KEGG ORTHOLOGY: K01590

ORTHOLOGY: K01590

Entry

K01590                      KO

Symbol

hdc, HDC

Name

histidine decarboxylase [EC:4.1.1.22]

Pathway

map00340

Histidine metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R01167

L-histidine carboxy-lyase (histamine-forming)

Disease

H00862

Tourette syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00340 Histidine metabolism
    K01590  hdc, HDC; histidine decarboxylase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.22  histidine decarboxylase
     K01590  hdc, HDC; histidine decarboxylase

Other DBs

GO:

0004398

Genes

HSA:

3067(HDC)

PTR:	453425(HDC)

PPS:	100968932(HDC)

GGO:	101133251(HDC)

PON:	100435706(HDC)

PPYG:

129014460(HDC)

NLE:	100583943(HDC)

HMH:	116481662(HDC)

SSYN:

129482758(HDC)

MCC:	715287(HDC)

MCF:	102140159(HDC)

MTHB:

126958691

MNI:	105490522(HDC)

CSAB:

103245641(HDC)

CATY:

105588221(HDC)

PANU:

101023980 116268502

TGE:	112627767(HDC)

MLEU:

105550757(HDC)

RRO:	104656909(HDC)

RBB:	108544824(HDC)

TFN:	117070674(HDC)

PTEH:

111552806(HDC)

CANG:

105502201(HDC)

CJC:	100407107(HDC)

SBQ:	101028065(HDC)

CIMI:

108315568(HDC)

ANAN:

105710127(HDC)

MMUR:

105870716(HDC)

LCAT:

123633854(HDC)

PCOQ:

105814297(HDC)

OGA:	100948057(HDC)

MMU:	15186(Hdc)

MCAL:

110285423(Hdc)

MPAH:

110318815(Hdc)

RNO:	24443(Hdc)

MCOC:

116092343(Hdc)

ANU:	117703783(Hdc)

MUN:	110551948(Hdc)

CGE:	100753889(Hdc)

MAUA:

101829692(Hdc)

PROB:

127221508(Hdc)

PLEU:

114709080(Hdc)

MORG:

121465786(Hdc)

MFOT:

126496846

AAMP:

119814181(Hdc)

NGI:	103733044(Hdc)

HGL:	101711940(Hdc)

CPOC:

100719978(Hdc)

CCAN:

109699102(Hdc)

DORD:

105981108(Hdc)

DSP:	122114434(Hdc)

PLOP:

125340282(Hdc)

NCAR:

124977495

MMMA:

107137622(Hdc)

OCU:

100352602

OPI:	101535008(HDC)

TUP:	102473985(HDC)

GVR:	103585823(HDC)

CFA:	487551(HDC)

CLUD:

112675947(HDC)

VVP:	112920057(HDC)

VLG:	121477960(HDC)

NPO:	129506443(HDC)

AML:	100483602(HDC)

UMR:	103676731(HDC)

UAH:	113269608(HDC)

UAR:	123801866(HDC)

ELK:

111140259

LLV:

125105599

MPUF:

101692154(HDC)

MNP:	131999747(HDC)

MLK:	131836272(HDC)

NVS:	122893182(HDC)

ORO:	101379199(HDC)

EJU:	114206458(HDC)

ZCA:	113909833(HDC)

MLX:	118003227(HDC)

NSU:	110583962(HDC)

LWW:	102749485(HDC)

FCA:	101096483(HDC)

PYU:	121041686(HDC)

PCOO:

112856142(HDC)

PBG:	122468659(HDC)

PVIV:

125169067(HDC)

LRUF:

124508599

PTG:	102958176(HDC)

PPAD:

109263003(HDC)

PUC:

125908847

AJU:

106967229

HHV:	120235025(HDC)

BTA:	515950(HDC)

BOM:	102288176(HDC)

BIU:	109565138(HDC)

BBUB:

102400426(HDC)

BBIS:

104988250(HDC)

CHX:	102176332(HDC)

OAS:	101108052(HDC)

BTAX:

128054546(HDC)

ODA:	120852975(HDC)

CCAD:

122443619 122443620

MBEZ:

129562735(HDC)

SSC:	100156724(HDC)

CFR:	102515254(HDC)

CBAI:

105077015(HDC)

CDK:	105102455(HDC)

VPC:	102525879(HDC)

BACU:

103017595(HDC)

BMUS:

118888402(HDC)

LVE:	103084683(HDC)

OOR:	101285813(HDC)

DLE:	111181547(HDC)

PCAD:

102987046(HDC)

PSIU:

116749973(HDC)

NASI:

112411032(HDC)

ECB:	100069939(HDC)

EPZ:	103546940(HDC)

EAI:	106838475(HDC)

MYB:	102259283(HDC)

MYD:	102758428(HDC)

MMYO:

118651667(HDC)

MLF:	102426149(HDC)

MDT:	132237376(HDC)

PKL:	118721476(HDC)

EFUS:

103287420(HDC)

MNA:	107534892(HDC)

DRO:	112311591(HDC)

SHON:

118992611(HDC)

AJM:	119057623(HDC)

PDIC:

114492872(HDC)

PHAS:

123808492(HDC)

MMF:	118618840(HDC)

PPAM:

129063743(HDC)

HAI:	109394261(HDC)

RFQ:	117022779(HDC)

PALE:

102886268(HDC)

PGIG:

120623113(HDC)

PVP:	105288742(HDC)

RAY:	107502016(HDC)

TOD:	119237924(HDC)

SARA:

101554581(HDC)

SETR:

126020006(HDC)

LAV:	100655681(HDC)

TMU:

101361713

ETF:	101659637(HDC)

DNM:	101440241(HDC)

MDO:	100031203(HDC)

GAS:	123235997(HDC)

SHR:	100928753(HDC)

AFZ:

127551140

PCW:	110203020(HDC)

TVP:	118830267(HDC)

OAA:	100075371(HDC)

GGA:	415454(HDC)

PCOC:

116225336(HDC)

MGP:	100538642(HDC)

CJO:	107318706(HDC)

TPAI:

128075618(HDC)

LMUT:

125698442(HDC)

NMEL:

110403614(HDC)

APLA:

101793174(HDC)

ACYG:

106043373(HDC)

CATA:

118252011(HDC)

AFUL:

116493508(HDC)

TGU:	100229258(HDC)

LSR:	110474176(HDC)

SCAN:

103816036(HDC)

PMOA:

120508873(HDC)

OTC:	121343644(HDC)

PRUF:

121354401(HDC)

GFR:	102039864(HDC)

FAB:	101813047(HDC)

OMA:	130257550(HDC)

PHI:	102107166(HDC)

PMAJ:

107209245(HDC)

CCAE:

111934090(HDC)

CCW:	104683975(HDC)

CBRC:

103621273(HDC)

ETL:	114059937(HDC)

ZAB:	102070884(HDC)

ZLE:	135452163(HDC)

ACHL:

103801804(HDC)

SVG:	106860072(HDC)

MMEA:

130575793(HDC)

HRT:	120758709(HDC)

SATI:

136367028(HDC)

FPG:	101923835(HDC)

FCH:	102051866(HDC)

CCRI:

104160616(HDC)

NNT:	104406953(HDC)

SHAB:

115613090(HDC)

ACUN:

113484020(HDC)

TALA:

104359584(HDC)

ACHC:

115342300(HDC)

HALD:

104320294(HDC)

HLE:	104834519(HDC)

AGEN:

