KEGG   ORTHOLOGY: K01617
Entry
K01617                      KO                                     
Symbol
dmpH, xylI, nahK
Name
2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77]
Pathway
map00362  Benzoate degradation
map00621  Dioxin degradation
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Reaction
R02602  4-oxalocrotonate carboxy-lyase
R05374  2-oxo-5-methyl-cis-muconate carboxy-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01617  dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase
   00622 Xylene degradation
    K01617  dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase
   00621 Dioxin degradation
    K01617  dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.77  2-oxo-3-hexenedioate decarboxylase
     K01617  dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase
Other DBs
GO: 0047437
Genes
PGE: LG71_12235
SLQ: M495_05200
PSD: DSC_09165
LSY: H8L67_00485(dmpH)
RTH: LRK53_10280(dmpH)
RBD: ALSL_0876
PPSE: BN5_3617(nahK)
PFUW: KF707C_15590(bzaI) KF707C_16040(SalI)
PCQ: PcP3B5_23510(amnE)
PNT: G5B91_07440(dmpH)
PPW: PputW619_2010
PPI: ND083(nahK)
PPJ: RK21_04234
PVR: PverR02_14695
PKC: PKB_3258(amne1) PKB_3606(amne3)
PALK: PSAKL28_05950
PSOS: POS17_2260
PFK: PFAS1_28760
PSET: THL1_489
PALL: UYA_06735 UYA_06965 UYA_20140
PSEP: C4K39_5744
PPII: QL104_12010
PTRT: HU722_0015015
PTAE: NCTC10697_02308(amnE)
PHF: NLY38_02340
PPHN: HU825_04975(dmpH)
PSOA: PSm6_34030
PKJ: Q1W70_06555
PLAU: I0D68_00635(dmpH)
PSC: A458_06505
PSTU: UIB01_22755
PBM: CL52_14725
AVN: Avin_08680(xylI) Avin_30600(lapH)
AVL: AvCA_08680(xylI) AvCA_30600(lapH)
AVD: AvCA6_08680(xylI) AvCA6_30600(lapH)
ACX: Achr_32760(xylI)
HPEG: EAO82_00540(dmpH) EAO82_09440(dmpH)
HAES: LO767_17685(dmpH)
PPHA: BVH74_06170
MAD: HP15_1116 HP15_4037
MSR: AU15_09345 AU15_21065 AU15_22100
MLQ: ASQ50_09200
MSQ: BKP64_13835
MARJ: MARI_05470(tesE)
MALL: PBN92_01685(dmpH)
MSHE: MAALD49_03420 MAALD49_03890
MANP: EHN06_02460(dmpH)
SWD: Swoo_1406
SEUR: FM038_016465
TPSY: RGQ13_14535
TNN: RI845_05130
TFT: RI844_19355
LAL: AT746_01265
SALH: HMF8227_02737(hpaH)
KIM: G3T16_05370
AFUS: EYZ66_02600(dmpH)
CYQ: Q91_0511
CZA: CYCME_2100
CYY: CPC19_10500(dmpH)
BLEP: AL038_01285(dmpH)
THIS: HZT40_10620(dmpH)
TBN: TBH_C0931
HCS: FF32_08365
HBP: HPTD01_721
HAXH: J4377_02205
HABD: OM794_22355
HALK: CUU95_03815
HVN: EI420_02115
HTX: EKK97_09975
APAC: S7S_07005
MGEO: CFI10_00440(dmpH) CFI10_04975(dmpH)
MSEC: LN244_11315(dmpH)
NCU: F0U83_03060(dmpH)
NJP: NEJAP_0674
NIK: F5I99_10090(dmpH) F5I99_10505(dmpH)
AJP: AMJAP_2996
ASIM: FE240_03475(dmpH)
ZDF: AN401_14610
SINI: GT972_13735(dmpH)
GBI: PG2T_09680
NZO: SAMEA4504057_0445(mhpD)
NCI: NCTC10296_00916(xylJ_2)
NWD: H3L96_04770(dmpH)
NDU: LVJ88_00585(dmpH)
VFF: VITFI_CDS1371
VMS: LVJ82_11890
PTES: JQU52_04855(dmpH)
USU: LVJ78_03655(dmpH)
CHRO: CXB49_03845(dmpH)
CRZ: D1345_11510
CHAE: CH06BL_23590
AQS: DKK66_07205
AQL: BXU06_16890
RSO: RSp0892
RSE: F504_4325
RPU: CDC45_22075
RNC: GO999_18490
RSM: CMR15_mp10876
RPI: Rpic_4619
RPF: Rpic12D_3543
RPJ: N234_08155 N234_12210
RIN: ACS15_4682(amnE)
REH: H16_B0549(h16_B0549)
CNC: CNE_2c04950(dmpH) CNE_BB1p11980(xylI) CNE_BB1p13270(dmpH)
REU: Reut_B5500 Reut_B5692
RME: Rmet_1318(dmpH) Rmet_5210(amnE)
CBW: RR42_m1052 RR42_s2483
CCUP: BKK81_23320 BKK81_27095
CUP: BKK80_29225 BKK80_32995
CUU: BKK79_23880 BKK79_35175
COX: E0W60_03750 E0W60_07780(dmpH)
CCAX: KZ686_10010(dmpH)
CUK: KB879_20195(dmpH)
CNAN: A2G96_22775
BVI: Bcep1808_7606
BUR: Bcep18194_B2958 Bcep18194_C7643
