KEGG   ORTHOLOGY: K01587
Entry
K01587                      KO                                     
Symbol
PAICS
Name
phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Reaction
R04209  1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase
R04591  1-(5-phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21  phosphoribosylaminoimidazole carboxylase
     K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase
     K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
Other DBs
GO: 0004638 0004639
Genes
HSA: 10606(PAICS)
PTR: 471236(PAICS)
PPS: 100993147
GGO: 101132763(PAICS)
PON: 100190835(PAICS)
PPYG: 129034893(PAICS)
NLE: 100580950
HMH: 116467849(PAICS) 116483296
SSYN: 129462621 129490997(PAICS)
MCC: 694743
MCF: 101864855(PAICS)
MTHB: 126955444
MNI: 105463551
CATY: 105591967 105591969(PAICS)
PANU: 101011883(PAICS) 103884449
TGE: 112625131(PAICS)
MLEU: 105552705(PAICS)
RRO: 104655715(PAICS)
RBB: 108513484(PAICS)
TFN: 117085582(PAICS) 117090262
PTEH: 111526496(PAICS)
CANG: 105507807 105525579(PAICS)
CJC: 100390231(PAICS)
SBQ: 101031274(PAICS) 104651700
CIMI: 108296113(PAICS) 108296114
ANAN: 105709234(PAICS)
CSYR: 103249285(PAICS)
MMUR: 105867854 105867855(PAICS)
LCAT: 123624098(PAICS) 123637056
ERUF: 138374114(PAICS)
PCOQ: 105807688(PAICS)
OGA: 100950463(PAICS)
MMU: 67054(Paics)
MCAL: 110293933
MPAH: 110330578(Paics)
RNO: 140946(Paics)
MCOC: 116071305(Paics)
ANU: 117712646(Paics)
ASYL: 127696683(Paics)
MUN: 110565016(Paics)
CGE: 100753190 100758991(Paics)
MAUA: 101829734(Paics) 121142783
PROB: 127232266(Paics)
PLEU: 114681836(Paics)
PMAV: 102926710(Paics)
MORG: 121432328 121460627(Paics)
AAMP: 119808557(Paics) 119810165
CNL: 130871772 130876212(Paics)
NGI: 103734378(Paics)
HGL: 101721606(Paics)
CPOC: 100727779(Paics)
CCAN: 109697886(Paics)
DORD: 105980289(Paics)
DSP: 122106650(Paics)
DMER: 138821034(Paics)
PLOP: 125364939(Paics)
MMMA: 107139249(Paics)
ITI: 101961407
OPI: 101534729(PAICS)
OCZ: 121147095(PAICS)
TUP: 102484181(PAICS)
GVR: 103606004(PAICS)
CFA: 100855769(PAICS)
CLUD: 112652356
VVP: 112923709
VLG: 121473255(PAICS)
NPO: 129519591(PAICS)
AML: 100482672(PAICS)
UMR: 103672750(PAICS)
UAH: 113262521(PAICS)
UAR: 123803985(PAICS)
ELK: 111149362
LLV: 125093749
MPUF: 101670430(PAICS) 106004002
MNP: 132006541(PAICS)
MLK: 131823800(PAICS)
NVS: 122889803(PAICS)
ORO: 101383279(PAICS)
EJU: 114206674(PAICS) 114206809
ZCA: 113924518 113924521(PAICS)
MLX: 118010506(PAICS)
NSU: 110588151 110590760(PAICS)
LWW: 102746659(PAICS)
FCA: 101084705(PAICS)
PYU: 121035341
PCOO: 112858402(PAICS)
PBG: 122497369(PAICS)
PVIV: 125163377(PAICS)
LRUF: 124520511
LGF: 123595955(PAICS)
AJU: 106971666
PTG: 102951236(PAICS)
PPAD: 109278673
PUC: 125922747
PLEZ: 122218208(PAICS)
HHV: 120243038(PAICS)
BTA: 404170(PAICS)
BOM: 102281546(PAICS)
BIU: 109560492
BBUB: 102392736(PAICS)
CHX: 102182773
BTAX: 128050024(PAICS) 128054482
CSUM: 138078225 138081745(PAICS)
CCAD: 122428484(PAICS)
MREE: 136153078(PAICS)
OVR: 110135551(PAICS)
MBEZ: 129554833 129561729(PAICS)
SSC: 100521281(PAICS)
CFR: 102522524
CBAI: 105077682(PAICS)
CDK: 105091550
VPC: 102531568(PAICS)
BACU: 103009147(PAICS)
BMUS: 118895967(PAICS)
LVE: 103076533(PAICS)
OOR: 101287712(PAICS)
LALB: 132519829(PAICS)
GMF: 115865656(PAICS)
DDP: 132425956(PAICS)
DLE: 111169417
PCAD: 102974361 102994548(PAICS)
PSIU: 116754769(PAICS)
PPHC: 136123332(PAICS)
NASI: 112400791(PAICS)
ECB: 100058501(PAICS)
EPZ: 103556488(PAICS)
EAI: 106841680(PAICS)
MYB: 102239537(PAICS)
MYD: 102757395(PAICS)
MMYO: 118669110(PAICS)
MLF: 102437295(PAICS)
MDT: 132218788(PAICS)
MYUM: 138995631(PAICS)
PKL: 118706364(PAICS)
EFUS: 103284981(PAICS)
MNA: 107532951(PAICS)
DRO: 112320919(PAICS) 112322805
SHON: 118978572(PAICS)
AJM: 119061634(PAICS)
PDIC: 114492579(PAICS)
PHAS: 123815730(PAICS)
MMF: 118632016(PAICS)
PPAM: 129065527(PAICS)
HAI: 109373280 109394361(PAICS)
RFQ: 117019647 117022388(PAICS)
PALE: 102899036(PAICS)
PGIG: 120588101 120588103(PAICS)
PVP: 105293760(PAICS) 111741353
RAY: 107517721(PAICS)
MJV: 108395834(PAICS) 118969144
SARA: 101547712(PAICS)
SFUM: 130020741(PAICS)
SETR: 126028746 126032284(PAICS)
LAV: 100658417
TMU: 101346245
DNM: 101418600(PAICS)
MDO: 100012535(PAICS)
SHR: 100923019(PAICS)
AFZ: 127541800
PCW: 110200170(PAICS)
PBRV: 138175027(PAICS)
MLAO: 141517909
OAA: 100086365
TACU: 119947589
GGA: 396534(PAICS)
PCOC: 116225927(PAICS)
MGP: 100539860(PAICS)
CJO: 107313717(PAICS) 116653347
TPAI: 128080320
NMEL: 110398445
APLA: 101797218
CATA: 118248082(PAICS)
TGU: 100225152(PAICS)
LSR: 110471777(PAICS)
SCAN: 103825290(PAICS) 103826194
PMOA: 120497414
OTC: 121335133(PAICS)
PRUF: 121358717(PAICS)
ATRC: 139592432(PAICS)
GFR: 102043382 102043552(PAICS)
FAB: 101807763 101808142(PAICS)
PHI: 102111686(PAICS) 106628861
PMAJ: 107202963 107203210(PAICS)
