Entry
Name
malate synthase;
L-malate glyoxylate-lyase (CoA-acetylating);
glyoxylate transacetylase;
glyoxylate transacetase;
glyoxylic transacetase;
malate condensing enzyme;
malate synthetase;
malic synthetase;
malic-condensing enzyme;
acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming]
Reaction(IUBMB)
acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA [RN:
R00472 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.
History
EC 2.3.3.9 created 1961 as EC 4.1.3.2, transferred 2002 to EC 2.3.3.9
Pathway
ec00630 Glyoxylate and dicarboxylate metabolism
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
Genes
CBR : CBG_06335(Cbr-icl-1)
CSAT : 104708740 104734409 104768574
GMX : 100782820 100813906 732628(MS)
GSJ : 114393247 114394120 114412039
PVU : PHAVU_003G209100g PHAVU_003G209200g
CCAJ : 109800058 109800100
LJA : Lj4g3v1388820.1(Lj4g3v1388820.1)
AHF : 112715245 112722218 112804858 112804894 114927283
PDUL : 117627533 117627996
CPEP : 111783058 111786505
QSU : 111989934 112000584 112013364
SLY : 101263993 101267103 101267395
SPEN : 107014498 107015269 107015270
SOT : 102589458 102589788 102590117
CANN : 107862684 107862685
SSPL : 121783687 121787809 121805115
PSOM : 113276535 113281538
DOSA : Os04t0486950-01(Os04g0486950)
TAES : 123041565 123053707 123189581
PVIR : 120641311 120682384
SMO : SELMODRAFT_169003 SELMODRAFT_229879
SCE : YIR031C(DAL7) YNL117W(MLS1)
NCS : NCAS_0D04890(NCAS0D04890) NCAS_0G02510(NCAS0G02510)
NDI : NDAI_0F00990(NDAI0F00990) NDAI_0F02780(NDAI0F02780)
TPF : TPHA_0F01860(TPHA0F01860)
TBL : TBLA_0B01250(TBLA0B01250)
TDL : TDEL_0B05190(TDEL0B05190)
KAF : KAFR_0B04610(KAFR0B04610)
PPA : PAS_chr1-4_0459 PAS_chr4_0191
PIC : PICST_53620(MLS1.1) PICST_90814(MLS1.2)
SPAA : SPAPADRAFT_139829(MLS1) SPAPADRAFT_59277
CAL : CAALFM_C109690WA(MLS1)
YLI : YALI0D19140g YALI0E15708g
CLU : CLUG_01275 CLUG_02817
CLUS : A9F13_06g00759 A9F13_07g00110
SLB : AWJ20_1673(DAL7) AWJ20_4065(MLS1)
NTE : NEUTE1DRAFT113578(NEUTE1DRAFT_113578)
NHE : NECHADRAFT_40252 NECHADRAFT_67443
TRE : TRIREDRAFT_79271(acu9)
ANG : ANI_1_320134(An15g01860)
PNO : SNOG_07548(AY508881)
ADL : AURDEDRAFT_111151 AURDEDRAFT_115689
ABP : AGABI1DRAFT123142(AGABI1DRAFT_123142)
ABV : AGABI2DRAFT188880(AGABI2DRAFT_188880)
DDI : DDB_G0275887(masA) DDB_G0282969(masB)
DPP : DICPUDRAFT_25628 DICPUDRAFT_48509
DFA : DFA_01815(masA) DFA_08981(masB)
ACAN : ACA1_201370 ACA1_360150
PTI : PHATRDRAFT_54478(MS)
PIF : PITG_03440 PITG_03441 PITG_21117
SPAR : SPRG_02338 SPRG_07018
ECO : b2976(glcB) b4014(aceB)
ECJ : JW2943(glcB) JW3974(aceB)
ECD : ECDH10B_3152(glcB) ECDH10B_4203(aceB)
EBW : BWG_2694(glcB) BWG_3670(aceB)
EOI : ECO111_3797(glcB) ECO111_4826(aceB)
EOJ : ECO26_4076(glcB) ECO26_5118(aceB)
EOH : ECO103_3652(glcB) ECO103_4758(aceB)
ECOO : ECRM13514_3871(glcB) ECRM13514_5136(aceB)
ECOH : ECRM13516_3739(glcB) ECRM13516_4873(aceB)
ECK : EC55989_3385(glcB) EC55989_4499(aceB)
ECG : E2348C_3255(glcB) E2348C_4317(aceB)
EOK : G2583_3694(glcB) G2583_4831(aceB)
ELR : ECO55CA74_17585 ECO55CA74_23105