BCJ: BCAM2123
BCEN: DM39_4831(dmpH)
BCEO: I35_6005
BMUL: NP80_3871(amnE)
BCT: GEM_5400
BCED: DM42_4990(dmpH)
BCON: NL30_24585
BDF: WI26_16000
BTEI: WS51_00575
BPSL: WS57_12150
BSTL: BBJ41_10525 BBJ41_33955
BANN: JFN94_19140(dmpH)
BARI: NLX30_35150
BAEN: L3V59_30410(dmpH)
BUG: BC1001_0834
BUQ: AC233_11180
BXE: Bxe_A1150(amnE)
BXB: DR64_3309(amnE)
BPX: BUPH_05359
BPY: Bphyt_1469
BFN: OI25_254(amnE)
PARB: CJU94_37885(dmpH) CJU94_38130(dmpH)
PTER: C2L65_38850
PBRY: NDK50_06185
PPAI: E1956_27315
PHUN: U0042_26785(dmpH)
BRH: RBRH_00201
PPK: U875_01885 U875_18215
PPNO: DA70_10725
PPNM: LV28_20330
PRB: X636_07585 X636_15900
PPUL: RO07_14670
PSPU: NA29_22520
PAPI: SG18_14500
PVE: UC34_05805
POX: MB84_10225
PFG: AB870_16830
PNR: AT302_01280
PAND: DRB87_05210
PFIB: PI93_022455
PCOM: NTU39_06715
PANN: PanNE5_04140
PANX: OYT13_05070
CABA: SBC2_61030(amnE)
LIMN: HKT17_03835(dmpH)
BHZ: ACR54_00827(amnE)
BOJ: CBF45_01485 CBF45_04495 CBF45_06950 CBF45_16995
APES: FOC84_00280 FOC84_00315(dmpH)
PUD: G9Q38_15000
AKA: TKWG_04045
AMIM: MIM_c06230
CDN: BN940_01171 BN940_04311
PIG: EGT29_19205
KGY: EHF36_01670(dmpH) EHF36_04880(dmpH) EHF36_16935
RLH: MIZ03_0647 MIZ03_1027
POL: Bpro_1513 Bpro_5137
AJS: Ajs_0225
ACID: CBP33_01120
ACIP: CBP36_01215
ACIN: CBP34_01125
ACIS: CBP35_17735
AMON: H9L24_14170(dmpH)
VEI: Veis_2784
VPD: VAPA_1c22830
VBO: CKY39_28490(dmpH)
VAV: IG196_08145(dmpH)
CTT: CtCNB1_3146
COF: FOZ74_08325(dmpH)
CRJ: QMY55_24790
ADN: Alide_0340
ADK: Alide2_0285
OTD: J1M35_00030(dmpH)
HYL: LPB072_18185
HPSE: HPF_01820(tesE2) HPF_01865(tesE3)
HYN: F9K07_02755(dmpH)
HTN: KI616_01940 KI616_01960(dmpH)
DIH: G7047_01665(dmpH) G7047_06945
DRG: H9K76_11650(dmpH) H9K76_22950
SIMP: C6571_13630(dmpH)
MELA: C6568_07845(dmpH)
MJE: LVC68_01035(dmpH)
STHM: IS481_10535(dmpH)
SAQA: OMP39_09115(dmpH)
MPT: Mpe_A2272 Mpe_A3324
METP: C1M51_06455(dmpH) C1M51_15395(dmpH)
RDP: RD2015_407
MIU: ABE85_21105
SNN: EWH46_19320(dmpH)
SMIO: CATMQ487_04100 CATMQ487_17570
IDC: LRM40_19575(dmpH)
LCH: Lcho_3342
JAG: GJA_235(dmpH)
JAJ: EKL02_01820(dmpH) EKL02_15560
HEE: hmeg3_19570
TMJ: P0M04_30670(dmpH)
RBU: PG1C_09715 PG1C_14085
AIQ: Azoinq_09670
DAR: Daro_2773 Daro_3781
DEY: HYN24_14125(dmpH) HYN24_14195(dmpH)
DDEN: KI615_16865(dmpH)
FLE: KI610_08580(dmpH) KI610_13440(dmpH) KI610_15445(dmpH)
AZO: azo1854(lapH) azo2430(nahK)
AOA: dqs_2007 dqs_2574
AZD: CDA09_10340(dmpH) CDA09_10445(dmpH)
AZR: CJ010_12255(dmpH) CJ010_15200(dmpH)
TMZ: Tmz1t_3090
THU: AC731_001825
THAU: C4PIVTH_2810(dmpH)
THK: CCZ27_10765(dmpH) CCZ27_16280(dmpH)
THAG: CKCBHOJB_03305(hpcG)
AZQ: G3580_00540(dmpH) G3580_08285(dmpH)
RLE: pRL120704
ARA: Arad_7266
BIC: LMTR13_06470
MRD: Mrad2831_4067
MET: M446_1050
MSL: Msil_1480
MTUN: MTUNDRAET4_3891(amnE)
DSAL: K1X15_13430
MAAD: AZF01_08270 AZF01_21095
MLUT: JET14_11070
ACUT: MRB58_02670
BBUL: U0030_00110
OCT: FTO60_10555
CEH: CEW89_11450
SUAM: BOO69_22210
TEC: AKL02_008260(dmpH)
NAR: Saro_3851
NPP: PP1Y_AT15722 PP1Y_AT31571
NPN: JI59_24645
NOG: GKE62_05080
NHUM: PQ457_19220
SMAG: AN936_00740
SMAZ: LH19_00750
STER: AOA14_03895
SGI: SGRAN_3551(amnE)
SPHO: C3E99_12570
SPEG: SPYCW_2518
SWI: Swit_0912 Swit_3521
SPHD: HY78_06675 HY78_22125
SPKC: KC8_11575
SJP: SJA_C1-11880(hpaH_xylI)
SINB: SIDU_08325
SYB: TZ53_09015 TZ53_23460
SHYD: CJD35_06495(dmpH)
SUFL: FIL70_19000
SBAR: H5V43_20650 H5V43_22345
SPPH: KFK14_16525
SPAG: sphantq_04471(amnE)
SPHY: CHN51_06980
SPHJ: BSL82_10450
ALTN: LBX01_05455
CNA: AB433_18115
ERY: CP97_03155 CP97_14235
KSC: CD178_01495(amnE)