126043725

GCL:

127020736

CSTI:

104558772(HDC)

LDI:	104345902(HDC)

MNB:	103770463(HDC)

DPUB:

104297349(HDC)

AVIT:

104275848(HDC)

BRHI:

104499700

EGZ:	104130933(HDC)

NNI:

104017114

PCRI:

104034099(HDC)

PCAO:

104051540(HDC)

PADL:

103922735(HDC)

AFOR:

103896636(HDC)

FGA:	104070291(HDC)

GSTE:

104251321(HDC)

CLV:	102098924(HDC)

MUI:	104548919(HDC)

PGUU:

104458579(HDC)

PLET:

104624169(HDC)

EHS:	104514785(HDC)

CMAC:

104477096(HDC)

CUCA:

104055715(HDC)

TEO:	104373874(HDC)

BREG:

104634058(HDC)

OHA:	104334607(HDC)

ACAR:

104532686(HDC)

CPEA:

104385942(HDC)

CVF:	104287458(HDC)

RTD:	128914582(HDC)

AAM:	106496427(HDC)

AROW:

112963513(HDC)

NPD:	112952813(HDC)

TGT:	104567418(HDC)

DNE:	112995985(HDC)

SCAM:

104148241(HDC)

ASN:	102388705(HDC)

AMJ:	102567703(HDC)

CPOO:

109309069(HDC)

GGN:	109288566(HDC)

PSS:	102445403(HDC)

CMY:	102939386(HDC)

CCAY:

125644237(HDC)

DCC:	119862925(HDC)

CPIC:

101938873(HDC)

TST:	117884418(HDC)

CABI:

116830925(HDC)

MRV:	120372756(HDC)

ACS:	100558434(hdc)

ASAO:

132762667(HDC)

PVT:	110077265(HDC)

SUND:

121934314(HDC)

PBI:	103064200(HDC)

PMUR:

107302508(HDC)

CTIG:

120315215(HDC)

TSR:

106544979

PGUT:

117675750(HDC)

APRI:

131184610(HDC)

PTEX:

113442240(HDC)

NSS:	113418335(HDC)

VKO:	123027598(HDC)

PMUA:

114584406(HDC)

PRAF:

128401724(HDC)

ZVI:	118092716(HDC)

HCG:	128334987(HDC)

GJA:	107122719(HDC)

STOW:

125424530(HDC)

EMC:	129345407(HDC)

XLA:	108711413 108712469

XTR:	100497702(hdc)

NPR:	108804808(HDC)

RTEM:

120931288(HDC)

BBUF:

120987159(HDC)

BGAR:

122929627(HDC)

MUO:	115460655(HDC)

GSH:	117348715(HDC)

DRE:	793609(hdc)

SRX:	107727402(hdc)

SANH:

107703948(hdc)

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122362714(hdc)

LROH:

127157458(hdc)

OMC:	131524127(hdc)

PPRM:

120484865(hdc)

RKG:	130088809(hdc)

MAMB:

125254730(hdc)

CIDE:

127499768

CERY:

137023515(hdc)

MASI:

127417433 127456382

TROS:

130562612(hdc)

TDW:	130435684(hdc)

MANU:

129419228(hdc)

IPU:

128629564

IFU:	128607138(hdc)

PHYP:

113526698(hdc)

SMEO:

124395440(hdc)

TFD:	113638761(hdc)

TVC:	132851522(hdc)

TRN:	134323203(hdc)

AMEX:

103025570(hdc)

CMAO:

118803980(hdc)

EEE:

113585359

CHAR:

105889006(hdc)

TRU:	101064778(hdc)

TFS:	130515247(hdc)

TNG:	GSTEN00018049G001

LCO:	104919799(hdc)

NCC:	104953029(hdc)

TBEN:

117471812(hdc)

CGOB:

115003687(hdc)

PGEO:

117465220(hdc)

GACU:

117549288(hdc)

EMAC:

134863236(hdc)

ELY:	117256878(hdc)

EFO:	125903959(hdc)

PLEP:

121945095(hdc)

SLUC:

116054504(hdc)

ECRA:

117947419(hdc)

ESP:	116687484(hdc)

GAT:

120811246

PPUG:

119225668(hdc)

AFB:	129100906(hdc)

CLUM:

117751240(hdc)

PSWI:

130192697(hdc)

MSAM:

119890795(hdc)

SCHU:

122875478(hdc)

CUD:	121510975(hdc)

ALAT:

119018684(hdc)

MZE:	101486176(hdc)

ONL:	100712505(hdc)

OAU:	116311714(hdc)

OLA:	101172886(hdc)

OML:	112160818(hdc)

CSAI:

133459945(hdc)

XMA:	102221037(hdc)

XCO:	114143012(hdc)

XHE:	116718913(hdc)

PRET:

103462054(hdc)

PFOR:

103143585(hdc)

PLAI:

106952001(hdc)

PMEI:

106919684(hdc)

GAF:	122841198(hdc)

PPRL:

129369443(hdc)

CVG:	107085331(hdc)

CTUL:

119771729(hdc)

GMU:	124867334(hdc)

NFU:	107381896(hdc)

KMR:	108251273(hdc)

ALIM:

106530921(hdc)

NWH:	119429295(hdc)

AOCE:

111577617(hdc)

MCEP:

125005990(hdc)

CSEM:

103379072

POV:	109624805 109641325

SSEN:

122772466(hdc)

HHIP:

117754192(hdc)

HSP:	118115221 118116306(hdc)

PPLT:

128437575(hdc)

SMAU:

118302353(hdc)

LCF:

108887923

SDU:	111223180(hdc)

SLAL:

111656878(hdc)

XGL:	120794369(hdc)

HCQ:	109525743(hdc)

SSCV:

125966980 125967121

SBIA:

133497487(hdc)

PEE:	133416670(hdc)

PTAO:

133467353(hdc)

BPEC:

110173045(hdc)

MALB:

109963375

BSPL:

114851949(hdc)

SJO:	128380162(hdc)

SASA:

106587893 106595316

STRU:

115166759

OMY:	110514654 118936597

OGO:	124035389 124035476

OKI:

116359637

OKE:

127918913

SNH:	120036179 120037157

CCLU:

121546656(hdc)

ELS:	105025343(hdc)

SFM:	108940862(hdc)

PKI:	111844931(hdc)

AANG:

118215589(hdc)

LOC:	102698881(hdc)

PSPA:

121294326 121298899

ARUT:

117428518 117429746

PSEX:

120541317(hdc)

LCM:	102353176(HDC)

CMK:

121852095

RTP:	109917424(hdc)

CPLA:

122539585(hdc)

HOC:	132834239(hdc)

LERI:

129712678(hdc)

PMRN:

116939959 116939967 116939973 116941860 116941876

LRJ:	133346349 133346655 133346664 133346669 133346670

BFO:

BBEL:

SPU:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG3454(Hdc)

DER:

6543244

DSE:

6608476

DSI:	Dsimw501_GD10721(Dsim_GD10721)

DYA:	Dyak_GE19346

DAN:

DSR:

DPO:

DPE:

DMN:	108159920 117191451

DWI:

6646037

DGR:

6561303

DMO:	Dmoj_GI19320

DAZ:

108615799

DNV:

108653725

DHE:	111592082 115483389

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119674944 119680077

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009897

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105679173(Hdc)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206235

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_304481

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

119089735 119090419 119114033 119114035

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136978879(Hdc)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_119964

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

DGT:

KPNK:

BN49_pI0079(hdc)

EAE:

EAE_02560

EAR:

CCG33472

REE:	electrica_00039(hdc)

ROR:	RORB6_18940

RAO:	DSD31_00220

CIF:	AL515_20490

CPAR:

CUC49_16220

CITZ:

E4Z61_19945

IZH:	FEM41_21745

PSHI:

SAMEA2665130_1235(hdc_1) SAMEA2665130_2542(hdc_2)

SRZ:	AXX16_0320

SRHZ:

FO014_08885

DDD:	Dda3937_00519

DZE:	Dd1591_0272

DDC:	Dd586_3787

DSO:	A4U42_07075

CED:	LH89_14435

DFN:	CVE23_20465

DDQ:

DDI_3894

DAQ:	DAQ1742_04111

DLC:	O1Q98_13360

DDA:	Dd703_0354

LBQ:	CKQ53_07495

EPE:	CI789_14010

ERWI:

GN242_16690

PAO:	Pat9b_5732

PPHO:

CTZ24_22580

TCI:	A7K98_19280

TATU:

EFZ10_01520

PLUM:

A4R40_20620

PAY:	PAU_02211(hdc)

XPO:	XPG1_1072(hdc)

MMK:

MU9_3525

HIF:	HIBPF_17370

HIL:	HICON_08330

HAY:	C3V42_04280

HAEG:

NCTC8502_00552(hdc)

VVU:

VV2_1425

VVM:	VVMO6_03218

VVL:	VV93_v1c32460

VHA:	VIBHAR_02100

VCA:	M892_02790

VNI:	VIBNI_A2877(hdc) VIBNI_A3076

LAG:	N175_19410

VAU:	VANGNB10_67p044(angH)

VCY:	IX92_23370

VCT:	JV59_16180

VTU:	IX91_08650

VEU:	IXK98_17340

VSI:	MTO69_05815

VGA:	BSQ33_18745

VTA:

B0460

VAQ:	FIV01_05665(hdc1) FIV01_17635(hdc2)

VSR:	Vspart_04269(hdc)

VNV:	IF132_05765

AWD:	AWOD_I_1509

PDS:	CAY62_02270

PHOT:

L4174_020255

SKS:	FCN78_07785

PMOL:

CLJ08_25595

PFC:	PflA506_2784(pmsA)

PEN:	PSEEN2506(pmsA)

PRH:	LT40_08460

PSEC:

CCOS191_2635(hdc)

PMAM:

KSS90_12805

ACB:

A1S_2379

ABY:	ABAYE1098(hdc)

ABC:	ACICU_02576(basG)

ABN:

AB57_2808

ABB:	ABBFA_01049(hdc)

ABX:

ABK1_2695

ABZ:	ABZJ_02770

ABR:	ABTJ_01137

ABD:	ABTW07_2825(basG)

ABH:

M3Q_2843

ABAD:

ABD1_23740(basG)

ABJ:	BJAB07104_02734

ABAB:

BJAB0715_02782

ABAJ:

BJAB0868_02616

ABAZ:

P795_5030

ABK:	LX00_13110

ABAU:

IX87_08645

ABAA:

IX88_15190

ABW:	BL01_04695

ABAL:

ABLAC_10820

ACC:	BDGL_001867(hdc)

ACW:	A0J50_05180

ACIE:

KIP84_05395(basG)

SWD:

Swoo_0827

PTU:	PTUN_b0285(hdc)

CATE:

C2869_09130

MCEL:

LPW13_14245

MPAF:

R5R33_11320

ASIP:

AQUSIP_12020(hdc)

MCA:

MMEO:

MEIY:

MCAU:

FTU:	FTT_0664c(hdc)

FTQ:

RO31_0759

FTF:	FTF0664c(hdc)

FTW:

FTW_1064

FTR:	NE061598_03805

FTT:	FTV_0623(hdc)

FTG:	FTU_0707(hdc)

FTL:

FTL_0938

FTH:	FTH_0917(hdc)

FTA:

FTA_0986

FTS:

F92_05160

FTI:	FTS_0921(hdc)

FTO:	X557_04905

FTC:

DA46_1869

FTV:

CH67_1274

FTZ:

CH68_1006

FTM:	FTM_1194(hdc)

FTN:	FTN_1019(hdc)

FTX:

AW25_988

FTD:

AS84_1504

FTY:

CH70_924

FCF:	FNFX1_1058

FCN:	FN3523_0651

FHI:	FSC454_06720

FPT:

BZ13_47

FNA:

OOM_1676

FNL:	M973_06615

FRM:	BBG19_1035

FOO:	CGC45_05225

BLEP:

AL038_11940

THIS:

HZT40_04285

HEL:	HELO_2826(hdc)

MMW:	Mmwyl1_1637

MME:	Marme_2739

BSAN:

CHH28_10065

AHD:	AI20_19915

AHI:	VU14_00745

ASA:	ASA_4380(hdc)

AEO:	O23A_p3640

ADH:	CK627_03395

CRZ:	D1345_00055

CHAE:

CH06BL_00090(hdc)

IFL:	C1H71_02965

PTX:	ABW99_12245

OUR:	CEQ07_03535

PACA:

ID47_00865

MLO:

mlr6209

RLS:	HB780_09590

BBRA:

QA636_35670

LABR:

CHH27_03250

RPOP:

K1718_17795(hdcA)

YAN:	AYJ57_22490

THAA:

CFI11_08090

ANT:	Arnit_1162

SUN:

SUN_0880

DAO:	Desac_2880

SCU:	SCE1572_36655

PIJ:	QEJ31_05820 QEJ31_10230 QEJ31_14785

SAQI:

PSUA:

SSAC:

STAS:

LRE:

LRF:

LRT:

LVA:	LV515_08410

LPOR:

PRK60_00540(hdcA)

LLE:	AYR59_06675

LFV:	LF543_00500

LPAR:

FAM21731_00900

BOG:	MOO47_02760(hdcA)

BFP:	MOO45_00755(hdcA)

CPE:

CPF:

CPR:

CTC:

CTET:

CBV:

CTH:

CTX:	Clo1313_0579

ANR:	Ana3638_09050

PSOR:

RSJ16_02400

RHOM:

FRIFI_2669

ELE:

Elen_2499

EGD:	GS424_014430

GPA:

GPA_07450

RTS:	CE91St31_15080

NTP:	CRH09_23415

NAH:	F5544_38485

NIE:	KV110_17230

STRM:

M444_02955

SCLF:

BB341_30190

SSIA:

A7J05_00490 A7J05_36245

SSUB:

CP968_33130

SFUG:

CNQ36_34300

SPLA:

CP981_31155

SGK:	PET44_01500

SFIY:

F0344_09625

SRPA:

HEP86_37370

SCT:	SCAT_p0093

SCY:	SCATT_p16510

KSK:	KSE_09080(vlmD)

KIT:	CFP65_4692

KCH:	O1G21_03330

AGLA:

OIE69_43335 OIE69_44515

NAL:

B005_4073

SESP:

BN6_39910

SSYI:

EKG83_20315

LED:	BBK82_42310

MAU:	Micau_6135

MICB:

MTUA:

MICH:

MTEM:

VMA:	VAB18032_16155

MHAW:

RMN56_22045

ACTN:

L083_0280

ASIC:

Q0Z83_012420 Q0Z83_053490 Q0Z83_110290

AOU:	ACTOB_003654

DVC:	Dvina_41305

CCAZ:

COUCH_14260 COUCH_14570

AEY:	CDG81_15220

AMR:	AM1_6060(hdc)

LBO:

LBWT_7240

LEP:	Lepto7376_0439

GVI:

gll2219

NPU:	Npun_F1479

NOS:	Nos7107_1111

NSH:

GXM_05986

NED:	HUN01_24655

NPZ:	ACX27_16255

NLK:	NIES25_38800 NIES25_47400

NCW:	NIES2107_74800

FIS:	FIS3754_44630

SCS:	Sta7437_1197

STAN:

STA3757_05490(hdc)

LAMB:

KBB96_03670

LUI:	llg_41160(hdc)

VBC:	C5Q97_19650

FVA:	FV113G1_26110(hdc)

FUL:	C4N20_10620

CSOM:

MKD34_01625(hdcA)

BFR:

BF1487

BFS:	BF9343_1349

BFG:	BF638R_1500

BFB:	VU15_06230

BNO:	K8P02_11330

BSAL:

K6V25_18650

SBAO:

L6469_12850

ALQ:	C7Y71_004095

CBAE:

COR50_16185

COY:	HF329_07585

CHF:	KTO58_11405

CHIM:

CK934_17480

FLA:	SY85_24805

FLS:	GLV81_03340

FLC:	KJS93_02675

AUP:	AsAng_0041270

PEP:	AQ505_02510 AQ505_10545

PCM:	AY601_1282 AY601_2413

PSTY:

BFS30_07255

PEK:	FFJ24_024010

PROE:

H9L23_24475

PRK:	H9N25_22340

PGJ:	QG516_05015 QG516_12775

SHG:	Sph21_0649

SBAM:

SCB77_04735

SOP:	PQ465_07275

SCN:	Solca_2061 Solca_2352

SLAS:

L2B55_09735 L2B55_13000

MGIN:

FRZ54_04370

OLI:	FKG96_00105 FKG96_21605

SBX:	CA265_23415

CAMU:

CA2015_3965

ATK:	AUTU_20080(hdc)

GRL:	LPB144_07895

FCV:	AWN65_11245

FSD:	LXD69_09855

FCS:	TRV642_2011(hdc)

FAN:	GENT5_00210(hdc)

FKE:	MG292_00120

MARM:

YQ22_11570

CLY:	Celly_1761

CLH:	IX49_08670

COMN:

PBN93_08635

ZGA:	ZOBELLIA_4435(hdc)

ZLA:	Q5W13_19550

TDI:	AUW17_08620

TMAR:

MARIT_0983(hdc)

TMP:	F9Y86_02545

TOV:	PG911_04825 PG911_12090

TPAC:

PG913_03375 PG913_04600

TFI:	PJJ26_09210

TSIG:

D6T69_01230 D6T69_07220

FOP:	FNB79_16140

SMIS:

LDL76_08000

AQR:	HN014_18280

ZSP:	MQE36_05565

AEST:

RBH94_12815

MANG:

RBH95_01205

FBU:	UJ101_01321(hdc\|HDC)

ORH:	Ornrh_0964

ORI:	Q785_05410

CGN:	OK18_03110 OK18_08355

CIH:	ATE47_09455

OHO:	Oweho_0967

MBA:	Mbar_A2979

MBW:	MSBRW_1757

» show all

Reference

PMID:2125007

Authors

Yamamoto J, Yatsunami K, Ohmori E, Sugimoto Y, Fukui T, Katayama T, Ichikawa A

Title

cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma P-815 cells.

Journal

FEBS Lett 276:214-8 (1990)
DOI:10.1016/0014-5793(90)80545-t

Sequence

[mmu:15186]

Reference

PMID:3021766

Authors

Vanderslice P, Copeland WC, Robertus JD

Title

Cloning and nucleotide sequence of wild type and a mutant histidine decarboxylase from Lactobacillus 30a.

Journal

J Biol Chem 261:15186-91 (1986)

Reference

PMID:2033044

Authors

Kamath AV, Vaaler GL, Snell EE

Title

Pyridoxal phosphate-dependent histidine decarboxylases. Cloning, sequencing, and expression of genes from Klebsiella planticola and Enterobacter aerogenes and properties of the overexpressed enzymes.

Journal

J Biol Chem 266:9432-7 (1991)
DOI:10.1016/s0021-9258(18)92838-3

Sequence

[ror:RORB6_18940] [eae:EAE_02560]

LinkDB

ENZYME: 4.1.1.22

Entry

EC 4.1.1.22                 Enzyme

Name

histidine decarboxylase;
L-histidine decarboxylase;
L-histidine carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

L-histidine carboxy-lyase (histamine-forming)

Reaction(IUBMB)

L-histidine = histamine + CO2 [RN:R01167]

Reaction(KEGG)

R01167

Substrate

L-histidine [CPD:C00135]

Product

histamine [CPD:C00388];
CO2 [CPD:C00011]

Comment

The enzyme from animal tissues contains a pyridoxal 5'-phosphate cofactor. The bacterial enzyme contains a tightly-bound pyruvoyl cofactor.

History

EC 4.1.1.22 created 1961

Pathway

ec00340

Histidine metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K01590

histidine decarboxylase

Genes

HSA:

3067(HDC)

PTR:	453425(HDC)

PPS:	100968932(HDC)

GGO:	101133251(HDC)

PON:	100435706(HDC)

PPYG:

129014460(HDC)

NLE:	100583943(HDC)

HMH:	116481662(HDC)

SSYN:

129482758(HDC)

MCC:	715287(HDC)

MCF:	102140159(HDC)

MTHB:

126958691

MNI:	105490522(HDC)

CSAB:

103245641(HDC)

CATY:

105588221(HDC)

PANU:

101023980 116268502

TGE:	112627767(HDC)

MLEU:

105550757(HDC)

RRO:	104656909(HDC)

RBB:	108544824(HDC)

TFN:	117070674(HDC)

PTEH:

111552806(HDC)

CANG:

105502201(HDC)

CJC:	100407107(HDC)

SBQ:	101028065(HDC)

CIMI:

108315568(HDC)

ANAN:

105710127(HDC)

MMUR:

105870716(HDC)

LCAT:

123633854(HDC)

PCOQ:

105814297(HDC)

OGA:	100948057(HDC)

MMU:	15186(Hdc)

MCAL:

110285423(Hdc)

MPAH:

110318815(Hdc)

RNO:	24443(Hdc)

MCOC:

116092343(Hdc)

ANU:	117703783(Hdc)

MUN:	110551948(Hdc)

CGE:	100753889(Hdc)

MAUA:

101829692(Hdc)

PROB:

127221508(Hdc)

PLEU:

114709080(Hdc)

MORG:

121465786(Hdc)

MFOT:

126496846

AAMP:

119814181(Hdc)

NGI:	103733044(Hdc)

HGL:	101711940(Hdc)

CPOC:

100719978(Hdc)

CCAN:

109699102(Hdc)

DORD:

105981108(Hdc)

DSP:	122114434(Hdc)

PLOP:

125340282(Hdc)

NCAR:

124977495

MMMA:

107137622(Hdc)

OCU:

100352602

OPI:	101535008(HDC)

TUP:	102473985(HDC)

GVR:	103585823(HDC)

CFA:	487551(HDC)

CLUD:

112675947(HDC)

VVP:	112920057(HDC)

VLG:	121477960(HDC)

NPO:	129506443(HDC)

AML:	100483602(HDC)