ECW : EcE24377A_3435(glcB) EcE24377A_4556(aceB)
EUN : UMNK88_3725(glcB) UMNK88_4858(aceB)
ENA : ECNA114_3051(glcB) ECNA114_4163(aceB)
ECOS : EC958_3361(glcB) EC958_4461(aceB)
ECV : APECO1_2462(aceB) APECO1_3451(glcB)
ECOA : APECO78_00815 APECO78_18635
ECX : EcHS_A3148(glcB) EcHS_A4248(aceB)
ECM : EcSMS35_3253(glcB) EcSMS35_4468(aceB)
ECR : ECIAI1_3117(glcB) ECIAI1_4234(aceB)
ECQ : ECED1_3618(glcB) ECED1_4721(aceB)
EUM : ECUMN_3451(glcB) ECUMN_4540(aceB)
ECT : ECIAI39_3463(glcB) ECIAI39_4400(aceB)
EOC : CE10_3501(glcB) CE10_4694(aceB)
EBR : ECB_02844(glcB) ECB_03886(aceB)
EBL : ECD_02844(glcB) ECD_03886(aceB)
EBE : B21_02794(glcB) B21_03846(aceB)
ECI : UTI89_C3392(glcB) UTI89_C4573(aceB)
EIH : ECOK1_3387(glcB) ECOK1_4491(aceB)
ECZ : ECS88_3350(glcB) ECS88_4479(aceB)
ECC : c3705(glcB) c4971(aceB)
ELO : EC042_3258(glcB) EC042_4376(aceB)
ELN : NRG857_14730 NRG857_20010
ECL : EcolC_0725 EcolC_4016
EKO : EKO11_0745 EKO11_4311
EKF : KO11_02325(aceB) KO11_07835(glcB)
EAB : ECABU_c33740(glcB) ECABU_c45300(aceB)
EDH : EcDH1_0721 EcDH1_3983
EDJ : ECDH1ME8569_2875(glcB) ECDH1ME8569_3870(aceB)
ELU : UM146_01520 UM146_20130
ELW : ECW_m3242(glcB) ECW_m4373(aceB)
ELL : WFL_15835(glcB) WFL_21260(aceB)
ELC : i14_3396(glcB) i14_4561(aceB)
ELD : i02_3396(glcB) i02_4561(aceB)
ELF : LF82_0013(aceB) LF82_0829(glcB)
ECOL : LY180_15375 LY180_21060
ECOI : ECOPMV1_03273(glcB_2) ECOPMV1_04386(aceB)
ECOJ : P423_16785 P423_22240
EAL : EAKF1_ch1906c(aceB) EAKF1_ch2980
ESZ : FEM44_05900(glcB) FEM44_11805(aceB)
SFT : NCTC1_03265(glcB) NCTC1_04433(aceB_2)
SHQ : A0259_01660 A0259_18580
RTG : NCTC13098_06912(aceB_2)
REE : electrica_04793(aceB)
CLAP : NCTC11466_04328(aceB)
KIE : NCTC12125_03488(aceB)
AHN : NCTC12129_04635(aceB)
PSHI : SAMEA2665130_0551(aceB)
YPG : YpAngola_A0639(aceB)
YPI : YpsIP31758_0294(aceB)
SMW : SMWW4_v1c44660(aceB)
SFG : AV650_00955 AV650_27795
SFJ : SAMEA4384070_4463(aceB)
SOF : NCTC11214_02113(aceB_1)
PAQU : DMB82_0018075(aceB)
DIC : Dpoa569_000445(aceB)
PHEI : NCTC12003_00426(aceB)
PRJ : NCTC6933_00494(aceB_2)
ANS : ArsFIN_40630(aceB_1)
XFU : XFF4834R_chr02290(aceB)
XPH : XppCFBP6546_10615(XppCFBP6546P_10615)
XHD : LMG31886_02770(aceB)
VVU : VV1_0450(aceB) VV2_1647
VVM : VVMO6_02453 VVMO6_03414
VVL : VV93_v1c06870 VV93_v1c34410
VPK : M636_00340 M636_18900
VPF : M634_04815 M634_19195
VPH : VPUCM_0569 VPUCM_20194
VHA : VIBHAR_01041 VIBHAR_06695
VCA : M892_07700 M892_18990
VEX : VEA_000798 VEA_004372
VDB : AL552_02245 AL552_11265
VHR : AL538_12275 AL538_20735
VNI : VIBNI_A1520(glcB) VIBNI_B1440(aceB)
LAG : N175_11785 N175_16205
VAU : VANGNB10_cI0652(aceB) VANGNB10_cII0875c
VCY : IX92_02540 IX92_16170
VCT : JV59_22965 JV59_36165
VTU : IX91_03270 IX91_23460
VEU : IXK98_02030 IXK98_04220 IXK98_11825
VSH : BSZ05_13395 BSZ05_18540 BSZ05_18905
VNL : D3H41_02800 D3H41_21610
VCC : FAZ90_17385 FAZ90_19600 FAZ90_19675
VAS : GT360_11265 GT360_21090
VAQ : FIV01_02945(aceB) FIV01_17265(glcB)
VSR : Vspart_00734(aceB) Vspart_04397(glcB)
VKA : BTD91_15685 BTD91_16615 BTD91_18360 BTD91_18435