NCB: C0V82_23405
MAGQ: MGMAQ_0652
GSO: PH603_12390
HTL: HPTL_0045
ACIB: ACBT_0258(dmpH)
AFC: AFAEC_1843(dmpH)
AAQI: AAQM_0983(dmpH)
ACLO: ACLO_a0138(dmpH)
ADZ: ADFLV_2550(dmpH)
ARC: ABLL_2441
AROS: NJU99_01655(dmpH)
ALK: ALEK_0384(dmpH)
AANA: AANAER_1261(dmpH)
MXA: MXAN_0925
MSD: MYSTI_00945
MYM: A176_006054
MFB: MFUL124B02_05300
MLAN: JY572_21820
CCX: COCOR_00872(dmpH)
MFU: LILAB_04080
MMAS: MYMAC_000948
PPAK: JY651_34505
SUR: STAUR_2722
AGE: AA314_01330
AVM: JQX13_18930
PCAY: FRD00_17510
BBAE: FRD01_19450
BDQ: CIK05_11235
BLI: BL03907
BLD: BLi03993(xylI)
BLH: BaLi_c40070
BSON: S101395_00392(dmpH)
BCA: BCE_2158
BCX: BCA_2156
BCF: bcf_10220
BCER: BCK_24215
BCEF: BcrFT9_01690
BTL: BALH_1845
BMYC: DJ92_4639
BTRO: FJR70_09215
BNT: GSN03_10155
BSM: BSM4216_0950
BGY: BGLY_4397
BFD: NCTC4823_00794(xylJ)
BACI: B1NLA3E_08440 B1NLA3E_09300
GST: HW35_13045
BACO: OXB_2505
BACQ: DOE78_09235
BAQU: K6959_02310
BHK: B4U37_13930
BMQ: BMQ_3586
BMD: BMD_3571
BMEG: BG04_460
BPF: BpOF4_12615
BDA: FSZ17_11250
OCN: CUC15_03685
GTN: GTNG_3150(nbaG)
GYC: GYMC61_2299
GYA: GYMC52_1427
GCT: GC56T3_2054
GMC: GY4MC1_1597
GGH: GHH_c14850
GJF: M493_17910
GEJ: A0V43_04660
GZA: IC807_03370
GTH: Geoth_1680
PTL: AOT13_14435
PCAL: BV455_00226(tesE_1)
PARG: PspKH34_14930 PspKH34_15490
ASED: IRT44_17615
LGY: T479_19640
LYB: C3943_22670
LYZ: DCE79_01760
LPAK: GDS87_20225
LYC: FH508_0003705
LLB: R6U77_10600
VIG: BKP57_09375
VNT: OLD84_14650
VIK: KFZ58_14495
LAO: AOX59_17255
FPN: ABE65_004750
FAR: ABE41_004890
APAK: AP3564_06555
ACOP: RI196_01650
BSJ: UP17_10530
PASA: BAOM_0499
PFRI: L8956_11395
RUE: DT065_12670 DT065_13795 DT065_15120 DT065_15210
SALE: EPH95_15045
NTM: BTDUT50_14545
NDT: L1999_11900 L1999_17840
NCM: QNK12_05495
NNV: QNH39_12250 QNH39_24865
AIA: AWH56_018055
ROSS: V2W31_07750
BOU: I5818_04805
GAJ: MY490_08575
HYI: K2M58_09700 K2M58_09725
BBE: BBR47_29790
BFM: BP422_09725
BCHS: JNE38_24125
BHUI: LOK74_00615
BAYD: BSPP4475_07470(dmpH)
BBOR: RFB14_22150
PNP: IJ22_00700 IJ22_32390 IJ22_48600
ANX: ACH33_11700
ASOC: CB4_02453(amnF)
ATHE: K3F53_07240
AUD: PO771_09010
ANEU: PP175_12695
COH: EAV92_02610
AAC: Aaci_1618
AAD: TC41_1514
AACO: K1I37_06165
ADAU: NZD86_00710 NZD86_06140
AFAS: NZD89_10115
ALIC: GI364_17535
BTS: Btus_0970
KYR: CVV65_10340 CVV65_11285
EFF: skT53_33780
FFE: LSG31_21080
SOB: CSE16_14625
PSHE: QWY16_07660
SPAE: E2C16_04465 E2C16_12275
SPOO: J3U78_11170
SURL: BI350_00150
AUI: APT62_01025
AVS: AWM76_09545
CARN: FPV25_04350
SAY: TPY_0643
SAP: Sulac_2996
MIT: OCO_14790
MIA: OCU_15230
MMAN: MMAN_42240
MJL: Mjls_4208
MYV: G155_08390 G155_08470
MFT: XA26_16790 XA26_16950
MLL: B1R94_25050
MHEV: MHEL_01620
MMAT: MMAGJ_45260 MMAGJ_45420
MMON: EWR22_21590
MGO: AFA91_00030
MHOL: K3U96_19110
MAUS: JN090_26255
CHN: A605_04755
CEE: CENDO_03490(amnE)
COK: COCCU_04385(amnE)
NFA: NFA_30430
NFR: ERS450000_00296(xylJ_1) ERS450000_01021(xylJ_2)
NNO: NONO_c62050
NTP: CRH09_30230
NWL: NWFMUON74_07310
RHA: RHA1_ro03880
RER: RER_04710 RER_59340
REY: O5Y_02265
REB: XU06_02465
RQI: C1M55_02650
ROP: ROP_37490 ROP_54170
RPY: Y013_12560
RBY: CEJ39_00065
RAV: AAT18_08105
RRZ: CS378_23120
RHQ: IM25_04200
RHOD: AOT96_13015
RRT: 4535765_01257(amnE)
RKO: JWS14_41315
RGO: KYT97_21980
ROZ: CBI38_22780
RPSK: JWS13_12560 JWS13_18955
RHOO: RA302_02495
RHOU: KZJ41_08670
RHOW: A4U64_16475
RHOJ: JVH1_17120 JVH1_20175 JVH1_39410
REQ: REQ_05050(amnD)
PDEF: P9209_00360
GBR: Gbro_0225
GTA: BCM27_21915
GOC: CXX93_11295
GOS: QAD21_20950
GOJ: GR168_20010