CCAE: 111928008 111928009(PAICS)
CCW: 104690617(PAICS) 104690618
CBRC: 103622559(PAICS) 108449136
ACOE: 138109830(PAICS)
ETL: 114058312 114058315(PAICS)
ZAB: 102070226
ZLE: 135446541(PAICS)
ACHL: 103810554(PAICS)
SVG: 106851478(PAICS)
HRT: 120752708(PAICS)
FPG: 101919014(PAICS)
FCH: 102045839 102046009(PAICS)
CCRI: 104163262(PAICS)
NNT: 104400497
SHAB: 115610194
ACUN: 113479039 113479040(PAICS)
HALD: 104313976(PAICS)
HLE: 104836135(PAICS)
GCL: 127015555
CSTI: 104556851(PAICS) 104561187
LDI: 104348101(PAICS)
MNB: 103772148(PAICS)
DPUB: 104302244(PAICS)
PPUS: 135178389(PAICS)
AVIT: 104280921
BRHI: 104494915(PAICS) 104498823
EGZ: 104129452(PAICS)
NNI: 104020782
PCRI: 104024908
PCAO: 104050423(PAICS) 104051816
AFOR: 103897396 103897432(PAICS)
FGA: 104070300(PAICS)
CBOR: 142081864(PAICS)
GSTE: 104251707(PAICS)
CBOY: 140652469(PAICS)
CLV: 102085431 102094220(PAICS)
CNIC: 135988403(PAICS)
MUI: 104534205
PGUU: 104463756(PAICS)
PLET: 104614437(PAICS)
EHS: 104505978(PAICS)
CMAC: 104473864(PAICS)
TEO: 104370341(PAICS)
BREG: 104641570(PAICS)
GAME: 129205549
OHA: 104334899
ACAR: 104532390(PAICS)
CPEA: 104393033
NARQ: 141469054
AAM: 106490207(PAICS)
AROW: 112976747(PAICS)
NPD: 112942546
TGT: 104572965
DNE: 112979521
SCAM: 104138555
ASN: 102380243
AMJ: 102565809(PAICS)
PSS: 102446966(PAICS) 102447225
CIZ: 142012256(PAICS)
CMY: 102937687(PAICS)
CCAY: 125635887(PAICS)
LKP: 140910984(PAICS)
NDS: 141986641
DCC: 119854539(PAICS)
CPIC: 101942651(PAICS)
TST: 117877973(PAICS) 117878023
CABI: 116834617(PAICS)
ACS: 100566555(paics)
ASAO: 132776662(PAICS)
PVT: 110077009 110077010(PAICS)
SUND: 121931240
PBI: 103060841(PAICS)
PMUR: 107297224(PAICS)
TSR: 106554316(PAICS) 106554752
PGUT: 117662104
PCAE: 139320473(PAICS)
VKO: 123016987(PAICS)
PMUA: 114603707
PRAF: 128420983(PAICS)
ZVI: 118083784(PAICS)
GJA: 107123142(PAICS)
EMC: 129336478(PAICS)
XLA: 379855(paics.1.L) 431975(paics.2.L) 444677(paics.1.S)
XTR: 100036662(paics.2) 100488155(paics.1)
NPR: 108794756(PAICS)
ACAT: 141114579(PAICS)
PADS: 140327471(PAICS) 140327802
BBUF: 120990191(PAICS) 120990192
DTC: 141096779 141096780(PAICS)
DRE: 321193(paics)
CCAR: 109064121(paics) 109113011
PTET: 122325378(paics)
LROH: 127182968(paics)
GRF: 141348737(paics)
OMC: 131527253(paics)
PPRM: 120493429(paics)
RKG: 130091798(paics)
MAMB: 125277864(paics)
CIDE: 127502654
CERY: 137018942(paics)
TROS: 130565424(paics)
TDW: 130434255(paics)
MANU: 129429251(paics)
PDAB: 135738874(paics) 135738879
IPU: 108257759(paics)
IFU: 128601397(paics)
PHYP: 113545223(paics)
SMEO: 124376692(paics)
TFD: 113642559(paics)
TVC: 132843443(paics)
CGAR: 128514679(paics)
NGRA: 132883632(paics)
AMEX: 103037884(paics)
CMAO: 118815403(paics)
EEE: 113586370
TRU: 101073764(paics)
TFS: 130528961 130528965(paics)
LCO: 104919099(paics)
NCC: 104947087(paics)
TBEN: 117495070(paics)
CGOB: 115007230(paics)
GACU: 117555197 117555199(paics)
EMAC: 134869549(paics)
ELY: 117253892(paics)
EFO: 125895511(paics)
PLEP: 121940268(paics)
SLUC: 116058805(paics)
ECRA: 117950144(paics)
ESP: 116695595
PFLV: 114562112
GAT: 120824171(paics)
PPUG: 119216565(paics)
AFB: 129094579(paics)
CLUM: 117729933 117729935(paics)
PSWI: 130193822(paics)
CVE: 137883707(paics)
MSAM: 119901058(paics)
SCHU: 122877194(paics)
CUD: 121511738(paics)
SPUL: 138607296(paics)
LMIX: 132955715(paics)
HTC: 141789028(paics)
ALAT: 119029246 119029249(paics)
ASTR: 137599230(paics)
PKLU: 139203128
OLA: 101171736(paics)
OML: 112136857(paics)
CSAI: 133458279(paics)
XMA: 102236450
XCO: 114151174(paics)
XHE: 116725943
PRET: 103463823
GAF: 122838035(paics)
PPRL: 129369792(paics)
CVG: 107091569
CTUL: 119780629(paics)
NFU: 107393397
KMR: 108243405(paics)
ALIM: 106534470
NWH: 119430855(paics)
AOCE: 111569591(paics)
EJA: 138198908(paics)
BFRE: 138621286(paics)
CSEM: 103376690(paics)
POV: 109646212(paics)
SSEN: 122762456(paics)
SSOE: 131465664(paics)
HHIP: 117760547(paics)
HSP: 118121417(paics)
PPLT: 128448130(paics)
SMAU: 118318436(paics)
LCF: 108879073
SDU: 111226365(paics)
XGL: 120791276 120791279(paics)
HCQ: 109532211(paics)
SSCV: 125994705(paics)
SBIA: 133503459(paics)
PEE: 133405976(paics)
PTAO: 133480896(paics)
BPEC: 110154796(paics)
MALB: 109962065
BSPL: 114853784(paics)
SJO: 128362114(paics)
SSCO: 133984937(paics)
TTY: 137188534(paics)
GMH: 115555973 115555976(paics)
OTW: 112249249(paics) 112251146
OMY: 110521683(paics) 110524564
OGO: 123996807 124037869(paics)
OKE: 118359024(paics) 118392653
SNH: 120052592(paics) 120054934
SFON: 129855405(paics) 129869617
CCLU: 121533956 121540141(paics)
ELS: 105011850
OEP: 134011014(paics)
SFM: 108922797
PKI: 111834756(paics)
AANG: 118225698(paics)
AROT: 135254059(paics)
CCOG: 133126192(paics)
LOC: 102695780(paics) 107077190
PSEX: 120527461(paics)
LCM: 102354332(PAICS)
CMK: 103178180(paics)
