 142002777(ACE)
CMY: 102933955(ACE)
CCAY: 125626761(ACE)
LKP: 140904029(ACE)
NDS: 141978692(ACE)
DCC: 119848931(ACE)
CPIC: 101930790(ACE)
TST: 117869220(ACE)
EOB: 135894414(ACE)
CABI: 116839490(ACE)
MRV: 120392083(ACE)
EMQ: 137148331(ACE)
ACS: 100558092(ace)
ASAO: 132778400(ACE)
PVT: 110080291(ACE)
SUND: 121935169(ACE)
PBI: 103067603(ACE)
PMUR: 107302404(ACE)
CTIG: 120302639(ACE)
TSR: 106545809(ACE)
PGUT: 117664820(ACE)
APRI: 131198534(ACE)
PTEX: 113447248(ACE)
NSS: 113420071(ACE)
VKO: 123031857(ACE)
PMUA: 114581443(ACE)
PRAF: 128401008(ACE)
ZVI: 118095294(ACE)
HCG: 128331749(ACE)
GJA: 107125675(ACE)
STOW: 125444577(ACE)
EMC: 129340516(ACE)
XLA: 108701765
XTR: 100144634(ace)
NPR: 108785994(ACE)
RTEM: 120919027(ACE)
ACAT: 141114160(ACE)
PADS: 140333154(ACE)
BGAR: 122941140(ACE)
DTC: 141095994(ACE)
HSQ: 130296534(ACE)
PCOB: 135055669(ACE)
PWL: 138299604(ACE)
MUO: 115481874(ACE)
GSH: 117347738(ACE)
DRE: 565980(ace)
DAES: 130238833(ace)
SRX: 107708876(ace) 107743967
SGH: 107557358(ace) 107598651
PTET: 122355822(ace)
LROH: 127173941
GRF: 141297388(ace)
OMC: 131550651(ace)
PPRM: 120474469(ace)
RKG: 130080540(ace)
SCEP: 307146714(ace)
PPHX: 306989115(ace)
MAMB: 125255089(ace)
CIDE: 127523680
CERY: 137007964(ace)
TROS: 130569206(ace)
TDW: 130439256(ace) 130439451
MANU: 129421044(ace)
PDAB: 135720552(ace)
IPU: 108274082
IFU: 128616542(ace)
PHYP: 113527416(ace)
SMEO: 124388635(ace)
TFD: 113653553(ace)
TVC: 132841584(ace)
CGAR: 128541385(ace)
NGRA: 132898139(ace)
TRN: 134321563(ace)
AMEX: 103040258(ace)
CMAO: 118809154(ace)
EEE: 113584762(ace)
CHAR: 105891181(ace)
SPIL: 134070386(ace)
ASAD: 121699602(ace)
TRU: 101076790(ace)
TFS: 130528547(ace)
NCC: 104966409(ace)
TBEN: 117473838(ace)
CGOB: 115024501(ace)
PGEO: 117464370(ace)
GACU: 117545140(ace)
EMAC: 134870693(ace)
ELY: 117247632(ace)
EFO: 125881066(ace)
PLEP: 121959090
SLUC: 116044258(ace)
SVIT: 144536766(ace)
ECRA: 117936645(ace)
ESP: 116671151(ace)
PFLV: 114547837(ace)
PFLT: 120550840(ace)
GAT: 120819300(ace)
PPUG: 119212747(ace)
AFB: 129091090(ace)
CLUM: 117749244(ace)
PSWI: 130203567(ace)
CANA: 137789465(ace)
TBU: 306732843(ace)
AMIR: 142951916(ace)
MSAM: 119915522(ace)
SCHU: 122868105(ace)
EARM: 139303073(ace)
CUD: 121528232(ace)
SPUL: 138593441(ace)
LMIX: 132955511(ace)
HTC: 141784791(ace)
ALAT: 119009665(ace)
ASTR: 137588185(ace)
PKLU: 139219429(ace)
LCO: 104923252(ace)
AMMM: 307266992(ace)
MZE: 101470840(ace)
ONL: 100712518(ace)
OAU: 116320154(ace)
OML: 112154380 112154658(ace)
CSAI: 133419459(ace)
XMA: 102221242(ace) 102238075
XCO: 114151374(ace) 114151607
XHE: 116727094(ace) 116727735