GOI: LK459_10160
GHN: MVF96_20965
GSI: P5P27_10835
DIZ: CT688_01890
TOY: FO059_00305
SANL: KZO11_33900
SCB: SCAB_15181
SSX: SACTE_4113
SRC: M271_50380
SBH: SBI_01536
STRT: A8713_24465
SVU: B1H20_29090
SGE: DWG14_08258(amnE)
SNK: CP967_06830
SSUB: CP968_28065
SPLA: CP981_35170
SCAL: I6J39_28940
SROI: IAG44_01280
STRY: EQG64_09025
SGOB: test1122_23000
SDRZ: NEH16_30290
STUD: STRTU_001643 STRTU_001677
SANT: QR300_10270
SPRF: K4G22_29945
SLUO: PS467_00410
KIT: CFP65_1237
YIA: LO772_34585
MLIY: RYJ27_00290
MAUG: KV397_17135
MSUF: KV394_04965
MVD: AWU67_16690
AGY: ATC03_02580
AMAU: DSM26151_04170(amnE)
ASOI: MTP13_01920
PSAI: C3B54_11904
SALD: FVA74_00730
LTR: EVS81_03255
HEA: HL652_17940
ACIT: HPK19_02435
ARZ: AUT26_08860
PSLS: KTR40_08350
ICA: Intca_1093
JTE: ASJ30_00110
JLI: EXU32_15355
JME: EEW87_015420
JAY: H7A72_00110
JCR: O9K63_12595
PEI: H9L10_13720
OCP: NF557_14855 NF557_15600
AUS: IPK37_11690
RAIN: Rai3103_12620
NCA: Noca_2055
NPI: G7071_16490
TCU: Tcur_0537
ACTW: F7P10_40030
AGRA: AGRA3207_000779 AGRA3207_003642
AMAZ: LUW76_22725 LUW76_47885
ACIR: OG979_20775 OG979_41955
SPIQ: OHA34_00545
SRO: Sros_9112
NGN: LCN96_28045
MHAI: OHB01_10135
FRI: FraEuI1c_1245
NML: Namu_0794
AMD: AMED_8622
AMN: RAM_44250
AMM: AMES_8491
AMZ: B737_8492
AOI: AORI_7401
AJA: AJAP_01985
AMQ: AMETH_5437
AMYC: CU254_17665 CU254_35760
AMYB: BKN51_30410
AORI: SD37_03455
AACD: LWP59_38180
APRT: MUY14_40600
AROO: NQK81_00865 NQK81_28575
ATHM: L1857_30175
ARHD: VSH64_19090 VSH64_30305 VSH64_35370
AMOG: QRX60_15530
ACYN: ORV05_22405
ACOR: LCL61_08955 LCL61_24560
PDX: Psed_2523 Psed_4292
PBRO: HOP40_26620 HOP40_31750
PPEL: H6H00_29790
PSDS: K1T35_35335
KUT: JJ691_102210 JJ691_11960
ALO: CRK56594
PMAD: BAY61_16755
ACTY: OG774_08010 OG774_09250
STP: Strop_3524
SAQ: Sare_3899
MAU: Micau_4937
MIL: ML5_3358
MICB: MicB006_3969
MTUA: CSH63_33405
MTEM: GCE86_19380
MCAB: HXZ27_25040
VMA: VAB18032_17780 VAB18032_28741
MCRA: ID554_21670 ID554_30890
VER: HUT12_13555 HUT12_26050
MENO: Jiend_41040
MCHL: PVK74_15030
MFEU: H1D33_00380
MPRN: Q3V37_13160
MHAW: RMN56_18005
MICF: QQG74_13325 QQG74_25585
PFLA: Pflav_027520
PSUU: Psuf_068140
PRY: Prubr_10590 Prubr_59260
CATI: CS0771_01260
DFU: Dfulv_27715
DACT: KZZ52_26440 KZZ52_45190
NHY: JQS43_06620
PVN: A7sIIA15_04525
JCY: M6B22_02780
BSOL: FSW04_07220
IIS: EYM_02850
AG: CAA43228(dmpH)
 » show all
Reference
PMID:1732207
  Authors
Shingler V, Powlowski J, Marklund U
  Title
Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 174:711-24 (1992)
DOI:10.1128/JB.174.3.711-724.1992
  Sequence
[ag:CAA43228]
LinkDB

KEGG   ENZYME: 4.1.1.77
Entry
EC 4.1.1.77                 Enzyme                                 
Name
2-oxo-3-hexenedioate decarboxylase;
4-oxalocrotonate carboxy-lyase (misleading);
4-oxalocrotonate decarboxylase (misleading);
cnbF (gene name);
praD (gene name);
amnE (gene name);
nbaG (gene name);
xylI (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
(3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming)
Reaction(IUBMB)
(3E)-2-oxohex-3-enedioate = 2-oxopent-4-enoate + CO2 [RN:R02602]
Reaction(KEGG)
R02602;
(other) R05374
Substrate
(3E)-2-oxohex-3-enedioate
Product
2-oxopent-4-enoate [CPD:C00596];
CO2 [CPD:C00011]
Comment
Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enzyme has been reported to accept multiple tautomeric forms [1-4]. However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, 2-hydroxymuconate tautomerase, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate [4].