VFI : VF_1973(aceB) VF_A0257
PPR : PBPRA0737(C4971) PBPRA2276(ACEB)
PGH : FH974_12460 FH974_18540
PAEB : NCGM1900_0494(glcB)
PAEU : BN889_00559(glcB_2)
PRE : PCA10_04650(glcB) PCA10_27940(glcB)
PPSE : BN5_0124(glcB1) BN5_3925(glcB3)
PCQ : PcP3B5_06210(glcB_1) PcP3B5_60800(glcB_2)
PPW : PputW619_2302 PputW619_4846
PPT : PPS_0352 PPS_3217 PPS_3378
PPUH : B479_02260 B479_15995
PPUT : L483_01820 L483_19615
PPUN : PP4_03870(glcB) PP4_20400(glcB)
PPUD : DW66_0366 DW66_3488
PMON : X969_00085 X969_15485
PMOT : X970_00085 X970_15130
PPJ : RK21_01421 RK21_04662
PST : PSPTO_0480(glcB-1) PSPTO_3559(glcB-2)
PSYR : N018_02305 N018_16735
PCI : PCH70_32280 PCH70_47500
PAVL : BKM03_02725 BKM03_11415
PVD : CFBP1590_0551(glcB1) CFBP1590__3441(glcB2)
PCAB : JGS08_01635 JGS08_10240
PPRC : PFLCHA0_c56510(glcB)
PFW : PF1751_v1c50490(glcB)
PSZ : PSTAB_0466 PSTAB_3856
PSR : PSTAA_0488 PSTAA_4023
PSC : A458_01835 A458_19205
PSJ : PSJM300_01945 PSJM300_17475
PSH : Psest_0354 Psest_3837
PSTU : UIB01_01750 UIB01_19425
PSTT : CH92_01815 CH92_19435
PCHL : LLJ08_01805 LLJ08_18440
PBM : CL52_02010 CL52_18700
PLUL : FOB45_26825 FOB45_27045
PPUU : PputUW4_04990(glcB)
PSES : PSCI_1301 PSCI_3579
PSIL : PMA3_16665 PMA3_27810
PSED : DM292_16525 DM292_21020
PALL : UYA_00870 UYA_21840
PGG : FX982_01158 FX982_03237
PSEJ : HNQ25_00580 HNQ25_04180
PKH : JLK41_00825 JLK41_22390
PTY : JWV26_07530 JWV26_11210
PMAO : PMYSY11_3878(glcB) PMYSY11_4369(glcB)
PVW : HU752_013635 HU752_029930
PQI : KH389_16990 KH389_24885
PANH : HU763_001650 HU763_010470
PFAK : KSS94_02055 KSS94_12240
PWZ : J7655_01430 J7655_19365
PTW : TUM18999_06720(glcB)
PTAE : NCTC10697_00415(glcB) NCTC10697_01919(glcB-2)
AVN : Avin_05920(glcB) Avin_43290(glcB)
AVL : AvCA_05920(glcB) AvCA_43290(glcB2)
AVD : AvCA6_05920(glcB) AvCA6_43290(glcB2)
HPEG : EAO82_16390 EAO82_19260
PSYC : DABAL43B_2158(glcB)
ATN : FM020_05740 FM020_09195
MCAT : MC25239_01547(glcB)
MCUN : NCTC10297_00214(glcB)
SON : SO_1483(aceB) SO_4706
SPSW : Sps_00767 Sps_03850 Sps_03945
SLJ : EGC82_05240 EGC82_07230
SPOL : FH971_03650 FH971_14520
SCAA : TUM17387_26340(aceB)
SPSH : FM037_09260(aceB) FM037_13025
SEUR : FM038_011485 FM038_012780 FM038_016250
SGLA : FJ709_03310 FJ709_13485
SINV : K8B83_06235 K8B83_08675(aceB)
CPS : CPS_1228(glcB) CPS_4874
COM : CMT41_04915 CMT41_17575
COZ : A3Q34_01660 A3Q34_13635
COLW : A3Q33_04900 A3Q33_19605
COLA : DBO93_08345 DBO93_15455
CBER : B5D82_01225 B5D82_17175 B5D82_18875
PSEN : PNC201_19665(glcB2)
PSYM : J1N51_07390 J1N51_11235
SALH : HMF8227_00785(aceB)
KIM : G3T16_05655 G3T16_15770
LWA : SAMEA4504053_1448(aceB)
TNI : TVNIR_2240(glcB_[H])
WOC : BA177_08980 BA177_12260
GAI : IMCC3135_23135(glcB_3)
MARS : A8C75_01825 A8C75_12400
MSEC : LN244_01385 LN244_04625
RFO : REIFOR_01341 REIFOR_01755
AEL : NCTC12917_02749(aceB)
SEDS : AAY24_00990 AAY24_10830
NWE : SAMEA3174300_1199(glcB)
NZO : SAMEA4504057_0736(glcB)
NCI : NCTC10296_01206(glcB)
NANI : NCTC12227_01283(glcB)
VOG : LCH97_01920 LCH97_08885(aceB)
BMV : BMASAVP1_A2092(aceB)
BML : BMA10229_A3220(aceB)