PRET: 103481980 103482159(ace)
PFOR: 103142748 103143124(ace)
PLAI: 106958690(ace) 106964438
GAF: 122823727(ace)
PPRL: 129352312
CVG: 107100492(ace)
CTUL: 119792874(ace)
GMU: 124875539(ace)
KMR: 108237275(ace)
ALIM: 106517337(ace) 106535188
LTU: 140278917(ace)
TBT: 306771955(ace)
MCEP: 125022266(ace)
AOCE: 111570427(ace)
EJA: 138202133(ace)
BFRE: 138616846(ace)
LCF: 108875837
CSEM: 103382106(ace)
POV: 109626948(ace)
SSEN: 122759089(ace)
SSOE: 131448288(ace)
HHIP: 117752627(ace)
HSP: 118100408(ace)
PPLT: 128427114(ace)
SMAU: 118287466(ace)
SDU: 111220374(ace)
SLAL: 111672022(ace)
XGL: 120794236(ace)
HCQ: 109515983(ace)
SSCV: 125991473(ace)
SBIA: 133495195(ace)
PEE: 133395188(ace)
PTAO: 133468927(ace)
BPEC: 110159607(ace)
ENY: 140368840(ace)
MALB: 109963664
BSPL: 114845366(ace)
SJO: 128381218(ace)
SSCO: 134003221(ace)
TTY: 137171637(ace)
GMH: 115530849(ace)
ZFA: 307245950(ace)
ELS: 105024522(ace)
OEP: 134030753(ace)
SFM: 108928079(ace)
PKI: 111848632(ace)
LOC: 102692099(ace)
PSPA: 121301717(ace)
PSEX: 120517329(ace)
CMK: 103187713(ace)
RTP: 109937228(ace)
CPLA: 122540046(ace)
CPUN: 140465506(ace)
HOC: 132830710(ace)
SCAU: 119953974(ace)
LERI: 129710228(ace)
HAKA: 140741065(ace)
PMRN: 116941101(ACE) 116948568
PMIN: 119744580
AJC: 117122612
DME: Dmel_CG10142(Ance-5) Dmel_CG10593(Acer) Dmel_CG16869(Ance-2) Dmel_CG17988(Ance-3) Dmel_CG8196(Ance-4) Dmel_CG8827(Ance)
DSI: Dsimw501_GD10112(Dsim_GD10112) Dsimw501_GD23554(Dsim_GD23554) Dsimw501_GD23936(Dsim_Ance) Dsimw501_GD23937(Dsim_GD23937) Dsimw501_GD23939(Dsim_GD23939) Dsimw501_GD24910(Dsim_GD24910)
DVI: 6627173(Ance-4) 6628146(Acer) 6633976(Ance) 6634022(Ance-3) 6635836(Ance-5)
BOD: 106621484(Ance-5) 106621485 106623515(Ance-3) 106623751(Acer) 106624532(Ance-4) 106625489 106625490(Ance-2) 118681660
RZE: 108359735(Ance-4) 108365732(LOC108365732) 108370741(LOC108370741) 108370742(Ance-2) 108374079(Acer) 108374899(LOC108374899) 108377844(LOC108377844)
CVJ: 135950867(Ance-2) 135951380(Ance-3) 135951770(Ance) 135951771(Acer) 135960186(Ance-4) 135962152 135962326
CFEL: 113388422
VCD: 124532359(LOC124532359) 124532538(LOC124532538) 124532604(Ance-3) 124535369(LOC124535369) 124541139(LOC124541139) 124541274(LOC124541274)
PXY: 105381320(LOC105381320) 105381904(LOC105381904) 105383330(LOC105383330) 105383332(Ance-3) 105392336(LOC105392336)
BFER: 139990908(Ance-3)
APUR: 144468126(Ance-3)
MZT: 108724827 108725572(Ance-3)
TNY: 139772914 139778720(Ance-3)
IEL: 124158588(LOC124158588) 124159602(LOC124159602) 124169233(LOC124169233)
HAMR: 139689974(Ance-3) 139690098
VDE: 111244364
VJA: 111271363
GOE: 100898438