History
EC 4.1.1.77 created 1999, modified 2011, modified 2012
Pathway
ec00362  Benzoate degradation
ec00621  Dioxin degradation
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01617  2-oxo-3-hexenedioate decarboxylase
Genes
PGE: LG71_12235
SLQ: M495_05200
PSD: DSC_09165
LSY: H8L67_00485(dmpH)
RTH: LRK53_10280(dmpH)
RBD: ALSL_0876
PPSE: BN5_3617(nahK)
PFUW: KF707C_15590(bzaI) KF707C_16040(SalI)
PCQ: PcP3B5_23510(amnE)
PNT: G5B91_07440(dmpH)
PPW: PputW619_2010
PPI: ND083(nahK)
PPJ: RK21_04234
PVR: PverR02_14695
PKC: PKB_3258(amne1) PKB_3606(amne3)
PALK: PSAKL28_05950
PSOS: POS17_2260
PFK: PFAS1_28760
PSET: THL1_489
PALL: UYA_06735 UYA_06965 UYA_20140
PSEP: C4K39_5744
PPII: QL104_12010
PTRT: HU722_0015015
PTAE: NCTC10697_02308(amnE)
PHF: NLY38_02340
PPHN: HU825_04975(dmpH)
PSOA: PSm6_34030
PKJ: Q1W70_06555
PLAU: I0D68_00635(dmpH)
PSC: A458_06505
PSTU: UIB01_22755
PBM: CL52_14725
AVN: Avin_08680(xylI) Avin_30600(lapH)
AVL: AvCA_08680(xylI) AvCA_30600(lapH)
AVD: AvCA6_08680(xylI) AvCA6_30600(lapH)
ACX: Achr_32760(xylI)
HPEG: EAO82_00540(dmpH) EAO82_09440(dmpH)
HAES: LO767_17685(dmpH)
PPHA: BVH74_06170
MAD: HP15_1116 HP15_4037
MSR: AU15_09345 AU15_21065 AU15_22100
MLQ: ASQ50_09200
MSQ: BKP64_13835
MARJ: MARI_05470(tesE)
MALL: PBN92_01685(dmpH)
MSHE: MAALD49_03420 MAALD49_03890
MANP: EHN06_02460(dmpH)
SWD: Swoo_1406
SEUR: FM038_016465
TPSY: RGQ13_14535
TNN: RI845_05130
TFT: RI844_19355
LAL: AT746_01265
SALH: HMF8227_02737(hpaH)
KIM: G3T16_05370
AFUS: EYZ66_02600(dmpH)
CYQ: Q91_0511
CZA: CYCME_2100
CYY: CPC19_10500(dmpH)
BLEP: AL038_01285(dmpH)
THIS: HZT40_10620(dmpH)
TBN: TBH_C0931
HCS: FF32_08365
HBP: HPTD01_721
HAXH: J4377_02205
HABD: OM794_22355
HALK: CUU95_03815
HVN: EI420_02115
HTX: EKK97_09975
APAC: S7S_07005
MGEO: CFI10_00440(dmpH) CFI10_04975(dmpH)
MSEC: LN244_11315(dmpH)
NCU: F0U83_03060(dmpH)
NJP: NEJAP_0674
NIK: F5I99_10090(dmpH) F5I99_10505(dmpH)
AJP: AMJAP_2996
ASIM: FE240_03475(dmpH)
ZDF: AN401_14610
SINI: GT972_13735(dmpH)
GBI: PG2T_09680
NZO: SAMEA4504057_0445(mhpD)
NCI: NCTC10296_00916(xylJ_2)
NWD: H3L96_04770(dmpH)
NDU: LVJ88_00585(dmpH)
VFF: VITFI_CDS1371
VMS: LVJ82_11890
PTES: JQU52_04855(dmpH)
USU: LVJ78_03655(dmpH)
CHRO: CXB49_03845(dmpH)
CRZ: D1345_11510
CHAE: CH06BL_23590
AQS: DKK66_07205
AQL: BXU06_16890
RSO: RSp0892
RSE: F504_4325
RPU: CDC45_22075
RNC: GO999_18490
RSM: CMR15_mp10876
RPI: Rpic_4619
RPF: Rpic12D_3543
RPJ: N234_08155 N234_12210
RIN: ACS15_4682(amnE)
REH: H16_B0549(h16_B0549)
CNC: CNE_2c04950(dmpH) CNE_BB1p11980(xylI) CNE_BB1p13270(dmpH)
REU: Reut_B5500 Reut_B5692
RME: Rmet_1318(dmpH) Rmet_5210(amnE)
CBW: RR42_m1052 RR42_s2483
CCUP: BKK81_23320 BKK81_27095
CUP: BKK80_29225 BKK80_32995
CUU: BKK79_23880 BKK79_35175
COX: E0W60_03750 E0W60_07780(dmpH)
CCAX: KZ686_10010(dmpH)
CUK: KB879_20195(dmpH)
CNAN: A2G96_22775
BVI: Bcep1808_7606
BUR: Bcep18194_B2958 Bcep18194_C7643
BCJ: BCAM2123
BCEN: DM39_4831(dmpH)
BCEO: I35_6005
BMUL: NP80_3871(amnE)
BCT: GEM_5400
BCED: DM42_4990(dmpH)
BCON: NL30_24585
BDF: WI26_16000
BTEI: WS51_00575
BPSL: WS57_12150
BSTL: BBJ41_10525 BBJ41_33955
BANN: JFN94_19140(dmpH)
BARI: NLX30_35150
BAEN: L3V59_30410(dmpH)
BUG: BC1001_0834
BUQ: AC233_11180
BXE: Bxe_A1150(amnE)
BXB: DR64_3309(amnE)
BPX: BUPH_05359
BPY: Bphyt_1469
BFN: OI25_254(amnE)
PARB: CJU94_37885(dmpH) CJU94_38130(dmpH)
PTER: C2L65_38850
PBRY: NDK50_06185
PPAI: E1956_27315
PHUN: U0042_26785(dmpH)
BRH: RBRH_00201
PPK: U875_01885 U875_18215
PPNO: DA70_10725
PPNM: LV28_20330
PRB: X636_07585 X636_15900
PPUL: RO07_14670
PSPU: NA29_22520
PAPI: SG18_14500
PVE: UC34_05805
POX: MB84_10225
