KEGG   ORTHOLOGY: K01442
Entry
K01442                      KO                                     
Symbol
cbh
Name
choloylglycine hydrolase [EC:3.5.1.24]
Pathway
map00120  Primary bile acid biosynthesis
map00121  Secondary bile acid biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K01442  cbh; choloylglycine hydrolase
   00121 Secondary bile acid biosynthesis
    K01442  cbh; choloylglycine hydrolase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01442  cbh; choloylglycine hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.24  choloylglycine hydrolase
     K01442  cbh; choloylglycine hydrolase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C59
   K01442  cbh; choloylglycine hydrolase
Other DBs
RN: R02797 R03975 R03977 R04486 R04487 R05835
COG: COG3049
GO: 0045302
Genes
EUN: UMNK88_pK8826
ECY: ECSE_P3-0046
END: A4308_12525
ADP: NCTC12871_00060(cbh)
VHA: VIBHAR_02193
VCA: M892_02375
VHR: AL538_01075
VOW: A9237_00885
VRO: BSZ04_16345
VSC: VSVS12_01375
VFI: VF_A0241
SHL: Shal_0591
SWD: Swoo_2365
LOK: Loa_02519
LSS: NCTC12082_00361(yxeI)
LADL: NCTC12735_00521(yxeI)
FPH: Fphi_1659
FPT: BZ13_337
FPI: BF30_1937
FPM: LA56_512
FPX: KU46_1638
FPJ: LA02_1356
HMAR: HVMH_1071
HCL: NCTC13205_00078(cbh)
SUN: SUN_1118
DPS: DP1182
DBK: DGMP_22020(cbaH)
DBR: Deba_2031
BME: BMEI0543
BMEL: DK63_882
BMEE: DK62_2064
BMF: BAB1_1488
BABO: DK55_1449
BABR: DO74_441
BABT: DK49_1206
BABB: DK48_671
BABU: DK53_1432
BABS: DK51_27
BABC: DO78_1353
BMS: BR1468
BSZ: DK67_843
BOV: BOV_1422
BCAR: DK60_1494
BCAS: DA85_07030
BMR: BMI_I1480
BPP: BPI_I1520
BPV: DK65_2014
OAN: Oant_1703
OAH: DR92_1186
MSL: Msil_3557
MCG: GL4_0503
BLAG: BLTE_23450(cbaH)
MMED: Mame_02037(cbh_1) Mame_02196(cbh_2)
PSF: PSE_3526
LMO: lmo2067
LMOC: LMOSLCC5850_2128(bsh)
LMOD: LMON_2137
LMOW: AX10_04575
LMOQ: LM6179_2838(cbh)
LMR: LMR479A_2178(cbh)
LMOM: IJ09_14875
LMF: LMOf2365_2098(cbH)
LMOG: BN389_20960(cbh)
LMP: MUO_10605
LMOL: LMOL312_2080(bsh)
LMOX: AX24_08170
LMQ: LMM7_2157(bsh)
LML: lmo4a_2118(bsh)
LMS: LMLG_0361
LMW: LMOSLCC2755_2129(bsh)
LMX: LMOSLCC2372_2133(bsh)
LMZ: LMOSLCC2482_2125(bsh)
LMON: LMOSLCC2376_2021(bsh)
LMOS: LMOSLCC7179_2038(bsh)
LMOO: LMOSLCC2378_2091(bsh)
LMOY: LMOSLCC2479_2130(bsh)
LMOT: LMOSLCC2540_2160(bsh)
LMOA: LMOATCC19117_2087(bsh)
LMOK: CQ02_10710
LSG: lse_2056(bsh)
LIV: LIV_2050(bsh)
LMAR: LAX80_010100(bsh)
LAC: LBA0892(bshA) LBA1078(bshB)
LAF: SD55_0913(bshA) SD55_1090(bshB)
LGA: LGAS_0959
LHL: LBHH_1220(cbh)
LHH: LBH_0786(cbh)
LCR: LCRIS_00906(cbh)
LPL: lp_3536(bsh1)
LPJ: JDM1_2822(bsh1)
