Entry Name malate synthase;
Class Transferases;BRITE hierarchy
Sysname acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming]
Reaction(IUBMB) acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA [RN:
R00472 ]
Reaction(KEGG) Substrate Product Comment The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.
History EC 2.3.3.9 created 1961 as EC 4.1.3.2, transferred 2002 to EC 2.3.3.9
Pathway ec00630 Glyoxylate and dicarboxylate metabolism
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology Genes CBR : CBG_06335(Cbr-icl-1)
CSAT : 104708740 104734409 104768574
GMX : 100782820 100813906 732628(MS)
GSJ : 114393247 114394120 114412039
PVU : PHAVU_003G209100g PHAVU_003G209200g
CCAJ : 109800058 109800100
LJA : Lj4g3v1388820.1(Lj4g3v1388820.1)
AHF : 112715245 112722218 112804858 112804894 114927283
PDUL : 117627533 117627996
CPEP : 111783058 111786505
SLY : 101263993 101267103 101267395
SPEN : 107014498 107015269 107015270
SOT : 102589458 102589788 102590117
SSTN : 125860941 125860942
CANN : 107862684 107862685
SSPL : 121783687 121787809 121805115
SMIL : 130994342 130994343 131011365 131021608 131021635
APAN : 127240909 127243181
PSOM : 113276535 113281538
DOSA : Os04t0486950-01(Os04g0486950)
TAES : 123041565 123053707 123189581
PVIR : 120641311 120682384
SMO : SELMODRAFT_169003 SELMODRAFT_229879
SCE : YIR031C(DAL7) YNL117W(MLS1)
SEUB : DI49_2810 DI49_4618
SPAO : SPAR_I01860 SPAR_N01970
NCS : NCAS_0D04890(NCAS0D04890) NCAS_0G02510(NCAS0G02510)
NDI : NDAI_0F00990(NDAI0F00990) NDAI_0F02780(NDAI0F02780)
TPF : TPHA_0F01860(TPHA0F01860)
TBL : TBLA_0B01250(TBLA0B01250)
TDL : TDEL_0B05190(TDEL0B05190)
KAF : KAFR_0B04610(KAFR0B04610)
KNG : KNAG_0D03110(KNAG0D03110) KNAG_0I02100(KNAG0I02100)
PPA : PAS_chr1-4_0459 PAS_chr4_0191
PIC : PICST_53620(MLS1.1) PICST_90814(MLS1.2)
SPAA : SPAPADRAFT_139829(MLS1) SPAPADRAFT_59277
CAL : CAALFM_C109690WA(MLS1)
YLI : YALI0D19140g YALI0E15708g
CLU : CLUG_01275 CLUG_02817
CLUS : A9F13_06g00759 A9F13_07g00110
SLB : AWJ20_1673(DAL7) AWJ20_4065(MLS1)
NTE : NEUTE1DRAFT113578(NEUTE1DRAFT_113578)
NHE : NECHADRAFT_40252 NECHADRAFT_67443
FFC : NCS54_00407400 NCS54_00637700
TRE : TRIREDRAFT_79271(acu9)
CHIG : CH63R_03681 CH63R_07554
ANG : ANI_1_320134(An15g01860)
PNO : SNOG_07548(AY508881)
ADL : AURDEDRAFT_111151 AURDEDRAFT_115689
ABP : AGABI1DRAFT123142(AGABI1DRAFT_123142)
ABV : AGABI2DRAFT188880(AGABI2DRAFT_188880)
SCM : SCHCO_02631920(SCHCODRAFT_02631920)
DDI : DDB_G0275887(masA) DDB_G0282969(masB)
DPP : DICPUDRAFT_25628 DICPUDRAFT_48509
DFA : DFA_01815(masA) DFA_08981(masB)
ACAN : ACA1_201370 ACA1_360150
PTI : PHATRDRAFT_54478(MS)
PIF : PITG_03440 PITG_03441 PITG_21117
SPAR : SPRG_02338 SPRG_07018
ECO : b2976(glcB) b4014(aceB)
ECJ : JW2943(glcB) JW3974(aceB)
ECD : ECDH10B_3152(glcB) ECDH10B_4203(aceB)
EBW : BWG_2694(glcB) BWG_3670(aceB)
EOI : ECO111_3797(glcB) ECO111_4826(aceB)
EOJ : ECO26_4076(glcB) ECO26_5118(aceB)
EOH : ECO103_3652(glcB) ECO103_4758(aceB)
ECOO : ECRM13514_3871(glcB) ECRM13514_5136(aceB)
ECOH : ECRM13516_3739(glcB) ECRM13516_4873(aceB)
ECK : EC55989_3385(glcB) EC55989_4499(aceB)
ECG : E2348C_3255(glcB) E2348C_4317(aceB)
EOK : G2583_3694(glcB) G2583_4831(aceB)
ELR : ECO55CA74_17585 ECO55CA74_23105
ECW : EcE24377A_3435(glcB) EcE24377A_4556(aceB)
EUN : UMNK88_3725(glcB) UMNK88_4858(aceB)
ENA : ECNA114_3051(glcB) ECNA114_4163(aceB)
ECOS : EC958_3361(glcB) EC958_4461(aceB)
ECV : APECO1_2462(aceB) APECO1_3451(glcB)