RTP: 109915470(paics)
CPLA: 122550019(paics)
CPUN: 140476889(paics)
HOC: 132819206(paics)
SCAU: 119962893(paics)
LERI: 129697301(paics)
PMRN: 116943019(PAICS)
LRJ: 133343052(PAICS)
BBEL: 109479396
CIN: 100177417
SCLV: 120331954
SPU: 575874
LPIC: 129261039
AJJ: 139979534
APLC: 110988626
ARUN: 117293910
AAMU: 139935784
AFIL: 140160865
AJC: 117108681
PFLL: 139130784
DME: Dmel_CG3989(Paics)
DER: 6551233
DSI: Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)
DYA: Dyak_GE16201(Dyak_ade5)
DSR: 110180572
DPO: 4814561
DPE: 6599097
DMN: 108161668
DWI: 6644514
DGR: 6565145
DAZ: 108619905
DNV: 108656029
DHE: 111602405
DVI: 6633868(Paics)
CCAT: 101455100
BOD: 106625714
BDR: 105233168
AOQ: 129238737
ALUD: 128858667
TDA: 119669080
SCAC: 106092606
LCQ: 111687676
CVJ: 135956897(Paics)
GFS: 119633828
ECOE: 129944480
CLON: 129605353
HIS: 119656658
AGA: 1272084
ACOZ: 120947737
AARA: 120906513
AMER: 121591361
ASTE: 118513258
AMAP: 126558020
AFUN: 125767887
AMOU: 128306787
AMRS: 128707217
AALI: 118463640
ADAR: 125951915
ACOS: 131269484
AAG: 5578622
ASUA: 134206446
CPII: 120413362
CBRI: 134833770
CNS: 116341883
BCOO: 119068988
LLL: 129786097
PPAP: 129799420
AME: 551966
ACER: 108004086
ALAB: 122714131
ADR: 102671162
AFLR: 100872691
BIM: 100749872
BBIF: 117208120
BVK: 117235554
BVAN: 117154111
BHUN: 126864830
BTER: 100649872
BAFF: 126916404
BPYO: 122565783
BPAS: 132905409
FVI: 122534822
CCAL: 108629228
OBB: 114879276
OLG: 117610744
MGEN: 117227688
NMEA: 116432024
CGIG: 122398570
SOC: 105195586
MPHA: 105835135
AEC: 105144565
ACEP: 105618440
ACOC: 108685062
MZT: 108722389(Paics)
CCOA: 108773848
TCZ: 108765574
TSEP: 108750581
PBAR: 105431681
VEM: 105569749
COBS: 139103523(Paics)
TLN: 139819519(Paics)
TAME: 143907876(Paics)
HST: 105184394
DQU: 106746186
CFO: 105253371
FEX: 115234376
PMEC: 138941710(Paics)
LHU: 105673924(Paics)
PGC: 109857193
OBO: 105278330
PCF: 106787577
PFUC: 122525817
VPS: 122633239
VCRB: 124429674
VVE: 124953716
NVI: 100122105
CSOL: 105364366
TPRE: 106655517
LBD: 127280069
MDL: 103569558
CGLO: 123272470
CTYP: 141536499(Paics)
FAS: 105273501
DAM: 107035651
AGIF: 122859183
CINS: 118073739
VCAN: 122410618
CCIN: 107270852
DSM: 124407665
NPT: 124214232(Paics)
NFB: 124177769
NLO: 107217478
NVG: 124300374
AROA: 105684598
TCA: 656066
DPA: 109546155
ESIM: 136412211(Paics)
EFOR: 136341049(Paics)
SOY: 115884553
RFG: 143195847(Paics)
AGRG: 126734352
ATD: 109598511
CSET: 123316162
HAXR: 123676511
AGB: 108915132
LDC: 111512243
NVL: 108561415
APLN: 108738575
PPYR: 116175172
OTU: 111417005
BMOR: 732910
BMAN: 114242655
BANY: 112055181
MJU: 123864941
NIQ: 126777364
VCD: 124539226
MCIX: 123661138
PMAC: 106711899
PXU: 106117402
BPHI: 137929426(Paics)
PRAP: 111000679
PBX: 123711880
PNAP: 125063530
CCRC: 123705114
LSIN: 126964659
AAGE: 121729263
HAW: 126055027
HZE: 124636806
TNL: 113494584
SLIU: 111351565
OFU: 114350954
ONU: 135079933
ATRA: 106130953
GMW: 113522778
PXY: 105393713
PGW: 126380449
LGLY: 125241630
CSTB: 134755173
CFUM: 141433627(Paics)
CCRN: 123294246
API: 100169501
DNX: 107169969
AGS: 114121209
RMD: 113548300
ACOO: 126847076
DVT: 126894157
CLEC: 106673658
HHAL: 106677324(Paics)
NLU: 111047647
LDA: 142328136(Paics)
MQU: 128991924
FOC: 113205894
TPAL: 117640819
ZNE: 110838439
CSEC: 111874922
PAME: 138713815(Paics)
SGRE: 126299365
BROR: 134545219
IEL: 124168472
HAMR: 139690937(Paics)
FCD: 110857027
PVM: 113818328(Paics)
PJA: 122255345
PCHN: 125031798
PMOO: 119593846
HAME: 121866313
PCLA: 123772116(Paics)
CQD: 128688414(Paics)
ESN: 126999937
MNZ: 135200147
MRJ: 136827980(Paics)
PORN: 139766528(Paics)
HAZT: 108672159
OOT: 143039772(Paics)
PPOI: 119091740
ISC: 8024797
DSV: 119449786
DALB: 135902979(Paics)
RSAN: 119382846
RMP: 119170043
OTI: 135394985
VDE: 111245399
VJA: 111267570
GOE: 100897842
TUT: 107361566
DPTE: 113792963
DFR: 124493911
CSCU: 111642214
CVS: 136988126(Paics)
PTEP: 107441412
ABRU: 129962615
UDV: 129227709
SDM: 118187838
LPOL: 106471938
PMEO: 129594308
CEL: CELE_B0286.3(paic-1)
CBR: CBG_03675
TSP: Tsp_02239
PVUL: 126830190
LSAX: 138968667
BARL: 143283655
BGT: 106051207
GAE: 121375145
HRF: 124132688
HRJ: 124279536
HASI: 137274450
HCRA: 139449731
CRG: 105333392
CANU: 128193132
CVN: 111127492
OED: 125682095
MYI: 110447155
PMAX: 117329261
AIRR: 138327724
YBA: 132544795
MCAF: 127714300
DPOL: 127878162
MAEA: 128228258
OBI: 106881666
OSN: 115219101
LJP: 135473085
LLON: 135494005
NVE: 5500615
EPA: 110243452
ATEN: 116293642
ADF: 107351950
AMIL: 114970396
MCAZ: 138016485
MFOO: 138000068
PDAM: 113666335
SPIS: 111338988
DGT: 114527900
XEN: 124446730
HMG: 100210246
RES: 135686374
DDI: DDB_G0283987(purC/E)
DFA: DFA_08571(purC/E)
 » show all
Reference
  Authors
O'Donnell AF, Tiong S, Nash D, Clark DV
  Title
The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway.