PFG: AB870_16830
PNR: AT302_01280
PAND: DRB87_05210
PFIB: PI93_022455
PCOM: NTU39_06715
PANN: PanNE5_04140
PANX: OYT13_05070
CABA: SBC2_61030(amnE)
LIMN: HKT17_03835(dmpH)
BHZ: ACR54_00827(amnE)
BOJ: CBF45_01485 CBF45_04495 CBF45_06950 CBF45_16995
APES: FOC84_00280 FOC84_00315(dmpH)
PUD: G9Q38_15000
AKA: TKWG_04045
AMIM: MIM_c06230
CDN: BN940_01171 BN940_04311
PIG: EGT29_19205
KGY: EHF36_01670(dmpH) EHF36_04880(dmpH) EHF36_16935
RLH: MIZ03_0647 MIZ03_1027
POL: Bpro_1513 Bpro_5137
AJS: Ajs_0225
ACID: CBP33_01120
ACIP: CBP36_01215
ACIN: CBP34_01125
ACIS: CBP35_17735
AMON: H9L24_14170(dmpH)
VEI: Veis_2784
VPD: VAPA_1c22830
VBO: CKY39_28490(dmpH)
VAV: IG196_08145(dmpH)
CTT: CtCNB1_3146
COF: FOZ74_08325(dmpH)
CRJ: QMY55_24790
ADN: Alide_0340
ADK: Alide2_0285
OTD: J1M35_00030(dmpH)
HYL: LPB072_18185
HPSE: HPF_01820(tesE2) HPF_01865(tesE3)
HYN: F9K07_02755(dmpH)
HTN: KI616_01940 KI616_01960(dmpH)
DIH: G7047_01665(dmpH) G7047_06945
DRG: H9K76_11650(dmpH) H9K76_22950
SIMP: C6571_13630(dmpH)
MELA: C6568_07845(dmpH)
MJE: LVC68_01035(dmpH)
STHM: IS481_10535(dmpH)
SAQA: OMP39_09115(dmpH)
MPT: Mpe_A2272 Mpe_A3324
METP: C1M51_06455(dmpH) C1M51_15395(dmpH)
RDP: RD2015_407
MIU: ABE85_21105
SNN: EWH46_19320(dmpH)
SMIO: CATMQ487_04100 CATMQ487_17570
IDC: LRM40_19575(dmpH)
LCH: Lcho_3342
JAG: GJA_235(dmpH)
JAJ: EKL02_01820(dmpH) EKL02_15560
HEE: hmeg3_19570
TMJ: P0M04_30670(dmpH)
RBU: PG1C_09715 PG1C_14085
AIQ: Azoinq_09670
DAR: Daro_2773 Daro_3781
DEY: HYN24_14125(dmpH) HYN24_14195(dmpH)
DDEN: KI615_16865(dmpH)
FLE: KI610_08580(dmpH) KI610_13440(dmpH) KI610_15445(dmpH)
AZO: azo1854(lapH) azo2430(nahK)
AOA: dqs_2007 dqs_2574
AZD: CDA09_10340(dmpH) CDA09_10445(dmpH)
AZR: CJ010_12255(dmpH) CJ010_15200(dmpH)
TMZ: Tmz1t_3090
THU: AC731_001825
THAU: C4PIVTH_2810(dmpH)
THK: CCZ27_10765(dmpH) CCZ27_16280(dmpH)
THAG: CKCBHOJB_03305(hpcG)
AZQ: G3580_00540(dmpH) G3580_08285(dmpH)
RLE: pRL120704
ARA: Arad_7266
BIC: LMTR13_06470
MRD: Mrad2831_4067
MET: M446_1050
MSL: Msil_1480
MTUN: MTUNDRAET4_3891(amnE)
DSAL: K1X15_13430
MAAD: AZF01_08270 AZF01_21095
MLUT: JET14_11070
ACUT: MRB58_02670
BBUL: U0030_00110
OCT: FTO60_10555
CEH: CEW89_11450
SUAM: BOO69_22210
TEC: AKL02_008260(dmpH)
NAR: Saro_3851
NPP: PP1Y_AT15722 PP1Y_AT31571
NPN: JI59_24645
NOG: GKE62_05080
NHUM: PQ457_19220
SMAG: AN936_00740
SMAZ: LH19_00750
STER: AOA14_03895
SGI: SGRAN_3551(amnE)
SPHO: C3E99_12570
SPEG: SPYCW_2518
SWI: Swit_0912 Swit_3521
SPHD: HY78_06675 HY78_22125
SPKC: KC8_11575
SJP: SJA_C1-11880(hpaH_xylI)
SINB: SIDU_08325
SYB: TZ53_09015 TZ53_23460
SHYD: CJD35_06495(dmpH)
SUFL: FIL70_19000
SBAR: H5V43_20650 H5V43_22345
SPPH: KFK14_16525
SPAG: sphantq_04471(amnE)
SPHY: CHN51_06980
SPHJ: BSL82_10450
ALTN: LBX01_05455
CNA: AB433_18115
ERY: CP97_03155 CP97_14235
KSC: CD178_01495(amnE)
NCB: C0V82_23405
MAGQ: MGMAQ_0652
GSO: PH603_12390
HTL: HPTL_0045
ACIB: ACBT_0258(dmpH)
AFC: AFAEC_1843(dmpH)
AAQI: AAQM_0983(dmpH)
ACLO: ACLO_a0138(dmpH)
ADZ: ADFLV_2550(dmpH)
ARC: ABLL_2441
AROS: NJU99_01655(dmpH)
ALK: ALEK_0384(dmpH)
AANA: AANAER_1261(dmpH)
MXA: MXAN_0925
MSD: MYSTI_00945
MYM: A176_006054
MFB: MFUL124B02_05300
MLAN: JY572_21820
CCX: COCOR_00872(dmpH)
MFU: LILAB_04080
MMAS: MYMAC_000948
PPAK: JY651_34505
SUR: STAUR_2722
AGE: AA314_01330
AVM: JQX13_18930
PCAY: FRD00_17510
BBAE: FRD01_19450
BDQ: CIK05_11235
BLI: BL03907
BLD: BLi03993(xylI)
BLH: BaLi_c40070
BSON: S101395_00392(dmpH)
BCA: BCE_2158
BCX: BCA_2156
BCF: bcf_10220
BCER: BCK_24215
BCEF: BcrFT9_01690
BTL: BALH_1845
BMYC: DJ92_4639
BTRO: FJR70_09215
BNT: GSN03_10155
BSM: BSM4216_0950
BGY: BGLY_4397