TUT: 107368139
CVS: 136983192
SDM: 118184501(LOC118184501) 118195242(LOC118195242) 118205234(LOC118205234)
CEL: CELE_C42D8.5(acn-1)
CBR: CBG_14607(Cbr-acn-1)
BMY: BM_BM2712(Bma-acn-1)
TSP: Tsp_01435
GAE: 121371990
HASI: 137299141
PMAX: 117320026
OSN: 115213195
LJP: 135464482
AMIL: 114956778
OPG: 144663642(LOC144663642)
HMG: 100202515(LOC100202515) 100206770(LOC100206770) 100210213(LOC100210213)
XCC: XCC1116
XCB: XC_3130
XCP: XCR_1338
XCV: XCV1249
XAX: XACM_1192
XAC: XAC1217
XOM: XOO3345(XOO3345)
XOO: XOO3539
XOP: PXO_04473
XOR: XOC_1282
XAL: XALC_0887
SML: Smlt3574
SMT: Smal_2996
SMZ: SMD_3147
STEO: PEM_12410
PSUW: WQ53_02775
PSD: DSC_06070
LAB: LA76x_3622(ace)
LCP: LC55x_3591(ace)
LEZ: GLE_1570
LEM: LEN_3391
DKO: I596_1523
SON: SO_2494
SDN: Sden_2117
SFR: Sfri_1887
SAZ: Sama_1817
SLO: Shew_2053
SSE: Ssed_2057
SPL: Spea_2340
SWD: Swoo_2544
SWP: swp_2383
SVO: SVI_2322
SPSW: Sps_01127
CPS: CPS_1585
PSEO: OM33_11595
PSPO: PSPO_a1844
PART: PARC_a2553
PAGA: PAGA_a2437
PSAZ: PA25_13420
PSKA: KAN5_15120
AMAL: I607_08070
AMAE: I876_08335
AMAO: I634_08440
AMAD: I636_08870
AMAI: I635_09140
AMAG: I533_08380
AMAC: MASE_07965
GNI: GNIT_1032
SAGA: M5M_17395
MICZ: GL2_26280
LLO: LLO_1982
KKO: Kkor_1388
KGE: TQ33_1115
PSF: PSE_0360
CAK: Caul_0184
PZU: PHZ_c0316
ASTD: ATDW_18400
HNE: HNE_1947
HBA: Hbal_0598
SPHM: G432_00930
STAX: MC45_04745
SPHI: TS85_09285
SSAN: NX02_12980
SPKC: KC8_02095
SAL: Sala_0456
SPHP: LH20_16505
SMAZ: LH19_18700
SGI: SGRAN_3476(ace)
SPEG: SPYCW_2784
SPFD: SPYCA_2223
SPHU: SPPYR_0141
SWI: Swit_2667
SPHD: HY78_12175
SSY: SLG_23650
SPHR: BSY17_2968
BLAS: BSY18_285
SMIC: SmB9_12650
ALB: AEB_P1567
AAY: WYH_00229
ELI: ELI_07405
ADE: Adeh_2024
AORY: AMOR_58830
MXA: MXAN_3581
HOH: Hoch_6422
BGOK: Pr1d_29260
FTJ: FTUN_6918
SACI: Sinac_2369
TPLA: ElP_70180
SUS: Acid_4844
THYD: TTHT_1108
GBA: J421_0092
HSW: Hsw_1814
FBU: UJ101_00896(ACE)
GVI: gll3143
GLJ: GKIL_2224
 » show all
Reference
PMID:2849100
  Authors
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P
  Title
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
  Journal
Proc Natl Acad Sci U S A 85:9386-90 (1988)
DOI:10.1073/pnas.85.24.9386
  Sequence
[hsa:1636]
Reference
PMID:1320019
  Authors
Wei L, Clauser E, Alhenc-Gelas F, Corvol P
  Title
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.
  Journal
J Biol Chem 267:13398-405 (1992)
Reference
PMID:8973330
  Authors
Taylor CA, Coates D, Shirras AD
  Title
The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.
  Journal
Gene 181:191-7 (1996)
DOI:10.1016/S0378-1119(96)00503-3
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