  Journal
Genetics 154:1239-53 (2000)
DOI:10.1093/genetics/154.3.1239
  Sequence
LinkDB

KEGG   ORTHOLOGY: K11808
Entry
K11808                      KO                                     
Symbol
ADE2
Name
phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Reaction
R04209  1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K11808  ADE2; phosphoribosylaminoimidazole carboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21  phosphoribosylaminoimidazole carboxylase
     K11808  ADE2; phosphoribosylaminoimidazole carboxylase
Other DBs
GO: 0004638
Genes
ATH: AT2G37690
ALY: 9317611
CRB: 17887570
CSAT: 104782201 104785717 104792562
EUS: EUTSA_v10016367mg
BRP: 103857728 103865624
BNA: 106392916 106410642 106427767 125585663 125601293
BOE: 106328958 106342429
RSZ: 108830244 108844546
THJ: 104799866 104808027
CPAP: 110807756
CIT: 102626933
MINC: 123208675
TCC: 18600133
DZI: 111295264
EGR: 104421141
PVU: 137829932
VRA: 106772452
VAR: 108323122
VUN: 114190497
VUM: 124826119
CCAJ: 109795409
APRC: 113872785
MTR: 11405596
CAM: 101492527
PSAT: 127098564
VVO: 131644161
LJA: 130718530
ADU: 107465696
AIP: 107618371
FVE: 101294659
AANS: 126793871
RCN: 112193541
PPER: 18774979
PMUM: 103318670
PAVI: 110754361
PDUL: 117633014
ZJU: 107412170
MNT: 21407287
CSAV: 115719673
HLP: 133790712
CSV: 101220975
CMO: 103485386
BHJ: 120076308
MCHA: 111020171
RCU: 8268191
MEAN: 126675457
HBR: 110638277
MESC: 110600716
PEU: 105109809
JRE: 108992651
CILL: 122318430
CAVE: 132172741
AGLU: 133852318
CSAA: 142610832
TWL: 119987566
VVI: 100250122
VRI: 117931118
SLY: 101255944
SPEN: 107004897
SOT: 102597319
SSTN: 125844841
SDUL: 129900437
CANN: 107851129
LBB: 132614254
NTA: 107826110
NSY: 104210402
NTO: 104116449
NAU: 109214079
EGT: 105958306
SMIL: 130985195
SHIS: 125208971
APAN: 127246807
HPUM: 140890521
PEBU: 140836948
PTAB: 142523137
ECAD: 122581774
LSV: 111878896
CCAV: 112510261
AGRV: 141668097
CSIN: 114266917
DLT: 127798224
SOE: 110803454
ATRI: 130814669
MOF: 131160176
TSS: 122671416
OSA: 4327345
OBR: 102703081
OGL: 127770586
BDI: 100840405
ATS: 109769837
TUA: 125543128
HVG: 123443117
LPER: 127341823
LRD: 124661925
SBI: 8084329
SITA: 101771655
SVS: 117857790
PHAI: 112894377
TANG: 140768784
PDA: 103708454
EGU: 105040545
DCT: 110098127
PEQ: 110034028
AOF: 109824587
MSIN: 131251449
ACAK: 137958524
NCOL: 116259327
ATR: 18438490
PPP: 112295424
APRO: F751_2359
SCE: YOR128C(ADE2)
SEUB: DI49_4963
ERC: Ecym_4634
KMX: KLMA_20598(ADE2)
CGR: 2890129(ADE2)
NCS: NCAS_0H02150(NCAS0H02150)
NDI: NDAI_0C01500(NDAI0C01500)
TPF: TPHA_0J02670(TPHA0J02670)
TBL: TBLA_0A02680(TBLA0A02680)
TDL: TDEL_0D02460(TDEL0D02460)
KAF: KAFR_0D05120(KAFR0D05120)
KNG: KNAG_0B04140(KNAG0B04140)
PIC: PICST_81265(ADE2)
LEL: PVL30_003512(ADE2)
LBG: 92208749(LODBEIA_P35530)
CAL: CAALFM_C304520CA(ADE2)
CTEN: 18247287(ADE2)
ASAU: 88175112(PUMCH_004049)
BNN: FOA43_000670(ADE1_2)
BBRX: BRETT_003290(ADE2)
YLI: 2906747(YALI2_C00602g)
SLB: AWJ20_1637(ADE2)
NCR: NCU03194
NTE: NEUTE1DRAFT72443(NEUTE1DRAFT_72443)
SMP: 10805873(SMAC4_02914)
RTHE: 98127573(VTJ83DRAFT_624)
MGR: MGG_01256
SSCK: SPSK_07276
TATV: 90959042(TrAtP1_002451)
TASP: 36611142(TrAFT101_000217)
MAW: 19244336(J3458_000133)
MAJ: MAA_01998
MBRN: 26239590(ADE2)
UVI: 66065953(UV8b_05175)
CMT: CCM_06867
PLJ: 28885475(PLICBS_007033)
DCON: 63720650(DCS_08007)
CDET: 87939388(CDEST_02885)
BFU: BCIN_07g01690(Bcade2)
MBE: MBM_05356
ALUC: AKAW2_20869A(ADE2)
ACHE: ACHE_10306A(ADE2)
APUU: APUU_60252A(ADE2)
PPSF: 300795212(PFLUO_LOCUS8885)
CPW: 9691758(ADE2)
ABE: ARB_04901
TVE: TRV_05910
PTE: PTT_18788
PTRR: 6349752(PtrM4_001310)
ADAC: 96083534(ACET3X_003212)
SPO: 2538734(ade6)
SOM: SOMG_00727(ade6)
CNE: CNE02500
CNB: CNBE2520
CDEU: CNBG_4007
CDEC: 89991245(IAS62_004473)
CTEG: 91990121(I308_103265)
CBAS: 91984472(I312_104427)
CDEP: 91086248(L203_102036)
KMG: 30163353(I203_102555)
KNE: 92182198(IAR55_004940)
KDJ: 28971006(I303_108366)
KBI: 30212623(I302_109080)
KPIN: 30174456(I206_107754)
KSH: 87958723(IL334_006593)
KER: 91101377(V865_002573)
KSN: 43590165(CI109_104705)
KBO: 90015303(L199_004319)
KEP: 91098328(L201_007660)
TASA: A1Q1_06001
CCAC: CcaHIS019_0406440(ADE2)
ABP: AGABI1DRAFT63686(AGABI1DRAFT_63686)
ABV: AGABI2DRAFT230061(AGABI2DRAFT_230061)
MORE: E1B28_012184(ADE2)
SCM: SCHCO_02496475(SCHCODRAFT_02496475)
MGL: MGL_2675
MRT: MRET_2669
BLAC: 94345388(CCR75_001615)
SPAR: SPRG_11850
 » show all
Reference
PMID:2253890
  Authors
Stotz A, Linder P
  Title
The ADE2 gene from Saccharomyces cerevisiae: sequence and new vectors.
  Journal
Gene 95:91-8 (1990)
DOI:10.1016/0378-1119(90)90418-q
  Sequence
[sce:YOR128C]
Reference
PMID:9500840
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch Biochem Biophys 351:123-34 (1998)
DOI:10.1006/abbi.1997.0512
LinkDB

KEGG   ENZYME: 4.1.1.21
Entry
EC 4.1.1.21                 Enzyme                                 
Name
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]
Reaction(KEGG)
R04209
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]
Product
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]
Comment
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
History
EC 4.1.1.21 created 1961, modified 2000, modified 2006
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K11808  phosphoribosylaminoimidazole carboxylase
Genes
HSA10606(PAICS)
PTR471236(PAICS)
PPS100993147
GGO101132763(PAICS)
PON100190835(PAICS)
PPYG129034893(PAICS)
NLE100580950
HMH116467849(PAICS) 116483296
SSYN129462621 129490997(PAICS)
MCC694743
MCF101864855(PAICS)
MTHB126955444
MNI105463551
CSAB103235649 103237366
CATY105591967 105591969(PAICS)
PANU101011883(PAICS) 103884449