ECOA : APECO78_00815 APECO78_18635
ECX : EcHS_A3148(glcB) EcHS_A4248(aceB)
ECM : EcSMS35_3253(glcB) EcSMS35_4468(aceB)
ECR : ECIAI1_3117(glcB) ECIAI1_4234(aceB)
ECQ : ECED1_3618(glcB) ECED1_4721(aceB)
EUM : ECUMN_3451(glcB) ECUMN_4540(aceB)
ECT : ECIAI39_3463(glcB) ECIAI39_4400(aceB)
EOC : CE10_3501(glcB) CE10_4694(aceB)
EBR : ECB_02844(glcB) ECB_03886(aceB)
EBL : ECD_02844(glcB) ECD_03886(aceB)
EBE : B21_02794(glcB) B21_03846(aceB)
ECI : UTI89_C3392(glcB) UTI89_C4573(aceB)
EIH : ECOK1_3387(glcB) ECOK1_4491(aceB)
ECZ : ECS88_3350(glcB) ECS88_4479(aceB)
ECC : c3705(glcB) c4971(aceB)
ELO : EC042_3258(glcB) EC042_4376(aceB)
ELN : NRG857_14730 NRG857_20010
ECL : EcolC_0725 EcolC_4016
EKO : EKO11_0745 EKO11_4311
EKF : KO11_02325(aceB) KO11_07835(glcB)
EAB : ECABU_c33740(glcB) ECABU_c45300(aceB)
EDH : EcDH1_0721 EcDH1_3983
EDJ : ECDH1ME8569_2875(glcB) ECDH1ME8569_3870(aceB)
ELU : UM146_01520 UM146_20130
ELW : ECW_m3242(glcB) ECW_m4373(aceB)
ELL : WFL_15835(glcB) WFL_21260(aceB)
ELC : i14_3396(glcB) i14_4561(aceB)
ELD : i02_3396(glcB) i02_4561(aceB)
ELF : LF82_0013(aceB) LF82_0829(glcB)
ECOL : LY180_15375 LY180_21060
ECOI : ECOPMV1_03273(glcB_2) ECOPMV1_04386(aceB)
ECOJ : P423_16785 P423_22240
EAL : EAKF1_ch1906c(aceB) EAKF1_ch2980
ESZ : FEM44_05900(glcB) FEM44_11805(aceB)
ERUY : OSH18_14405(aceB) OSH18_16720(glcB)
SFT : NCTC1_03265(glcB) NCTC1_04433(aceB_2)
SHQ : A0259_01660 A0259_18580
RTG : NCTC13098_06912(aceB_2)
REE : electrica_04793(aceB)
CLAP : NCTC11466_04328(aceB)
KIE : NCTC12125_03488(aceB)
AHN : NCTC12129_04635(aceB)
PSHI : SAMEA2665130_0551(aceB)
YPG : YpAngola_A0639(aceB)
YPI : YpsIP31758_0294(aceB)
SMW : SMWW4_v1c44660(aceB)
SFG : AV650_00955 AV650_27795
SFJ : SAMEA4384070_4463(aceB)
SOF : NCTC11214_02113(aceB_1)
PAQU : DMB82_0018075(aceB)
DIC : Dpoa569_000445(aceB)
PHEI : NCTC12003_00426(aceB)
PRJ : NCTC6933_00494(aceB_2)
ANS : ArsFIN_40630(aceB_1)
XFU : XFF4834R_chr02290(aceB)
XPH : XppCFBP6546_10615(XppCFBP6546P_10615)
XHD : LMG31886_02770(aceB)
LLZ : LYB30171_02493(aceB)
VVU : VV1_0450(aceB) VV2_1647
VVM : VVMO6_02453 VVMO6_03414
VVL : VV93_v1c06870 VV93_v1c34410
VPK : M636_00340 M636_18900
VPF : M634_04815 M634_19195
VPH : VPUCM_0569 VPUCM_20194
VHA : VIBHAR_01041 VIBHAR_06695
VCA : M892_07700 M892_18990
VEX : VEA_000798 VEA_004372
VDB : AL552_02245 AL552_11265
VHR : AL538_12275 AL538_20735
VNI : VIBNI_A1520(glcB) VIBNI_B1440(aceB)
LAG : N175_11785 N175_16205
VAU : VANGNB10_cI0652(aceB) VANGNB10_cII0875c
VCY : IX92_02540 IX92_16170
VCT : JV59_22965 JV59_36165
VTU : IX91_03270 IX91_23460
VEU : IXK98_04220 IXK98_11825
VSH : BSZ05_13395 BSZ05_18540 BSZ05_18905
VNL : D3H41_02800 D3H41_21610
VCC : FAZ90_17385 FAZ90_19600 FAZ90_19675
VAS : GT360_11265 GT360_21090
VSR : Vspart_00734(aceB) Vspart_04397(glcB)
VKA : BTD91_15685 BTD91_16615 BTD91_18360 BTD91_18435
VGI : MID13_17110 MID13_17185 MID13_22880(aceB)
VSL : LTQ54_17675(aceB) LTQ54_18655 LTQ54_23070
VPL : SA104470976_01994(aceB)
VJP : NP165_10110(aceB) NP165_14010 NP165_14035
VPG : LZI70_14300(aceB) LZI70_14965 LZI70_18340 LZI70_18345
VOS : KNV97_03735 KNV97_15145(aceB)
VCRA : IS519_18910 IS519_18985 IS519_23585 IS519_24955
VLE : ISX51_15850(aceB) ISX51_16690 ISX51_16765 ISX51_20915
VSY : K08M4_32420(glcB_1) K08M4_32440(glcB_2) K08M4_33010(glcB_3)
VFI : VF_1973(aceB) VF_A0257
PPR : PBPRA0737(C4971) PBPRA2276(ACEB)
PGH : FH974_12460 FH974_18540
GKD : K6Q96_13620(aceB) K6Q96_20095(aceB)