BFD: NCTC4823_00794(xylJ)
BACI: B1NLA3E_08440 B1NLA3E_09300
GST: HW35_13045
BACO: OXB_2505
BACQ: DOE78_09235
BAQU: K6959_02310
BHK: B4U37_13930
BMQ: BMQ_3586
BMD: BMD_3571
BMEG: BG04_460
BPF: BpOF4_12615
BDA: FSZ17_11250
OCN: CUC15_03685
GTN: GTNG_3150(nbaG)
GYC: GYMC61_2299
GYA: GYMC52_1427
GCT: GC56T3_2054
GMC: GY4MC1_1597
GGH: GHH_c14850
GJF: M493_17910
GEJ: A0V43_04660
GZA: IC807_03370
GTH: Geoth_1680
PTL: AOT13_14435
PCAL: BV455_00226(tesE_1)
PARG: PspKH34_14930 PspKH34_15490
ASED: IRT44_17615
LGY: T479_19640
LYB: C3943_22670
LYZ: DCE79_01760
LPAK: GDS87_20225
LYC: FH508_0003705
LLB: R6U77_10600
VIG: BKP57_09375
VNT: OLD84_14650
VIK: KFZ58_14495
LAO: AOX59_17255
FPN: ABE65_004750
FAR: ABE41_004890
APAK: AP3564_06555
ACOP: RI196_01650
BSJ: UP17_10530
PASA: BAOM_0499
PFRI: L8956_11395
RUE: DT065_12670 DT065_13795 DT065_15120 DT065_15210
SALE: EPH95_15045
NTM: BTDUT50_14545
NDT: L1999_11900 L1999_17840
NCM: QNK12_05495
NNV: QNH39_12250 QNH39_24865
AIA: AWH56_018055
ROSS: V2W31_07750
BOU: I5818_04805
GAJ: MY490_08575
HYI: K2M58_09700 K2M58_09725
BBE: BBR47_29790
BFM: BP422_09725
BCHS: JNE38_24125
BHUI: LOK74_00615
BAYD: BSPP4475_07470(dmpH)
BBOR: RFB14_22150
PNP: IJ22_00700 IJ22_32390 IJ22_48600
ANX: ACH33_11700
ASOC: CB4_02453(amnF)
ATHE: K3F53_07240
AUD: PO771_09010
ANEU: PP175_12695
COH: EAV92_02610
AAC: Aaci_1618
AAD: TC41_1514
AACO: K1I37_06165
ADAU: NZD86_00710 NZD86_06140
AFAS: NZD89_10115
ALIC: GI364_17535
BTS: Btus_0970
KYR: CVV65_10340 CVV65_11285
EFF: skT53_33780
FFE: LSG31_21080
SOB: CSE16_14625
PSHE: QWY16_07660
SPAE: E2C16_04465 E2C16_12275
SPOO: J3U78_11170
SURL: BI350_00150
AUI: APT62_01025
AVS: AWM76_09545
CARN: FPV25_04350
SAY: TPY_0643
SAP: Sulac_2996
MIT: OCO_14790
MIA: OCU_15230
MMAN: MMAN_42240
MJL: Mjls_4208
MYV: G155_08390 G155_08470
MFT: XA26_16790 XA26_16950
MLL: B1R94_25050
MHEV: MHEL_01620
MMAT: MMAGJ_45260 MMAGJ_45420
MMON: EWR22_21590
MGO: AFA91_00030
MHOL: K3U96_19110
MAUS: JN090_26255
CHN: A605_04755
CEE: CENDO_03490(amnE)
COK: COCCU_04385(amnE)
NFA: NFA_30430
NFR: ERS450000_00296(xylJ_1) ERS450000_01021(xylJ_2)
NNO: NONO_c62050
NTP: CRH09_30230
NWL: NWFMUON74_07310
RHA: RHA1_ro03880
RER: RER_04710 RER_59340
REY: O5Y_02265
REB: XU06_02465
RQI: C1M55_02650
ROP: ROP_37490 ROP_54170
RPY: Y013_12560
RBY: CEJ39_00065
RAV: AAT18_08105
RRZ: CS378_23120
RHQ: IM25_04200
RHOD: AOT96_13015
RRT: 4535765_01257(amnE)
RKO: JWS14_41315
RGO: KYT97_21980
ROZ: CBI38_22780
RPSK: JWS13_12560 JWS13_18955
RHOO: RA302_02495
RHOU: KZJ41_08670
RHOW: A4U64_16475
RHOJ: JVH1_17120 JVH1_20175 JVH1_39410
REQ: REQ_05050(amnD)
PDEF: P9209_00360
GBR: Gbro_0225
GTA: BCM27_21915
GOC: CXX93_11295
GOS: QAD21_20950
GOJ: GR168_20010
GOI: LK459_10160
GHN: MVF96_20965
GSI: P5P27_10835
DIZ: CT688_01890
TOY: FO059_00305
SANL: KZO11_33900
SCB: SCAB_15181
SSX: SACTE_4113
SRC: M271_50380
SBH: SBI_01536
STRT: A8713_24465
SVU: B1H20_29090
SGE: DWG14_08258(amnE)
SNK: CP967_06830
SSUB: CP968_28065
SPLA: CP981_35170
SCAL: I6J39_28940
SROI: IAG44_01280
STRY: EQG64_09025
SGOB: test1122_23000
SDRZ: NEH16_30290
STUD: STRTU_001643 STRTU_001677
SANT: QR300_10270
SPRF: K4G22_29945
SLUO: PS467_00410
KIT: CFP65_1237
YIA: LO772_34585
MLIY: RYJ27_00290
MAUG: KV397_17135
MSUF: KV394_04965
MVD: AWU67_16690
AGY: ATC03_02580
AMAU: DSM26151_04170(amnE)
ASOI: MTP13_01920
PSAI: C3B54_11904
SALD: FVA74_00730
LTR: EVS81_03255
HEA: HL652_17940
ACIT: HPK19_02435
ARZ: AUT26_08860
PSLS: KTR40_08350
ICA: Intca_1093
JTE: ASJ30_00110
JLI: EXU32_15355
JME: EEW87_015420
JAY: H7A72_00110
JCR: O9K63_12595
PEI: H9L10_13720
OCP: NF557_14855 NF557_15600