TGE112625131(PAICS)
MLEU105552705(PAICS)
RRO104655715(PAICS)
RBB108513484(PAICS)
TFN117085582(PAICS) 117090262
PTEH111526496(PAICS)
CANG105507807 105525579(PAICS)
CJC100390231(PAICS)
SBQ101031274(PAICS) 104651700
CIMI108296113(PAICS) 108296114
ANAN105709234(PAICS)
CSYR103249285(PAICS)
MMUR105867854 105867855(PAICS)
LCAT123624098(PAICS) 123637056
ERUF138374114(PAICS)
PCOQ105807688(PAICS)
OGA100950463(PAICS)
MMU67054(Paics)
MCAL110293933
MPAH110330578(Paics)
RNO140946(Paics)
MCOC116071305(Paics)
ANU117712646(Paics)
ASYL127696683(Paics)
MUN110565016(Paics)
CGE100753190 100758991(Paics)
MAUA101829734(Paics) 121142783
PROB127232266(Paics)
PLEU114681836(Paics)
PMAV102926710(Paics)
MORG121432328 121460627(Paics)
MFOT126506556 126515426
AAMP119808557(Paics) 119810165
CNL130871772 130876212(Paics)
NGI103734378(Paics)
HGL101721606(Paics)
CPOC100727779(Paics)
CCAN109697886(Paics)
DORD105980289(Paics)
DSP122106650(Paics)
DMER138821034(Paics)
PLOP125364939(Paics)
NCAR124985584 124994669
MMMA107139249(Paics)
ITI101961407
OCU100343740 127489901
OPI101534729(PAICS)
OCZ121147095(PAICS)
TUP102484181(PAICS)
GVR103606004(PAICS)
CFA100855769(PAICS)
CLUD112652356
VVP112923709
VLG121473255(PAICS)
NPO129519591(PAICS)
AML100482672(PAICS)
UMR103672750(PAICS)
UAH113262521(PAICS)
UAR123803985(PAICS)
ELK111149362
LLV125093749
MPUF101670430(PAICS) 106004002
MNP132006541(PAICS)
MLK131823800(PAICS)
NVS122889803(PAICS)
ORO101383279(PAICS)
EJU114206674(PAICS) 114206809
ZCA113924518 113924521(PAICS)
MLX118010506(PAICS)
NSU110588151 110590760(PAICS)
LWW102746659(PAICS)
FCA101084705(PAICS)
PYU121035341
PCOO112858402(PAICS)
PBG122497369(PAICS)
PVIV125163377(PAICS)
LRUF124520511
LGF123595955(PAICS)
AJU106971666
PTG102951236(PAICS)
PPAD109278673
PUC125922747
PLEZ122218208(PAICS)
HHV120243038(PAICS)
BTA404170(PAICS)
BOM102281546(PAICS)
BIU109560492
BBUB102392736(PAICS)
BBIS105002829 105002831
CHX102182773
OAS101115345 101117419(PAICS) 114115884
BTAX128050024(PAICS) 128054482
CSUM138078225 138081745(PAICS)
ODA120853000 120862146 120881137
CCAD122428484(PAICS)
MREE136153078(PAICS)
OVR110135551(PAICS)
MBEZ129554833 129561729(PAICS)
SSC100521281(PAICS)
CFR102522524
CBAI105077682(PAICS)
CDK105091550
VPC102531568(PAICS)
BACU103009147(PAICS)
BMUS118895967(PAICS)
LVE103076533(PAICS)
OOR101287712(PAICS)
LALB132519829(PAICS)
GMF115865656(PAICS)
DDP132425956(PAICS)
DLE111169417
PCAD102974361 102994548(PAICS)
PSIU116754769(PAICS)
PPHC136123332(PAICS)
NASI112400791(PAICS)
ECB100058501(PAICS)
EPZ103556488(PAICS)
EAI106841680(PAICS)
MYB102239537(PAICS)
MYD102757395(PAICS)
MMYO118669110(PAICS)
MLF102437295(PAICS)
MDT132218788(PAICS)
MYUM138995631(PAICS)
PKL118706364(PAICS)
EFUS103284981(PAICS)
MNA107532951(PAICS)
DRO112320919(PAICS) 112322805
SHON118978572(PAICS)
AJM119061634(PAICS)
PDIC114492579(PAICS)
PHAS123815730(PAICS)
MMF118632016(PAICS)
PPAM129065527(PAICS)
HAI109373280 109394361(PAICS)
RFQ117019647 117022388(PAICS)
PALE102899036(PAICS)
PGIG120588101 120588103(PAICS)
PVP105293760(PAICS) 111741353
RAY107517721(PAICS)
MJV108395834(PAICS) 118969144
SARA101547712(PAICS)
SFUM130020741(PAICS)
SETR126028746 126032284(PAICS)
LAV100658417
TMU101346245
ETF101641703 101659036
DNM101418600(PAICS)
MDO100012535(PAICS)
GAS123231909 123250015 123250979(PAICS)
SHR100923019(PAICS)
AFZ127541800
PCW110200170(PAICS)
TVP118848492 118852716 118853100(PAICS)
PBRV138175027(PAICS)
MLAO141517909
OAA100086365
TACU119947589
GGA396534(PAICS)
PCOC116225927(PAICS)
MGP100539860(PAICS)
CJO107313717(PAICS) 116653347
TPAI128080320
NMEL110398445
APLA101797218
CATA118248082(PAICS)
TGU100225152(PAICS)
LSR110471777(PAICS)
SCAN103825290(PAICS) 103826194
PMOA120497414
OTC121335133(PAICS)
PRUF121358717(PAICS)
ATRC139592432(PAICS)
GFR102043382 102043552(PAICS)
FAB101807763 101808142(PAICS)
OMA130252536 130252539
PHI102111686(PAICS) 106628861
PMAJ107202963 107203210(PAICS)
CCAE111928008 111928009(PAICS)
CCW104690617(PAICS) 104690618
CBRC103622559(PAICS) 108449136
ACOE138109830(PAICS)
ETL114058312 114058315(PAICS)
ZAB102070226
ZLE135446541(PAICS)
ACHL103810554(PAICS)
SVG106851478(PAICS)
MMEA130579388 130579389
HRT120752708(PAICS)
CCIC134044340 134044343
FPG101919014(PAICS)
FCH102045839 102046009(PAICS)
CCRI104163262(PAICS)
NNT104400497
SHAB115610194
ACUN113479039 113479040(PAICS)
ACHC115348362 121232396
HALD104313976(PAICS)
HLE104836135(PAICS)
AGEN126035542 126035563
GCL127015555
CSTI104556851(PAICS) 104561187
LDI104348101(PAICS)
MNB103772148(PAICS)
DPUB104302244(PAICS)
PPUS135178389(PAICS)
AVIT104280921
BRHI104494915(PAICS) 104498823
EGZ104129452(PAICS)
NNI104020782
PCRI104024908
PCAO104050423(PAICS) 104051816
PADL103926281 103926342
AFOR103897396 103897432(PAICS)
FGA104070300(PAICS)
CBOR142081864(PAICS)
GSTE104251707(PAICS)
CBOY140652469(PAICS)
CLV102085431 102094220(PAICS)
CNIC135988403(PAICS)
MUI104534205
PGUU104463756(PAICS)
PLET104614437(PAICS)
EHS104505978(PAICS)
CMAC104473864(PAICS)
TEO104370341(PAICS)
BREG104641570(PAICS)
GAME129205549
OHA104334899
ACAR104532390(PAICS)
CPEA104393033
CVF104286445 104286446
NARQ141469054
AAM106490207(PAICS)
AROW112976747(PAICS)
NPD112942546
TGT104572965
DNE112979521
SCAM104138555
ASN102380243
AMJ102565809(PAICS)
PSS102446966(PAICS) 102447225
CIZ142012256(PAICS)
CMY102937687(PAICS)
CCAY125635887(PAICS)
LKP140910984(PAICS)
NDS141986641
DCC119854539(PAICS)
CPIC101942651(PAICS)
TST117877973(PAICS) 117878023
CABI116834617(PAICS)
ACS100566555(paics)
ASAO132776662(PAICS)
PVT110077009 110077010(PAICS)
SUND121931240
PBI103060841(PAICS)
PMUR107297224(PAICS)
TSR106554316(PAICS) 106554752
PGUT117662104
PCAE139320473(PAICS)
APRI131203468 131203474