LPT: zj316_0150(cbh)
LPS: LPST_C2886(bsh1)
LPZ: Lp16_2762
LRE: Lreu_0730
LRF: LAR_0701
LRT: LRI_1179
LPAS: KZE55_04905(bsh)
LSL: LSL_1801
LSI: HN6_01574
EFA: EF0521
EFL: EF62_0879(cbh)
EFD: EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFS: EFS1_0461
ECAS: ECBG_02025
EMU: EMQU_1455
EDU: LIU_08430
ECEC: NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
CML: BN424_2909(cbH)
CPE: CPE0709
CPF: CPF_0705(cbh)
CBB: CLD_2374
CBF: CLI_2250
CBM: CBF_2236
CLT: CM240_1766(cbh)
DLO: K5I24_10170(bsh) K5I24_15435(bsh)
PHX: KGNDJEFE_01093(cbh)
ELM: ELI_1322
AMUO: KWG62_00310(bsh) KWG62_12690(bsh)
CCHO: CCHOA_10235(cbh)
NAD: NCTC11293_00282(yxeI)
RRT: 4535765_04107(cbh)
RCR: NCTC10994_01103(cbh)
MOY: CVS54_00163(cbh)
BLO: BL0796
BLJ: BLD_0536(cbaH)
BLN: Blon_1453
BLON: BLIJ_1499
BLF: BLIF_0937
BLL: BLJ_0948
BLB: BBMN68_536(cbaH)
BLM: BLLJ_0817
BLG: BIL_10200
BAD: BAD_0856
BADL: BADO_0911
BLA: BLA_1379
BLC: Balac_0863(bsh)
BLT: Balat_0863(bsh)
BBB: BIF_00207
BBC: BLC1_0823
BLV: BalV_0829(bsh)
BLW: W7Y_0865
BLS: W91_0886
BANI: Bl12_0805
BANL: BLAC_04390
BANM: EN10_04380
BDE: BDP_1106(cbh)
BDN: BBDE_1060
BBP: BBPR_0850(cbh)
BBI: BBIF_0879(cbh)
BBF: BBB_0854(cbh)
BBRU: Bbr_0971(cbh)
BBRE: B12L_0890
BBRV: B689b_0983
BBRJ: B7017_1020
BBRC: B7019_1045
BBRN: B2258_0935
BBRS: BS27_0970(cbh)
BBRD: BBBR_0919
BTP: D805_0402
BKS: BBKW_0991
BCAT: BBCT_0907
BPSP: AH67_04680
BPSC: BBPC_0908
ROL: CA51_28730(cbh)
PCOR: KS4_01870(cbh)
BFS: BF9343_1433(cbh)
BXY: BXY_10230
BOA: Bovatus_02350(cbh_2)
BEG: INE88_03395(cbh_1)
BVU: BVU_2699
PDI: BDI_1550
AFD: Alfi_1795
FLM: MY04_4579
WIN: WPG_3359
MFC: BRM9_1563
MFI: DSM1535_2252(cbh)
MCUB: MCBB_0969(cbh)
 » show all
Reference
PMID:6016335
  Authors
Nair PP, Gordon M, Reback J
  Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
  Journal
J Biol Chem 242:7-11 (1967)
Reference
PMID:1476424
  Authors
Christiaens H, Leer RJ, Pouwels PH, Verstraete W
  Title
Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay.
  Journal
Appl Environ Microbiol 58:3792-8 (1992)
DOI:10.1128/AEM.58.12.3792-3798.1992
  Sequence
[lpl:lp_3536]
LinkDB

KEGG   ENZYME: 3.5.1.24
Entry
EC 3.5.1.24                 Enzyme                                 
Name
choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
glycocholate amidohydrolase
Reaction(IUBMB)
glycocholate + H2O = cholate + glycine [RN:R05835]
Reaction(KEGG)
Substrate
glycocholate [CPD:C01921];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
glycine [CPD:C00037]
Comment
Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.