UMR:	103676731(HDC)

UAH:	113269608(HDC)

UAR:	123801866(HDC)

ELK:

111140259

LLV:

125105599

MPUF:

101692154(HDC)

MNP:	131999747(HDC)

MLK:	131836272(HDC)

NVS:	122893182(HDC)

ORO:	101379199(HDC)

EJU:	114206458(HDC)

ZCA:	113909833(HDC)

MLX:	118003227(HDC)

NSU:	110583962(HDC)

LWW:	102749485(HDC)

FCA:	101096483(HDC)

PYU:	121041686(HDC)

PCOO:

112856142(HDC)

PBG:	122468659(HDC)

PVIV:

125169067(HDC)

LRUF:

124508599

PTG:	102958176(HDC)

PPAD:

109263003(HDC)

PUC:

125908847

AJU:

106967229

HHV:	120235025(HDC)

BTA:	515950(HDC)

BOM:	102288176(HDC)

BIU:	109565138(HDC)

BBUB:

102400426(HDC)

BBIS:

104988250(HDC)

CHX:	102176332(HDC)

OAS:	101108052(HDC)

BTAX:

128054546(HDC)

ODA:	120852975(HDC)

CCAD:

122443619 122443620

MBEZ:

129562735(HDC)

SSC:	100156724(HDC)

CFR:	102515254(HDC)

CBAI:

105077015(HDC)

CDK:	105102455(HDC)

VPC:	102525879(HDC)

BACU:

103017595(HDC)

BMUS:

118888402(HDC)

LVE:	103084683(HDC)

OOR:	101285813(HDC)

DLE:	111181547(HDC)

PCAD:

102987046(HDC)

PSIU:

116749973(HDC)

NASI:

112411032(HDC)

ECB:	100069939(HDC)

EPZ:	103546940(HDC)

EAI:	106838475(HDC)

MYB:	102259283(HDC)

MYD:	102758428(HDC)

MMYO:

118651667(HDC)

MLF:	102426149(HDC)

MDT:	132237376(HDC)

PKL:	118721476(HDC)

EFUS:

103287420(HDC)

MNA:	107534892(HDC)

DRO:	112311591(HDC)

SHON:

118992611(HDC)

AJM:	119057623(HDC)

PDIC:

114492872(HDC)

PHAS:

123808492(HDC)

MMF:	118618840(HDC)

PPAM:

129063743(HDC)

HAI:	109394261(HDC)

RFQ:	117022779(HDC)

PALE:

102886268(HDC)

PGIG:

120623113(HDC)

PVP:	105288742(HDC)

RAY:	107502016(HDC)

TOD:	119237924(HDC)

SARA:

101554581(HDC)

SETR:

126020006(HDC)

LAV:	100655681(HDC)

TMU:

101361713

ETF:	101659637(HDC)

DNM:	101440241(HDC)

MDO:	100031203(HDC)

GAS:	123235997(HDC)

SHR:	100928753(HDC)

AFZ:

127551140

PCW:	110203020(HDC)

TVP:	118830267(HDC)

OAA:	100075371(HDC)

GGA:	415454(HDC)

PCOC:

116225336(HDC)

MGP:	100538642(HDC)

CJO:	107318706(HDC)

TPAI:

128075618(HDC)

LMUT:

125698442(HDC)

NMEL:

110403614(HDC)

APLA:

101793174(HDC)

ACYG:

106043373(HDC)

CATA:

118252011(HDC)

AFUL:

116493508(HDC)

TGU:	100229258(HDC)

LSR:	110474176(HDC)

SCAN:

103816036(HDC)

PMOA:

120508873(HDC)

OTC:	121343644(HDC)

PRUF:

121354401(HDC)

GFR:	102039864(HDC)

FAB:	101813047(HDC)

OMA:	130257550(HDC)

PHI:	102107166(HDC)

PMAJ:

107209245(HDC)

CCAE:

111934090(HDC)

CCW:	104683975(HDC)

CBRC:

103621273(HDC)

ETL:	114059937(HDC)

ZAB:	102070884(HDC)

ZLE:	135452163(HDC)

ACHL:

103801804(HDC)

SVG:	106860072(HDC)

MMEA:

130575793(HDC)

HRT:	120758709(HDC)

SATI:

136367028(HDC)

FPG:	101923835(HDC)

FCH:	102051866(HDC)

CCRI:

104160616(HDC)

NNT:	104406953(HDC)

SHAB:

115613090(HDC)

ACUN:

113484020(HDC)

TALA:

104359584(HDC)

ACHC:

115342300(HDC)

HALD:

104320294(HDC)

HLE:	104834519(HDC)

AGEN:

126043725

GCL:

127020736

CSTI:

104558772(HDC)

LDI:	104345902(HDC)

MNB:	103770463(HDC)

DPUB:

104297349(HDC)

AVIT:

104275848(HDC)

BRHI:

104499700

EGZ:	104130933(HDC)

NNI:

104017114

PCRI:

104034099(HDC)

PCAO:

104051540(HDC)

PADL:

103922735(HDC)

AFOR:

103896636(HDC)

FGA:	104070291(HDC)

GSTE:

104251321(HDC)

CLV:	102098924(HDC)

MUI:	104548919(HDC)

PGUU:

104458579(HDC)

PLET:

104624169(HDC)

EHS:	104514785(HDC)

CMAC:

104477096(HDC)

CUCA:

104055715(HDC)

TEO:	104373874(HDC)

BREG:

104634058(HDC)

OHA:	104334607(HDC)

ACAR:

104532686(HDC)

CPEA:

104385942(HDC)

CVF:	104287458(HDC)

RTD:	128914582(HDC)

AAM:	106496427(HDC)

AROW:

112963513(HDC)

NPD:	112952813(HDC)

TGT:	104567418(HDC)

DNE:	112995985(HDC)

SCAM:

104148241(HDC)

ASN:	102388705(HDC)

AMJ:	102567703(HDC)

CPOO:

109309069(HDC)

GGN:	109288566(HDC)

PSS:	102445403(HDC)

CMY:	102939386(HDC)

CCAY:

125644237(HDC)

DCC:	119862925(HDC)

CPIC:

101938873(HDC)

TST:	117884418(HDC)

CABI:

116830925(HDC)

MRV:	120372756(HDC)

ACS:	100558434(hdc)

ASAO:

132762667(HDC)

PVT:	110077265(HDC)

SUND:

121934314(HDC)

PBI:	103064200(HDC)

PMUR:

107302508(HDC)

CTIG:

120315215(HDC)

TSR:

106544979

PGUT:

117675750(HDC)

APRI:

131184610(HDC)

PTEX:

113442240(HDC)

NSS:	113418335(HDC)

VKO:	123027598(HDC)

PMUA:

114584406(HDC)

PRAF:

128401724(HDC)

ZVI:	118092716(HDC)

HCG:	128334987(HDC)

GJA:	107122719(HDC)

STOW:

125424530(HDC)

EMC:	129345407(HDC)

XLA:	108711413 108712469

XTR:	100497702(hdc)

NPR:	108804808(HDC)

RTEM:

120931288(HDC)

BBUF:

120987159(HDC)

BGAR:

122929627(HDC)

MUO:	115460655(HDC)

GSH:	117348715(HDC)

DRE:	793609(hdc)

SRX:	107727402(hdc)

SANH:

107703948(hdc)

SGH:

107569986

CCAR:

109070931

CAUA:

113118435

CGIB:

127933994

PTET:

122362714(hdc)

LROH:

127157458(hdc)

OMC:	131524127(hdc)

PPRM:

120484865(hdc)

RKG:	130088809(hdc)

MAMB:

125254730(hdc)

CIDE:

127499768

CERY:

137023515(hdc)

MASI:

127417433 127456382

TROS:

130562612(hdc)

TDW:	130435684(hdc)

MANU:

129419228(hdc)

IPU:

128629564

IFU:	128607138(hdc)

PHYP:

113526698(hdc)

SMEO:

124395440(hdc)

TFD:	113638761(hdc)

TVC:	132851522(hdc)

TRN:	134323203(hdc)

AMEX:

103025570(hdc)

CMAO:

118803980(hdc)

EEE:

113585359

CHAR:

105889006(hdc)

TRU:	101064778(hdc)

TFS:	130515247(hdc)

TNG:	GSTEN00018049G001

LCO:	104919799(hdc)

NCC:	104953029(hdc)

TBEN:

117471812(hdc)

CGOB:

115003687(hdc)

PGEO:

117465220(hdc)

GACU:

117549288(hdc)

EMAC:

134863236(hdc)

ELY:	117256878(hdc)

EFO:	125903959(hdc)

PLEP:

121945095(hdc)

SLUC:

116054504(hdc)

ECRA:

117947419(hdc)

ESP:	116687484(hdc)

GAT:

120811246

PPUG:

119225668(hdc)

AFB:	129100906(hdc)

CLUM:

117751240(hdc)

PSWI:

130192697(hdc)

MSAM:

119890795(hdc)

SCHU:

122875478(hdc)

CUD:	121510975(hdc)

ALAT:

119018684(hdc)

MZE:	101486176(hdc)

ONL:	100712505(hdc)

OAU:	116311714(hdc)

OLA:	101172886(hdc)

OML:	112160818(hdc)

CSAI:

133459945(hdc)

XMA:	102221037(hdc)

XCO:	114143012(hdc)

XHE:	116718913(hdc)

PRET:

103462054(hdc)

PFOR:

103143585(hdc)

PLAI:

106952001(hdc)

PMEI:

106919684(hdc)

GAF:	122841198(hdc)

PPRL:

129369443(hdc)

CVG:	107085331(hdc)

CTUL:

119771729(hdc)

GMU:	124867334(hdc)

NFU:	107381896(hdc)

KMR:	108251273(hdc)

ALIM:

106530921(hdc)

NWH:	119429295(hdc)

AOCE:

111577617(hdc)

MCEP:

125005990(hdc)

CSEM:

103379072

POV:	109624805 109641325

SSEN:

122772466(hdc)

HHIP:

117754192(hdc)

HSP:	118115221 118116306(hdc)

PPLT:

128437575(hdc)

SMAU:

118302353(hdc)

LCF:

108887923

SDU:	111223180(hdc)

SLAL:

111656878(hdc)

XGL:	120794369(hdc)

HCQ:	109525743(hdc)

SSCV:

125966980 125967121

SBIA:

133497487(hdc)

PEE:	133416670(hdc)

PTAO:

133467353(hdc)

BPEC:

110173045(hdc)

MALB:

109963375

BSPL:

114851949(hdc)

SJO:	128380162(hdc)

SASA:

106587893 106595316

STRU:

115166759

OMY:	110514654 118936597

OGO:	124035389 124035476

OKI:

116359637

OKE:

127918913

SNH:	120036179 120037157

CCLU:

121546656(hdc)

ELS:	105025343(hdc)

SFM:	108940862(hdc)

PKI:	111844931(hdc)

AANG:

118215589(hdc)

LOC:	102698881(hdc)

PSPA:

121294326 121298899

ARUT:

117428518 117429746

PSEX:

120541317(hdc)

LCM:	102353176(HDC)

CMK:

121852095

RTP:	109917424(hdc)

CPLA:

122539585(hdc)

HOC:	132834239(hdc)

LERI:

129712678(hdc)

PMRN:

116939959 116939967 116939973 116941860 116941876

LRJ:	133346349 133346655 133346664 133346669 133346670

BFO:

118412289

BBEL:

109468657

SPU:

548615

APLC:

110987761

ARUN:

117288253

AJC:

117103171

SKO:

100313635

DME:	Dmel_CG3454(Hdc)

DER:

6543244

DSE:

6608476

DSI:	Dsimw501_GD10721(Dsim_GD10721)

DYA:	Dyak_GE19346

DAN:

6495630

DSR:

110178288

DPO:

4804203

DPE:

6590521

DMN:	108159920 117191451

DWI:

6646037

DGR:

6561303

DMO:	Dmoj_GI19320

DAZ:

108615799

DNV:

108653725

DHE:	111592082 115483389

CCAT:

101452027

BOD:

106615337

BDR:

105229708

RZE:

108358968

AOQ:

129243791

TDA:	119674944 119680077

MDE:

101901068

SCAC:

106084585

LCQ:

111674485

LSQ:

119601346

GFS:

119640898

ECOE:

129952212

CLON:

129616305

HIS:

119646648

AGA:

1279960

ACOZ:

120957839

AARA:

120901262

AMER:

121596786

ASTE:

118508970

AFUN:

125764464

AMOU:

128305569

AALI:

118457911

AAG:

5564807

AALB:

109417567 109417775

ASUA:

134213036

CQU:	CpipJ_CPIJ009897

CPII:

120424415

CNS:

116336652

BCOO:

119083776

AME:

408587

ACER:

108003560

ALAB:

122720769

ADR:

102674933

AFLR:

100868626

BIM:

100747061

BBIF:

117209704

BVK:

117238954

BVAN:

117164224

BTER:

100643518

BAFF:

126919824

BPYO:

122568756

BPAS:

132910984

FVI:

122533188

CCAL:

108625613

OBB:

114872585

OLG:

117601080

MGEN:

117229264

NMEA:

116424723

CGIG:

122400372

SOC:

105193202

MPHA:

105836992

AEC:

105152935

ACEP:

105622639

PBAR:

105425786

VEM:

105560846

HST:

105191881

DQU:

106744317

CFO:

105249475

FEX:

115244690

LHU:	105679173(Hdc)

PGC:

109856628

OBO:

105286450

PCF:

106791028

PFUC:

122515713

VPS:

122635251

VCRB:

124431365

VVE:

124955177

NVI:

100119434

CSOL:

105359799

TPRE:

106658959

LHT:

122501644

LBD:

127279824

MDL:

103574233

CGLO:

123263347

FAS:

105269473

DAM:

107048619

AGIF:

122853234

CINS:

118072123

VCAN:

122418446

CCIN:

107264877

DSM:

124409495

NPT:

124217146

NFB:

124180125

NLO:

107223840

NVG:

124303132

AROA:

105691189

TCA:

664593

DPA:

109536318

SOY:

115889016

AGRG:

126742961

ATD:

109595135

CSET:

123307245

AGB:

108910565

LDC:

111518010

DVV:

114333516

NVL:

108567253

APLN:

108735124

PPYR:

116170947 116171023

OTU:

111425586

BMOR:

101745115

BMAN:

114242029

MSEX:

115441582

DPL:	KGM_206235

BANY:

112050017

MJU:

123879223

NIQ:

126779059

VCD:

124541037

MCIX:

123667747

PMAC:

106715276

PPOT:

106101912

PXU:

106124531

PRAP:

110995341

PBX:

123717100

PNAP:

125055184

ZCE:

119836418

CCRC:

123704158

LSIN:

126968304

AAGE:

121740020

HAW:

110384609

HZE:

124643184

TNL:

113504121

SLIU:

111349931

OFU:

114365450

ATRA:

106129479

GMW:

113515349

PGW:

126378368

LGLY:

125238942

CFEL:

113376288 113376294

CCRN:

123299965

API:

100159557

DNX:

107167737

AGS:

114129464

RMD:

113559422

ACOO:

126837100

DVT:

126899199

BTAB:

109044724

DCI:

103514557

CLEC:

106664514

HHAL:

106691859

NLU:

111049406

HVI:

124369662

MQU:

128997739

FOC:

113206554

TPAL:

117653933

ZNE:

110836139

CSEC:

111870717

SGRE:

126297689

BROR:

134531227 134539649

IEL:

124165337

FCD:

110842279

DPX:	DAPPUDRAFT_304481

DMK:

116921661

DPZ:

124336119

PJA:

122260901

PCHN:

125038377

PMOO:

119587115

HAME:

121864112

PCLA:

123745308

CQD:

128685229

PTRU:

123519628

ESN:

127003406

MNZ:

135221991

HAZT:

108677699

EAF:

111705055

LSM:

121121924

TCF:

131888195

PPOI:

119089735 119090419 119114033 119114035

DSV:

119456021

RSAN:

119393852

VDE:

111249401

VJA:

111270048

TUT:

107364962

DPTE:

113795525

DFR:

124491035

CSCU:

111626285

CVS:	136978879(Hdc)

PTEP:

107456663

ABRU:

129966555

UDV:

129233306

SDM:

118180876

LPOL:

106466273

PMEO:

129593480

LGI:	LOTGIDRAFT_119964

PVUL:

126814621

PCAN:

112556141

BGT:

106057991

GAE:

121373443

HRF:

124131219

HRJ:

124292334

CRG:

105338240

CANU:

128172339

CVN:

111113817

OED:

125660712

MYI:

110458956

PMAX:

117315931

MCAF:

127721838

RPHI:

132747607

DPOL:

127867297 127867298

MAEA:

128221562 128221585

OBI:

106868611

OSN:

115219006

LJP:

135462592

LAK:

106167343

LLON:

135498720

DGT:

114526159

KPNK:

BN49_pI0079(hdc)

EAE:

EAE_02560

EAR:

CCG33472

REE:	electrica_00039(hdc)

ROR:	RORB6_18940

RAO:	DSD31_00220

CIF:	AL515_20490

CPAR:

CUC49_16220

CITZ:

E4Z61_19945

IZH:	FEM41_21745

PSHI:

SAMEA2665130_1235(hdc_1) SAMEA2665130_2542(hdc_2)

SRZ:	AXX16_0320

SRHZ:

FO014_08885

DDD:	Dda3937_00519

DZE:	Dd1591_0272

DDC:	Dd586_3787

DSO:	A4U42_07075

CED:	LH89_14435

DFN:	CVE23_20465

DDQ:

DDI_3894

DAQ:	DAQ1742_04111

DLC:	O1Q98_13360

DDA:	Dd703_0354

LBQ:	CKQ53_07495

EPE:	CI789_14010

ERWI:

GN242_16690

PAO:	Pat9b_5732

PPHO:

CTZ24_22580

TCI:	A7K98_19280

TATU:

EFZ10_01520

PLUM:

A4R40_20620

PAY:	PAU_02211(hdc)

XPO:	XPG1_1072(hdc)

MMK:

MU9_3525

HIF:	HIBPF_17370

HIL:	HICON_08330

HAY:	C3V42_04280

HAEG:

NCTC8502_00552(hdc)

VVU:

VV2_1425

VVM:	VVMO6_03218

VVL:	VV93_v1c32460

VHA:	VIBHAR_02100

VCA:	M892_02790

VNI:	VIBNI_A2877(hdc) VIBNI_A3076

LAG:	N175_19410

VAU:	VANGNB10_67p044(angH)

VCY:	IX92_23370

VCT:	JV59_16180

VTU:	IX91_08650

VEU:	IXK98_17340

VSI:	MTO69_05815

VGA:	BSQ33_18745

VTA:

B0460

VAQ:	FIV01_05665(hdc1) FIV01_17635(hdc2)

VSR:	Vspart_04269(hdc)

VNV:	IF132_05765

AWD:	AWOD_I_1509

PDS:	CAY62_02270

PHOT:

L4174_020255

SKS:	FCN78_07785

PMOL:

CLJ08_25595

PFC:	PflA506_2784(pmsA)

PEN:	PSEEN2506(pmsA)

PRH:	LT40_08460

PSEC:

CCOS191_2635(hdc)

PMAM:

KSS90_12805

ACB:

A1S_2379

ABY:	ABAYE1098(hdc)

ABC:	ACICU_02576(basG)

ABN:

AB57_2808

ABB:	ABBFA_01049(hdc)

ABX:

ABK1_2695

ABZ:	ABZJ_02770

ABR:	ABTJ_01137

ABD:	ABTW07_2825(basG)

ABH:

M3Q_2843

ABAD:

ABD1_23740(basG)

ABJ:	BJAB07104_02734

ABAB:

BJAB0715_02782

ABAJ:

BJAB0868_02616

ABAZ:

P795_5030

ABK:	LX00_13110

ABAU:

IX87_08645

ABAA:

IX88_15190

ABW:	BL01_04695

ABAL:

ABLAC_10820

ACC:	BDGL_001867(hdc)

ACW:	A0J50_05180

ACIE:

KIP84_05395(basG)

SWD:

Swoo_0827

PTU:	PTUN_b0285(hdc)

CATE:

C2869_09130

MCEL:

LPW13_14245

MPAF:

R5R33_11320

ASIP:

AQUSIP_12020(hdc)

MCA:

MCA2307

MMEO:

OOT43_17115

MEIY:

MIN45_P2092

MCAU:

MIT9_P1031

FTU:	FTT_0664c(hdc)

FTQ:

RO31_0759

FTF:	FTF0664c(hdc)

FTW:

FTW_1064

FTR:	NE061598_03805

FTT:	FTV_0623(hdc)

FTG:	FTU_0707(hdc)

FTL:

FTL_0938

FTH:	FTH_0917(hdc)

FTA:

FTA_0986

FTS:

F92_05160

FTI:	FTS_0921(hdc)

FTO:	X557_04905

FTC:

DA46_1869

FTV:

CH67_1274

FTZ:

CH68_1006

FTM:	FTM_1194(hdc)

FTN:	FTN_1019(hdc)

FTX:

AW25_988

FTD:

AS84_1504

FTY:

CH70_924

FCF:	FNFX1_1058

FCN:	FN3523_0651

FHI:	FSC454_06720

FPT:

BZ13_47

FNA:

OOM_1676

FNL:	M973_06615

FRM:	BBG19_1035

FOO:	CGC45_05225

BLEP:

AL038_11940

THIS:

HZT40_04285

HEL:	HELO_2826(hdc)

MMW:	Mmwyl1_1637

MME:	Marme_2739

BSAN:

CHH28_10065

AHD:	AI20_19915

AHI:	VU14_00745

ASA:	ASA_4380(hdc)

AEO:	O23A_p3640

ADH:	CK627_03395

CRZ:	D1345_00055

CHAE:

CH06BL_00090(hdc)

IFL:	C1H71_02965

PTX:	ABW99_12245

OUR:	CEQ07_03535

PACA:

ID47_00865

MLO:

mlr6209

RLS:	HB780_09590

BBRA:

QA636_35670

LABR:

CHH27_03250

RPOP:

K1718_17795(hdcA)

YAN:	AYJ57_22490

THAA:

CFI11_08090

ANT:	Arnit_1162

SUN:

SUN_0880

DAO:	Desac_2880

SCU:	SCE1572_36655

PIJ:	QEJ31_05820 QEJ31_10230 QEJ31_14785

SAQI:

AXG55_13200

PSUA:

FLK61_25040

SSAC:

I6I31_03740

STAS:

HYI43_11960

LRE:

Lreu_1832

LRF:

LAR_1717

LRT:

LRI_1920

LVA:	LV515_08410

LPOR:

PRK60_00540(hdcA)

LLE:	AYR59_06675

LFV:	LF543_00500

LPAR:

FAM21731_00900

BOG:	MOO47_02760(hdcA)

BFP:	MOO45_00755(hdcA)

CPE:

CPE0390

CPF:

CPF_0378

CPR:

CPR_0373

CTC:

CTC_01478

CTET:

BN906_01640

CBV:

U729_2405

CTH:

Cthe_3028

CTX:	Clo1313_0579

ANR:	Ana3638_09050

PSOR:

RSJ16_02400

RHOM:

FRIFI_2669

ELE:

Elen_2499

EGD:	GS424_014430

GPA:

GPA_07450

RTS:	CE91St31_15080

NTP:	CRH09_23415

NAH:	F5544_38485

NIE:	KV110_17230

STRM:

M444_02955

SCLF:

BB341_30190

SSIA:

A7J05_00490 A7J05_36245

SSUB:

CP968_33130

SFUG:

CNQ36_34300

SPLA:

CP981_31155

SGK:	PET44_01500

SFIY:

F0344_09625

SRPA:

HEP86_37370

SCT:	SCAT_p0093

SCY:	SCATT_p16510

KSK:	KSE_09080(vlmD)

KIT:	CFP65_4692

KCH:	O1G21_03330

AGLA:

OIE69_43335 OIE69_44515

NAL:

B005_4073

SESP:

BN6_39910

SSYI:

EKG83_20315

LED:	BBK82_42310

MAU:	Micau_6135

MICB:

MicB006_4748

MTUA:

CSH63_04380

MICH:

FJK98_21660

MTEM:

GCE86_15670

VMA:	VAB18032_16155

MHAW:

RMN56_22045

ACTN:

L083_0280

ASIC:

Q0Z83_012420 Q0Z83_053490 Q0Z83_110290

AOU:	ACTOB_003654

DVC:	Dvina_41305

CCAZ:

COUCH_14260 COUCH_14570

AEY:	CDG81_15220

AMR:	AM1_6060(hdc)

LBO:

LBWT_7240

LEP:	Lepto7376_0439

GVI:

gll2219

NPU:	Npun_F1479

NOS:	Nos7107_1111

NSH:

GXM_05986

NED:	HUN01_24655

NPZ:	ACX27_16255

NLK:	NIES25_38800 NIES25_47400

NCW:	NIES2107_74800

FIS:	FIS3754_44630

SCS:	Sta7437_1197

STAN:

STA3757_05490(hdc)

LAMB:

KBB96_03670

LUI:	llg_41160(hdc)

VBC:	C5Q97_19650

FVA:	FV113G1_26110(hdc)

FUL:	C4N20_10620

CSOM:

MKD34_01625(hdcA)

BFR:

BF1487

BFS:	BF9343_1349

BFG:	BF638R_1500

BFB:	VU15_06230

BNO:	K8P02_11330

BSAL:

K6V25_18650

SBAO:

L6469_12850

ALQ:	C7Y71_004095

CBAE:

COR50_16185

COY:	HF329_07585

CHF:	KTO58_11405

CHIM:

CK934_17480

FLA:	SY85_24805

FLS:	GLV81_03340

FLC:	KJS93_02675

AUP:	AsAng_0041270

PEP:	AQ505_02510 AQ505_10545

PCM:	AY601_1282 AY601_2413

PSTY:

BFS30_07255

PEK:	FFJ24_024010

PROE:

H9L23_24475

PRK:	H9N25_22340

PGJ:	QG516_05015 QG516_12775

SHG:	Sph21_0649

SBAM:

SCB77_04735

SOP:	PQ465_07275

SCN:	Solca_2061 Solca_2352

SLAS:

L2B55_09735 L2B55_13000

MGIN:

FRZ54_04370

OLI:	FKG96_00105 FKG96_21605

SBX:	CA265_23415

CAMU:

CA2015_3965

ATK:	AUTU_20080(hdc)

GRL:	LPB144_07895

FCV:	AWN65_11245

FSD:	LXD69_09855

FCS:	TRV642_2011(hdc)

FAN:	GENT5_00210(hdc)

FKE:	MG292_00120

MARM:

YQ22_11570

CLY:	Celly_1761

CLH:	IX49_08670

COMN:

PBN93_08635

ZGA:	ZOBELLIA_4435(hdc)

ZLA:	Q5W13_19550

TDI:	AUW17_08620

TMAR:

MARIT_0983(hdc)

TMP:	F9Y86_02545

TOV:	PG911_04825 PG911_12090

TPAC:

PG913_03375 PG913_04600

TFI:	PJJ26_09210

TSIG:

D6T69_01230 D6T69_07220

FOP:	FNB79_16140

SMIS:

LDL76_08000

AQR:	HN014_18280

ZSP:	MQE36_05565

AEST:

RBH94_12815

MANG:

RBH95_01205

FBU:	UJ101_01321(hdc\|HDC)

ORH:	Ornrh_0964

ORI:	Q785_05410

CGN:	OK18_03110 OK18_08355

CIH:	ATE47_09455

OHO:	Oweho_0967

MBA:	Mbar_A2979

MBW:	MSBRW_1757

» show all

Reference

1 [PMID:16747851]

Authors

Epps HM

Title

Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A.

Journal

Biochem J 39:42-6 (1945)
DOI:10.1042/bj0390042

Reference

2 [PMID:5681461]

Authors

Riley WD, Snell EE.

Title

Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group.

Journal

Biochemistry 7:3520-8 (1968)
DOI:10.1021/bi00850a029

Reference

3 [PMID:5216347]

Authors

Rosenthaler J, Guirard BM, Chang GW, Snell EE.

Title

Purification and properties of histidine decarboxylase from Lactobacillus 30a.

Journal

Proc Natl Acad Sci U S A 54:152-8 (1965)
DOI:10.1073/pnas.54.1.152

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.22

IUBMB Enzyme Nomenclature:

4.1.1.22

ExPASy - ENZYME nomenclature database:

4.1.1.22

BRENDA, the Enzyme Database:

4.1.1.22

CAS:

9024-61-7

LinkDB

REACTION: R01167

Entry

R01167                      Reaction

Name

L-histidine carboxy-lyase (histamine-forming)

Definition

L-Histidine <=> Histamine + CO2

Equation

C00135 <=> C00388 + C00011

Reaction class

RC00299

C00135_C00388

Enzyme

4.1.1.22

Pathway

rn00340

Histidine metabolism

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.22
     R01167  L-Histidine <=> Histamine + CO2

Orthology

K01590

histidine decarboxylase [EC:4.1.1.22]

Other DBs

RHEA:

20843

LinkDB

DBGET integrated database retrieval system