VKO123016987(PAICS)
PMUA114603707
PRAF128420983(PAICS)
ZVI118083784(PAICS)
GJA107123142(PAICS)
EMC129336478(PAICS)
XLA379855(paics.1.L) 431975(paics.2.L) 444677(paics.1.S)
XTR100036662(paics.2) 100488155(paics.1)
NPR108794756(PAICS)
ACAT141114579(PAICS)
PADS140327471(PAICS) 140327802
BBUF120990191(PAICS) 120990192
BGAR122939229 122941977
DTC141096779 141096780(PAICS)
DRE321193(paics)
SRX107721365 107737306
SANH107665310 107683924
SGH107555752 107556158
CCAR109064121(paics) 109113011
CAUA113062925 113120971
CGIB127938623 127984087
PTET122325378(paics)
LROH127182968(paics)
GRF141348737(paics)
OMC131527253(paics)
PPRM120493429(paics)
RKG130091798(paics)
MAMB125277864(paics)
CIDE127502654
CERY137018942(paics)
MASI127410005 127415945
TROS130565424(paics)
TDW130434255(paics)
MANU129429251(paics)
PDAB135738874(paics) 135738879
IPU108257759(paics)
IFU128601397(paics)
PHYP113545223(paics)
SMEO124376692(paics)
TFD113642559(paics)
TVC132843443(paics)
CGAR128514679(paics)
NGRA132883632(paics)
AMEX103037884(paics)
CMAO118815403(paics)
EEE113586370
TRU101073764(paics)
TFS130528961 130528965(paics)
TNGGSTEN00032745G001
LCO104919099(paics)
NCC104947087(paics)
TBEN117495070(paics)
CGOB115007230(paics)
PGEO117444932 117444934
GACU117555197 117555199(paics)
EMAC134869549(paics)
ELY117253892(paics)
EFO125895511(paics)
PLEP121940268(paics)
SLUC116058805(paics)
ECRA117950144(paics)
ESP116695595
PFLV114562112
GAT120824171(paics)
PPUG119216565(paics)
AFB129094579(paics)
CLUM117729933 117729935(paics)
PSWI130193822(paics)
CVE137883707(paics)
MSAM119901058(paics)
SCHU122877194(paics)
EARM139287518 139287672
CUD121511738(paics)
SPUL138607296(paics)
LMIX132955715(paics)
HTC141789028(paics)
ALAT119029246 119029249(paics)
ASTR137599230(paics)
PKLU139203128
MZE101476340(paics) 101482534 106676564 112431584
ONL100704318 102077476 102078617 102079785 109194371 109199026 109199183
OAU116316740 116331053(paics) 116334329 120434429
OLA101171736(paics)
OML112136857(paics)
CSAI133458279(paics)
XMA102236450
XCO114151174(paics)
XHE116725943
PRET103463823
GAF122838035(paics)
PPRL129369792(paics)
CVG107091569
CTUL119780629(paics)
NFU107393397
KMR108243405(paics)
ALIM106534470
NWH119430855(paics)
AOCE111569591(paics)
EJA138198908(paics)
BFRE138621286(paics)
CSEM103376690(paics)
POV109646212(paics)
SSEN122762456(paics)
SSOE131465664(paics)
HHIP117760547(paics)
HSP118121417(paics)
PPLT128448130(paics)
SMAU118318436(paics)
LCF108879073
SDU111226365(paics)
XGL120791276 120791279(paics)
HCQ109532211(paics)
SSCV125994705(paics)
SBIA133503459(paics)
PEE133405976(paics)
PTAO133480896(paics)
BPEC110154796(paics)
ENY140353414 140354274
MALB109962065
BSPL114853784(paics)
SJO128362114(paics)
SSCO133984937(paics)
TTY137188534(paics)
GMH115555973 115555976(paics)
SASA106560280 106584129
STRU115158545 115192372
OTW112249249(paics) 112251146
OMY110521683(paics) 110524564
OGO123996807 124037869(paics)
ONE115108542 115145144
OKI109898037 109902723
OKE118359024(paics) 118392653
OMM135513027 135556294
OCLA139406709 139409373
SALP111972328 111975271
SNH120052592(paics) 120054934
SFON129855405(paics) 129869617
CCLU121533956 121540141(paics)
ELS105011850
OEP134011014(paics)
SFM108922797
PKI111834756(paics)
AANG118225698(paics)
AROT135254059(paics)
CCOG133126192(paics)
LOC102695780(paics) 107077190
PSPA121320173 121326752
ARUT117409359(paics) 117421369 117962728
PSEX120527461(paics)
LCM102354332(PAICS)
CMK103178180(paics)
RTP109915470(paics)
CPLA122550019(paics)
CPUN140476889(paics)
HOC132819206(paics)
SCAU119962893(paics)
LERI129697301(paics)
HAKA140737545 140737871
PMRN116943019(PAICS)
LRJ133343052(PAICS)
BFO118415422 118417541
BBEL109479396
CIN100177417
SCLV120331954
CLEP143450656 143468303
SPU575874
LPIC129261039
LVG121410898 121411141
AJJ139979534
APLC110988626
ARUN117293910
AAMU139935784
AFIL140160865
AJC117108681
PFLL139130784
DMEDmel_CG3989(Paics)
DER6551233
DSE6617746 6618591
DSIDsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)
DYADyak_GE16201(Dyak_ade5)
DAN6503583 6503584
DSR110180572
DPO4814561
DPE6599097
DMN108161668
DWI6644514
DGR6565145
DMODmoj_GI14693
DAZ108619905
DNV108656029
DHE111602405
DVI6633868(Paics)
CCAT101455100
BOD106625714
BDR105233168
RZE108371476 108380553
AOQ129238737
ALUD128858667
TDA119669080
MDE101893760 131804426
SCAC106092606
LCQ111687676
LSQ119602720 119613245 119615291 119615292
CVJ135956897(Paics)
GFS119633828
ECOE129944480
CLON129605353
HIS119656658
AGA1272084
ACOZ120947737
AARA120906513
AMER121591361
ASTE118513258
AMAP126558020
AFUN125767887
AMOU128306787
AMRS128707217
AALI118463640
ADAR125951915
ACOS131269484
AAG5578622
AALB109422142 109432621
ASUA134206446
CQUCpipJ_CPIJ009002
CPII120413362
CBRI134833770
CNS116341883
BCOO119068988
LLL129786097
PPAP129799420
AME551966
ACER108004086
ALAB122714131
ADR102671162
AFLR100872691
BIM100749872
BBIF117208120
BVK117235554
BVAN117154111
BHUN126864830
BTER100649872
BAFF126916404
BPYO122565783
BPAS132905409
FVI122534822
CCAL108629228
OBB114879276
OLG117610744
MGEN117227688
NMEA116432024
CGIG122398570
SOC105195586
MPHA105835135
AEC105144565
ACEP105618440
ACOC108685062
MZT108722389(Paics)
CCOA108773848
TCZ108765574
TSEP108750581
PBAR105431681
VEM105569749
COBS139103523(Paics)
TLN139819519(Paics)
TAME143907876(Paics)
HST105184394
DQU106746186
CFO105253371
FEX115234376
PMEC138941710(Paics)
LHU105673924(Paics)
PGC109857193
OBO105278330
PCF106787577
PFUC122525817
VPS122633239
VCRB124429674
VVE124953716
NVI100122105
CSOL105364366
TPRE106655517
LHT122509806 122509809
LBD127280069
MDL103569558
CGLO123272470
CTYP141536499(Paics)
FAS105273501
DAM107035651
AGIF122859183