History
EC 3.5.1.24 created 1972
Pathway
ec00120  Primary bile acid biosynthesis
ec00121  Secondary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K01442  choloylglycine hydrolase
Genes
EUNUMNK88_pK8826
ECYECSE_P3-0046
ENDA4308_12525
ADPNCTC12871_00060(cbh)
VHAVIBHAR_02193
VCAM892_02375
VHRAL538_01075
VOWA9237_00885
VROBSZ04_16345
VSCVSVS12_01375
VSHBSZ05_14500
VAFD1115_07550
VFIVF_A0241
VFMVFMJ11_A0276
PDSCAY62_18360
SHLShal_0591
SWDSwoo_2365
SKHSTH12_02744
THAPFNC98_05995
HJABST95_01440
LOKLoa_02519
LIBE4T55_08905
LSSNCTC12082_00361(yxeI)
LADLNCTC12735_00521(yxeI)
FPHFphi_1659
FPTBZ13_337
FPIBF30_1937
FPMLA56_512
FPXKU46_1638
FPJLA02_1356
FRTF7308_1470
FMIF0R74_02775
FSRKQR59_04385
AFRIE3E15_03970
HTREPV75_08300
HMARHVMH_1071
THIOAYJ59_05605
TSYTHSYN_15570
HCSFF32_04300
HAGBB497_10035
HALKCUU95_07905
NBACUN60_05670
PEWKZJ38_25220
PUDG9Q38_03850
AAQUD3M96_12145
PHNPAEH1_09890
BOZDBV39_15650
CKEB5M06_12040
HCLNCTC13205_00078(cbh)
SPALFM071_02045
NSANitsa_1273
SUNSUN_1118
DSDGD606_11185
DCBC3Y92_01835
DMSE8L03_12800 E8L03_19155
PSELGM415_09795
DSXGD604_14285
PBIZLWC08_15255
DPSDP1182
DBKDGMP_22020(cbaH)
DWDDSCW_29670
DBRDeba_2031
KMNHW532_10045
KAIK32_37770 K32_46880
BMEBMEI0543
BMELDK63_882
BMIBMEA_A1518
BMZBM28_A1479
BMGBM590_A1467
BMWBMNI_I1418
BMEEDK62_2064
BMFBAB1_1488
BMBBruAb1_1463
BMCBAbS19_I13900
BAABAA13334_I01625
BABODK55_1449
BABRDO74_441
BABTDK49_1206
BABBDK48_671
BABUDK53_1432
BABSDK51_27
BABCDO78_1353
BMSBR1468
BSIBS1330_I1462
BSFBSS2_I1426
BSUIBSSP1_I1486
BSUPBSPT1_I1500
BSUVBSPT2_I1483
BSUCBSSP2_I1489
BMTBSUIS_A1521
BSZDK67_843
BSVBSVBI22_A1462
BSWIY71_07215
BSGIY72_06965
BOVBOV_1422
BCSBCAN_A1503
BSKBCA52141_I2834
BOLBCOUA_I1468
BCARDK60_1494
BCASDA85_07030
BMRBMI_I1480
BPPBPI_I1520
BPVDK65_2014
BCETV910_100537
BVLBF3285c1_0073
BRUBFS01_07065
BRJBKD03_14560
OINIAR37_14585
BIOBR141012304_11248
OANOant_1703
OAHDR92_1186
OPSA8A54_06885 A8A54_20325
OCHCES85_1617
OCRHGK82_07795
OCLGTN27_08150
PSCQKHQ08_06870
STARG3545_07605
ANCGBB76_05275
APRAG3A50_02730 G3A50_18980
MSLMsil_3557
MTUNMTUNDRAET4_3160
MLGCWB41_15845
MCGGL4_0503
METGHT051_01810 HT051_01815 HT051_02635
BLAGBLTE_23450(cbaH)
MHEYH2LOC_004005
MEYTM49_03610 TM49_20510
MAADAZF01_03040 AZF01_05250 AZF01_16710
MMEDMame_02037(cbh_1) Mame_02196(cbh_2)
MLUTJET14_06540 JET14_18915
PSINCAK95_26095
NOHG5V57_14685
PSFPSE_3526
SIWGH266_09320
ACUTMRB58_00230
PRDF7984_02150
LMOlmo2067
LMNLM5578_2268
LMYLM5923_2219
LMTLMRG_01217
LMOCLMOSLCC5850_2128(bsh)
LMODLMON_2137