AUS: IPK37_11690
RAIN: Rai3103_12620
NCA: Noca_2055
NPI: G7071_16490
TCU: Tcur_0537
ACTW: F7P10_40030
AGRA: AGRA3207_000779 AGRA3207_003642
AMAZ: LUW76_22725 LUW76_47885
ACIR: OG979_20775 OG979_41955
SPIQ: OHA34_00545
SRO: Sros_9112
NGN: LCN96_28045
MHAI: OHB01_10135
FRI: FraEuI1c_1245
NML: Namu_0794
AMD: AMED_8622
AMN: RAM_44250
AMM: AMES_8491
AMZ: B737_8492
AOI: AORI_7401
AJA: AJAP_01985
AMQ: AMETH_5437
AMYC: CU254_17665 CU254_35760
AMYB: BKN51_30410
AORI: SD37_03455
AACD: LWP59_38180
APRT: MUY14_40600
AROO: NQK81_00865 NQK81_28575
ATHM: L1857_30175
ARHD: VSH64_19090 VSH64_30305 VSH64_35370
AMOG: QRX60_15530
ACYN: ORV05_22405
ACOR: LCL61_08955 LCL61_24560
PDX: Psed_2523 Psed_4292
PBRO: HOP40_26620 HOP40_31750
PPEL: H6H00_29790
PSDS: K1T35_35335
KUT: JJ691_102210 JJ691_11960
ALO: CRK56594
PMAD: BAY61_16755
ACTY: OG774_08010 OG774_09250
STP: Strop_3524
SAQ: Sare_3899
MAU: Micau_4937
MIL: ML5_3358
MICB: MicB006_3969
MTUA: CSH63_33405
MTEM: GCE86_19380
MCAB: HXZ27_25040
VMA: VAB18032_17780 VAB18032_28741
MCRA: ID554_21670 ID554_30890
VER: HUT12_13555 HUT12_26050
MENO: Jiend_41040
MCHL: PVK74_15030
MFEU: H1D33_00380
MPRN: Q3V37_13160
MHAW: RMN56_18005
MICF: QQG74_13325 QQG74_25585
PFLA: Pflav_027520
PSUU: Psuf_068140
PRY: Prubr_10590 Prubr_59260
CATI: CS0771_01260
DFU: Dfulv_27715
DACT: KZZ52_26440 KZZ52_45190
NHY: JQS43_06620
PVN: A7sIIA15_04525
JCY: M6B22_02780
BSOL: FSW04_07220
IIS: EYM_02850
 » show all
Reference
1  [PMID:1732207]
  Authors
Shingler V, Powlowski J, Marklund U
  Title
Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 174:711-24 (1992)
DOI:10.1128/JB.174.3.711-724.1992
  Sequence
[ag:CAA43228]
Reference
2  [PMID:9683650]
  Authors
Takenaka S, Murakami S, Shinke R, Aoki K
  Title
Metabolism of 2-aminophenol by Pseudomonas sp. AP-3: modified meta-cleavage pathway.
  Journal
Arch Microbiol 170:132-7 (1998)
DOI:10.1007/s002030050624
Reference
3  [PMID:10651637]
  Authors
Stanley TM, Johnson WH Jr, Burks EA, Whitman CP, Hwang CC, Cook PF
  Title
Expression and stereochemical and isotope effect studies of active 4-oxalocrotonate decarboxylase.
  Journal
Biochemistry 39:718-26 (2000)
DOI:10.1021/bi9918902
Reference
4  [PMID:17902707]
  Authors
Wang SC, Johnson WH Jr, Czerwinski RM, Stamps SL, Whitman CP
  Title
Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions.
  Journal
Biochemistry 46:11919-29 (2007)
DOI:10.1021/bi701231a
Reference
5  [PMID:19717587]
  Authors
Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E
  Title
Uncovering the protocatechuate 2,3-cleavage pathway genes.
  Journal
J Bacteriol 191:6758-68 (2009)
DOI:10.1128/JB.00840-09
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.77
IUBMB Enzyme Nomenclature: 4.1.1.77
ExPASy - ENZYME nomenclature database: 4.1.1.77
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.77
BRENDA, the Enzyme Database: 4.1.1.77
CAS: 37325-55-6
LinkDB

KEGG   REACTION: R05374
Entry
R05374                      Reaction                               
Name
2-oxo-5-methyl-cis-muconate carboxy-lyase
Definition
2-Oxo-5-methyl-cis-muconate <=> 2-Hydroxy-cis-hex-2,4-dienoate + CO2
Equation
C07479 <=> C11354 + C00011
Comment
Ref.: 1. Jounal of bacteriology Vol.177 No5 1196-1201
Ref.:2. J Bacteriol 1989 ;171(11) :6251-6258
Reaction class
RC02672  C07479_C11354
Enzyme
4.1.1.77
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.77
     R05374  2-Oxo-5-methyl-cis-muconate <=> 2-Hydroxy-cis-hex-2,4-dienoate + CO2
Orthology
K01617  2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77]
LinkDB

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