CINS118073739
VCAN122410618
CCIN107270852
DSM124407665
NPT124214232(Paics)
NFB124177769
NLO107217478
NVG124300374
AROA105684598
TCA656066
TMOL138136498 138137500 138137504(Paics)
DPA109546155
ESIM136412211(Paics)
EFOR136341049(Paics)
SOY115884553
RFG143195847(Paics)
AGRG126734352
ATD109598511
CSET123316162
HAXR123676511
AGB108915132
LDC111512243
DVV114335014 126892770
NVL108561415
APLN108738575
PPYR116175172
OTU111417005
BMOR732910
BMAN114242655
MSEX115450465 119188545
DPLKGM_208829
BANY112055181
MJU123864941
NIQ126777364
VCD124539226
MCIX123661138
PMAC106711899
PXU106117402
BPHI137929426(Paics)
PRAP111000679
PBX123711880
PNAP125063530
ZCE119830235 119830386
CCRC123705114
LSIN126964659
AAGE121729263
HAW126055027
HZE124636806
TNL113494584
SLIU111351565
OFU114350954
ONU135079933
ATRA106130953
GMW113522778
PXY105393713
PGW126380449
LGLY125241630
CSTB134755173
CFUM141433627(Paics)
CFEL113373201 113373674
CCRN123294246
API100169501
DNX107169969
AGS114121209
RMD113548300
ACOO126847076
DVT126894157
BTAB109040170 109041589
CLEC106673658
HHAL106677324(Paics)
NLU111047647
LDA142328136(Paics)
MQU128991924
PHUPhum_PHUM430820
FOC113205894
TPAL117640819
ZNE110838439
CSEC111874922
PAME138713815(Paics)
SGRE126299365
BROR134545219
IEL124168472
HAMR139690937(Paics)
FCD110857027
PVM113818328(Paics)
PJA122255345
PCHN125031798
PMOO119593846
HAME121866313
PCLA123772116(Paics)
CQD128688414(Paics)
ESN126999937
MNZ135200147
MRJ136827980(Paics)
PORN139766528(Paics)
HAZT108672159
OOT143039772(Paics)
PPOI119091740
ISC8024797
DSV119449786
DALB135902979(Paics)
RSAN119382846
RMP119170043
OTI135394985
VDE111245399
VJA111267570
GOE100897842
TUT107361566
DPTE113792963
DFR124493911
CSCU111642214
CVS136988126(Paics)
PTEP107441412
ABRU129962615
UDV129227709
SDM118187838
LPOL106471938
PMEO129594308
CELCELE_B0286.3(paic-1)
CBRCBG_03675
CRQGCK72_004561
NAINECAME_06175
TSPTsp_02239
HROHELRODRAFT_186294
LGILOTGIDRAFT_182233
PVUL126830190
PCAN112560932 112560933
LSAX138968667
BARL143283655
BGT106051207
GAE121375145
HRF124132688
HRJ124279536
HASI137274450
HCRA139449731
CRG105333392
CANU128193132
CVN111127492
OED125682095
MYI110447155
PMAX117329261
AIRR138327724
YBA132544795
MCAF127714300
RPHI132734889 132759339
DPOL127878162
MAEA128228258
OBI106881666
OSN115219101
LJP135473085
LAK106173523 106177955
LLON135494005
NVE5500615
EPA110243452
ATEN116293642
ADF107351950
AMIL114970396
MCAZ138016485
MFOO138000068
PDAM113666335
SPIS111338988
DGT114527900
XEN124446730
HMG100210246
HSY130654877 130655238
RES135686374
TADTRIADDRAFT_56870
ATHAT2G37690
ALY9317611
CRB17887570
CSAT104782201 104785717 104792562
EUSEUTSA_v10016367mg
BRP103857728 103865624
BNA106392916 106410642 106427767 125585663 125601293
BOE106328958 106342429
RSZ108830244 108844546
THJ104799866 104808027
CPAP110807756
CIT102626933
CICCICLE_v10003992mg CICLE_v10027983mg
PVY116111936 116128981
MINC123208675
TCC18600133
GRA105782260 105804662
GHI107889325 107926745 107949056 121225607
GAB108454374 108472012 108473667
HSYR120174201 120189750
DZI111295264
EGR104421141
RARG115727041 115755742
GMX100787182 100812377
GSJ114371965 114403281
PVU137829932
VRA106772452
VAR108323122
VUN114190497
VUM124826119
CCAJ109795409
APRC113872785
MTR11405596
TPRA123884336 123903144
CAM101492527
PSAT127098564
VVO131644161
LJA130718530
ADU107465696
AIP107618371
AHF112711008 112776399
LANG109345404 109355206
QSAO6P43_007650 O6P43_011231
FVE101294659
AANS126793871
RCN112193541
PPER18774979
PMUM103318670
PAVI110754361
PDUL117633014
MDM103434186 103451046
MSYL126594208 126619431
PXB103954378 103961338
PCOX137722686 137745286
ZJU107412170
MNT21407287
CSAV115719673
HLP133790712
CSV101220975
CMO103485386
BHJ120076308
MCHA111020171
CMAX111487615 111489012
CMOS111444942 111456832
CPEP111808154 111808341
RCU8268191
MEAN126675457
HBR110638277
MESC110600716
POP18108079 7487686
PEU105109809
PALZ118037883 118038270 118044016
PNZ133669163 133706344
JRE108992651
CILL122318430
CAVE132172741
AGLU133852318
QSU111985940 112028403
QLO115953009 115986390
CSAA142610832
TWL119987566
VVI100250122
VRI117931118
SLY101255944
SPEN107004897
SOT102597319
SSTN125844841
SDUL129900437
CANN107851129
LBB132614254
NTA107826110
NSY104210402
NTO104116449
NAU109214079
INI109177453 109183529
ITR115999660 116021020 116027506
SIND105162621 105179969
EGT105958306
SSPL121747796 121787463
SMIL130985195
SHIS125208971
APAN127246807
HPUM140890521
PEBU140836948
PTAB142523137
CARB113730619 113730620
HAN110936856 110941521
BHW143545545 143584680 143615849
ECAD122581774
LSV111878896
CCAV112510261
DCR108200242 108209412
AGRV141668097
CSIN114266917
RVL131324585 131327049
AEW130759572 130764187
DLT127798224
BVG104884365 104902182
SOE110803454
CQI110712887 110716796
ATRI130814669
SLAF141617352 141617840
MOF131160176
NNU104589619 104610105
MING122072792 122081867
TSS122671416
PSOM113289538 113297995 113305505 113356177 113359473
OSA4327345
DOSAOs01g0199900
OBR102703081
OGL127770586
BDI100840405
ATS109769837
TDC119267456 119275372
TAES123060587 123069188 123077712
TUA125543128
HVG123443117
LPER127341823
LRD124661925
SBI8084329
ZMA100501865 103630165
MFLO136449435 136461521
SITA101771655
SVS117857790
PVIR120673914 120705683
PHAI112894377
PAUA133898812 133916088
TANG140768784
PDA103708454
EGU105040545
ZOF122040602 122045131
DCT110098127
PEQ110034028
AOF109824587
MSIN131251449
ACAK137958524
NCOL116259327
ATR18438490
CJF131049869 131060514
SMOSELMODRAFT_121407 SELMODRAFT_123573 SELMODRAFT_79988
PPP112295424
CRECHLRE_12g503300v5
VCNVOLCADRAFT_88132
MNGMNEG_15346
CSLCOCSUDRAFT_56990
CVRCHLNCDRAFT_24868
APROF751_2359
OLUOSTLU_33376
OTAOT_ostta09g00792