LMOWAX10_04575
LMOQLM6179_2838(cbh)
LMRLMR479A_2178(cbh)
LMOMIJ09_14875
LMFLMOf2365_2098(cbH)
LMCLm4b_02088
LMOGBN389_20960(cbh)
LMPMUO_10605
LMOLLMOL312_2080(bsh)
LMOJLM220_01025
LMOZLM1816_13317
LMOXAX24_08170
LMHLMHCC_0491
LMQLMM7_2157(bsh)
LMLlmo4a_2118(bsh)
LMGLMKG_00256
LMSLMLG_0361
LMJLMOG_01160
LMWLMOSLCC2755_2129(bsh)
LMXLMOSLCC2372_2133(bsh)
LMZLMOSLCC2482_2125(bsh)
LMONLMOSLCC2376_2021(bsh)
LMOSLMOSLCC7179_2038(bsh)
LMOOLMOSLCC2378_2091(bsh)
LMOYLMOSLCC2479_2130(bsh)
LMOTLMOSLCC2540_2160(bsh)
LMOALMOATCC19117_2087(bsh)
LMOKCQ02_10710
LMVY193_05195
LSGlse_2056(bsh)
LIVLIV_2050(bsh)
LIIJL52_10765
LIWAX25_10935
LMARLAX80_010100(bsh)
PKUAUO94_08995
PFAEAJGP001_08295
SPATA0O21_03545
SCHJDDV21_007255
LJOLJ_1147 LJ_1412
LJFFI9785_1052 FI9785_854
LJHLJP_0828 LJP_1011c
LJNT285_05035
LACLBA0892(bshA) LBA1078(bshB)
LADLA14_0914 LA14_1092
LAFSD55_0913(bshA) SD55_1090(bshB)
LGALGAS_0959
LHLLBHH_1220(cbh)
LHHLBH_0786(cbh)
LCRLCRIS_00906(cbh)
LAMLA2_04690 LA2_06130
LAILAC30SC_04505 LAC30SC_05780
LAYLAB52_04465 LAB52_05565
LPWLpgJCM5343_07940
LUUH4B44_06670
LPLlp_3536(bsh1)
LPJJDM1_2822(bsh1)
LPTzj316_0150(cbh)
LPSLPST_C2886(bsh1)
LPRLBP_cg2864
LPZLp16_2762
LPBSH83_14665
LARGLPA65_15095
LRELreu_0730
LRFLAR_0701
LRTLRI_1179
LRRN134_04300
LMULBLM1_10135
LVALV515_03785
LFNLF145_03730
LPASKZE55_04905(bsh)
LSLLSL_1801
LSIHN6_01574
LSJLSJ_0788 LSJ_2111
LAGLBEN83_06190
LANIFAX13_01030
LMURCPS94_09990
EFAEF0521
EFLEF62_0879(cbh)
EFDEFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFSEFS1_0461
EFNDENG_00539
EFCEFAU004_01766 EFAU004_01892
EFAUEFAU085_01787 EFAU085_01918
EFUHMPREF0351_11722(cbh2) HMPREF0351_11857(cbh3)
EFMM7W_1078 M7W_1119 M7W_1156
EFTM395_05290
EHREHR_09940 EHR_11510
ECASECBG_02025
EMUEMQU_1455
EDULIU_08430
EGAAL523_11285
ETHCK496_06880
ELACI4Q40_04945
ECECNCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
EIEENLAB_30050
VFVK5K99_06205
CMLBN424_2909(cbH)
CPECPE0709
CPFCPF_0705(cbh)
CBBCLD_2374
CBFCLI_2250
CBMCBF_2236
CBJH04402_02216
CLTCM240_1766(cbh)
CLDCLSPO_c22400
PBIFKXZ80_01940 KXZ80_16485(bsh)
PFAAMM59RIKEN_19130
VFAMM35RIKEN_11690
CLEClole_2713
CEWEKH84_16375
DLOK5I24_10170(bsh) K5I24_15435(bsh)
WCPH9Q76_09090 H9Q76_10825
ROCHF520_07105
PHXKGNDJEFE_01093(cbh)
FWADCMF_14235
ELMELI_1322
EMTCPZ25_011475
ELIMB2M23_16225
CMIUB1H56_09150
AARGAargi30884_20240
ABSIA9CBEGH2_18120
AMUOKWG62_00310(bsh) KWG62_12690(bsh)
ALLOKWG61_09625
TURAT726_06045 AT726_08870
TSGHLK68_04930 HLK68_07680 HLK68_08040
CCHOCCHOA_10235(cbh)
NADNCTC11293_00282(yxeI)