BPGBathy10g03620
MISMICPUN_98347
MPPMICPUCDRAFT_15308
SCEYOR128C(ADE2)
SEUBDI49_4963
SPAOSPAR_O02600
AGOAGOS_ACR210C
ERCEcym_4634
KLAKLLA0_E02685g
KMXKLMA_20598(ADE2)
LTHKLTH0F15532g
VPOKpol_440p3
ZROZYRO0G04400g
CGR2890129(ADE2)
NCSNCAS_0H02150(NCAS0H02150)
NDINDAI_0C01500(NDAI0C01500)
TPFTPHA_0J02670(TPHA0J02670)
TBLTBLA_0A02680(TBLA0A02680)
TGBHG536_0F02600
TDLTDEL_0D02460(TDEL0D02460)
KAFKAFR_0D05120(KAFR0D05120)
KNGKNAG_0B04140(KNAG0B04140)
ZMKHG535_0C04380
SLUDSCDLUD_003240
DHADEHA2G13772g
PICPICST_81265(ADE2)
PGUPGUG_04377
SPAASPAPADRAFT_62222
LELPVL30_003512(ADE2)
LBG92208749(LODBEIA_P35530)
CALCAALFM_C304520CA(ADE2)
CTPCTRG_02291
COTCORT_0C03210
CDUCD36_84460
CTEN18247287(ADE2)
CLUCLUG_04693
CLUSA9F13_11g01177
CAURCJI96_0002528
ASAU88175112(PUMCH_004049)
PPAPAS_chr3_0085
PKZC5L36_0A02730
BNNFOA43_000670(ADE1_2)
BBRXBRETT_003290(ADE2)
OPAHPODL_03845
YLI2906747(YALI2_C00602g)
SLBAWJ20_1637(ADE2)
NCRNCU03194
NTENEUTE1DRAFT72443(NEUTE1DRAFT_72443)
SMP10805873(SMAC4_02914)
PANPODANSg5612
PBELQC761_109160
PPSDQC762_109160
PPSPQC763_109160
PPSAQC764_109160
TTTTHITE_2122013
MTMMYCTH_2106437
CTHRCTHT_0054820
RTHE98127573(VTJ83DRAFT_624)
MGRMGG_01256
PPEIPpBr36_00763
TMNUCRPA7_8298
SSCKSPSK_07276
FGRFGSG_10669
FPUFPSE_05696
FPOAFPOAC1_003848
FVNFVRRES_04306
FVRFVEG_03306
FOXFOXG_04841
NHENECHADRAFT_57703
FFCNCS54_00167900
FKRNCS57_00165400
FMUJ7337_006208
TRETRIREDRAFT_105832
TRRM419DRAFT_34104
TATV90959042(TrAtP1_002451)
TASP36611142(TrAFT101_000217)
MAW19244336(J3458_000133)
MAJMAA_01998
MBRN26239590(ADE2)
PCHMVFPPC_01781
UVI66065953(UV8b_05175)
CMTCCM_06867
AMUSLMH87_002107
PLJ28885475(PLICBS_007033)
PTKZJDV02_001700
DCON63720650(DCS_08007)
VALVDBG_04892
VDAVDAG_04435
CFJCFIO01_08613
CLUPCLUP02_05480
CHIGCH63R_00671
CDET87939388(CDEST_02885)
SAPOSAPIO_CDS5738
ELAUCREL1_1956
PFYPFICI_00262
SSLSS1G_09902
BFUBCIN_07g01690(Bcade2)
MBEMBM_05356
PSCOLY89DRAFT_683580
GLZGLAREA_02172
ANIANIA_03626
AFMAFUA_4G12600
ACTACLA_051590
NFINFIA_103710
AORAO090009000333
ANGAn01g08090
AFVAFLA_011025
ALUCAKAW2_20869A(ADE2)
ACHEACHE_10306A(ADE2)
APUUAPUU_60252A(ADE2)
PCSN7525_005771
PDPPDIP_43260
POUPOX_a01367
PPSF300795212(PFLUO_LOCUS8885)
TMFEYB26_005226
TRGTRUGW13939_02718
CIMCIMG_00790
CPW9691758(ADE2)
UREUREG_00756
ABEARB_04901
TVETRV_05910
PBLPAAG_06211
PBNPADG_12229
AJEHCAG_03809
BGHBDBG_05577
PNOSNOG_09661
PTEPTT_18788
PTRR6349752(PtrM4_001310)
BZECOCCADRAFT_86084
BSCCOCSADRAFT_37238
BORCOCMIDRAFT_28685
AALTCC77DRAFT_1018523
ADAC96083534(ACET3X_003212)
ARABEKO05_0000234
ZTRMYCGRDRAFT_73277
PFJMYCFIDRAFT_215799
FFUCLAFUR5_09769
CBETCB0940_10644
BCOMBAUCODRAFT_506580
NPAUCRNP2_7084
TMLGSTUM_00003827001
SPO2538734(ade6)
SOMSOMG_00727(ade6)
CNECNE02500
CNBCNBE2520
CNGCNAG_02294
CGICGB_E3300W
CDEUCNBG_4007
CDEC89991245(IAS62_004473)
CTEG91990121(I308_103265)
CBAS91984472(I312_104427)
CDEP91086248(L203_102036)
KMG30163353(I203_102555)
KNE92182198(IAR55_004940)
KDJ28971006(I303_108366)
KBI30212623(I302_109080)
KPIN30174456(I206_107754)
KSH87958723(IL334_006593)
KER91101377(V865_002573)
KSN43590165(CI109_104705)
KBO90015303(L199_004319)
KEP91098328(L201_007660)
TMSTREMEDRAFT_42952
TASAA1Q1_06001
CCACCcaHIS019_0406440(ADE2)
PPLPOSPLDRAFT_90700
TVSTRAVEDRAFT_144724
DSQDICSQDRAFT_94493
PCOPHACADRAFT_249143
SHSSTEHIDRAFT_100223
HIRHETIRDRAFT_313681
PSQPUNSTDRAFT_96255
ADLAURDEDRAFT_160414
FMEFOMMEDRAFT_157872
GTRGLOTRDRAFT_71482
RSXRhiXN_04201
LBCLACBIDRAFT_318305
CCICC1G_11091
ABPAGABI1DRAFT63686(AGABI1DRAFT_63686)
ABVAGABI2DRAFT230061(AGABI2DRAFT_230061)
PCUBJR316_0005281 JR316_0005292
MPRMPER_11161
MRRMoror_13808
MOREE1B28_012184(ADE2)
SCMSCHCO_02496475(SCHCODRAFT_02496475)
CPUTCONPUDRAFT_164622
SLASERLADRAFT_454448
WSEWALSEDRAFT_33155
WICJ056_000475
UMAUMAG_10790
PFPPFL1_01053
SGRAEX895_006207
MGLMGL_2675
MRTMRET_2669
MSYMMSY001_0173
PGRPGTG_13944
PTRCPtA15_10A435 PtA15_15A419
PSTRPst134EA_027824
MLRMELLADRAFT_114877
RIEOCT59_016677
MBRMONBRDRAFT_34384 MONBRDRAFT_9068
DDIDDB_G0283987(purC/E)
DPPDICPUDRAFT_147031
DFADFA_08571(purC/E)
ACANACA1_106300
PTIPHATRDRAFT_56626
FCYFRACYDRAFT_277172
TPSTHAPSDRAFT_21670
PIFPITG_09726
PSOJPHYSODRAFT_510589
BLAC94345388(CCR75_001615)
SPARSPRG_11850
EHXEMIHUDRAFT_421581 EMIHUDRAFT_424259
RHZRHPLAN_45860
BBGWUT28_C0001G0672
 » show all
Reference
1  [PMID:13672967]
  Authors
LUKENS LN, BUCHANAN JM.
  Title
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
  Journal
J Biol Chem 234:1799-805 (1959)
Reference
2  [PMID:7918411]
  Authors
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
  Title
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
  Journal
Biochemistry 33:11927-34 (1994)
DOI:10.1021/bi00205a031
Reference
3  [PMID:9500840]
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch Biochem Biophys 351:123-34 (1998)
DOI:10.1006/abbi.1997.0512
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.21
IUBMB Enzyme Nomenclature: 4.1.1.21
ExPASy - ENZYME nomenclature database: 4.1.1.21
BRENDA, the Enzyme Database: 4.1.1.21
CAS: 9032-04-6
LinkDB

KEGG   REACTION: R04209
Entry
R04209                      Reaction                               
Name
1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase
Definition
1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2
Equation
Reaction class
RC00590  C03373_C04751
Enzyme
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21
     R04209  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2
Orthology
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]
K11808  phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21]
Other DBs
RHEA: 10795
LinkDB

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