RHQIM25_02745
RRT4535765_04107(cbh)
RCRNCTC10994_01103(cbh)
DIZCT688_16215
DPCA6048_10685
MPALBO218_13760
MWAE4K62_09545
MOYCVS54_00163(cbh)
MSFIT882_10130
MCAWF6J84_01105
MLZF6J85_09165
MICSC1N74_13405
MYLC3E77_00485
SALDFVA74_05805
MANTBHD05_03695
NOIFCL41_09945
AEZC3E78_15230
AEFGEV26_07670
BLOBL0796
BLJBLD_0536(cbaH)
BLNBlon_1453
BLONBLIJ_1499
BLFBLIF_0937
BLLBLJ_0948
BLBBBMN68_536(cbaH)
BLMBLLJ_0817
BLKBLNIAS_01547
BLGBIL_10200
BLZBLGT_05070
BLXGS08_04925
BADBAD_0856
BADLBADO_0911
BADOBBMN23_0992
BLABLA_1379
BLCBalac_0863(bsh)
BLTBalat_0863(bsh)
BBBBIF_00207
BBCBLC1_0823
BNMBALAC2494_00268
BLVBalV_0829(bsh)
BLWW7Y_0865
BLSW91_0886
BANIBl12_0805
BANLBLAC_04390
BNIBANAN_04270
BANMEN10_04380
BDEBDP_1106(cbh)
BDNBBDE_1060
BBPBBPR_0850(cbh)
BBIBBIF_0879(cbh)
BBFBBB_0854(cbh)
BBVHMPREF9228_0895
BBRUBbr_0971(cbh)
BBREB12L_0890
BBRVB689b_0983
BBRJB7017_1020
BBRCB7019_1045
BBRNB2258_0935
BBRSBS27_0970(cbh)
BBRDBBBR_0919
BTPD805_0402
BKAAH68_05530
BKSBBKW_0991
BCATBBCT_0907
BPSPAH67_04680
BPSCBBPC_0908
BCHOBcFMB_07045
AHATADCFC_10310
SYNCCB0101_03470
SNGSNE_A17210
RUFIK0V07_01085
RMLFF011L_31620
ROLCA51_28730(cbh)
GMRGmarT_23860
ULIETAA1_63420
PCORKS4_01870(cbh)
SCORJ3U87_31995
FVAFV113G1_28320 FV113G1_29080
FULC4N20_09600
FMOC4N19_07925
BFSBF9343_1433(cbh)
BFBVU15_14395
BXYBXY_10230
BOABovatus_02350(cbh_2)
BCAEA4V03_14545
BISDXK01_017585
BUNBun01g_25460
BEGINE88_03395(cbh_1)
BVUBVU_2699
BSABacsa_1560
BDOEL88_06530
BDHGV66_14440
PCOPI6J50_16520
DYSG7050_12935
PDIBDI_1550
PARCCI960_12015
PGOLK6V26_16620
BVSBARVI_00680
COPRCop2CBH44_13780
BVIRI6J59_00230
AFDAlfi_1795
ACOUA5CBH24_17950
ADAA5CPEGH6_23320
AITAI2BBH_10610 AI2BBH_19080
COYHF329_17165
FLMMY04_4579
FYAKMW28_05260 KMW28_06095
WINWPG_3359
PRSB9H02_11275
MFCBRM9_1563
MFIDSM1535_2252(cbh)
MCUBMCBB_0969(cbh)
MSUBBK009_01470
METNBK008_09455
METOCIT02_03540
 » show all
Reference
1  [PMID:6016335]
  Authors
Nair PP, Gordon M, Reback J
  Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
  Journal
J Biol Chem 242:7-11 (1967)
Reference
2  [PMID:10993]
  Authors
Stellwag EJ, Hylemon PB.
  Title
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.
  Journal
Biochim Biophys Acta 452:165-76 (1976)
DOI:10.1016/0005-2744(76)90068-1
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.24
IUBMB Enzyme Nomenclature: 3.5.1.24
ExPASy - ENZYME nomenclature database: 3.5.1.24
BRENDA, the Enzyme Database: 3.5.1.24
CAS: 37289-07-9
LinkDB

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